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Q29HG0

- PGAM5_DROPS

UniProt

Q29HG0 - PGAM5_DROPS

Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5 homolog
    Gene namesi
    Name:Pgam5
    ORF Names:GA13269
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0073306. Dpse\GA13269.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000288790Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with Pk92B/ASK1.By similarity

    Protein-protein interaction databases

    STRINGi7237.FBpp0282923.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29HG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71348.
    InParanoidiQ29HG0.
    KOiK15637.
    OMAiDTGFMPV.
    OrthoDBiEOG7966H1.
    PhylomeDBiQ29HG0.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q29HG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKFTAFACG TGAGLLTFYL TKLNEPKAAV HNSWTRSEKP VDPCALWDHN    50
    WDLRDPKSLV KPVKNDLSQE QNRYNSELEK VVPKHARHII LIRHGEYLDV 100
    GDTDETHHLT ERGREQAKYT GKRLCELGIK WDKVIASTMV RAQETADIIL 150
    NEIDYEKAKV KNCAFLREGA PIPPQPPVGH WKPEASQFFR DGARIEAAFR 200
    RYFYRAYPDQ TKDSYTLLVG HGNVIRYFVC RALQFPPEAW LRISINHASI 250
    TWLTISPSGN VSIKYLGDTG FMPVNHLTNR IPRAAKNVV 289
    Length:289
    Mass (Da):33,069
    Last modified:April 4, 2006 - v1
    Checksum:i7F67EB09A3BFC81B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379064 Genomic DNA. Translation: EAL31798.1.
    RefSeqiXP_001354743.1. XM_001354707.2.

    Genome annotation databases

    EnsemblMetazoaiFBtr0284485; FBpp0282923; FBgn0073306.
    GeneIDi4815173.
    KEGGidpo:Dpse_GA13269.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379064 Genomic DNA. Translation: EAL31798.1 .
    RefSeqi XP_001354743.1. XM_001354707.2.

    3D structure databases

    ProteinModelPortali Q29HG0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0282923.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0284485 ; FBpp0282923 ; FBgn0073306 .
    GeneIDi 4815173.
    KEGGi dpo:Dpse_GA13269.

    Organism-specific databases

    FlyBasei FBgn0073306. Dpse\GA13269.

    Phylogenomic databases

    eggNOGi NOG71348.
    InParanoidi Q29HG0.
    KOi K15637.
    OMAi DTGFMPV.
    OrthoDBi EOG7966H1.
    PhylomeDBi Q29HG0.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiPGAM5_DROPS
    AccessioniPrimary (citable) accession number: Q29HG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3