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Protein

Homeobox protein extradenticle

Gene

exd

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi238 – 300Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein extradenticle
Gene namesi
Name:exdBy similarity
ORF Names:GA21419
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0081406. Dpse\GA21419.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415101 – 376Homeobox protein extradenticleAdd BLAST376

Expressioni

Gene expression databases

BgeeiFBgn0081406.

Interactioni

Subunit structurei

Interacts with Ubx and hth.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7237.FBpp0288246.

Structurei

3D structure databases

ProteinModelPortaliQ29CT2.
SMRiQ29CT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

InParanoidiQ29CT2.
KOiK09355.
OMAiSMQSLNG.
PhylomeDBiQ29CT2.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR005542. PBX.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29CT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPNRMMAH TGGMMAPQGY SLSGQDDGQN TGNENEVRKQ KDIGEILQQI
60 70 80 90 100
MSISEQSLDE AQARKHTLNC HRMKPALFSV LCEIKEKTVL SIRNTQEEEP
110 120 130 140 150
PDPQLMRLDN MLIAEGVAGP EKGGGGAAAA SAAAASQGGS LSIDGADNAI
160 170 180 190 200
EHSDYRAKLA QIRQIYHQEL EKYEQACNEF TTHVMNLLRE QSRTRPITPK
210 220 230 240 250
EIERMVQIIH KKFSSIQMQL KQSTCEAVMI LRSRFLDARR KRRNFSKQAS
260 270 280 290 300
EILNEYFYSH LSNPYPSEEA KEELARKCGI TVSQVSNWFG NKRIRYKKNI
310 320 330 340 350
GKAQEEANLY AAKKAAGASP YSMAGPPSGT TTPMMSPAPP QDSMGYTMGS
360 370
GGYDQQQPYD NSMGGYDPNL HQDLSP
Length:376
Mass (Da):41,801
Last modified:April 4, 2006 - v1
Checksum:i238208F36C04FE7C
GO

Sequence cautioni

The sequence EAL29404 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH475411 Genomic DNA. Translation: EAL29404.1. Sequence problems.
RefSeqiXP_001352352.1. XM_001352316.3.

Genome annotation databases

EnsemblMetazoaiFBtr0289808; FBpp0288246; FBgn0081406.
GeneIDi4811784.
KEGGidpo:Dpse_GA21419.

Similar proteinsi

Entry informationi

Entry nameiEXD_DROPS
AccessioniPrimary (citable) accession number: Q29CT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families