Q29DF7 (Q29DF7_DROPS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
GA21391 EMBL EAL30457.2
EC=2.1.1.43 EMBL EAL30457.2

Gene names

Name:	GA21391 FlyBase FBgn0081379
Synonyms:	Dpse\GA21391 EMBL EAL30457.2
ORF Names:	Dpse_GA21391 EMBL EAL30457.2

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome] EMBL EAL30457.2

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › pseudoobscura subgroup › Drosophila pseudoobscura

Protein attributes

Sequence length	2266 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214
Sequence similarities	Contains 1 SET domain. SAAS SAAS001214 RuleBase RU004538 Contains 1 post-SET domain. RuleBase RU004541 SAAS SAAS001214

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Domain	Zinc-finger SAAS SAAS001965
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase RuleBase RU004541 SAAS SAAS001214 EMBL EAL30457.2 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q29DF7 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 7B337984431337D0	FASTA	2,266	249,650
	10 20 30 40 50 60 MRHQQQQRFW KRNVHKNPAE TDSITDQSSQ SKSAKSATQF SVVQRSDTDG LRMRISAIRP 70 80 90 100 110 120 LSVICKNPLK SRKMSTQDTE SGCSEAKNKA ASKKIKVKRK KITSGSSSTH NKTQQHAEHT 130 140 150 160 170 180 AKSKKGMLSA FSSDSEDDLP LKVHQQRAPR LLLTAISQAA QSASKPLDIG ISSSDNDLPN 190 200 210 220 230 240 LVQAAIKRVE SDTEDTTVEG SFRKAAKSKN LPQYQSTLLQ DFMEKTQMLG QTGNSKLTEK 250 260 270 280 290 300 QLPKAKEETQ LLANVPRKRR GRPKKTPVVV PPSRSSGPAI NESADSGVIS TTSTTQSTTP 310 320 330 340 350 360 SPKMQTENIV PSGTAGAPAA ATSNKPKIDM AYLDKRMYAT ERVLYPSPRN KRRQNNKKPS 370 380 390 400 410 420 SSTNKEELQL DPLWREIDVN KKFRLRSVSV GAGAASGAGG ASTTICSKIL AAKSGYVSDY 430 440 450 460 470 480 GSVRHQKSSH NHNSGYKSDA SCKSRYSTKS CMSRRSRAKS CGYRSDCKES GKSGMRMRRK 490 500 510 520 530 540 RRASMLLKNG AAQEDPTDDL DILLLAGLSL GQSSEESNEY ISKPSLQSLP TTSASKKYGE 550 560 570 580 590 600 INRYVTTGQY FGRGGGSGSS SLPTTNPEIF ISKMMNQRKE TPAPSKSSCK IKSRRSSAAS 610 620 630 640 650 660 MCSSYVSGVS RVRRRHRRKS FSHSKSLNID SKLLTEIEII TSTFHSRCRI QDDRLTGSSG 670 680 690 700 710 720 KEKLLAEATK LQATLAAPNT AQQLVLNGGG GGSAASGAAA LPKPLKRAQK KRKLSEPLVD 730 740 750 760 770 780 FAMLSASANA SVSGTPNGSG SSNGTAKRRH KKSQSNSSSS PDDHKLPLKK RHYLLTPGER 790 800 810 820 830 840 PLAEAAFANG KLNAEAWAAA AATAKSTAST KSQAQFDAKS GKSALTPKKR HLLEQPAAAG 850 860 870 880 890 900 VAAAASSASN SPLRIVVDNN SISGGKLLDI SPSSLGSLKQ QRRGGVAKQQ KVPHSARDLI 910 920 930 940 950 960 QLQSPSGSYP PPGIFEPSVE LEIQIPIGKL NESVITKTEV ESPLLSALDI KEDTKKEIGQ 970 980 990 1000 1010 1020 RVVETLLHKT GGNLLLKRKR KKINRTGFPT VKKKKRKVSV EQQQQPAVVM VDHPILGMQQ 1030 1040 1050 1060 1070 1080 ADEEPLQPIR ETRSSSSAQV QIPANPLLDC ERVPLIGEAR ETFVARSNQR APRLSVVALE 1090 1100 1110 1120 1130 1140 RLQRPQTPAP RGRPRGRRPK DKEALPVVVP PPPPPPVLDV KPPAKKRGRQ PKPKVEVEHP 1150 1160 1170 1180 1190 1200 AAVPQQVKPP QKLNNIKLPA GVGLKSCQIR LKRRKNLQAT VVDQPQPATV LPVPVEVVSP 1210 1220 1230 1240 1250 1260 MEMHATQEEI DAAAEAKRLE EIPIEHDPLP VSESLHPLPP DNASLSDAGS EDKASTVSTV 1270 1280 1290 1300 1310 1320 SASQRKHSKV KKNYLVAGLF SNYYKQSPMP PPGNKVNKKP GATGQEEQHV AQGGSLLPPP 1330 1340 1350 1360 1370 1380 PYCEKYYRQT EMDFELPYDI WWAYTNDKLP TRHIVPSWNY RKIRTNVYAE SVRPNLAGFD 1390 1400 1410 1420 1430 1440 HPTCNCKNQG EKACLDNCLN RMVYTECSPS NCPAAEKCRN QKIQRHEVAP GVERFMTLDK 1450 1460 1470 1480 1490 1500 GWGVRTKLPI AKGTYILEYV GEVVTEREFK QRMASIYLND THHYCLHLDG GLVIDGQRMG 1510 1520 1530 1540 1550 1560 SDCRFVNHSC EPNCEMQKWS VNGLSRMVLF AKRPIEQGEE LTYDYNFSLF NPSEGQPCRC 1570 1580 1590 1600 1610 1620 NMPQCRGVIG GKSQRVKPLP AVEAKPVEGC PARNGRQRKH KAKKHAQRMT GKESPAALAV 1630 1640 1650 1660 1670 1680 AKAKMQPLSE KEKKLVKQFN AFLIRNFEKI RKLQAKRAAA SDSPIHAASN GDGLPGSRPS 1690 1700 1710 1720 1730 1740 TPSSNSLLAT QISALCTQRN MKTRGLTQAV QDPELDKMAK MAVILRDICN AVEALKMSEL 1750 1760 1770 1780 1790 1800 LMTVPSNKKK KAMKNSNGKT HGSGTGSAAR VEFKSIQAHV EQGHYKTPLE YDLQMLQLFA 1810 1820 1830 1840 1850 1860 EAKQQHSDDE GKSKAVQKLL ECYEQQKMAC YTHLLEILGE SESLQSFRPK EEAAPVEEKP 1870 1880 1890 1900 1910 1920 PEIPEVAPLA LATVPLPAVE ASPDEDVIRC ICGLYKDEGL MIQCAKCMVW QHTECTKADI 1930 1940 1950 1960 1970 1980 DADNYQCERC EPREVDREIP LDEYTEEGHR YFLTLMRGNL QVRQGDAVYV LRDIPIKDAA 1990 2000 2010 2020 2030 2040 GNILPSQKHT YETIGAIDYQ ECDIFRVEHL WKNDDGKRFI FGHHFLRPHE TFHEPSRRFY 2050 2060 2070 2080 2090 2100 PNEVVRVSLY EVVPIELVIG RCWVLDRTTF CKGRPMECPD EDHCFICELR VDKTARFFSK 2110 2120 2130 2140 2150 2160 AKANHPACTK SYAFRKFPEK LKICKSYAPH DVDPSLLKTK KHKTDLEVGG AVPATMHKTS 2170 2180 2190 2200 2210 2220 GRQEQQQQQK AGGRKQRGNS AAAAEATGGA TTVHVVAPVA PNGQVLEKKR SRLENVLKTV 2230 2240 2250 2260 KLKCMDAQTA QEQPIDLSYL WSGRGARQRK TNNQTSSSSN SVTPSA

References

[1]

"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH379070 Genomic DNA. Translation: EAL30457.2.
RefSeq	XP_001352956.2. XM_001352920.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	7237.FBpp0286080.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0287642; FBpp0286080; FBgn0081379.
GeneID	4812467.
KEGG	dpo:Dpse_GA21391.
Organism-specific databases
FlyBase	FBgn0081379. Dpse\GA21391.
Phylogenomic databases
InParanoid	Q29DF7.
KO	K06101.
OrthoDB	EOG408KPX.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR017956. AT_hook_DNA-bd_motif. IPR006560. AWS. IPR001025. BAH_dom. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF01426. BAH. 1 hit. PF00628. PHD. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00384. AT_hook. 3 hits. SM00570. AWS. 1 hit. SM00439. BAH. 1 hit. SM00249. PHD. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS51215. AWS. 1 hit. PS51038. BAH. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q29DF7_DROPS

Accession

Primary (citable) accession number: Q29DF7

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)