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Protein

O-glucosyltransferase rumi

Gene

rumi

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has O-glucosyltransferase activity: catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch (By similarity).By similarity

Pathway:iprotein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Notch signaling pathway

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
O-glucosyltransferase rumi (EC:2.4.1.-)
Gene namesi
Name:rumiBy similarity
ORF Names:GA16050
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819 Componentsi: Chromosome 2, Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0076066. Dpse\GA16050.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 409389O-glucosyltransferase rumiSequence AnalysisPRO_0000342688Add
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi406 – 4094Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the glycosyltransferase 90 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
InParanoidiQ29AU6.
KOiK13667.
OMAiDANDANC.
OrthoDBiEOG7R831J.
PhylomeDBiQ29AU6.

Family and domain databases

InterProiIPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29AU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLINVVLIIL LVGLNGKASG QNQGLCSPDE NASCADSSDT QDEFSFNILR
60 70 80 90 100
KIKKALASYQ PCSSDANDAN CSCHAAVIKS DLAPYKATGV SRQMIESSAR
110 120 130 140 150
YGTRYKIYEK RLYREENCMF PARCQGIEHF LLPLVATLPD MDLVINTRDY
160 170 180 190 200
PQINMAWGNG AQGPILSFSK TKDHRDIMYP AWTFWAGGPA TKLHPRGIGR
210 220 230 240 250
WDLMREKLEK RAAAIPWSQK RELGFFRGSR TSDERDSLIL LSRRNPELVE
260 270 280 290 300
AQYTKNQGWK SPKDTLDAPP AGEVSFEDHC KYKYLFNFRG VAASFRLKHL
310 320 330 340 350
FLCQSLVFHV GDEWQEFFYD QLKPWVHYVP LKNYPSQQEY EELLTFFRKN
360 370 380 390 400
DALAQEIAQR GRDFIWQHLR MKDIKCYWRR LLKSYVKLLT YEVQPEDQLI

HIQPAKDEL
Length:409
Mass (Da):47,314
Last modified:April 4, 2006 - v1
Checksum:iEC695CBD0699DCE3
GO

Sequence cautioni

The sequence EAL27253.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000070 Genomic DNA. Translation: EAL27253.1. Sequence problems.
RefSeqiXP_001358116.1. XM_001358079.2.

Genome annotation databases

EnsemblMetazoaiFBtr0285031; FBpp0283469; FBgn0076066.
GeneIDi4800928.
KEGGidpo:Dpse_GA16050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000070 Genomic DNA. Translation: EAL27253.1. Sequence problems.
RefSeqiXP_001358116.1. XM_001358079.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0285031; FBpp0283469; FBgn0076066.
GeneIDi4800928.
KEGGidpo:Dpse_GA16050.

Organism-specific databases

FlyBaseiFBgn0076066. Dpse\GA16050.

Phylogenomic databases

eggNOGiNOG248922.
InParanoidiQ29AU6.
KOiK13667.
OMAiDANDANC.
OrthoDBiEOG7R831J.
PhylomeDBiQ29AU6.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiRUMI_DROPS
AccessioniPrimary (citable) accession number: Q29AU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: April 4, 2006
Last modified: July 22, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.