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Q29HG0 (PGAM5_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene names
Name:Pgam5
ORF Names:GA13269
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with Pk92B/ASK1 By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000288790

Regions

Transmembrane7 – 2317Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q29HG0 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 7F67EB09A3BFC81B

FASTA28933,069
        10         20         30         40         50         60 
MRKFTAFACG TGAGLLTFYL TKLNEPKAAV HNSWTRSEKP VDPCALWDHN WDLRDPKSLV 

        70         80         90        100        110        120 
KPVKNDLSQE QNRYNSELEK VVPKHARHII LIRHGEYLDV GDTDETHHLT ERGREQAKYT 

       130        140        150        160        170        180 
GKRLCELGIK WDKVIASTMV RAQETADIIL NEIDYEKAKV KNCAFLREGA PIPPQPPVGH 

       190        200        210        220        230        240 
WKPEASQFFR DGARIEAAFR RYFYRAYPDQ TKDSYTLLVG HGNVIRYFVC RALQFPPEAW 

       250        260        270        280 
LRISINHASI TWLTISPSGN VSIKYLGDTG FMPVNHLTNR IPRAAKNVV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH379064 Genomic DNA. Translation: EAL31798.1.
RefSeqXP_001354743.1. XM_001354707.2.

3D structure databases

ProteinModelPortalQ29HG0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0282923.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0284485; FBpp0282923; FBgn0073306.
GeneID4815173.
KEGGdpo:Dpse_GA13269.

Organism-specific databases

FlyBaseFBgn0073306. Dpse\GA13269.

Phylogenomic databases

eggNOGNOG71348.
InParanoidQ29HG0.
KOK15637.
OMADTGFMPV.
OrthoDBEOG7966H1.
PhylomeDBQ29HG0.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGAM5_DROPS
AccessionPrimary (citable) accession number: Q29HG0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase