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Q29FS9 (Q29FS9_DROPS) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:GA17642 FlyBase FBgn0077653
Synonyms:Dpse\GA17642 EMBL EAL31500.1
ORF Names:Dpse_GA17642 EMBL EAL31500.1
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 166NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding34 – 363NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding76 – 783NADP By similarity PIRSR PIRSR000109-3
Region130 – 1323Substrate binding By similarity PIRSR PIRSR000109-2
Region187 – 1882Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1841Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1911Proton donor By similarity PIRSR PIRSR000109-1
Binding site1041NADP By similarity PIRSR PIRSR000109-3
Binding site1041Substrate By similarity PIRSR PIRSR000109-2
Binding site1921Substrate By similarity PIRSR PIRSR000109-2
Binding site2591Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2861Substrate By similarity PIRSR PIRSR000109-2
Binding site4451Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4511Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q29FS9 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 50373C5537048EE7

FASTA48152,533
        10         20         30         40         50         60 
MSGKADIALI GLAVMGQNLI LNMDEKGFVV CAYNRTVAKV KEFLANEAKG TNVIGAESLK 

        70         80         90        100        110        120 
DMVEKLKTPR KIMLLVKAGS AVDDFIEQLV PLLSRGDVII DGGNSEYQDT SRRCAELEKL 

       130        140        150        160        170        180 
GLLFVGSGVS GGEEGARHGP SLMPGGHEAA WPLIKPIFQA ICAKADGEPC CEWVGDGGAG 

       190        200        210        220        230        240 
HFVKMVHNGI EYGDMQLICE AYHIMQSLGL SATQMADEFG KWNSAELDSF LIEITRDILK 

       250        260        270        280        290        300 
YKDTKGHLLE RIRDTAGQKG TGKWTAIAAL QYGVPVTLIG EAVFSRCLSA LKQERVHASG 

       310        320        330        340        350        360 
VLKGSSVKPS VANVTKFLDD IKHALYCSKI VSYAQGFMLM REAAKENNWR LNYGGIALMW 

       370        380        390        400        410        420 
RGGCIIRSVF LGNIKDAYTS QPQLSNLLLD DFFKKAIERG QDSWREVVAN SFRWGIPVPA 

       430        440        450        460        470        480 
LSTALSFYDG YRTAKLPANL LQAQRDYFGA HTYELLGDEG KFHHTNWTGT GGNVSASTYQ 


A

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH379065 Genomic DNA. Translation: EAL31500.1.
RefSeqXP_001354447.1. XM_001354411.1.

3D structure databases

ProteinModelPortalQ29FS9.
SMRQ29FS9. Positions 3-472.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4814420.
KEGGdpo:Dpse_GA17642.

Organism-specific databases

FlyBaseFBgn0077653. Dpse\GA17642.

Phylogenomic databases

InParanoidQ29FS9.
OMASNYPDTN.
OrthoDBEOG4SN040.
PhylomeDBQ29FS9.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ29FS9_DROPS
AccessionPrimary (citable) accession number: Q29FS9
Entry history
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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