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Protein

Moesin/ezrin/radixin homolog 1

Gene

Moe

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in connections of major cytoskeletal structures to the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Moesin/ezrin/radixin homolog 1By similarity
Gene namesi
Name:MoeBy similarity
ORF Names:GA10507
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0070564 Dpse\GA10507

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003550951 – 593Moesin/ezrin/radixin homolog 1Add BLAST593

Proteomic databases

PRIDEiQ29GR8

Interactioni

Subunit structurei

Interacts with Mer and arm at the adherens junction. Interacts with cytoskeletal actin at apical buds of microvilli in the precellularised embryo (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ29GR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 314FERMPROSITE-ProRule annotationAdd BLAST291

Phylogenomic databases

InParanoidiQ29GR8

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.1020, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR011174 ERM
IPR011259 ERM_C_dom
IPR000798 Ez/rad/moesin-like
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR008954 Moesin_tail_sf
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00769 ERM, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PIRSFiPIRSF002305 ERM, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF48678 SSF48678, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q29GR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVVSDSRVR MPRYGGVSVK RKTLNVRVTT MDAELEFAIQ STTTGKQLFD
60 70 80 90 100
QVVKTIGLRE VWFFGLQYTD SKGDSTWIKL YKKVMNQDVK KENPLQFRFR
110 120 130 140 150
AKFYPEDVAE ELIQDITLRL FYLQVKNAIL TDEIYCPPET SVLLASYAVQ
160 170 180 190 200
ARHGDHNKTT HTAGFLANDR LLPQRVIDQH KMSKDEWEQS IMTWWQEHRS
210 220 230 240 250
MLREDAMMEY LKIAQDLEMY GVNYFEIRNK KGTDLWLGVD ALGLNIYEQD
260 270 280 290 300
DRLTPKIGFP WSEIRNISFS EKKFIIKPID KKAPDFMFFA PRVRINKRIL
310 320 330 340 350
ALCMGNHELY MRRRKPDTID VQQMKAQARE EKNAKQQERE KLQLALAARE
360 370 380 390 400
RAEKKQQEYE DRLKQMQEEM ERSQRDLLEA QEMIRRLEEQ LKQLQAAKDE
410 420 430 440 450
LELRQKELQS MLQRLEEAKN MEAVEKIKLE EEIMAKQMEV QRIQDEVNAK
460 470 480 490 500
DEETKRLQDE VEEARRKQAE AAAALLAAST TPQHHHVAED ENENEEELTN
510 520 530 540 550
GDAGGDVSRD LDTDEHIKDP IEDRRTLAER NERLHDQLKA LKQDLAQSRD
560 570 580 590
ETKETANDKI HRENVRQGRD KYKTLREIRK GNTKRRVDQF ENM
Length:593
Mass (Da):69,991
Last modified:December 16, 2008 - v3
Checksum:i4850FF531FBAAF28
GO

Sequence cautioni

The sequence EAL32041 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA Translation: EAL32041.2 Sequence problems.
RefSeqiXP_001354985.2, XM_001354949.3
XP_015041867.1, XM_015186381.1

Genome annotation databases

EnsemblMetazoaiFBtr0372580; FBpp0334538; FBgn0070564
GeneIDi4815377
KEGGidpo:Dpse_GA10507

Similar proteinsi

Entry informationi

Entry nameiMOEH_DROPS
AccessioniPrimary (citable) accession number: Q29GR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health