Q29983 (MICA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MHC class I polypeptide-related sequence A
Short name=MIC-A

Gene names

Name:	MICA
Synonyms:	PERB11.1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Ref.28 Ref.32 Ref.39
Subunit structure	Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142. Ref.26 Ref.27 Ref.32 Ref.33 Ref.35 Ref.36 Ref.39 Ref.48
Subcellular location	Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note: Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. Ref.26 Ref.30 Ref.39 Ref.50
Tissue specificity	Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells. Ref.26 Ref.27 Ref.30 Ref.31 Ref.34 Ref.39 Ref.45 Ref.49
Induction	By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele. Ref.26 Ref.27 Ref.28 Ref.30 Ref.32 Ref.33 Ref.38 Ref.39 Ref.40 Ref.44 Ref.46 Ref.47 Ref.50
Post-translational modification	N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation. Ref.26 Ref.39 Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation. Ref.42 Ref.43
Polymorphism	The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.
Involvement in disease	Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma. Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Miscellaneous	Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection. Ref.35
Sequence similarities	Belongs to the MHC class I family. MIC subfamily. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Adaptive immunity Cytolysis Host-virus interaction Immunity
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell mediated cytotoxicity Inferred from direct assay Ref.32. Source: UniProtKB antigen processing and presentation Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from direct assay Ref.38Ref.44. Source: UniProtKB defense response to virus Inferred from direct assay Ref.40Ref.47. Source: UniProtKB gamma-delta T cell activation Inferred from direct assay Ref.28. Source: UniProtKB immune response to tumor cell Inferred from direct assay Ref.31. Source: UniProtKB natural killer cell mediated cytotoxicity Inferred from direct assay Ref.32. Source: UniProtKB response to DNA damage stimulus Inferred from direct assay Ref.46. Source: UniProtKB response to heat Inferred from direct assay Ref.26. Source: UniProtKB virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: InterPro cell surface Inferred from direct assay Ref.26. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from direct assay PubMed 18676862. Source: BHF-UCL integral to plasma membrane Inferred from direct assay PubMed 18676862. Source: BHF-UCL
Molecular_function	natural killer cell lectin-like receptor binding Inferred from direct assay Ref.39. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]

Isoform 1 Ref.41 (identifier: Q29983-1)

Also known as: MICA1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.41 (identifier: Q29983-2)

Also known as: MICA2;

The sequence of this isoform is not available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Chain

24 – 383

360

MHC class I polypeptide-related sequence A

PRO_0000337146

Regions

Topological domain

24 – 307

284

Extracellular Potential

Transmembrane

308 – 328

21

Helical; Potential

Topological domain

329 – 383

55

Cytoplasmic Potential

Domain

207 – 296

90

Ig-like C1-type

Amino acid modifications

Glycosylation

31

1

N-linked (GlcNAc...) Potential

Glycosylation

79

1

N-linked (GlcNAc...) Potential

Glycosylation

210

1

N-linked (GlcNAc...) Potential

Glycosylation

220

1

N-linked (GlcNAc...) Potential

Glycosylation

261

1

N-linked (GlcNAc...) Potential

Disulfide bond

59 ↔ 64

Ref.41 Ref.52

Disulfide bond

119 ↔ 187

Ref.41 Ref.52

Disulfide bond

225 ↔ 282

Ref.41 Ref.52

Natural variations

Natural variant

29

1

R → P in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding. Ref.37
Corresponds to variant rs9380254 [ dbSNP | Ensembl ].

VAR_043625

Natural variant

37

1

W → G in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055.
Corresponds to variant rs1063630 [ dbSNP | Ensembl ].

VAR_043626

Natural variant

47

1

T → A in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056.
Corresponds to variant rs1051785 [ dbSNP | Ensembl ].

VAR_043627

Natural variant

49

1

V → G in allele MICA*041.
Corresponds to variant rs17200158 [ dbSNP | Ensembl ].

VAR_043628

Natural variant

59

1

C → Y in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051786 [ dbSNP | Ensembl ].

VAR_043629

Natural variant

114

1

Q → R in allele MICA*017.
Corresponds to variant rs41558312 [ dbSNP | Ensembl ].

VAR_043630

Natural variant

128

1

R → K in allele MICA*036.
Corresponds to variant rs41557113 [ dbSNP | Ensembl ].

VAR_043631

Natural variant

137

1

G → R in allele MICA*014 and allele MICA*015.
Corresponds to variant rs41556715 [ dbSNP | Ensembl ].

VAR_043632

Natural variant

145

1

L → V in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*044 and allele MICA*049.
Corresponds to variant rs1051790 [ dbSNP | Ensembl ].

VAR_043633

Natural variant

147

1

T → S in allele MICA*033.
Corresponds to variant rs41539919 [ dbSNP | Ensembl ].

VAR_043634

Natural variant

148

1

K → E in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*012, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*018, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056.
Corresponds to variant rs1051791 [ dbSNP | Ensembl ].

VAR_043635

Natural variant

152

1

M → V in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056; reduces binding affinity for KLRK1. Ref.39
Corresponds to variant rs1051792 [ dbSNP | Ensembl ].

VAR_043636

Natural variant

165

1

V → I in allele MICA*029.
Corresponds to variant rs3819269 [ dbSNP | Ensembl ].

VAR_043637

Natural variant

174

1

M → V in allele MICA*011 and allele MICA*034.
Corresponds to variant rs41560824 [ dbSNP | Ensembl ].

VAR_043638

Natural variant

179

1

H → L in allele MICA*012, allele MICA*032 and allele MICA*043.
Corresponds to variant rs3819268 [ dbSNP | Ensembl ].

VAR_043639

Natural variant

196

1

K → E in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*014, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051794 [ dbSNP | Ensembl ].

VAR_043640

Natural variant

198

1

G → S in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*031, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*049, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1131896 [ dbSNP | Ensembl ].

VAR_043641

Natural variant

199

1

V → I in allele MICA*006.
Corresponds to variant rs41549718 [ dbSNP | Ensembl ].

VAR_043642

Natural variant

204

1

T → R in allele MICA*004, allele MICA*014, allele MICA*032 and allele MICA*044.
Corresponds to variant rs1131897 [ dbSNP | Ensembl ].

VAR_043643

Natural variant

229

1

G → S in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1131898 [ dbSNP | Ensembl ].

VAR_043644

Natural variant

231

1

Y → C in allele MICA*046.
Corresponds to variant rs41546915 [ dbSNP | Ensembl ].

VAR_043645

Natural variant

233

1

W → R in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051798 [ dbSNP | Ensembl ].

VAR_043646

Natural variant

236

1

T → I in allele MICA*008, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1140700 [ dbSNP | Ensembl ].

VAR_043647

Natural variant

238

1

S → T in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051799 [ dbSNP | Ensembl ].

VAR_043648

Natural variant

244

1

V → L in allele MICA*016 and allele MICA*039.
Corresponds to variant rs41540613 [ dbSNP | Ensembl ].

VAR_043649

Natural variant

253

1

W → S in allele MICA*056.

VAR_043869

Natural variant

274

1

Q → R in allele MICA*005, allele MICA*008, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*045, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1063635 [ dbSNP | Ensembl ].

VAR_043650

Natural variant

279

1

R → S in allele MICA*043.
Corresponds to variant rs41557614 [ dbSNP | Ensembl ].

VAR_043651

Natural variant

291

1

S → G in allele MICA*054.

VAR_043652

Natural variant

294

1

P → A in allele MICA*011, allele MICA*030 and allele MICA*047.
Corresponds to variant rs41553616 [ dbSNP | Ensembl ].

VAR_043653

Natural variant

300 – 383

84

VLVLQ…STEGA → CWCFRVIGRHSMFLLLLLLL LLLLLFLLLLFSTSVVVRRK HQLQRVQSS in allele MICA*015 and allele MICA*017.

VAR_043654

Natural variant

318 – 383

66

AAIFV…STEGA → GCCYFCYYYFLCPLL in allele MICA*008, allele MICA*023, allele MICA*028 and allele MICA*053.

VAR_043655

Natural variant

319

1

A → AA in allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*027, allele MICA*033, allele MICA*048, allele MICA*054 and allele MICA*056.

VAR_043656

Natural variant

319

1

A → AAA in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*011, allele MICA*026, allele MICA*047 and allele MICA*049.

VAR_043657

Natural variant

319

1

A → AAAA in allele MICA*050.

VAR_043658

Natural variant

319

1

A → AAAAA in allele MICA*055.

VAR_043659

Natural variant

319

1

A → AAAAAA in allele MICA*002, allele MICA*041, allele MICA*046 and allele MICA*052.

VAR_043660

Natural variant

319

1

A → AAAAAAA in allele MICA*020.

VAR_043661

Natural variant

328

1

V → I in allele MICA*052.

VAR_043662

Natural variant

329

1

R → C in allele MICA*002, allele MICA*011, allele MICA*020, allele MICA*041, allele MICA*043, allele MICA*046, allele MICA*047, allele MICA*050 and allele MICA*052.
Corresponds to variant rs41554412 [ dbSNP | Ensembl ].

VAR_043663

Natural variant

356

1

T → M in allele MICA*049.

VAR_043664

Natural variant

373

1

D → A in allele MICA*004, allele MICA*006, allele MICA*010, allele MICA*011, allele MICA*016, allele MICA*019, allele MICA*048 and allele MICA*049.

VAR_043665

Natural variant

377

1

T → A in allele MICA*011.

VAR_043666

Natural variant

383

1

A → T in allele MICA*018.

VAR_043667

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

383

Helix Strand Turn

Details...

Beta strand

26 – 37

12

Beta strand

40 – 51

12

Beta strand

54 – 59

6

Beta strand

64 – 66

3

Beta strand

71 – 75

5

Helix

79 – 81

3

Helix

82 – 101

20

Beta strand

109 – 121

13

Beta strand

127 – 135

9

Beta strand

138 – 144

7

Turn

145 – 148

4

Beta strand

149 – 151

3

Helix

156 – 170

15

Helix

177 – 196

20

Beta strand

208 – 213

6

Beta strand

217 – 233

17

Beta strand

236 – 241

6

Turn

248 – 250

3

Beta strand

251 – 253

3

Beta strand

260 – 262

3

Beta strand

264 – 273

10

Helix

277 – 279

3

Beta strand

280 – 286

7

Beta strand

289 – 294

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MICA1) [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1FE084813DDA13A8	FASTA	383	42,915
	10 20 30 40 50 60 MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH LDGQPFLRCD 70 80 90 100 110 120 RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE 130 140 150 160 170 180 IHEDNSTRSS QHFYYDGELF LSQNLETKEW TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY 190 200 210 220 230 240 HAMHADCLQE LRRYLKSGVV LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR 250 260 270 280 290 300 QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV 310 320 330 340 350 360 LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD QHPVGTSDHR 370 380 DATQLGFQPL MSDLGSTGST EGA
	Isoform 2 (MICA2) (Sequence not available).		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A second lineage of mammalian major histocompatibility complex class I genes." Bahram S., Bresnahan M., Geraghty D.E., Spies T. Proc. Natl. Acad. Sci. U.S.A. 91:6259-6263(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICA*001).
[2]	"Nucleotide sequence of the human MHC class I MICA gene." Bahram S., Mizuki N., Inoko H., Spies T. Immunogenetics 44:80-81(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICA*004).
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICA*001 AND MICA*004).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE MICA*018). Tissue: Kidney.
[5]	"A new polymorphic and multicopy MHC gene family related to nonmammalian class I." Leelayuwat C., Townend D.C., Degli-Esposti M.A., Abraham L.J., Dawkins R.L. Immunogenetics 40:339-351(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-150 (ALLELES MICA*001; MICA*008 AND MICA*010).
[6]	"Allelic repertoire of the human MHC class I MICA gene." Fodil N., Laloux L., Wanner V., Pellet P., Hauptmann G., Mizuki N., Inoko H., Spies T., Theodorou I., Bahram S. Immunogenetics 44:351-357(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*001; MICA*002; MICA*004; MICA*005; MICA*006; MICA*007; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; MICA*013; MICA*014; MICA*015 AND MICA*016).
[7]	"Definition of new alleles of MIC-A using sequencing-based typing." Yao Z., Volgger A., Helmberg W., Keller E., Fan L.A., Chandanayingyong D., Albert E.D. Eur. J. Immunogenet. 26:225-232(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*007; MICA*008; MICA*009; MICA*010; MICA*012; MICA*016; MICA*017; MICA*018; MICA*022; MICA*024; MICA*025; MICA*028 AND MICA*029).
[8]	"MICA haplotypic diversity." Fodil N., Pellet P., Laloux L., Hauptmann G., Theodorou I., Bahram S. Immunogenetics 49:557-560(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*009; MICA*017; MICA*018 AND MICA*019).
[9]	"MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype." Komatsu-Wakui M., Tokunaga K., Ishikawa Y., Kashiwase K., Moriyama S., Tsuchiya N., Ando H., Shiina T., Geraghty D.E., Inoko H., Juji T. Immunogenetics 49:620-628(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*019).
[10]	"Identification of a novel MICA allele: MICA*051." Quiroga I., Sweeney D., Sutton P.M., Chapple S.D., Souto-Grando J.P., Barnardo M.C.N.M., Fuggle S.V. Tissue Antigens 63:466-469(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*051). Tissue: Blood.
[11]	"Sequencing-based typing of MICA reveals 33 alleles: a study on linkage with classical HLA genes." Visser C.J.T., Tilanus M.G.J., Tatari Z., van der Zwan A.-W., Bakker R., Rozemuller E.H., Schaeffer V., Tamouza R., Charron D. Immunogenetics 49:561-566(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*008; MICA*023 AND MICA*028), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*001; MICA*002; MICA*004; MICA*006; MICA*007; MICA*009; MICA*010; MICA*011; MICA*016; MICA*018; MICA*019; MICA*022; MICA*024; MICA*025; MICA*026; MICA*027; MICA*031; MICA*032; MICA*033; MICA*034; MICA*035; MICA*036; MICA*037; MICA*038; MICA*039 AND MICA*040).
[12]	"Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4." Obuchi N., Takahashi M., Nouchi T., Satoh M., Arimura T., Ueda K., Akai J., Ota M., Naruse T., Inoko H., Numano F., Kimura A. Tissue Antigens 57:520-535(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*001; MICA*002; MICA*006; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; MICA*015; MICA*016; MICA*017; MICA*018; MICA*019; MICA*048 AND MICA*049).
[13]	"Further polymorphism of the MICA gene." Perez-Rodriguez M., Arguello J.R., Fischer G., Corell A., Cox S.T., Robinson J., Hossain E., McWhinnie A., Travers P.J., Marsh S.G.E., Madrigal J.A. Eur. J. Immunogenet. 29:35-46(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELES MICA*008; MICA*017; MICA*018; MICA*019; MICA*027; MICA*029; MICA*033; MICA*041; MICA*043; MICA*045 AND MICA*046).
[14]	"MIC-A sequence in AH8.2." Kaur G., Shiina T., Hashimoto N., Kumar N., Inoko H., Mehra N.K. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELE MICA*008).
[15]	"A new MICA allele with ten alanine residues in the exon 5 microsatellite." Perez-Rodriguez M., Corell A., Fischer G., Arguello R., Cox S.T., McWhinnie A., Marsh S.G.E., Madrigal A. Tissue Antigens 55:162-165(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*020).
[16]	"Identification of a new MICA allele, MICA*047." Perez-Rodriguez M., Raimondi E., Marsh S.G.E., Madrigal J.A. Tissue Antigens 59:216-218(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*047).
[17]	"The identification of three novel MICA alleles by sequence-based typing." Quiroga I., Sweeney D., Sutton P.M., Ahmad T., Walton R., Barnardo M.C.N.M., Fuggle S.V. Tissue Antigens 67:321-325(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*007; MICA*018 AND MICA*053).
[18]	"Description of a new MICA allele." Mas V., Amezaga N., Arostegui J.I., Masso M., Plaza S., Rius F., Ercilla G., Vives J., Yague J. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*052).
[19]	"Description of a novel MICA allele, MICA*010v, discovered by sequencing based typing." Cox S.T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*054). Tissue: Blood.
[20]	"MICA*TM A8: a new allele with eight GCT repeats in the exon 5 microsatellite." Glas J., Maier K., Wetzke M., Henninger M., Euba A., Weiss E.H., Folwaczny M. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*055).
[21]	"Sequence of new MICA allele, similar to MICA*019." Cox S.T. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*056).
[22]	"Population study of allelic diversity in the human MHC class I-related MIC-A gene." Petersdorf E.W., Shuler K.B., Longton G.M., Spies T., Hansen J.A. Immunogenetics 49:605-612(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*009; MICA*017; MICA*018; MICA*019 AND MICA*030).
[23]	"New alleles of human non-classical class I MICA gene." Hirose T., Mitsuishi Y., Young C. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*008; MICA*012; MICA*041; MICA*042; MICA*043; MICA*044 AND MICA*045).
[24]	"Identification of a novel MICA allele by SBT." Yan L., Zhu F. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-283 (ALLELE MICA*019).
[25]	"A new allele within the transmembrane region of the human MICA gene with seven GCT repeats." Rueda B., Pascual M., Lopez-Nevot M.A., Gonzalez E., Martin J. Tissue Antigens 60:526-528(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 299-341 (ALLELE MICA*050).
[26]	"Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium." Groh V., Bahram S., Bauer S., Herman A., Beauchamp M., Spies T. Proc. Natl. Acad. Sci. U.S.A. 93:12445-12450(1996) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION.
[27]	"MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes." Zwirner N.W., Fernandez-Vina M.A., Stastny P. Immunogenetics 47:139-148(1998) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, TISSUE SPECIFICITY.
[28]	"Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells." Groh V., Steinle A., Bauer S., Spies T. Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[29]	"The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis." Gonzalez S., Martinez-Borra J., Torre-Alonso J.C., Gonzalez-Roces S., Sanchez del Rio J., Rodriguez Perez A., Brautbar C., Lopez-Larrea C. Arthritis Rheum. 42:1010-1016(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY.
[30]	"Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes." Zwirner N.W., Dole K., Stastny P. Hum. Immunol. 60:323-330(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[31]	"Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB." Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T. Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[32]	"Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T. Science 285:727-729(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH KLRK1.
[33]	"An activating immunoreceptor complex formed by NKG2D and DAP10." Wu J., Song Y., Bakker A.B.H., Bauer S., Spies T., Lanier L.L., Phillips J.H. Science 285:730-732(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[34]	"PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis." Tay G.K., Hui J., Gaudieri S., Schmitt-Egenolf M., Martinez O.P., Leelayuwat C., Williamson J.F., Eiermann T.H., Dawkins R.L. Clin. Exp. Immunol. 119:553-558(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, ASSOCIATION WITH PSORIASIS.
[35]	"Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients." Zwirner N.W., Marcos C.Y., Mirbaha F., Zou Y., Stastny P. Hum. Immunol. 61:917-924(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS AN ALLOANTIGEN.
[36]	"NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142." Ashiru O., Bennett N.J., Boyle L.H., Thomas M., Trowsdale J., Wills M.R. J. Virol. 83:12345-12354(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HHV-5 PROTEIN UL142.
[37]	"A single amino acid substitution causes loss of expression of a MICA allele." Li Z., Groh V., Strong R.K., Spies T. Immunogenetics 51:246-248(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PRO-29.
[38]	"MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function." Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., Bukowski J.F. Immunity 15:83-93(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[39]	"Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family." Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T. Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH KLRK1, EFFECT OF VARIANT VAL-152 ON BINDING TO KLRK1.
[40]	"Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells." Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R., Spies T. Nat. Immunol. 2:255-260(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[41]	"Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells." Zou Y., Stastny P. Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[42]	"Down-regulation of MICA on human tumors by proteolytic shedding." Salih H.R., Rammensee H.-G., Steinle A. J. Immunol. 169:4098-4102(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
[43]	"Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation." Groh V., Wu J., Yee C., Spies T. Nature 419:734-738(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
[44]	"Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA." Tieng V., Le Bouguenec C., du Merle L., Bertheau P., Desreumaux P., Janin A., Charron D., Toubert A. Proc. Natl. Acad. Sci. U.S.A. 99:2977-2982(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[45]	"Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells." Hue S., Monteiro R.C., Berrih-Aknin S., Caillat-Zucman S. J. Immunol. 171:1909-1917(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[46]	"The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor." Gasser S., Orsulic S., Brown E.J., Raulet D.H. Nature 436:1186-1190(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[47]	"Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142." Chalupny N.J., Rein-Weston A., Dosch S., Cosman D. Biochem. Biophys. Res. Commun. 346:175-181(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[48]	"Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands." Kaiser B.K., Yim D., Chow I.-T., Gonzalez S., Dai Z., Mann H.H., Strong R.K., Groh V., Spies T. Nature 447:482-486(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDIA6.
[49]	"In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer." Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S. PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[50]	"Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands MICA and MICB." McSharry B.P., Burgert H.-G., Owen D.P., Stanton R.J., Prod'homme V., Sester M., Koebernick K., Groh V., Spies T., Cox S.T., Little A.-M., Wang E.C.Y., Tomasec P., Wilkinson G.W. J. Virol. 82:4585-4594(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INDUCTION.
[51]	"MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma." Jinushi M., Vanneman M., Munshi N.C., Tai Y.-T., Prabhala R.H., Ritz J., Neuberg D., Anderson K.C., Carrasco D.R., Dranoff G. Proc. Natl. Acad. Sci. U.S.A. 105:1285-1290(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN MULTIPLE MYELOMA.
[52]	"Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand." Li P., Willie S.T., Bauer S., Morris D.L., Spies T., Strong R.K. Immunity 10:577-584(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 24-297, DISULFIDE BONDS.
[53]	"Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA." Li P., Morris D.L., Willcox B.E., Steinle A., Spies T., Strong R.K. Nat. Immunol. 2:443-451(2001) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-297 IN COMPLEX WITH KLRK1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L14848 mRNA. Translation: AAA21718.1.
X92841 Genomic DNA. Translation: CAA63427.1.
AL845443 Genomic DNA. Translation: CAI41907.1.
CR847852 Genomic DNA. Translation: CAQ11015.1.
BC016929 mRNA. Translation: AAH16929.1.
L29406 Genomic DNA. No translation available.
L29408 Genomic DNA. No translation available.
L29409 Genomic DNA. No translation available.
L29411 Genomic DNA. No translation available.
U56940 Genomic DNA. Translation: AAB41060.1.
U56941 Genomic DNA. Translation: AAB41061.1.
U56942 Genomic DNA. Translation: AAB41062.1.
U56943 Genomic DNA. Translation: AAB41063.1.
U56944 Genomic DNA. Translation: AAB41064.1.
U56945 Genomic DNA. Translation: AAB41065.1.
U56946 Genomic DNA. Translation: AAB41066.1.
U56947 Genomic DNA. Translation: AAB41067.1.
U56948 Genomic DNA. Translation: AAB41068.1.
U56949 Genomic DNA. Translation: AAB41069.1.
U56950 Genomic DNA. Translation: AAB41070.1.
U56951 Genomic DNA. Translation: AAB41071.1.
U56952 Genomic DNA. Translation: AAB41072.1.
U56953 Genomic DNA. Translation: AAB41073.1.
U56954 Genomic DNA. Translation: AAB41074.1.
U56955 Genomic DNA. Translation: AAB41075.1.
Y16801 Genomic DNA. Translation: CAA76393.1.
Y16802 Genomic DNA. Translation: CAA76394.1.
Y16803 Genomic DNA. Translation: CAA76395.1.
Y16804 Genomic DNA. Translation: CAA76396.1.
Y16805 Genomic DNA. Translation: CAA76397.1.
Y16806 Genomic DNA. Translation: CAA76398.1.
Y16807 Genomic DNA. Translation: CAA76399.1.
Y16808 Genomic DNA. Translation: CAA76400.1.
Y16809 Genomic DNA. Translation: CAA76401.1.
Y16810 Genomic DNA. Translation: CAA76402.1.
Y16811 Genomic DNA. Translation: CAA76403.1.
Y18110 Genomic DNA. Translation: CAA77029.1.
Y18111 Genomic DNA. Translation: CAA77030.1.
Y18112 Genomic DNA. Translation: CAA77031.1.
AF097403 Genomic DNA. Translation: AAD27006.1.
AF097404 Genomic DNA. Translation: AAD27007.1.
AF097405 Genomic DNA. Translation: AAD27008.1.
AF097406 Genomic DNA. Translation: AAD27009.1.
AB015600 Genomic DNA. Translation: BAA29034.1.
AJ563426 Genomic DNA. Translation: CAD91415.1.
AH007168 Genomic DNA. Translation: AAD01474.1.
AH007170 Genomic DNA. Translation: AAD01476.1.
AH007171 Genomic DNA. Translation: AAD01477.1.
AH007173 Genomic DNA. Translation: AAD01479.1.
AH007174 Genomic DNA. Translation: AAD01480.1.
AH007186 Genomic DNA. Translation: AAD01492.1.
AH007175 Genomic DNA. Translation: AAD01481.1.
AH007176 Genomic DNA. Translation: AAD01482.1.
AH007177 Genomic DNA. Translation: AAD01483.1.
AH007178 Genomic DNA. Translation: AAD01484.1.
AH007179 Genomic DNA. Translation: AAD01485.1.
AH007180 Genomic DNA. Translation: AAD01486.1.
AH007182 Genomic DNA. Translation: AAD01488.1.
AH007183 Genomic DNA. Translation: AAD01489.1.
AH007184 Genomic DNA. Translation: AAD01490.1.
AH007185 Genomic DNA. Translation: AAD01491.1.
AH008136 Genomic DNA. Translation: AAD52060.1.
AH008137 Genomic DNA. Translation: AAD52061.1.
AH008138 Genomic DNA. Translation: AAD52062.1.
AH008139 Genomic DNA. Translation: AAD52063.1.
AH008140 Genomic DNA. Translation: AAD52064.1.
AH008141 Genomic DNA. Translation: AAD52065.1.
AH008142 Genomic DNA. Translation: AAD52066.1.
AH008143 Genomic DNA. Translation: AAD52067.1.
AH008144 Genomic DNA. Translation: AAD52068.1.
AH008145 Genomic DNA. Translation: AAD52069.1.
AH008146 Genomic DNA. Translation: AAD52070.1.
AH008147 Genomic DNA. Translation: AAD52071.1.
AH008148 Genomic DNA. Translation: AAD52072.1.
AH007169 Genomic DNA. Translation: AAD01475.1.
AH007172 Genomic DNA. Translation: AAD01478.1.
AH007167 Genomic DNA. Translation: AAD01473.1.
AH007181 Genomic DNA. Translation: AAD01487.1.
AH010819 Genomic DNA. Translation: AAK58536.1.
AH011143 Genomic DNA. Translation: AAL13171.1.
AH010820 Genomic DNA. Translation: AAK58537.1.
AH010821 Genomic DNA. Translation: AAK58538.1.
AH010545 Genomic DNA. Translation: AAK19622.1.
AH010526 Genomic DNA. Translation: AAK17997.1.
AH010568 Genomic DNA. Translation: AAK25770.1.
AH010569 Genomic DNA. Translation: AAK25771.1.
AH010532 Genomic DNA. Translation: AAK18281.1.
AH010546 Genomic DNA. Translation: AAK19623.1.
AH010560 Genomic DNA. Translation: AAK20897.1.
AH010561 Genomic DNA. Translation: AAK20898.1.
AH010587 Genomic DNA. Translation: AAK27364.1.
AH010562 Genomic DNA. Translation: AAK20899.1.
AH010571 Genomic DNA. Translation: AAK26323.1.
AH010572 Genomic DNA. Translation: AAK26324.1.
AH010740 Genomic DNA. Translation: AAK51140.1.
AJ250499 Genomic DNA. Translation: CAC14280.1.
AJ250500 Genomic DNA. Translation: CAC14281.1.
AJ250501 Genomic DNA. Translation: CAC14282.1.
AJ250502 Genomic DNA. Translation: CAC14283.1.
AJ250503 Genomic DNA. Translation: CAC14284.1.
AJ250504 Genomic DNA. Translation: CAC14285.1.
AJ250505 Genomic DNA. Translation: CAC14286.1.
AJ250506 Genomic DNA. Translation: CAC14287.1.
AJ250507 Genomic DNA. Translation: CAC14288.1.
AJ250802 Genomic DNA. Translation: CAC15380.1.
AJ250803 Genomic DNA. Translation: CAC15381.1.
AJ250804 Genomic DNA. Translation: CAC15382.1.
AJ250805 Genomic DNA. Translation: CAC15383.1.
AJ250990 Genomic DNA. Translation: CAC16142.1.
AJ250991 Genomic DNA. Translation: CAC16143.1.
AJ271789 Genomic DNA. Translation: CAC27561.1.
AY603357 Genomic DNA. Translation: AAV39504.1.
AJ249394 Genomic DNA. Translation: CAB71317.1.
AJ295250, AJ295251 Genomic DNA. Translation: CAC88121.1.
AJ580805 Genomic DNA. Translation: CAE45581.1.
AJ580806 Genomic DNA. Translation: CAE45582.2.
AH014149 Genomic DNA. Translation: AAU95382.1.
AM899996 Genomic DNA. Translation: CAP12057.1.
EU254723 Genomic DNA. Translation: ABX54884.1.
AM944063 Genomic DNA. Translation: CAQ16171.1.
AH006330 Genomic DNA. Translation: AAC28941.1.
AH006331 Genomic DNA. Translation: AAC28942.1.
AH006332 Genomic DNA. Translation: AAC28943.1.
AH006333 Genomic DNA. Translation: AAC28944.1.
AH006334 Genomic DNA. Translation: AAC28945.1.
AH007472 Genomic DNA. Translation: AAD19598.1.
AH007473 Genomic DNA. Translation: AAD19599.1.
AH007474 Genomic DNA. Translation: AAD19600.1.
AH007475 Genomic DNA. Translation: AAD19601.1.
AH007476 Genomic DNA. Translation: AAD19602.1.
AH007477 Genomic DNA. Translation: AAD19603.1.
AF106652, AF106650, AF106651 Genomic DNA. Translation: AAD19604.1.
AH007479 Genomic DNA. Translation: AAD19605.1.
EU267602 Genomic DNA. Translation: ABX60404.1.
AY095537 Genomic DNA. Translation: AAM34484.1.

IPI

IPI00107380.

PIR

A55739.

RefSeq

NP_000238.1. NM_000247.1.

UniGene

Hs.130838.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B3J	X-ray	3.00	A	24-297	[»]
1HYR	X-ray	2.70	C	24-297	[»]

ProteinModelPortal

Q29983.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29681N.

IntAct

Q29983. 1 interaction.

MINT

MINT-8214461.

PTM databases

PhosphoSite

Q29983.

Polymorphism databases

DMDM

74740024.

Proteomic databases

PaxDb

Q29983.

PRIDE

Q29983.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000400325; ENSP00000383179; ENSG00000183214.
ENST00000418465; ENSP00000402134; ENSG00000235233.
ENST00000547609; ENSP00000446963; ENSG00000183214.

GeneID

100507436.

KEGG

hsa:100507436.

UCSC

uc021zpf.1. human.

Organism-specific databases

CTD

100507436.

GeneCards

GC06P031370.

HGNC

HGNC:7090. MICA.

MIM

177900. phenotype.
600169. gene.
607507. phenotype.

neXtProt

NX_Q29983.

PharmGKB

PA30811.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG299132.

HOVERGEN

HBG106364.

InParanoid

Q29983.

KO

K07985.

Gene expression databases

ArrayExpress

Q29983.

Genevestigator

Q29983.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

MICA. human.

EvolutionaryTrace

Q29983.

GenomeRNAi

100507436.

NextBio

34054692.

PMAP-CutDB

Q29983.

SOURCE

Search...

Entry information

Entry name

MICA_HUMAN

Accession

Primary (citable) accession number: Q29983
Secondary accession number(s): A8KQR0 , A9LRW5, A9QVE0, B1VJF1, O60917, O60918, O60919, O60920, O60933, O77956, O78150, O78151, O78152, O78153, O97987, O97988, O97989, O97990, O97991, O97992, O97993, O97994, O97995, O98234, O98235, O98236, O98237, O98238, P79506, P79507, P79508, P79509, P79510, P79511, P79512, P79513, P79514, P79515, P79516, P79517, P79518, P79519, P79520, P79521, Q5C9P8, Q5XM81, Q70I48, Q70I49, Q7JFH9, Q7JFI0, Q7JFI1, Q7JFI2, Q7YQ98, Q861I1, Q95464, Q95HA2, Q95HD6, Q95HN4, Q95HN5, Q95HN6, Q95IB2, Q95IY7, Q99692, Q9BCR3, Q9BCR4, Q9BCR5, Q9BCR6, Q9BCR7, Q9BCR8, Q9BCR9, Q9BCS0, Q9BCS1, Q9BCS2, Q9BCS3, Q9BCS4, Q9BD20, Q9GIZ1, Q9GIZ2, Q9GIZ3, Q9GIZ4, Q9GIZ5, Q9GIZ6, Q9GJ01, Q9GJ02, Q9GJ03, Q9GJ04, Q9GJ05, Q9GJ06, Q9GJ07, Q9GJ08, Q9GJ09, Q9MY21, Q9TQ86, Q9TQ87, Q9TQ88, Q9TQ89, Q9TQ92, Q9TQ93, Q9TQ94, Q9TQ95, Q9TQ96, Q9TQ97, Q9TQ98, Q9TQ99, Q9TQA0, Q9TQA1, Q9TQA2, Q9TQA3, Q9TQA4, Q9TQI9, Q9TQJ0, Q9TQJ1, Q9TQJ9, Q9TQK0, Q9TQK1, Q9TQK2, Q9TQK8, Q9TQK9, Q9TQL0, Q9TQL1, Q9TQL2, Q9TQL3, Q9TQL4, Q9UE04, Q9UE05, Q9UE06, Q9UE11

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.