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Q29AU6

- RUMI_DROPS

UniProt

Q29AU6 - RUMI_DROPS

Protein

O-glucosyltransferase rumi

Gene

rumi

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Has O-glucosyltransferase activity: catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. glucosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of Notch signaling pathway Source: UniProtKB
    2. Notch signaling pathway Source: UniProtKB-KW
    3. protein glycosylation in endoplasmic reticulum Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Notch signaling pathway

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    O-glucosyltransferase rumi (EC:2.4.1.-)
    Gene namesi
    Name:rumiBy similarity
    ORF Names:GA16050
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0076066. Dpse\GA16050.

    Subcellular locationi

    Endoplasmic reticulum lumen By similarityPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 409389O-glucosyltransferase rumiSequence AnalysisPRO_0000342688Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7237.FBpp0283469.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi406 – 4094Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the glycosyltransferase 90 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248922.
    InParanoidiQ29AU6.
    KOiK13667.
    OMAiSEIMACP.
    OrthoDBiEOG7R831J.
    PhylomeDBiQ29AU6.

    Family and domain databases

    InterProiIPR006598. LipoPS_modifying.
    [Graphical view]
    PfamiPF05686. Glyco_transf_90. 1 hit.
    [Graphical view]
    SMARTiSM00672. CAP10. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q29AU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLINVVLIIL LVGLNGKASG QNQGLCSPDE NASCADSSDT QDEFSFNILR    50
    KIKKALASYQ PCSSDANDAN CSCHAAVIKS DLAPYKATGV SRQMIESSAR 100
    YGTRYKIYEK RLYREENCMF PARCQGIEHF LLPLVATLPD MDLVINTRDY 150
    PQINMAWGNG AQGPILSFSK TKDHRDIMYP AWTFWAGGPA TKLHPRGIGR 200
    WDLMREKLEK RAAAIPWSQK RELGFFRGSR TSDERDSLIL LSRRNPELVE 250
    AQYTKNQGWK SPKDTLDAPP AGEVSFEDHC KYKYLFNFRG VAASFRLKHL 300
    FLCQSLVFHV GDEWQEFFYD QLKPWVHYVP LKNYPSQQEY EELLTFFRKN 350
    DALAQEIAQR GRDFIWQHLR MKDIKCYWRR LLKSYVKLLT YEVQPEDQLI 400
    HIQPAKDEL 409
    Length:409
    Mass (Da):47,314
    Last modified:April 4, 2006 - v1
    Checksum:iEC695CBD0699DCE3
    GO

    Sequence cautioni

    The sequence EAL27253.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000070 Genomic DNA. Translation: EAL27253.1. Sequence problems.
    RefSeqiXP_001358116.1. XM_001358079.2.

    Genome annotation databases

    EnsemblMetazoaiFBtr0285031; FBpp0283469; FBgn0076066.
    GeneIDi4800928.
    KEGGidpo:Dpse_GA16050.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000070 Genomic DNA. Translation: EAL27253.1 . Sequence problems.
    RefSeqi XP_001358116.1. XM_001358079.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0283469.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0285031 ; FBpp0283469 ; FBgn0076066 .
    GeneIDi 4800928.
    KEGGi dpo:Dpse_GA16050.

    Organism-specific databases

    FlyBasei FBgn0076066. Dpse\GA16050.

    Phylogenomic databases

    eggNOGi NOG248922.
    InParanoidi Q29AU6.
    KOi K13667.
    OMAi SEIMACP.
    OrthoDBi EOG7R831J.
    PhylomeDBi Q29AU6.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR006598. LipoPS_modifying.
    [Graphical view ]
    Pfami PF05686. Glyco_transf_90. 1 hit.
    [Graphical view ]
    SMARTi SM00672. CAP10. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiRUMI_DROPS
    AccessioniPrimary (citable) accession number: Q29AU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3