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Protein

Moesin/ezrin/radixin homolog 1

Gene

Moe

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in connections of major cytoskeletal structures to the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Moesin/ezrin/radixin homolog 1By similarity
Gene namesi
Name:MoeBy similarity
ORF Names:GA10507
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0070564. Dpse\GA10507.

Subcellular locationi

  • Cell junctionadherens junction By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Moesin/ezrin/radixin homolog 1PRO_0000355095Add
BLAST

Proteomic databases

PRIDEiQ29GR8.

Interactioni

Subunit structurei

Interacts with Mer and arm at the adherens junction. Interacts with cytoskeletal actin at apical buds of microvilli in the precellularised embryo (By similarity).By similarity

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 314291FERMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ29GR8.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29GR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVVSDSRVR MPRYGGVSVK RKTLNVRVTT MDAELEFAIQ STTTGKQLFD
60 70 80 90 100
QVVKTIGLRE VWFFGLQYTD SKGDSTWIKL YKKVMNQDVK KENPLQFRFR
110 120 130 140 150
AKFYPEDVAE ELIQDITLRL FYLQVKNAIL TDEIYCPPET SVLLASYAVQ
160 170 180 190 200
ARHGDHNKTT HTAGFLANDR LLPQRVIDQH KMSKDEWEQS IMTWWQEHRS
210 220 230 240 250
MLREDAMMEY LKIAQDLEMY GVNYFEIRNK KGTDLWLGVD ALGLNIYEQD
260 270 280 290 300
DRLTPKIGFP WSEIRNISFS EKKFIIKPID KKAPDFMFFA PRVRINKRIL
310 320 330 340 350
ALCMGNHELY MRRRKPDTID VQQMKAQARE EKNAKQQERE KLQLALAARE
360 370 380 390 400
RAEKKQQEYE DRLKQMQEEM ERSQRDLLEA QEMIRRLEEQ LKQLQAAKDE
410 420 430 440 450
LELRQKELQS MLQRLEEAKN MEAVEKIKLE EEIMAKQMEV QRIQDEVNAK
460 470 480 490 500
DEETKRLQDE VEEARRKQAE AAAALLAAST TPQHHHVAED ENENEEELTN
510 520 530 540 550
GDAGGDVSRD LDTDEHIKDP IEDRRTLAER NERLHDQLKA LKQDLAQSRD
560 570 580 590
ETKETANDKI HRENVRQGRD KYKTLREIRK GNTKRRVDQF ENM
Length:593
Mass (Da):69,991
Last modified:December 16, 2008 - v3
Checksum:i4850FF531FBAAF28
GO

Sequence cautioni

The sequence EAL32041 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA. Translation: EAL32041.2. Sequence problems.
RefSeqiXP_001354985.2. XM_001354949.3.
XP_015041867.1. XM_015186381.1.

Genome annotation databases

GeneIDi4815377.
KEGGidpo:Dpse_GA10507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA. Translation: EAL32041.2. Sequence problems.
RefSeqiXP_001354985.2. XM_001354949.3.
XP_015041867.1. XM_015186381.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ29GR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4815377.
KEGGidpo:Dpse_GA10507.

Organism-specific databases

FlyBaseiFBgn0070564. Dpse\GA10507.

Phylogenomic databases

InParanoidiQ29GR8.

Miscellaneous databases

ChiTaRSiMoe. fly.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOEH_DROPS
AccessioniPrimary (citable) accession number: Q29GR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.