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Q29HG0

- PGAM5_DROPS

UniProt

Q29HG0 - PGAM5_DROPS

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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene
Pgam5, GA13269
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene namesi
Name:Pgam5
ORF Names:GA13269
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0073306. Dpse\GA13269.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000288790Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1 By similarity.

Protein-protein interaction databases

STRINGi7237.FBpp0282923.

Structurei

3D structure databases

ProteinModelPortaliQ29HG0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71348.
InParanoidiQ29HG0.
KOiK15637.
OMAiDTGFMPV.
OrthoDBiEOG7966H1.
PhylomeDBiQ29HG0.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29HG0-1 [UniParc]FASTAAdd to Basket

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MRKFTAFACG TGAGLLTFYL TKLNEPKAAV HNSWTRSEKP VDPCALWDHN    50
WDLRDPKSLV KPVKNDLSQE QNRYNSELEK VVPKHARHII LIRHGEYLDV 100
GDTDETHHLT ERGREQAKYT GKRLCELGIK WDKVIASTMV RAQETADIIL 150
NEIDYEKAKV KNCAFLREGA PIPPQPPVGH WKPEASQFFR DGARIEAAFR 200
RYFYRAYPDQ TKDSYTLLVG HGNVIRYFVC RALQFPPEAW LRISINHASI 250
TWLTISPSGN VSIKYLGDTG FMPVNHLTNR IPRAAKNVV 289
Length:289
Mass (Da):33,069
Last modified:April 4, 2006 - v1
Checksum:i7F67EB09A3BFC81B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379064 Genomic DNA. Translation: EAL31798.1.
RefSeqiXP_001354743.1. XM_001354707.2.

Genome annotation databases

EnsemblMetazoaiFBtr0284485; FBpp0282923; FBgn0073306.
GeneIDi4815173.
KEGGidpo:Dpse_GA13269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379064 Genomic DNA. Translation: EAL31798.1 .
RefSeqi XP_001354743.1. XM_001354707.2.

3D structure databases

ProteinModelPortali Q29HG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0282923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0284485 ; FBpp0282923 ; FBgn0073306 .
GeneIDi 4815173.
KEGGi dpo:Dpse_GA13269.

Organism-specific databases

FlyBasei FBgn0073306. Dpse\GA13269.

Phylogenomic databases

eggNOGi NOG71348.
InParanoidi Q29HG0.
KOi K15637.
OMAi DTGFMPV.
OrthoDBi EOG7966H1.
PhylomeDBi Q29HG0.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiPGAM5_DROPS
AccessioniPrimary (citable) accession number: Q29HG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi