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Q29FC9

- OTU1_DROPS

UniProt

Q29FC9 - OTU1_DROPS

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Protein
Ubiquitin thioesterase OTU1
Gene
GA18292
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691 By similarity
Active sitei172 – 1721Nucleophile By similarity
Active sitei352 – 3521 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri328 – 35225C2H2-type
Add
BLAST

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular amino acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC85.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin thioesterase OTU1 (EC:3.4.19.12)
Gene namesi
ORF Names:GA18292
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0078297. Dpse\GA18292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Ubiquitin thioesterase OTU1
PRO_0000282363Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0278050.

Structurei

3D structure databases

ProteinModelPortaliQ29FC9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8783Ubiquitin-like
Add
BLAST
Domaini161 – 285125OTU
Add
BLAST

Sequence similaritiesi

Contains 1 OTU domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5539.
InParanoidiQ29FC9.
KOiK13719.
OMAiKSSRQFT.
OrthoDBiEOG7J1808.
PhylomeDBiQ29FC9.

Family and domain databases

InterProiIPR003323. OTU.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50802. OTU. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29FC9-1 [UniParc]FASTAAdd to Basket

« Hide

MTGSFSVKLK SKKGQFIVKD LNQNTTLGEL KTRIAQATAI QELQLHVLVG    50
YPPKPLDLSE NRENQNLKTV GINSGETLIV EEKAGAAGPT STPLASGSGS 100
STMEDDEALA RRLQAEEDAE HLRQVSSGGS IETGALNIVQ SLEPVISPEE 150
SGPNGNFNGI LLKKVVPADN SCLFTSIRFV LNGKVDNEGS EMMRHIIAQE 200
VSADTQQYND AVLGKSNSDY CAWIQKADSW GGAIEVSILS NYYGIEIDVV 250
DIQNAIINRF GEDKNFGLRV FLLFDGIHYD PLYMETQQNS VPATIFPVEE 300
MGVYQQAEQI ANEAKSSRQF TNVDKFTLRC MDCDVMLVGQ GQAQEHAKKT 350
GHENFEEI 358
Length:358
Mass (Da):39,210
Last modified:April 4, 2006 - v1
Checksum:i87FCB64C93082855
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379067 Genomic DNA. Translation: EAL31326.1.
RefSeqiXP_001354273.1. XM_001354237.2.

Genome annotation databases

EnsemblMetazoaiFBtr0279612; FBpp0278050; FBgn0078297.
GeneIDi4814165.
KEGGidpo:Dpse_GA18292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379067 Genomic DNA. Translation: EAL31326.1 .
RefSeqi XP_001354273.1. XM_001354237.2.

3D structure databases

ProteinModelPortali Q29FC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0278050.

Protein family/group databases

MEROPSi C85.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0279612 ; FBpp0278050 ; FBgn0078297 .
GeneIDi 4814165.
KEGGi dpo:Dpse_GA18292.

Organism-specific databases

FlyBasei FBgn0078297. Dpse\GA18292.

Phylogenomic databases

eggNOGi COG5539.
InParanoidi Q29FC9.
KOi K13719.
OMAi KSSRQFT.
OrthoDBi EOG7J1808.
PhylomeDBi Q29FC9.

Family and domain databases

InterProi IPR003323. OTU.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50802. OTU. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiOTU1_DROPS
AccessioniPrimary (citable) accession number: Q29FC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi