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Protein

Hexokinase

Gene

Dpse\GA15574

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Dpse\GA15574Imported
ORF Names:Dpse_GA15574Imported, GA15574Imported
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)Imported
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0075591. Dpse\GA15574.

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0275793.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

InParanoidiQ29GH0.
KOiK00844.
OMAiIKPGITF.
OrthoDBiEOG7S21X5.
PhylomeDBiQ29GH0.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29GH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQELNGAMR SVSINSNGLA ATPHLNGHSK DEPDNVRRVA AEGALSASAS
60 70 80 90 100
DAASAVSKAT NASTAAAAAR AIPAAASFAS TATEAASLSG LAGASDAEKK
110 120 130 140 150
KMVHELCQQL LLTDEQVQEL CYRILHEIRR GLAKDTHPKA NVKCFVTYVQ
160 170 180 190 200
DLPNGDERGK FLALDLGGTN FRVLLIHLQE NNDFQMESRI YAIPQHIMIG
210 220 230 240 250
SGTQLFDHIA ECLSNFMAEH NVYAERLPLG FTFSFPLRQL GLTCGLLETW
260 270 280 290 300
TKGFNCAGVV NEDVVQLLKD AIARRGDVQI DVCAILNDTT GTLMSCAWKN
310 320 330 340 350
HHCRIGLIVG TGSNACYVER VEEAELFDAQ GNRKPHVLIN TEWGAFGDNG
360 370 380 390 400
ALDFVRTEFD QDIDSHSINP GKQTFEKMIS GMYMGELVRL VLVKMTHAGI
410 420 430 440 450
LFKGQDSEVL NTRGLFFTKY VSEIEADEPG TFTNCRLVFE ELGLTNATDG
460 470 480 490 500
DCANVRYICE CVSKRAAHLV SAGIATLINK MDEPHVTVGV DGSVYRFHPK
510 520 530 540
FHNLMVEKIT KLIKPGITFD LMLSEDGSGR GAALVAAVAC REDIVNSKK
Length:549
Mass (Da):59,702
Last modified:April 4, 2006 - v1
Checksum:i43C02C169A8E7D14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA. Translation: EAL32139.1.
RefSeqiXP_001355083.1. XM_001355047.2.

Genome annotation databases

EnsemblMetazoaiFBtr0277355; FBpp0275793; FBgn0075591.
GeneIDi4815359.
KEGGidpo:Dpse_GA15574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA. Translation: EAL32139.1.
RefSeqiXP_001355083.1. XM_001355047.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7237.FBpp0275793.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0277355; FBpp0275793; FBgn0075591.
GeneIDi4815359.
KEGGidpo:Dpse_GA15574.

Organism-specific databases

FlyBaseiFBgn0075591. Dpse\GA15574.

Phylogenomic databases

InParanoidiQ29GH0.
KOiK00844.
OMAiIKPGITF.
OrthoDBiEOG7S21X5.
PhylomeDBiQ29GH0.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94Imported.
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25Imported.

Entry informationi

Entry nameiQ29GH0_DROPS
AccessioniPrimary (citable) accession number: Q29GH0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: April 29, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.