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Q29FC9

- OTU1_DROPS

UniProt

Q29FC9 - OTU1_DROPS

Protein

Ubiquitin thioesterase OTU1

Gene

GA18292

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei169 – 1691By similarity
    Active sitei172 – 1721NucleophileBy similarity
    Active sitei352 – 3521By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri328 – 35225C2H2-typeAdd
    BLAST

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular amino acid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC85.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin thioesterase OTU1 (EC:3.4.19.12)
    Gene namesi
    ORF Names:GA18292
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0078297. Dpse\GA18292.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Ubiquitin thioesterase OTU1PRO_0000282363Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7237.FBpp0278050.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29FC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 8783Ubiquitin-likeAdd
    BLAST
    Domaini161 – 285125OTUPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Curated
    Contains 1 OTU domain.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri328 – 35225C2H2-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5539.
    InParanoidiQ29FC9.
    KOiK13719.
    OMAiKSSRQFT.
    OrthoDBiEOG7J1808.
    PhylomeDBiQ29FC9.

    Family and domain databases

    InterProiIPR003323. OTU.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50802. OTU. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29FC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGSFSVKLK SKKGQFIVKD LNQNTTLGEL KTRIAQATAI QELQLHVLVG    50
    YPPKPLDLSE NRENQNLKTV GINSGETLIV EEKAGAAGPT STPLASGSGS 100
    STMEDDEALA RRLQAEEDAE HLRQVSSGGS IETGALNIVQ SLEPVISPEE 150
    SGPNGNFNGI LLKKVVPADN SCLFTSIRFV LNGKVDNEGS EMMRHIIAQE 200
    VSADTQQYND AVLGKSNSDY CAWIQKADSW GGAIEVSILS NYYGIEIDVV 250
    DIQNAIINRF GEDKNFGLRV FLLFDGIHYD PLYMETQQNS VPATIFPVEE 300
    MGVYQQAEQI ANEAKSSRQF TNVDKFTLRC MDCDVMLVGQ GQAQEHAKKT 350
    GHENFEEI 358
    Length:358
    Mass (Da):39,210
    Last modified:April 4, 2006 - v1
    Checksum:i87FCB64C93082855
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379067 Genomic DNA. Translation: EAL31326.1.
    RefSeqiXP_001354273.1. XM_001354237.2.

    Genome annotation databases

    EnsemblMetazoaiFBtr0279612; FBpp0278050; FBgn0078297.
    GeneIDi4814165.
    KEGGidpo:Dpse_GA18292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379067 Genomic DNA. Translation: EAL31326.1 .
    RefSeqi XP_001354273.1. XM_001354237.2.

    3D structure databases

    ProteinModelPortali Q29FC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0278050.

    Protein family/group databases

    MEROPSi C85.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0279612 ; FBpp0278050 ; FBgn0078297 .
    GeneIDi 4814165.
    KEGGi dpo:Dpse_GA18292.

    Organism-specific databases

    FlyBasei FBgn0078297. Dpse\GA18292.

    Phylogenomic databases

    eggNOGi COG5539.
    InParanoidi Q29FC9.
    KOi K13719.
    OMAi KSSRQFT.
    OrthoDBi EOG7J1808.
    PhylomeDBi Q29FC9.

    Family and domain databases

    InterProi IPR003323. OTU.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50802. OTU. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiOTU1_DROPS
    AccessioniPrimary (citable) accession number: Q29FC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3