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Q29AU6

- RUMI_DROPS

UniProt

Q29AU6 - RUMI_DROPS

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Protein

O-glucosyltransferase rumi

Gene

rumi

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Has O-glucosyltransferase activity: catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch (By similarity).By similarity

Pathwayi

GO - Molecular functioni

  1. glucosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of Notch signaling pathway Source: UniProtKB
  2. Notch signaling pathway Source: UniProtKB-KW
  3. protein glycosylation in endoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Notch signaling pathway

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
O-glucosyltransferase rumi (EC:2.4.1.-)
Gene namesi
Name:rumiBy similarity
ORF Names:GA16050
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0076066. Dpse\GA16050.

Subcellular locationi

Endoplasmic reticulum lumen By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 409389O-glucosyltransferase rumiSequence AnalysisPRO_0000342688Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0283469.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi406 – 4094Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the glycosyltransferase 90 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
InParanoidiQ29AU6.
KOiK13667.
OMAiSEIMACP.
OrthoDBiEOG7R831J.
PhylomeDBiQ29AU6.

Family and domain databases

InterProiIPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29AU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLINVVLIIL LVGLNGKASG QNQGLCSPDE NASCADSSDT QDEFSFNILR
60 70 80 90 100
KIKKALASYQ PCSSDANDAN CSCHAAVIKS DLAPYKATGV SRQMIESSAR
110 120 130 140 150
YGTRYKIYEK RLYREENCMF PARCQGIEHF LLPLVATLPD MDLVINTRDY
160 170 180 190 200
PQINMAWGNG AQGPILSFSK TKDHRDIMYP AWTFWAGGPA TKLHPRGIGR
210 220 230 240 250
WDLMREKLEK RAAAIPWSQK RELGFFRGSR TSDERDSLIL LSRRNPELVE
260 270 280 290 300
AQYTKNQGWK SPKDTLDAPP AGEVSFEDHC KYKYLFNFRG VAASFRLKHL
310 320 330 340 350
FLCQSLVFHV GDEWQEFFYD QLKPWVHYVP LKNYPSQQEY EELLTFFRKN
360 370 380 390 400
DALAQEIAQR GRDFIWQHLR MKDIKCYWRR LLKSYVKLLT YEVQPEDQLI

HIQPAKDEL
Length:409
Mass (Da):47,314
Last modified:April 4, 2006 - v1
Checksum:iEC695CBD0699DCE3
GO

Sequence cautioni

The sequence EAL27253.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000070 Genomic DNA. Translation: EAL27253.1. Sequence problems.
RefSeqiXP_001358116.1. XM_001358079.2.

Genome annotation databases

EnsemblMetazoaiFBtr0285031; FBpp0283469; FBgn0076066.
GeneIDi4800928.
KEGGidpo:Dpse_GA16050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000070 Genomic DNA. Translation: EAL27253.1 . Sequence problems.
RefSeqi XP_001358116.1. XM_001358079.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0283469.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0285031 ; FBpp0283469 ; FBgn0076066 .
GeneIDi 4800928.
KEGGi dpo:Dpse_GA16050.

Organism-specific databases

FlyBasei FBgn0076066. Dpse\GA16050.

Phylogenomic databases

eggNOGi NOG248922.
InParanoidi Q29AU6.
KOi K13667.
OMAi SEIMACP.
OrthoDBi EOG7R831J.
PhylomeDBi Q29AU6.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR006598. LipoPS_modifying.
[Graphical view ]
Pfami PF05686. Glyco_transf_90. 1 hit.
[Graphical view ]
SMARTi SM00672. CAP10. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiRUMI_DROPS
AccessioniPrimary (citable) accession number: Q29AU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: April 4, 2006
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3