Q29EX2 (EIF3E_DROPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 3 subunit E
Short name=eIF3e

Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6

Gene names

Name:	eIF3-S6
Synonyms:	Int6
ORF Names:	GA21959

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › pseudoobscura subgroup › Drosophila pseudoobscura

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03004
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eIF-3 subunit E family. Contains 1 PCI domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Eukaryotic translation initiation factor 3 subunit E HAMAP-Rule MF_03004		PRO_0000365968
Regions
	Domain	284 – 389	106	PCI

Sequences

	Sequence		Length	Mass (Da)
	Q29EX2 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: B5F002505FDC1E8B	FASTA	434	51,037
	10 20 30 40 50 60 MANFDLTRIN CQYLDRHLTF PLLEFLCGKE IYNQQELLEY ILETVNKTNM IDYTMDTRKR 70 80 90 100 110 120 LNLSQEMPDE LVQRKAEVLA TLKQLQNEVA PIMKATDILK NGESMKDSKT FVNALQKDYN 130 140 150 160 170 180 FKVEHLESAY KLAKYLYECG NYQESTSYLY FCLIVMSPND KNYLNVLWGK LAAEILTLNW 190 200 210 220 230 240 NTALEDLTRL RDYIDSANFS TIQALQQRTW LIHWSVLVFF NHPKGRDLII EMFLYKPLYL 250 260 270 280 290 300 NAIQTMCPHI MRYLATAVVI NRTRRNALKD LIKVIQQESY TYRDPITEFL ECLYVNFDFE 310 320 330 340 350 360 GARLKLHECQ TVILNDFFIV ACLNEFVEDA RLMIFETFCR IHQCITISML ADKLNMKPNE 370 380 390 400 410 420 AECWIVNLIR NARLNAKIDS KLGHVVMGTQ PLSPYQQLVE KIDSLSMRSE HLAGLIERKS 430 KQNNKESIDS WKYY

References

[1]

"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH379070 Genomic DNA. Translation: EAL29937.1.
RefSeq	XP_001352441.1. XM_001352405.2.
3D structure databases
ProteinModelPortal	Q29EX2.
ModBase	Search...
Protein-protein interaction databases
STRING	7237.FBpp0286544.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0288106; FBpp0286544; FBgn0081944.
GeneID	4812055.
KEGG	dpo:Dpse_GA21959.
Organism-specific databases
FlyBase	FBgn0081944. Dpse\GA21959.
Phylogenomic databases
eggNOG	NOG324642.
InParanoid	Q29EX2.
KO	K03250.
OMA	FLEHLYV.
OrthoDB	EOG4HQC0M.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
HAMAP	MF_03004. eIF3e.
InterPro	IPR019010. eIF3_su6_N. IPR000717. PCI_dom. IPR016650. Transl_init_fac_3_su6_euk. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF09440. eIF3_N. 1 hit. PF01399. PCI. 1 hit. [Graphical view]
PIRSF	PIRSF016255. eIF3e_su6. 1 hit.
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EIF3E_DROPS

Accession

Primary (citable) accession number: Q29EX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	April 4, 2006
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project