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Protein

Eukaryotic translation initiation factor 3 subunit E

Gene

eIF3-S6

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit EUniRule annotation
Short name:
eIF3eUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6UniRule annotation
Gene namesi
Name:eIF3-S6
Synonyms:Int6
ORF Names:GA21959
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0081944. Dpse\GA21959.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003659681 – 434Eukaryotic translation initiation factor 3 subunit EAdd BLAST434

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (By similarity).UniRule annotationBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ29EX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 389PCIUniRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.UniRule annotation

Phylogenomic databases

InParanoidiQ29EX2.
KOiK03250.
OMAiKGTNMVD.
PhylomeDBiQ29EX2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e. 1 hit.
InterProiView protein in InterPro
IPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiView protein in Pfam
PF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiView protein in SMART
SM01186. eIF3_N. 1 hit.
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29EX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFDLTRIN CQYLDRHLTF PLLEFLCGKE IYNQQELLEY ILETVNKTNM
60 70 80 90 100
IDYTMDTRKR LNLSQEMPDE LVQRKAEVLA TLKQLQNEVA PIMKATDILK
110 120 130 140 150
NGESMKDSKT FVNALQKDYN FKVEHLESAY KLAKYLYECG NYQESTSYLY
160 170 180 190 200
FCLIVMSPND KNYLNVLWGK LAAEILTLNW NTALEDLTRL RDYIDSANFS
210 220 230 240 250
TIQALQQRTW LIHWSVLVFF NHPKGRDLII EMFLYKPLYL NAIQTMCPHI
260 270 280 290 300
MRYLATAVVI NRTRRNALKD LIKVIQQESY TYRDPITEFL ECLYVNFDFE
310 320 330 340 350
GARLKLHECQ TVILNDFFIV ACLNEFVEDA RLMIFETFCR IHQCITISML
360 370 380 390 400
ADKLNMKPNE AECWIVNLIR NARLNAKIDS KLGHVVMGTQ PLSPYQQLVE
410 420 430
KIDSLSMRSE HLAGLIERKS KQNNKESIDS WKYY
Length:434
Mass (Da):51,037
Last modified:April 4, 2006 - v1
Checksum:iB5F002505FDC1E8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379070 Genomic DNA. Translation: EAL29937.1.
RefSeqiXP_001352441.1. XM_001352405.3.

Genome annotation databases

EnsemblMetazoaiFBtr0288106; FBpp0286544; FBgn0081944.
GeneIDi4812055.
KEGGidpo:Dpse_GA21959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379070 Genomic DNA. Translation: EAL29937.1.
RefSeqiXP_001352441.1. XM_001352405.3.

3D structure databases

ProteinModelPortaliQ29EX2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0288106; FBpp0286544; FBgn0081944.
GeneIDi4812055.
KEGGidpo:Dpse_GA21959.

Organism-specific databases

FlyBaseiFBgn0081944. Dpse\GA21959.

Phylogenomic databases

InParanoidiQ29EX2.
KOiK03250.
OMAiKGTNMVD.
PhylomeDBiQ29EX2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e. 1 hit.
InterProiView protein in InterPro
IPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiView protein in Pfam
PF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiView protein in SMART
SM01186. eIF3_N. 1 hit.
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3E_DROPS
AccessioniPrimary (citable) accession number: Q29EX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 4, 2006
Last modified: February 15, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.