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Q29983 (MICA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MHC class I polypeptide-related sequence A

Short name=MIC-A
Gene names
Name:MICA
Synonyms:PERB11.1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Ref.28 Ref.32 Ref.36 Ref.40 Ref.41

Subunit structure

Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142. Ref.26 Ref.27 Ref.32 Ref.33 Ref.37 Ref.40 Ref.49

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note: Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. Ref.26 Ref.30 Ref.51

Tissue specificity

Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells. Ref.26 Ref.27 Ref.30 Ref.31 Ref.34 Ref.46 Ref.50

Induction

By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele. Ref.26 Ref.27 Ref.28 Ref.32 Ref.33 Ref.39 Ref.40 Ref.41 Ref.45 Ref.47 Ref.48 Ref.51

Post-translational modification

N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation. Ref.26

Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation. Ref.43 Ref.44

Polymorphism

The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.

Involvement in disease

Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.

Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Miscellaneous

Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection. Ref.35

Sequence similarities

Belongs to the MHC class I family. MIC subfamily.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processAdaptive immunity
Cytolysis
Host-virus interaction
Immunity
   Cellular componentCell membrane
Cytoplasm
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell mediated cytotoxicity

Inferred from direct assay Ref.32. Source: UniProtKB

antigen processing and presentation

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to DNA damage stimulus

Inferred from direct assay Ref.47. Source: UniProtKB

cytolysis

Inferred from electronic annotation. Source: UniProtKB-KW

defense response to bacterium

Inferred from direct assay Ref.39Ref.45. Source: UniProtKB

defense response to virus

Inferred from direct assay Ref.41Ref.48. Source: UniProtKB

gamma-delta T cell activation

Inferred from direct assay Ref.28. Source: UniProtKB

immune response to tumor cell

Inferred from direct assay Ref.31. Source: UniProtKB

natural killer cell mediated cytotoxicity

Inferred from direct assay Ref.32. Source: UniProtKB

response to heat

Inferred from direct assay Ref.26. Source: UniProtKB

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell surface

Inferred from direct assay Ref.26. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular space

Inferred from direct assay PubMed 18676862. Source: BHF-UCL

integral component of plasma membrane

Inferred from direct assay PubMed 18676862. Source: BHF-UCL

   Molecular_functionantigen binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell lectin-like receptor binding

Inferred from direct assay Ref.40. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.54PubMed 21712812. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KLRK1P267182EBI-1031130,EBI-458344
LGALS3P179312EBI-1031130,EBI-1170392

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.42 (identifier: Q29983-1)

Also known as: MICA1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.42 (identifier: Q29983-2)

Also known as: MICA2;

The sequence of this isoform differs from the canonical sequence as follows:
     109-204: Missing.
Note: Found in about 10% of examined clones.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 383360MHC class I polypeptide-related sequence A
PRO_0000337146

Regions

Topological domain24 – 307284Extracellular Potential
Transmembrane308 – 32821Helical; Potential
Topological domain329 – 38355Cytoplasmic Potential
Domain207 – 29690Ig-like C1-type

Amino acid modifications

Glycosylation311N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Disulfide bond59 ↔ 64 Ref.53
Disulfide bond119 ↔ 187 Ref.53
Disulfide bond225 ↔ 282 Ref.53

Natural variations

Alternative sequence109 – 20496Missing in isoform 2.
VSP_055366
Natural variant291R → P in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding. Ref.38
Corresponds to variant rs9380254 [ dbSNP | Ensembl ].
VAR_043625
Natural variant371W → G in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055.
Corresponds to variant rs1063630 [ dbSNP | Ensembl ].
VAR_043626
Natural variant471T → A in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056.
Corresponds to variant rs1051785 [ dbSNP | Ensembl ].
VAR_043627
Natural variant491V → G in allele MICA*041.
Corresponds to variant rs17200158 [ dbSNP | Ensembl ].
VAR_043628
Natural variant591C → Y in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051786 [ dbSNP | Ensembl ].
VAR_043629
Natural variant1141Q → R in allele MICA*017.
Corresponds to variant rs41558312 [ dbSNP | Ensembl ].
VAR_043630
Natural variant1281R → K in allele MICA*036.
Corresponds to variant rs41557113 [ dbSNP | Ensembl ].
VAR_043631
Natural variant1371G → R in allele MICA*014 and allele MICA*015.
Corresponds to variant rs41556715 [ dbSNP | Ensembl ].
VAR_043632
Natural variant1451L → V in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*044 and allele MICA*049.
Corresponds to variant rs1051790 [ dbSNP | Ensembl ].
VAR_043633
Natural variant1471T → S in allele MICA*033.
Corresponds to variant rs41539919 [ dbSNP | Ensembl ].
VAR_043634
Natural variant1481K → E in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*012, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*018, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056.
Corresponds to variant rs1051791 [ dbSNP | Ensembl ].
VAR_043635
Natural variant1521M → V in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056; reduces binding affinity for KLRK1. Ref.40
Corresponds to variant rs1051792 [ dbSNP | Ensembl ].
VAR_043636
Natural variant1651V → I in allele MICA*029.
Corresponds to variant rs3819269 [ dbSNP | Ensembl ].
VAR_043637
Natural variant1741M → V in allele MICA*011 and allele MICA*034.
Corresponds to variant rs41560824 [ dbSNP | Ensembl ].
VAR_043638
Natural variant1791H → L in allele MICA*012, allele MICA*032 and allele MICA*043.
Corresponds to variant rs3819268 [ dbSNP | Ensembl ].
VAR_043639
Natural variant1961K → E in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*014, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051794 [ dbSNP | Ensembl ].
VAR_043640
Natural variant1981G → S in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*031, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*049, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1131896 [ dbSNP | Ensembl ].
VAR_043641
Natural variant1991V → I in allele MICA*006.
Corresponds to variant rs41549718 [ dbSNP | Ensembl ].
VAR_043642
Natural variant2041T → R in allele MICA*004, allele MICA*014, allele MICA*032 and allele MICA*044.
Corresponds to variant rs1131897 [ dbSNP | Ensembl ].
VAR_043643
Natural variant2291G → S in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1131898 [ dbSNP | Ensembl ].
VAR_043644
Natural variant2311Y → C in allele MICA*046.
Corresponds to variant rs41546915 [ dbSNP | Ensembl ].
VAR_043645
Natural variant2331W → R in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051798 [ dbSNP | Ensembl ].
VAR_043646
Natural variant2361T → I in allele MICA*008, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1140700 [ dbSNP | Ensembl ].
VAR_043647
Natural variant2381S → T in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051799 [ dbSNP | Ensembl ].
VAR_043648
Natural variant2441V → L in allele MICA*016 and allele MICA*039.
Corresponds to variant rs41540613 [ dbSNP | Ensembl ].
VAR_043649
Natural variant2531W → S in allele MICA*056.
VAR_043869
Natural variant2741Q → R in allele MICA*005, allele MICA*008, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*045, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1063635 [ dbSNP | Ensembl ].
VAR_043650
Natural variant2791R → S in allele MICA*043.
Corresponds to variant rs41557614 [ dbSNP | Ensembl ].
VAR_043651
Natural variant2911S → G in allele MICA*054.
VAR_043652
Natural variant2941P → A in allele MICA*011, allele MICA*030 and allele MICA*047.
Corresponds to variant rs41553616 [ dbSNP | Ensembl ].
VAR_043653
Natural variant300 – 38384VLVLQ…STEGA → CWCFRVIGRHSMFLLLLLLL LLLLLFLLLLFSTSVVVRRK HQLQRVQSS in allele MICA*015 and allele MICA*017.
VAR_043654
Natural variant318 – 38366AAIFV…STEGA → GCCYFCYYYFLCPLL in allele MICA*008, allele MICA*023, allele MICA*028 and allele MICA*053.
VAR_043655
Natural variant3191A → AA in allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*027, allele MICA*033, allele MICA*048, allele MICA*054 and allele MICA*056.
VAR_043656
Natural variant3191A → AAA in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*011, allele MICA*026, allele MICA*047 and allele MICA*049.
VAR_043657
Natural variant3191A → AAAA in allele MICA*050.
VAR_043658
Natural variant3191A → AAAAA in allele MICA*055.
VAR_043659
Natural variant3191A → AAAAAA in allele MICA*002, allele MICA*041, allele MICA*046 and allele MICA*052.
VAR_043660
Natural variant3191A → AAAAAAA in allele MICA*020.
VAR_043661
Natural variant3281V → I in allele MICA*052.
VAR_043662
Natural variant3291R → C in allele MICA*002, allele MICA*011, allele MICA*020, allele MICA*041, allele MICA*043, allele MICA*046, allele MICA*047, allele MICA*050 and allele MICA*052.
Corresponds to variant rs41554412 [ dbSNP | Ensembl ].
VAR_043663
Natural variant3561T → M in allele MICA*049.
VAR_043664
Natural variant3731D → A in allele MICA*004, allele MICA*006, allele MICA*010, allele MICA*011, allele MICA*016, allele MICA*019, allele MICA*048 and allele MICA*049.
VAR_043665
Natural variant3771T → A in allele MICA*011.
VAR_043666
Natural variant3831A → T in allele MICA*018.
VAR_043667

Secondary structure

............................................ 383
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (MICA1) [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1FE084813DDA13A8

FASTA38342,915
        10         20         30         40         50         60 
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH LDGQPFLRCD 

        70         80         90        100        110        120 
RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE 

       130        140        150        160        170        180 
IHEDNSTRSS QHFYYDGELF LSQNLETKEW TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY 

       190        200        210        220        230        240 
HAMHADCLQE LRRYLKSGVV LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR 

       250        260        270        280        290        300 
QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV 

       310        320        330        340        350        360 
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD QHPVGTSDHR 

       370        380 
DATQLGFQPL MSDLGSTGST EGA 

« Hide

Isoform 2 (MICA2) [UniParc].

Checksum: 0D41D7919769F469
Show »

FASTA28731,577

References

« Hide 'large scale' references
[1]"A second lineage of mammalian major histocompatibility complex class I genes."
Bahram S., Bresnahan M., Geraghty D.E., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 91:6259-6263(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICA*001).
[2]"Nucleotide sequence of the human MHC class I MICA gene."
Bahram S., Mizuki N., Inoko H., Spies T.
Immunogenetics 44:80-81(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICA*004).
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICA*001 AND MICA*004).
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE MICA*018), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-248 (ISOFORM 2).
Tissue: Bone and Kidney.
[5]"A new polymorphic and multicopy MHC gene family related to nonmammalian class I."
Leelayuwat C., Townend D.C., Degli-Esposti M.A., Abraham L.J., Dawkins R.L.
Immunogenetics 40:339-351(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-150 (ALLELES MICA*001; MICA*008 AND MICA*010).
[6]"Allelic repertoire of the human MHC class I MICA gene."
Fodil N., Laloux L., Wanner V., Pellet P., Hauptmann G., Mizuki N., Inoko H., Spies T., Theodorou I., Bahram S.
Immunogenetics 44:351-357(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*001; MICA*002; MICA*004; MICA*005; MICA*006; MICA*007; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; MICA*013; MICA*014; MICA*015 AND MICA*016).
[7]"Definition of new alleles of MIC-A using sequencing-based typing."
Yao Z., Volgger A., Helmberg W., Keller E., Fan L.A., Chandanayingyong D., Albert E.D.
Eur. J. Immunogenet. 26:225-232(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*007; MICA*008; MICA*009; MICA*010; MICA*012; MICA*016; MICA*017; MICA*018; MICA*022; MICA*024; MICA*025; MICA*028 AND MICA*029).
[8]"MICA haplotypic diversity."
Fodil N., Pellet P., Laloux L., Hauptmann G., Theodorou I., Bahram S.
Immunogenetics 49:557-560(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*009; MICA*017; MICA*018 AND MICA*019).
[9]"MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype."
Komatsu-Wakui M., Tokunaga K., Ishikawa Y., Kashiwase K., Moriyama S., Tsuchiya N., Ando H., Shiina T., Geraghty D.E., Inoko H., Juji T.
Immunogenetics 49:620-628(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*019).
[10]"Identification of a novel MICA allele: MICA*051."
Quiroga I., Sweeney D., Sutton P.M., Chapple S.D., Souto-Grando J.P., Barnardo M.C.N.M., Fuggle S.V.
Tissue Antigens 63:466-469(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*051).
Tissue: Blood.
[11]"Sequencing-based typing of MICA reveals 33 alleles: a study on linkage with classical HLA genes."
Visser C.J.T., Tilanus M.G.J., Tatari Z., van der Zwan A.-W., Bakker R., Rozemuller E.H., Schaeffer V., Tamouza R., Charron D.
Immunogenetics 49:561-566(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*008; MICA*023 AND MICA*028), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*001; MICA*002; MICA*004; MICA*006; MICA*007; MICA*009; MICA*010; MICA*011; MICA*016; MICA*018; MICA*019; MICA*022; MICA*024; MICA*025; MICA*026; MICA*027; MICA*031; MICA*032; MICA*033; MICA*034; MICA*035; MICA*036; MICA*037; MICA*038; MICA*039 AND MICA*040).
[12]"Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4."
Obuchi N., Takahashi M., Nouchi T., Satoh M., Arimura T., Ueda K., Akai J., Ota M., Naruse T., Inoko H., Numano F., Kimura A.
Tissue Antigens 57:520-535(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*001; MICA*002; MICA*006; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; MICA*015; MICA*016; MICA*017; MICA*018; MICA*019; MICA*048 AND MICA*049).
[13]"Further polymorphism of the MICA gene."
Perez-Rodriguez M., Arguello J.R., Fischer G., Corell A., Cox S.T., Robinson J., Hossain E., McWhinnie A., Travers P.J., Marsh S.G.E., Madrigal J.A.
Eur. J. Immunogenet. 29:35-46(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELES MICA*008; MICA*017; MICA*018; MICA*019; MICA*027; MICA*029; MICA*033; MICA*041; MICA*043; MICA*045 AND MICA*046).
[14]"MIC-A sequence in AH8.2."
Kaur G., Shiina T., Hashimoto N., Kumar N., Inoko H., Mehra N.K.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELE MICA*008).
[15]"A new MICA allele with ten alanine residues in the exon 5 microsatellite."
Perez-Rodriguez M., Corell A., Fischer G., Arguello R., Cox S.T., McWhinnie A., Marsh S.G.E., Madrigal A.
Tissue Antigens 55:162-165(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*020).
[16]"Identification of a new MICA allele, MICA*047."
Perez-Rodriguez M., Raimondi E., Marsh S.G.E., Madrigal J.A.
Tissue Antigens 59:216-218(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*047).
[17]"The identification of three novel MICA alleles by sequence-based typing."
Quiroga I., Sweeney D., Sutton P.M., Ahmad T., Walton R., Barnardo M.C.N.M., Fuggle S.V.
Tissue Antigens 67:321-325(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*007; MICA*018 AND MICA*053).
[18]"Description of a new MICA allele."
Mas V., Amezaga N., Arostegui J.I., Masso M., Plaza S., Rius F., Ercilla G., Vives J., Yague J.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*052).
[19]"Description of a novel MICA allele, MICA*010v, discovered by sequencing based typing."
Cox S.T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*054).
Tissue: Blood.
[20]"MICA*TM A8: a new allele with eight GCT repeats in the exon 5 microsatellite."
Glas J., Maier K., Wetzke M., Henninger M., Euba A., Weiss E.H., Folwaczny M.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*055).
[21]"Sequence of new MICA allele, similar to MICA*019."
Cox S.T.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*056).
[22]"Population study of allelic diversity in the human MHC class I-related MIC-A gene."
Petersdorf E.W., Shuler K.B., Longton G.M., Spies T., Hansen J.A.
Immunogenetics 49:605-612(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*009; MICA*017; MICA*018; MICA*019 AND MICA*030).
[23]"New alleles of human non-classical class I MICA gene."
Hirose T., Mitsuishi Y., Young C.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*008; MICA*012; MICA*041; MICA*042; MICA*043; MICA*044 AND MICA*045).
[24]"Identification of a novel MICA allele by SBT."
Yan L., Zhu F.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-283 (ALLELE MICA*019).
[25]"A new allele within the transmembrane region of the human MICA gene with seven GCT repeats."
Rueda B., Pascual M., Lopez-Nevot M.A., Gonzalez E., Martin J.
Tissue Antigens 60:526-528(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 299-341 (ALLELE MICA*050).
[26]"Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium."
Groh V., Bahram S., Bauer S., Herman A., Beauchamp M., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 93:12445-12450(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION.
[27]"MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes."
Zwirner N.W., Fernandez-Vina M.A., Stastny P.
Immunogenetics 47:139-148(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, TISSUE SPECIFICITY.
[28]"Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells."
Groh V., Steinle A., Bauer S., Spies T.
Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[29]"The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis."
Gonzalez S., Martinez-Borra J., Torre-Alonso J.C., Gonzalez-Roces S., Sanchez del Rio J., Rodriguez Perez A., Brautbar C., Lopez-Larrea C.
Arthritis Rheum. 42:1010-1016(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY.
[30]"Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes."
Zwirner N.W., Dole K., Stastny P.
Hum. Immunol. 60:323-330(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[31]"Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."
Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[32]"Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA."
Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T.
Science 285:727-729(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH KLRK1.
[33]"An activating immunoreceptor complex formed by NKG2D and DAP10."
Wu J., Song Y., Bakker A.B.H., Bauer S., Spies T., Lanier L.L., Phillips J.H.
Science 285:730-732(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[34]"PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis."
Tay G.K., Hui J., Gaudieri S., Schmitt-Egenolf M., Martinez O.P., Leelayuwat C., Williamson J.F., Eiermann T.H., Dawkins R.L.
Clin. Exp. Immunol. 119:553-558(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, ASSOCIATION WITH PSORIASIS.
[35]"Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients."
Zwirner N.W., Marcos C.Y., Mirbaha F., Zou Y., Stastny P.
Hum. Immunol. 61:917-924(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS AN ALLOANTIGEN.
[36]"UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."
Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D.
J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A LIGAND FOR KLRK1.
[37]"NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142."
Ashiru O., Bennett N.J., Boyle L.H., Thomas M., Trowsdale J., Wills M.R.
J. Virol. 83:12345-12354(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HHV-5 PROTEIN UL142.
[38]"A single amino acid substitution causes loss of expression of a MICA allele."
Li Z., Groh V., Strong R.K., Spies T.
Immunogenetics 51:246-248(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PRO-29.
[39]"MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function."
Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., Bukowski J.F.
Immunity 15:83-93(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[40]"Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."
Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T.
Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH KLRK1, EFFECT OF VARIANT VAL-152 ON BINDING TO KLRK1.
[41]"Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells."
Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R., Spies T.
Nat. Immunol. 2:255-260(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A LIGAND FOR KLRK1, INDUCTION.
[42]"Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells."
Zou Y., Stastny P.
Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
[43]"Down-regulation of MICA on human tumors by proteolytic shedding."
Salih H.R., Rammensee H.-G., Steinle A.
J. Immunol. 169:4098-4102(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
[44]"Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation."
Groh V., Wu J., Yee C., Spies T.
Nature 419:734-738(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
[45]"Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA."
Tieng V., Le Bouguenec C., du Merle L., Bertheau P., Desreumaux P., Janin A., Charron D., Toubert A.
Proc. Natl. Acad. Sci. U.S.A. 99:2977-2982(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[46]"Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells."
Hue S., Monteiro R.C., Berrih-Aknin S., Caillat-Zucman S.
J. Immunol. 171:1909-1917(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[47]"The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor."
Gasser S., Orsulic S., Brown E.J., Raulet D.H.
Nature 436:1186-1190(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[48]"Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142."
Chalupny N.J., Rein-Weston A., Dosch S., Cosman D.
Biochem. Biophys. Res. Commun. 346:175-181(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[49]"Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands."
Kaiser B.K., Yim D., Chow I.-T., Gonzalez S., Dai Z., Mann H.H., Strong R.K., Groh V., Spies T.
Nature 447:482-486(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PDIA6.
[50]"In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer."
Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.
PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[51]"Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands MICA and MICB."
McSharry B.P., Burgert H.-G., Owen D.P., Stanton R.J., Prod'homme V., Sester M., Koebernick K., Groh V., Spies T., Cox S.T., Little A.-M., Wang E.C.Y., Tomasec P., Wilkinson G.W.
J. Virol. 82:4585-4594(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INDUCTION.
[52]"MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma."
Jinushi M., Vanneman M., Munshi N.C., Tai Y.-T., Prabhala R.H., Ritz J., Neuberg D., Anderson K.C., Carrasco D.R., Dranoff G.
Proc. Natl. Acad. Sci. U.S.A. 105:1285-1290(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN MULTIPLE MYELOMA.
[53]"Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand."
Li P., Willie S.T., Bauer S., Morris D.L., Spies T., Strong R.K.
Immunity 10:577-584(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 24-297, DISULFIDE BONDS.
[54]"Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA."
Li P., Morris D.L., Willcox B.E., Steinle A., Spies T., Strong R.K.
Nat. Immunol. 2:443-451(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-297 IN COMPLEX WITH KLRK1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14848 mRNA. Translation: AAA21718.1.
X92841 Genomic DNA. Translation: CAA63427.1.
AL845443 Genomic DNA. Translation: CAI41907.1.
CR847852 Genomic DNA. Translation: CAQ11015.1.
BC016929 mRNA. Translation: AAH16929.1.
BG114064 mRNA. No translation available.
L29406 Genomic DNA. No translation available.
L29408 Genomic DNA. No translation available.
L29409 Genomic DNA. No translation available.
L29411 Genomic DNA. No translation available.
U56940 Genomic DNA. Translation: AAB41060.1.
U56941 Genomic DNA. Translation: AAB41061.1.
U56942 Genomic DNA. Translation: AAB41062.1.
U56943 Genomic DNA. Translation: AAB41063.1.
U56944 Genomic DNA. Translation: AAB41064.1.
U56945 Genomic DNA. Translation: AAB41065.1.
U56946 Genomic DNA. Translation: AAB41066.1.
U56947 Genomic DNA. Translation: AAB41067.1.
U56948 Genomic DNA. Translation: AAB41068.1.
U56949 Genomic DNA. Translation: AAB41069.1.
U56950 Genomic DNA. Translation: AAB41070.1.
U56951 Genomic DNA. Translation: AAB41071.1.
U56952 Genomic DNA. Translation: AAB41072.1.
U56953 Genomic DNA. Translation: AAB41073.1.
U56954 Genomic DNA. Translation: AAB41074.1.
U56955 Genomic DNA. Translation: AAB41075.1.
Y16801 Genomic DNA. Translation: CAA76393.1.
Y16802 Genomic DNA. Translation: CAA76394.1.
Y16803 Genomic DNA. Translation: CAA76395.1.
Y16804 Genomic DNA. Translation: CAA76396.1.
Y16805 Genomic DNA. Translation: CAA76397.1.
Y16806 Genomic DNA. Translation: CAA76398.1.
Y16807 Genomic DNA. Translation: CAA76399.1.
Y16808 Genomic DNA. Translation: CAA76400.1.
Y16809 Genomic DNA. Translation: CAA76401.1.
Y16810 Genomic DNA. Translation: CAA76402.1.
Y16811 Genomic DNA. Translation: CAA76403.1.
Y18110 Genomic DNA. Translation: CAA77029.1.
Y18111 Genomic DNA. Translation: CAA77030.1.
Y18112 Genomic DNA. Translation: CAA77031.1.
AF097403 Genomic DNA. Translation: AAD27006.1.
AF097404 Genomic DNA. Translation: AAD27007.1.
AF097405 Genomic DNA. Translation: AAD27008.1.
AF097406 Genomic DNA. Translation: AAD27009.1.
AB015600 Genomic DNA. Translation: BAA29034.1.
AJ563426 Genomic DNA. Translation: CAD91415.1.
AH007168 Genomic DNA. Translation: AAD01474.1.
AH007170 Genomic DNA. Translation: AAD01476.1.
AH007171 Genomic DNA. Translation: AAD01477.1.
AH007173 Genomic DNA. Translation: AAD01479.1.
AH007174 Genomic DNA. Translation: AAD01480.1.
AH007186 Genomic DNA. Translation: AAD01492.1.
AH007175 Genomic DNA. Translation: AAD01481.1.
AH007176 Genomic DNA. Translation: AAD01482.1.
AH007177 Genomic DNA. Translation: AAD01483.1.
AH007178 Genomic DNA. Translation: AAD01484.1.
AH007179 Genomic DNA. Translation: AAD01485.1.
AH007180 Genomic DNA. Translation: AAD01486.1.
AH007182 Genomic DNA. Translation: AAD01488.1.
AH007183 Genomic DNA. Translation: AAD01489.1.
AH007184 Genomic DNA. Translation: AAD01490.1.
AH007185 Genomic DNA. Translation: AAD01491.1.
AH008136 Genomic DNA. Translation: AAD52060.1.
AH008137 Genomic DNA. Translation: AAD52061.1.
AH008138 Genomic DNA. Translation: AAD52062.1.
AH008139 Genomic DNA. Translation: AAD52063.1.
AH008140 Genomic DNA. Translation: AAD52064.1.
AH008141 Genomic DNA. Translation: AAD52065.1.
AH008142 Genomic DNA. Translation: AAD52066.1.
AH008143 Genomic DNA. Translation: AAD52067.1.
AH008144 Genomic DNA. Translation: AAD52068.1.
AH008145 Genomic DNA. Translation: AAD52069.1.
AH008146 Genomic DNA. Translation: AAD52070.1.
AH008147 Genomic DNA. Translation: AAD52071.1.
AH008148 Genomic DNA. Translation: AAD52072.1.
AH007169 Genomic DNA. Translation: AAD01475.1.
AH007172 Genomic DNA. Translation: AAD01478.1.
AH007167 Genomic DNA. Translation: AAD01473.1.
AH007181 Genomic DNA. Translation: AAD01487.1.
AH010819 Genomic DNA. Translation: AAK58536.1.
AH011143 Genomic DNA. Translation: AAL13171.1.
AH010820 Genomic DNA. Translation: AAK58537.1.
AH010821 Genomic DNA. Translation: AAK58538.1.
AH010545 Genomic DNA. Translation: AAK19622.1.
AH010526 Genomic DNA. Translation: AAK17997.1.
AH010568 Genomic DNA. Translation: AAK25770.1.
AH010569 Genomic DNA. Translation: AAK25771.1.
AH010532 Genomic DNA. Translation: AAK18281.1.
AH010546 Genomic DNA. Translation: AAK19623.1.
AH010560 Genomic DNA. Translation: AAK20897.1.
AH010561 Genomic DNA. Translation: AAK20898.1.
AH010587 Genomic DNA. Translation: AAK27364.1.
AH010562 Genomic DNA. Translation: AAK20899.1.
AH010571 Genomic DNA. Translation: AAK26323.1.
AH010572 Genomic DNA. Translation: AAK26324.1.
AH010740 Genomic DNA. Translation: AAK51140.1.
AJ250499 Genomic DNA. Translation: CAC14280.1.
AJ250500 Genomic DNA. Translation: CAC14281.1.
AJ250501 Genomic DNA. Translation: CAC14282.1.
AJ250502 Genomic DNA. Translation: CAC14283.1.
AJ250503 Genomic DNA. Translation: CAC14284.1.
AJ250504 Genomic DNA. Translation: CAC14285.1.
AJ250505 Genomic DNA. Translation: CAC14286.1.
AJ250506 Genomic DNA. Translation: CAC14287.1.
AJ250507 Genomic DNA. Translation: CAC14288.1.
AJ250802 Genomic DNA. Translation: CAC15380.1.
AJ250803 Genomic DNA. Translation: CAC15381.1.
AJ250804 Genomic DNA. Translation: CAC15382.1.
AJ250805 Genomic DNA. Translation: CAC15383.1.
AJ250990 Genomic DNA. Translation: CAC16142.1.
AJ250991 Genomic DNA. Translation: CAC16143.1.
AJ271789 Genomic DNA. Translation: CAC27561.1.
AY603357 Genomic DNA. Translation: AAV39504.1.
AJ249394 Genomic DNA. Translation: CAB71317.1.
AJ295250, AJ295251 Genomic DNA. Translation: CAC88121.1.
AJ580805 Genomic DNA. Translation: CAE45581.1.
AJ580806 Genomic DNA. Translation: CAE45582.2.
AH014149 Genomic DNA. Translation: AAU95382.1.
AM899996 Genomic DNA. Translation: CAP12057.1.
EU254723 Genomic DNA. Translation: ABX54884.1.
AM944063 Genomic DNA. Translation: CAQ16171.1.
AH006330 Genomic DNA. Translation: AAC28941.1.
AH006331 Genomic DNA. Translation: AAC28942.1.
AH006332 Genomic DNA. Translation: AAC28943.1.
AH006333 Genomic DNA. Translation: AAC28944.1.
AH006334 Genomic DNA. Translation: AAC28945.1.
AH007472 Genomic DNA. Translation: AAD19598.1.
AH007473 Genomic DNA. Translation: AAD19599.1.
AH007474 Genomic DNA. Translation: AAD19600.1.
AH007475 Genomic DNA. Translation: AAD19601.1.
AH007476 Genomic DNA. Translation: AAD19602.1.
AH007477 Genomic DNA. Translation: AAD19603.1.
AF106652, AF106650, AF106651 Genomic DNA. Translation: AAD19604.1.
AH007479 Genomic DNA. Translation: AAD19605.1.
EU267602 Genomic DNA. Translation: ABX60404.1.
AY095537 Genomic DNA. Translation: AAM34484.1.
PIRA55739.
RefSeqNP_000238.1. NM_000247.2. [Q29983-1]
UniGeneHs.130838.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1B3JX-ray3.00A24-297[»]
1HYRX-ray2.70C24-297[»]
DisProtDP00670.
ProteinModelPortalQ29983.
SMRQ29983. Positions 24-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid319735. 1 interaction.
DIPDIP-29681N.
IntActQ29983. 2 interactions.
MINTMINT-8214461.

PTM databases

PhosphoSiteQ29983.

Polymorphism databases

DMDM74740024.

Proteomic databases

MaxQBQ29983.
PaxDbQ29983.
PRIDEQ29983.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000400325; ENSP00000383179; ENSG00000183214. [Q29983-1]
ENST00000418465; ENSP00000402134; ENSG00000235233.
ENST00000547609; ENSP00000446963; ENSG00000183214. [Q29983-1]
GeneID100507436.
KEGGhsa:100507436.
UCSCuc021zpf.1. human. [Q29983-1]

Organism-specific databases

CTD100507436.
GeneCardsGC06P031373.
GC06Pl31410.
GC06Pn31357.
HGNCHGNC:7090. MICA.
MIM177900. phenotype.
600169. gene.
607507. phenotype.
neXtProtNX_Q29983.
PharmGKBPA30811.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299132.
HOVERGENHBG106364.
InParanoidQ29983.
KOK07985.
OMAASGFYPW.
PhylomeDBQ29983.

Gene expression databases

GenevestigatorQ29983.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMICA. human.
EvolutionaryTraceQ29983.
GeneWikiMHC_class_I_polypeptide-related_sequence_A.
GenomeRNAi100507436.
NextBio34054692.
PMAP-CutDBQ29983.
PROQ29983.
SOURCESearch...

Entry information

Entry nameMICA_HUMAN
AccessionPrimary (citable) accession number: Q29983
Secondary accession number(s): A8KQR0 expand/collapse secondary AC list , A9LRW5, A9QVE0, B1VJF1, O60917, O60918, O60919, O60920, O60933, O77956, O78150, O78151, O78152, O78153, O97987, O97988, O97989, O97990, O97991, O97992, O97993, O97994, O97995, O98234, O98235, O98236, O98237, O98238, P79506, P79507, P79508, P79509, P79510, P79511, P79512, P79513, P79514, P79515, P79516, P79517, P79518, P79519, P79520, P79521, Q5C9P8, Q5XM81, Q70I48, Q70I49, Q7JFH9, Q7JFI0, Q7JFI1, Q7JFI2, Q7YQ98, Q861I1, Q95464, Q95HA2, Q95HD6, Q95HN4, Q95HN5, Q95HN6, Q95IB2, Q95IY7, Q99692, Q9BCR3, Q9BCR4, Q9BCR5, Q9BCR6, Q9BCR7, Q9BCR8, Q9BCR9, Q9BCS0, Q9BCS1, Q9BCS2, Q9BCS3, Q9BCS4, Q9BD20, Q9GIZ1, Q9GIZ2, Q9GIZ3, Q9GIZ4, Q9GIZ5, Q9GIZ6, Q9GJ01, Q9GJ02, Q9GJ03, Q9GJ04, Q9GJ05, Q9GJ06, Q9GJ07, Q9GJ08, Q9GJ09, Q9MY21, Q9TQ86, Q9TQ87, Q9TQ88, Q9TQ89, Q9TQ92, Q9TQ93, Q9TQ94, Q9TQ95, Q9TQ96, Q9TQ97, Q9TQ98, Q9TQ99, Q9TQA0, Q9TQA1, Q9TQA2, Q9TQA3, Q9TQA4, Q9TQI9, Q9TQJ0, Q9TQJ1, Q9TQJ9, Q9TQK0, Q9TQK1, Q9TQK2, Q9TQK8, Q9TQK9, Q9TQL0, Q9TQL1, Q9TQL2, Q9TQL3, Q9TQL4, Q9UE04, Q9UE05, Q9UE06, Q9UE11
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM