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Protein

Homeobox protein extradenticle

Gene

exd

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi238 – 300Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein extradenticle
Gene namesi
Name:exdBy similarity
ORF Names:GA21419
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0081406. Dpse\GA21419.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity

  • Note: Nuclear translocation requires interaction with hth.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415101 – 376Homeobox protein extradenticleAdd BLAST376

Interactioni

Subunit structurei

Interacts with Ubx and hth.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ29CT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Sequence analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

InParanoidiQ29CT2.
KOiK09355.
OMAiVQNSQTN.
PhylomeDBiQ29CT2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29CT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPNRMMAH TGGMMAPQGY SLSGQDDGQN TGNENEVRKQ KDIGEILQQI
60 70 80 90 100
MSISEQSLDE AQARKHTLNC HRMKPALFSV LCEIKEKTVL SIRNTQEEEP
110 120 130 140 150
PDPQLMRLDN MLIAEGVAGP EKGGGGAAAA SAAAASQGGS LSIDGADNAI
160 170 180 190 200
EHSDYRAKLA QIRQIYHQEL EKYEQACNEF TTHVMNLLRE QSRTRPITPK
210 220 230 240 250
EIERMVQIIH KKFSSIQMQL KQSTCEAVMI LRSRFLDARR KRRNFSKQAS
260 270 280 290 300
EILNEYFYSH LSNPYPSEEA KEELARKCGI TVSQVSNWFG NKRIRYKKNI
310 320 330 340 350
GKAQEEANLY AAKKAAGASP YSMAGPPSGT TTPMMSPAPP QDSMGYTMGS
360 370
GGYDQQQPYD NSMGGYDPNL HQDLSP
Length:376
Mass (Da):41,801
Last modified:April 4, 2006 - v1
Checksum:i238208F36C04FE7C
GO

Sequence cautioni

The sequence EAL29404 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH475411 Genomic DNA. Translation: EAL29404.1. Sequence problems.
RefSeqiXP_001352352.1. XM_001352316.3.

Genome annotation databases

EnsemblMetazoaiFBtr0289808; FBpp0288246; FBgn0081406.
GeneIDi4811784.
KEGGidpo:Dpse_GA21419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH475411 Genomic DNA. Translation: EAL29404.1. Sequence problems.
RefSeqiXP_001352352.1. XM_001352316.3.

3D structure databases

ProteinModelPortaliQ29CT2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0289808; FBpp0288246; FBgn0081406.
GeneIDi4811784.
KEGGidpo:Dpse_GA21419.

Organism-specific databases

FlyBaseiFBgn0081406. Dpse\GA21419.

Phylogenomic databases

InParanoidiQ29CT2.
KOiK09355.
OMAiVQNSQTN.
PhylomeDBiQ29CT2.

Miscellaneous databases

ChiTaRSiexd. fly.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEXD_DROPS
AccessioniPrimary (citable) accession number: Q29CT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 4, 2006
Last modified: October 5, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.