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Q29983

- MICA_HUMAN

UniProt

Q29983 - MICA_HUMAN

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Protein

MHC class I polypeptide-related sequence A

Gene

MICA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.5 Publications

GO - Molecular functioni

  1. natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation Source: InterPro
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB
  5. defense response to virus Source: UniProtKB
  6. gamma-delta T cell activation Source: UniProtKB
  7. immune response to tumor cell Source: UniProtKB
  8. natural killer cell mediated cytotoxicity Source: UniProtKB
  9. response to heat Source: UniProtKB
  10. T cell mediated cytotoxicity Source: UniProtKB
  11. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Cytolysis, Host-virus interaction, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
MHC class I polypeptide-related sequence A
Short name:
MIC-A
Gene namesi
Name:MICAImported
Synonyms:PERB11.11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:7090. MICA.

Subcellular locationi

Cell membrane 3 Publications; Single-pass type I membrane protein 3 Publications. Cytoplasm 3 Publications
Note: Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 307284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Topological domaini329 – 38355CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. extracellular space Source: BHF-UCL
  4. integral component of plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Organism-specific databases

MIMi177900. phenotype.
607507. phenotype.
PharmGKBiPA30811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 383360MHC class I polypeptide-related sequence ASequence AnalysisPRO_0000337146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi59 ↔ 641 PublicationPROSITE-ProRule annotation
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi119 ↔ 1871 PublicationPROSITE-ProRule annotation
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi225 ↔ 2821 PublicationPROSITE-ProRule annotation
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.1 Publication
Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ29983.
PaxDbiQ29983.
PRIDEiQ29983.

PTM databases

PhosphoSiteiQ29983.

Miscellaneous databases

PMAP-CutDBQ29983.

Expressioni

Tissue specificityi

Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.7 Publications

Inductioni

By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.8 Publications

Gene expression databases

GenevestigatoriQ29983.

Interactioni

Subunit structurei

Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRK1P267182EBI-1031130,EBI-458344
LGALS3P179312EBI-1031130,EBI-1170392

Protein-protein interaction databases

BioGridi319735. 20 interactions.
DIPiDIP-29681N.
IntActiQ29983. 2 interactions.
MINTiMINT-8214461.

Structurei

Secondary structure

1
383
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 3712Combined sources
Beta strandi40 – 5112Combined sources
Beta strandi54 – 596Combined sources
Beta strandi64 – 663Combined sources
Beta strandi71 – 755Combined sources
Helixi79 – 813Combined sources
Helixi82 – 10120Combined sources
Beta strandi109 – 12113Combined sources
Beta strandi127 – 1359Combined sources
Beta strandi138 – 1447Combined sources
Turni145 – 1484Combined sources
Beta strandi149 – 1513Combined sources
Helixi156 – 17015Combined sources
Helixi177 – 19620Combined sources
Beta strandi208 – 2136Combined sources
Beta strandi217 – 23317Combined sources
Beta strandi236 – 2416Combined sources
Turni248 – 2503Combined sources
Beta strandi251 – 2533Combined sources
Beta strandi260 – 2623Combined sources
Beta strandi264 – 27310Combined sources
Helixi277 – 2793Combined sources
Beta strandi280 – 2867Combined sources
Beta strandi289 – 2946Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B3JX-ray3.00A24-297[»]
1HYRX-ray2.70C24-297[»]
DisProtiDP00670.
ProteinModelPortaliQ29983.
SMRiQ29983. Positions 24-297.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ29983.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 29690Ig-like C1-typeSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family. MIC subfamily.Sequence Analysis

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299132.
HOVERGENiHBG106364.
InParanoidiQ29983.
KOiK07985.
OMAiASGFYPW.
PhylomeDBiQ29983.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q29983-1) [UniParc]FASTAAdd to Basket

Also known as: MICA11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH
60 70 80 90 100
LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL
110 120 130 140 150
AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETKEW
160 170 180 190 200
TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLKSGVV
210 220 230 240 250
LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR QDGVSLSHDT
260 270 280 290 300
QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV
310 320 330 340 350
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD
360 370 380
QHPVGTSDHR DATQLGFQPL MSDLGSTGST EGA
Length:383
Mass (Da):42,915
Last modified:November 1, 1996 - v1
Checksum:i1FE084813DDA13A8
GO
Isoform 21 Publication (identifier: Q29983-2) [UniParc]FASTAAdd to Basket

Also known as: MICA21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     109-204: Missing.

Note: Found in about 10% of examined clones.

Show »
Length:287
Mass (Da):31,577
Checksum:i0D41D7919769F469
GO

Polymorphismi

The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291R → P in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding. 1 Publication
Corresponds to variant rs9380254 [ dbSNP | Ensembl ].
VAR_043625
Natural varianti37 – 371W → G in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055.
Corresponds to variant rs1063630 [ dbSNP | Ensembl ].
VAR_043626
Natural varianti47 – 471T → A in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056.
Corresponds to variant rs1051785 [ dbSNP | Ensembl ].
VAR_043627
Natural varianti49 – 491V → G in allele MICA*041.
Corresponds to variant rs17200158 [ dbSNP | Ensembl ].
VAR_043628
Natural varianti59 – 591C → Y in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051786 [ dbSNP | Ensembl ].
VAR_043629
Natural varianti114 – 1141Q → R in allele MICA*017.
Corresponds to variant rs41558312 [ dbSNP | Ensembl ].
VAR_043630
Natural varianti128 – 1281R → K in allele MICA*036.
Corresponds to variant rs41557113 [ dbSNP | Ensembl ].
VAR_043631
Natural varianti137 – 1371G → R in allele MICA*014 and allele MICA*015.
Corresponds to variant rs41556715 [ dbSNP | Ensembl ].
VAR_043632
Natural varianti145 – 1451L → V in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*044 and allele MICA*049.
Corresponds to variant rs1051790 [ dbSNP | Ensembl ].
VAR_043633
Natural varianti147 – 1471T → S in allele MICA*033.
Corresponds to variant rs41539919 [ dbSNP | Ensembl ].
VAR_043634
Natural varianti148 – 1481K → E in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*012, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*018, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056.
Corresponds to variant rs1051791 [ dbSNP | Ensembl ].
VAR_043635
Natural varianti152 – 1521M → V in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056; reduces binding affinity for KLRK1.
Corresponds to variant rs1051792 [ dbSNP | Ensembl ].
VAR_043636
Natural varianti165 – 1651V → I in allele MICA*029.
Corresponds to variant rs3819269 [ dbSNP | Ensembl ].
VAR_043637
Natural varianti174 – 1741M → V in allele MICA*011 and allele MICA*034.
Corresponds to variant rs41560824 [ dbSNP | Ensembl ].
VAR_043638
Natural varianti179 – 1791H → L in allele MICA*012, allele MICA*032 and allele MICA*043.
Corresponds to variant rs3819268 [ dbSNP | Ensembl ].
VAR_043639
Natural varianti196 – 1961K → E in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*014, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051794 [ dbSNP | Ensembl ].
VAR_043640
Natural varianti198 – 1981G → S in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*031, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*049, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1131896 [ dbSNP | Ensembl ].
VAR_043641
Natural varianti199 – 1991V → I in allele MICA*006.
Corresponds to variant rs41549718 [ dbSNP | Ensembl ].
VAR_043642
Natural varianti204 – 2041T → R in allele MICA*004, allele MICA*014, allele MICA*032 and allele MICA*044.
Corresponds to variant rs1131897 [ dbSNP | Ensembl ].
VAR_043643
Natural varianti229 – 2291G → S in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1131898 [ dbSNP | Ensembl ].
VAR_043644
Natural varianti231 – 2311Y → C in allele MICA*046.
Corresponds to variant rs41546915 [ dbSNP | Ensembl ].
VAR_043645
Natural varianti233 – 2331W → R in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051798 [ dbSNP | Ensembl ].
VAR_043646
Natural varianti236 – 2361T → I in allele MICA*008, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1140700 [ dbSNP | Ensembl ].
VAR_043647
Natural varianti238 – 2381S → T in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1051799 [ dbSNP | Ensembl ].
VAR_043648
Natural varianti244 – 2441V → L in allele MICA*016 and allele MICA*039.
Corresponds to variant rs41540613 [ dbSNP | Ensembl ].
VAR_043649
Natural varianti253 – 2531W → S in allele MICA*056.
VAR_043869
Natural varianti274 – 2741Q → R in allele MICA*005, allele MICA*008, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*045, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056.
Corresponds to variant rs1063635 [ dbSNP | Ensembl ].
VAR_043650
Natural varianti279 – 2791R → S in allele MICA*043.
Corresponds to variant rs41557614 [ dbSNP | Ensembl ].
VAR_043651
Natural varianti291 – 2911S → G in allele MICA*054.
VAR_043652
Natural varianti294 – 2941P → A in allele MICA*011, allele MICA*030 and allele MICA*047.
Corresponds to variant rs41553616 [ dbSNP | Ensembl ].
VAR_043653
Natural varianti300 – 38384VLVLQ…STEGA → CWCFRVIGRHSMFLLLLLLL LLLLLFLLLLFSTSVVVRRK HQLQRVQSS in allele MICA*015 and allele MICA*017.
VAR_043654Add
BLAST
Natural varianti318 – 38366AAIFV…STEGA → GCCYFCYYYFLCPLL in allele MICA*008, allele MICA*023, allele MICA*028 and allele MICA*053.
VAR_043655Add
BLAST
Natural varianti319 – 3191A → AA in allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*027, allele MICA*033, allele MICA*048, allele MICA*054 and allele MICA*056.
VAR_043656
Natural varianti319 – 3191A → AAA in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*011, allele MICA*026, allele MICA*047 and allele MICA*049.
VAR_043657
Natural varianti319 – 3191A → AAAA in allele MICA*050.
VAR_043658
Natural varianti319 – 3191A → AAAAA in allele MICA*055.
VAR_043659
Natural varianti319 – 3191A → AAAAAA in allele MICA*002, allele MICA*041, allele MICA*046 and allele MICA*052.
VAR_043660
Natural varianti319 – 3191A → AAAAAAA in allele MICA*020.
VAR_043661
Natural varianti328 – 3281V → I in allele MICA*052.
VAR_043662
Natural varianti329 – 3291R → C in allele MICA*002, allele MICA*011, allele MICA*020, allele MICA*041, allele MICA*043, allele MICA*046, allele MICA*047, allele MICA*050 and allele MICA*052.
Corresponds to variant rs41554412 [ dbSNP | Ensembl ].
VAR_043663
Natural varianti356 – 3561T → M in allele MICA*049.
VAR_043664
Natural varianti373 – 3731D → A in allele MICA*004, allele MICA*006, allele MICA*010, allele MICA*011, allele MICA*016, allele MICA*019, allele MICA*048 and allele MICA*049.
VAR_043665
Natural varianti377 – 3771T → A in allele MICA*011.
VAR_043666
Natural varianti383 – 3831A → T in allele MICA*018.
VAR_043667

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 20496Missing in isoform 2. 1 PublicationVSP_055366Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14848 mRNA. Translation: AAA21718.1.
X92841 Genomic DNA. Translation: CAA63427.1.
AL845443 Genomic DNA. Translation: CAI41907.1.
CR847852 Genomic DNA. Translation: CAQ11015.1.
BC016929 mRNA. Translation: AAH16929.1.
BG114064 mRNA. No translation available.
L29406 Genomic DNA. No translation available.
L29408 Genomic DNA. No translation available.
L29409 Genomic DNA. No translation available.
L29411 Genomic DNA. No translation available.
U56940 Genomic DNA. Translation: AAB41060.1.
U56941 Genomic DNA. Translation: AAB41061.1.
U56942 Genomic DNA. Translation: AAB41062.1.
U56943 Genomic DNA. Translation: AAB41063.1.
U56944 Genomic DNA. Translation: AAB41064.1.
U56945 Genomic DNA. Translation: AAB41065.1.
U56946 Genomic DNA. Translation: AAB41066.1.
U56947 Genomic DNA. Translation: AAB41067.1.
U56948 Genomic DNA. Translation: AAB41068.1.
U56949 Genomic DNA. Translation: AAB41069.1.
U56950 Genomic DNA. Translation: AAB41070.1.
U56951 Genomic DNA. Translation: AAB41071.1.
U56952 Genomic DNA. Translation: AAB41072.1.
U56953 Genomic DNA. Translation: AAB41073.1.
U56954 Genomic DNA. Translation: AAB41074.1.
U56955 Genomic DNA. Translation: AAB41075.1.
Y16801 Genomic DNA. Translation: CAA76393.1.
Y16802 Genomic DNA. Translation: CAA76394.1.
Y16803 Genomic DNA. Translation: CAA76395.1.
Y16804 Genomic DNA. Translation: CAA76396.1.
Y16805 Genomic DNA. Translation: CAA76397.1.
Y16806 Genomic DNA. Translation: CAA76398.1.
Y16807 Genomic DNA. Translation: CAA76399.1.
Y16808 Genomic DNA. Translation: CAA76400.1.
Y16809 Genomic DNA. Translation: CAA76401.1.
Y16810 Genomic DNA. Translation: CAA76402.1.
Y16811 Genomic DNA. Translation: CAA76403.1.
Y18110 Genomic DNA. Translation: CAA77029.1.
Y18111 Genomic DNA. Translation: CAA77030.1.
Y18112 Genomic DNA. Translation: CAA77031.1.
AF097403 Genomic DNA. Translation: AAD27006.1.
AF097404 Genomic DNA. Translation: AAD27007.1.
AF097405 Genomic DNA. Translation: AAD27008.1.
AF097406 Genomic DNA. Translation: AAD27009.1.
AB015600 Genomic DNA. Translation: BAA29034.1.
AJ563426 Genomic DNA. Translation: CAD91415.1.
AH007168 Genomic DNA. Translation: AAD01474.1.
AH007170 Genomic DNA. Translation: AAD01476.1.
AH007171 Genomic DNA. Translation: AAD01477.1.
AH007173 Genomic DNA. Translation: AAD01479.1.
AH007174 Genomic DNA. Translation: AAD01480.1.
AH007186 Genomic DNA. Translation: AAD01492.1.
AH007175 Genomic DNA. Translation: AAD01481.1.
AH007176 Genomic DNA. Translation: AAD01482.1.
AH007177 Genomic DNA. Translation: AAD01483.1.
AH007178 Genomic DNA. Translation: AAD01484.1.
AH007179 Genomic DNA. Translation: AAD01485.1.
AH007180 Genomic DNA. Translation: AAD01486.1.
AH007182 Genomic DNA. Translation: AAD01488.1.
AH007183 Genomic DNA. Translation: AAD01489.1.
AH007184 Genomic DNA. Translation: AAD01490.1.
AH007185 Genomic DNA. Translation: AAD01491.1.
AH008136 Genomic DNA. Translation: AAD52060.1.
AH008137 Genomic DNA. Translation: AAD52061.1.
AH008138 Genomic DNA. Translation: AAD52062.1.
AH008139 Genomic DNA. Translation: AAD52063.1.
AH008140 Genomic DNA. Translation: AAD52064.1.
AH008141 Genomic DNA. Translation: AAD52065.1.
AH008142 Genomic DNA. Translation: AAD52066.1.
AH008143 Genomic DNA. Translation: AAD52067.1.
AH008144 Genomic DNA. Translation: AAD52068.1.
AH008145 Genomic DNA. Translation: AAD52069.1.
AH008146 Genomic DNA. Translation: AAD52070.1.
AH008147 Genomic DNA. Translation: AAD52071.1.
AH008148 Genomic DNA. Translation: AAD52072.1.
AH007169 Genomic DNA. Translation: AAD01475.1.
AH007172 Genomic DNA. Translation: AAD01478.1.
AH007167 Genomic DNA. Translation: AAD01473.1.
AH007181 Genomic DNA. Translation: AAD01487.1.
AH010819 Genomic DNA. Translation: AAK58536.1.
AH011143 Genomic DNA. Translation: AAL13171.1.
AH010820 Genomic DNA. Translation: AAK58537.1.
AH010821 Genomic DNA. Translation: AAK58538.1.
AH010545 Genomic DNA. Translation: AAK19622.1.
AH010526 Genomic DNA. Translation: AAK17997.1.
AH010568 Genomic DNA. Translation: AAK25770.1.
AH010569 Genomic DNA. Translation: AAK25771.1.
AH010532 Genomic DNA. Translation: AAK18281.1.
AH010546 Genomic DNA. Translation: AAK19623.1.
AH010560 Genomic DNA. Translation: AAK20897.1.
AH010561 Genomic DNA. Translation: AAK20898.1.
AH010587 Genomic DNA. Translation: AAK27364.1.
AH010562 Genomic DNA. Translation: AAK20899.1.
AH010571 Genomic DNA. Translation: AAK26323.1.
AH010572 Genomic DNA. Translation: AAK26324.1.
AH010740 Genomic DNA. Translation: AAK51140.1.
AJ250499 Genomic DNA. Translation: CAC14280.1.
AJ250500 Genomic DNA. Translation: CAC14281.1.
AJ250501 Genomic DNA. Translation: CAC14282.1.
AJ250502 Genomic DNA. Translation: CAC14283.1.
AJ250503 Genomic DNA. Translation: CAC14284.1.
AJ250504 Genomic DNA. Translation: CAC14285.1.
AJ250505 Genomic DNA. Translation: CAC14286.1.
AJ250506 Genomic DNA. Translation: CAC14287.1.
AJ250507 Genomic DNA. Translation: CAC14288.1.
AJ250802 Genomic DNA. Translation: CAC15380.1.
AJ250803 Genomic DNA. Translation: CAC15381.1.
AJ250804 Genomic DNA. Translation: CAC15382.1.
AJ250805 Genomic DNA. Translation: CAC15383.1.
AJ250990 Genomic DNA. Translation: CAC16142.1.
AJ250991 Genomic DNA. Translation: CAC16143.1.
AJ271789 Genomic DNA. Translation: CAC27561.1.
AY603357 Genomic DNA. Translation: AAV39504.1.
AJ249394 Genomic DNA. Translation: CAB71317.1.
AJ295250, AJ295251 Genomic DNA. Translation: CAC88121.1.
AJ580805 Genomic DNA. Translation: CAE45581.1.
AJ580806 Genomic DNA. Translation: CAE45582.2.
AH014149 Genomic DNA. Translation: AAU95382.1.
AM899996 Genomic DNA. Translation: CAP12057.1.
EU254723 Genomic DNA. Translation: ABX54884.1.
AM944063 Genomic DNA. Translation: CAQ16171.1.
AH006330 Genomic DNA. Translation: AAC28941.1.
AH006331 Genomic DNA. Translation: AAC28942.1.
AH006332 Genomic DNA. Translation: AAC28943.1.
AH006333 Genomic DNA. Translation: AAC28944.1.
AH006334 Genomic DNA. Translation: AAC28945.1.
AH007472 Genomic DNA. Translation: AAD19598.1.
AH007473 Genomic DNA. Translation: AAD19599.1.
AH007474 Genomic DNA. Translation: AAD19600.1.
AH007475 Genomic DNA. Translation: AAD19601.1.
AH007476 Genomic DNA. Translation: AAD19602.1.
AH007477 Genomic DNA. Translation: AAD19603.1.
AF106652, AF106650, AF106651 Genomic DNA. Translation: AAD19604.1.
AH007479 Genomic DNA. Translation: AAD19605.1.
EU267602 Genomic DNA. Translation: ABX60404.1.
AY095537 Genomic DNA. Translation: AAM34484.1.
PIRiA55739.
RefSeqiNP_000238.1. NM_000247.2. [Q29983-1]
UniGeneiHs.130838.

Genome annotation databases

EnsembliENST00000400325; ENSP00000383179; ENSG00000183214. [Q29983-1]
ENST00000418465; ENSP00000402134; ENSG00000235233.
ENST00000547609; ENSP00000446963; ENSG00000183214. [Q29983-1]
GeneIDi100507436.
KEGGihsa:100507436.
UCSCiuc021zpf.1. human. [Q29983-1]

Polymorphism databases

DMDMi74740024.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14848 mRNA. Translation: AAA21718.1 .
X92841 Genomic DNA. Translation: CAA63427.1 .
AL845443 Genomic DNA. Translation: CAI41907.1 .
CR847852 Genomic DNA. Translation: CAQ11015.1 .
BC016929 mRNA. Translation: AAH16929.1 .
BG114064 mRNA. No translation available.
L29406 Genomic DNA. No translation available.
L29408 Genomic DNA. No translation available.
L29409 Genomic DNA. No translation available.
L29411 Genomic DNA. No translation available.
U56940 Genomic DNA. Translation: AAB41060.1 .
U56941 Genomic DNA. Translation: AAB41061.1 .
U56942 Genomic DNA. Translation: AAB41062.1 .
U56943 Genomic DNA. Translation: AAB41063.1 .
U56944 Genomic DNA. Translation: AAB41064.1 .
U56945 Genomic DNA. Translation: AAB41065.1 .
U56946 Genomic DNA. Translation: AAB41066.1 .
U56947 Genomic DNA. Translation: AAB41067.1 .
U56948 Genomic DNA. Translation: AAB41068.1 .
U56949 Genomic DNA. Translation: AAB41069.1 .
U56950 Genomic DNA. Translation: AAB41070.1 .
U56951 Genomic DNA. Translation: AAB41071.1 .
U56952 Genomic DNA. Translation: AAB41072.1 .
U56953 Genomic DNA. Translation: AAB41073.1 .
U56954 Genomic DNA. Translation: AAB41074.1 .
U56955 Genomic DNA. Translation: AAB41075.1 .
Y16801 Genomic DNA. Translation: CAA76393.1 .
Y16802 Genomic DNA. Translation: CAA76394.1 .
Y16803 Genomic DNA. Translation: CAA76395.1 .
Y16804 Genomic DNA. Translation: CAA76396.1 .
Y16805 Genomic DNA. Translation: CAA76397.1 .
Y16806 Genomic DNA. Translation: CAA76398.1 .
Y16807 Genomic DNA. Translation: CAA76399.1 .
Y16808 Genomic DNA. Translation: CAA76400.1 .
Y16809 Genomic DNA. Translation: CAA76401.1 .
Y16810 Genomic DNA. Translation: CAA76402.1 .
Y16811 Genomic DNA. Translation: CAA76403.1 .
Y18110 Genomic DNA. Translation: CAA77029.1 .
Y18111 Genomic DNA. Translation: CAA77030.1 .
Y18112 Genomic DNA. Translation: CAA77031.1 .
AF097403 Genomic DNA. Translation: AAD27006.1 .
AF097404 Genomic DNA. Translation: AAD27007.1 .
AF097405 Genomic DNA. Translation: AAD27008.1 .
AF097406 Genomic DNA. Translation: AAD27009.1 .
AB015600 Genomic DNA. Translation: BAA29034.1 .
AJ563426 Genomic DNA. Translation: CAD91415.1 .
AH007168 Genomic DNA. Translation: AAD01474.1 .
AH007170 Genomic DNA. Translation: AAD01476.1 .
AH007171 Genomic DNA. Translation: AAD01477.1 .
AH007173 Genomic DNA. Translation: AAD01479.1 .
AH007174 Genomic DNA. Translation: AAD01480.1 .
AH007186 Genomic DNA. Translation: AAD01492.1 .
AH007175 Genomic DNA. Translation: AAD01481.1 .
AH007176 Genomic DNA. Translation: AAD01482.1 .
AH007177 Genomic DNA. Translation: AAD01483.1 .
AH007178 Genomic DNA. Translation: AAD01484.1 .
AH007179 Genomic DNA. Translation: AAD01485.1 .
AH007180 Genomic DNA. Translation: AAD01486.1 .
AH007182 Genomic DNA. Translation: AAD01488.1 .
AH007183 Genomic DNA. Translation: AAD01489.1 .
AH007184 Genomic DNA. Translation: AAD01490.1 .
AH007185 Genomic DNA. Translation: AAD01491.1 .
AH008136 Genomic DNA. Translation: AAD52060.1 .
AH008137 Genomic DNA. Translation: AAD52061.1 .
AH008138 Genomic DNA. Translation: AAD52062.1 .
AH008139 Genomic DNA. Translation: AAD52063.1 .
AH008140 Genomic DNA. Translation: AAD52064.1 .
AH008141 Genomic DNA. Translation: AAD52065.1 .
AH008142 Genomic DNA. Translation: AAD52066.1 .
AH008143 Genomic DNA. Translation: AAD52067.1 .
AH008144 Genomic DNA. Translation: AAD52068.1 .
AH008145 Genomic DNA. Translation: AAD52069.1 .
AH008146 Genomic DNA. Translation: AAD52070.1 .
AH008147 Genomic DNA. Translation: AAD52071.1 .
AH008148 Genomic DNA. Translation: AAD52072.1 .
AH007169 Genomic DNA. Translation: AAD01475.1 .
AH007172 Genomic DNA. Translation: AAD01478.1 .
AH007167 Genomic DNA. Translation: AAD01473.1 .
AH007181 Genomic DNA. Translation: AAD01487.1 .
AH010819 Genomic DNA. Translation: AAK58536.1 .
AH011143 Genomic DNA. Translation: AAL13171.1 .
AH010820 Genomic DNA. Translation: AAK58537.1 .
AH010821 Genomic DNA. Translation: AAK58538.1 .
AH010545 Genomic DNA. Translation: AAK19622.1 .
AH010526 Genomic DNA. Translation: AAK17997.1 .
AH010568 Genomic DNA. Translation: AAK25770.1 .
AH010569 Genomic DNA. Translation: AAK25771.1 .
AH010532 Genomic DNA. Translation: AAK18281.1 .
AH010546 Genomic DNA. Translation: AAK19623.1 .
AH010560 Genomic DNA. Translation: AAK20897.1 .
AH010561 Genomic DNA. Translation: AAK20898.1 .
AH010587 Genomic DNA. Translation: AAK27364.1 .
AH010562 Genomic DNA. Translation: AAK20899.1 .
AH010571 Genomic DNA. Translation: AAK26323.1 .
AH010572 Genomic DNA. Translation: AAK26324.1 .
AH010740 Genomic DNA. Translation: AAK51140.1 .
AJ250499 Genomic DNA. Translation: CAC14280.1 .
AJ250500 Genomic DNA. Translation: CAC14281.1 .
AJ250501 Genomic DNA. Translation: CAC14282.1 .
AJ250502 Genomic DNA. Translation: CAC14283.1 .
AJ250503 Genomic DNA. Translation: CAC14284.1 .
AJ250504 Genomic DNA. Translation: CAC14285.1 .
AJ250505 Genomic DNA. Translation: CAC14286.1 .
AJ250506 Genomic DNA. Translation: CAC14287.1 .
AJ250507 Genomic DNA. Translation: CAC14288.1 .
AJ250802 Genomic DNA. Translation: CAC15380.1 .
AJ250803 Genomic DNA. Translation: CAC15381.1 .
AJ250804 Genomic DNA. Translation: CAC15382.1 .
AJ250805 Genomic DNA. Translation: CAC15383.1 .
AJ250990 Genomic DNA. Translation: CAC16142.1 .
AJ250991 Genomic DNA. Translation: CAC16143.1 .
AJ271789 Genomic DNA. Translation: CAC27561.1 .
AY603357 Genomic DNA. Translation: AAV39504.1 .
AJ249394 Genomic DNA. Translation: CAB71317.1 .
AJ295250 , AJ295251 Genomic DNA. Translation: CAC88121.1 .
AJ580805 Genomic DNA. Translation: CAE45581.1 .
AJ580806 Genomic DNA. Translation: CAE45582.2 .
AH014149 Genomic DNA. Translation: AAU95382.1 .
AM899996 Genomic DNA. Translation: CAP12057.1 .
EU254723 Genomic DNA. Translation: ABX54884.1 .
AM944063 Genomic DNA. Translation: CAQ16171.1 .
AH006330 Genomic DNA. Translation: AAC28941.1 .
AH006331 Genomic DNA. Translation: AAC28942.1 .
AH006332 Genomic DNA. Translation: AAC28943.1 .
AH006333 Genomic DNA. Translation: AAC28944.1 .
AH006334 Genomic DNA. Translation: AAC28945.1 .
AH007472 Genomic DNA. Translation: AAD19598.1 .
AH007473 Genomic DNA. Translation: AAD19599.1 .
AH007474 Genomic DNA. Translation: AAD19600.1 .
AH007475 Genomic DNA. Translation: AAD19601.1 .
AH007476 Genomic DNA. Translation: AAD19602.1 .
AH007477 Genomic DNA. Translation: AAD19603.1 .
AF106652 , AF106650 , AF106651 Genomic DNA. Translation: AAD19604.1 .
AH007479 Genomic DNA. Translation: AAD19605.1 .
EU267602 Genomic DNA. Translation: ABX60404.1 .
AY095537 Genomic DNA. Translation: AAM34484.1 .
PIRi A55739.
RefSeqi NP_000238.1. NM_000247.2. [Q29983-1 ]
UniGenei Hs.130838.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B3J X-ray 3.00 A 24-297 [» ]
1HYR X-ray 2.70 C 24-297 [» ]
DisProti DP00670.
ProteinModelPortali Q29983.
SMRi Q29983. Positions 24-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 319735. 20 interactions.
DIPi DIP-29681N.
IntActi Q29983. 2 interactions.
MINTi MINT-8214461.

PTM databases

PhosphoSitei Q29983.

Polymorphism databases

DMDMi 74740024.

Proteomic databases

MaxQBi Q29983.
PaxDbi Q29983.
PRIDEi Q29983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400325 ; ENSP00000383179 ; ENSG00000183214 . [Q29983-1 ]
ENST00000418465 ; ENSP00000402134 ; ENSG00000235233 .
ENST00000547609 ; ENSP00000446963 ; ENSG00000183214 . [Q29983-1 ]
GeneIDi 100507436.
KEGGi hsa:100507436.
UCSCi uc021zpf.1. human. [Q29983-1 ]

Organism-specific databases

CTDi 100507436.
GeneCardsi GC06P031373.
GC06Pl31410.
GC06Pn31357.
HGNCi HGNC:7090. MICA.
MIMi 177900. phenotype.
600169. gene.
607507. phenotype.
neXtProti NX_Q29983.
PharmGKBi PA30811.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299132.
HOVERGENi HBG106364.
InParanoidi Q29983.
KOi K07985.
OMAi ASGFYPW.
PhylomeDBi Q29983.

Miscellaneous databases

ChiTaRSi MICA. human.
EvolutionaryTracei Q29983.
GeneWikii MHC_class_I_polypeptide-related_sequence_A.
GenomeRNAii 100507436.
NextBioi 34054692.
PMAP-CutDB Q29983.
PROi Q29983.
SOURCEi Search...

Gene expression databases

Genevestigatori Q29983.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A second lineage of mammalian major histocompatibility complex class I genes."
    Bahram S., Bresnahan M., Geraghty D.E., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 91:6259-6263(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICA*001).
  2. "Nucleotide sequence of the human MHC class I MICA gene."
    Bahram S., Mizuki N., Inoko H., Spies T.
    Immunogenetics 44:80-81(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICA*004).
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICA*001 AND MICA*004).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE MICA*018), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-248 (ISOFORM 2).
    Tissue: Bone and KidneyImported.
  5. "A new polymorphic and multicopy MHC gene family related to nonmammalian class I."
    Leelayuwat C., Townend D.C., Degli-Esposti M.A., Abraham L.J., Dawkins R.L.
    Immunogenetics 40:339-351(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-150 (ALLELES MICA*001; MICA*008 AND MICA*010).
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*001; MICA*002; MICA*004; MICA*005; MICA*006; MICA*007; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; MICA*013; MICA*014; MICA*015 AND MICA*016).
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*007; MICA*008; MICA*009; MICA*010; MICA*012; MICA*016; MICA*017; MICA*018; MICA*022; MICA*024; MICA*025; MICA*028 AND MICA*029).
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*009; MICA*017; MICA*018 AND MICA*019).
  9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*019).
  10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*051).
    Tissue: BloodImported.
  11. "Sequencing-based typing of MICA reveals 33 alleles: a study on linkage with classical HLA genes."
    Visser C.J.T., Tilanus M.G.J., Tatari Z., van der Zwan A.-W., Bakker R., Rozemuller E.H., Schaeffer V., Tamouza R., Charron D.
    Immunogenetics 49:561-566(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*008; MICA*023 AND MICA*028), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*001; MICA*002; MICA*004; MICA*006; MICA*007; MICA*009; MICA*010; MICA*011; MICA*016; MICA*018; MICA*019; MICA*022; MICA*024; MICA*025; MICA*026; MICA*027; MICA*031; MICA*032; MICA*033; MICA*034; MICA*035; MICA*036; MICA*037; MICA*038; MICA*039 AND MICA*040).
  12. "Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4."
    Obuchi N., Takahashi M., Nouchi T., Satoh M., Arimura T., Ueda K., Akai J., Ota M., Naruse T., Inoko H., Numano F., Kimura A.
    Tissue Antigens 57:520-535(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*001; MICA*002; MICA*006; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; MICA*015; MICA*016; MICA*017; MICA*018; MICA*019; MICA*048 AND MICA*049).
  13. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELES MICA*008; MICA*017; MICA*018; MICA*019; MICA*027; MICA*029; MICA*033; MICA*041; MICA*043; MICA*045 AND MICA*046).
  14. "MIC-A sequence in AH8.2."
    Kaur G., Shiina T., Hashimoto N., Kumar N., Inoko H., Mehra N.K.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELE MICA*008).
  15. "A new MICA allele with ten alanine residues in the exon 5 microsatellite."
    Perez-Rodriguez M., Corell A., Fischer G., Arguello R., Cox S.T., McWhinnie A., Marsh S.G.E., Madrigal A.
    Tissue Antigens 55:162-165(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*020).
  16. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*047).
  17. "The identification of three novel MICA alleles by sequence-based typing."
    Quiroga I., Sweeney D., Sutton P.M., Ahmad T., Walton R., Barnardo M.C.N.M., Fuggle S.V.
    Tissue Antigens 67:321-325(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*007; MICA*018 AND MICA*053).
  18. "Description of a new MICA allele."
    Mas V., Amezaga N., Arostegui J.I., Masso M., Plaza S., Rius F., Ercilla G., Vives J., Yague J.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*052).
  19. "Description of a novel MICA allele, MICA*010v, discovered by sequencing based typing."
    Cox S.T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*054).
    Tissue: BloodImported.
  20. "MICA*TM A8: a new allele with eight GCT repeats in the exon 5 microsatellite."
    Glas J., Maier K., Wetzke M., Henninger M., Euba A., Weiss E.H., Folwaczny M.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*055).
  21. "Sequence of new MICA allele, similar to MICA*019."
    Cox S.T.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*056).
  22. "Population study of allelic diversity in the human MHC class I-related MIC-A gene."
    Petersdorf E.W., Shuler K.B., Longton G.M., Spies T., Hansen J.A.
    Immunogenetics 49:605-612(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*009; MICA*017; MICA*018; MICA*019 AND MICA*030).
  23. "New alleles of human non-classical class I MICA gene."
    Hirose T., Mitsuishi Y., Young C.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*008; MICA*012; MICA*041; MICA*042; MICA*043; MICA*044 AND MICA*045).
  24. "Identification of a novel MICA allele by SBT."
    Yan L., Zhu F.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-283 (ALLELE MICA*019).
  25. "A new allele within the transmembrane region of the human MICA gene with seven GCT repeats."
    Rueda B., Pascual M., Lopez-Nevot M.A., Gonzalez E., Martin J.
    Tissue Antigens 60:526-528(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 299-341 (ALLELE MICA*050).
  26. "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium."
    Groh V., Bahram S., Bauer S., Herman A., Beauchamp M., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 93:12445-12450(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION.
  27. "MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes."
    Zwirner N.W., Fernandez-Vina M.A., Stastny P.
    Immunogenetics 47:139-148(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY.
  28. "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells."
    Groh V., Steinle A., Bauer S., Spies T.
    Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  29. "The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis."
    Gonzalez S., Martinez-Borra J., Torre-Alonso J.C., Gonzalez-Roces S., Sanchez del Rio J., Rodriguez Perez A., Brautbar C., Lopez-Larrea C.
    Arthritis Rheum. 42:1010-1016(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY.
  30. "Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes."
    Zwirner N.W., Dole K., Stastny P.
    Hum. Immunol. 60:323-330(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  31. "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."
    Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  32. "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA."
    Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T.
    Science 285:727-729(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KLRK1.
  33. "An activating immunoreceptor complex formed by NKG2D and DAP10."
    Wu J., Song Y., Bakker A.B.H., Bauer S., Spies T., Lanier L.L., Phillips J.H.
    Science 285:730-732(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  34. "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis."
    Tay G.K., Hui J., Gaudieri S., Schmitt-Egenolf M., Martinez O.P., Leelayuwat C., Williamson J.F., Eiermann T.H., Dawkins R.L.
    Clin. Exp. Immunol. 119:553-558(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ASSOCIATION WITH PSORIASIS.
  35. "Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients."
    Zwirner N.W., Marcos C.Y., Mirbaha F., Zou Y., Stastny P.
    Hum. Immunol. 61:917-924(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS AN ALLOANTIGEN.
  36. "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."
    Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D.
    J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A LIGAND FOR KLRK1.
  37. "NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142."
    Ashiru O., Bennett N.J., Boyle L.H., Thomas M., Trowsdale J., Wills M.R.
    J. Virol. 83:12345-12354(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-5 PROTEIN UL142.
  38. "A single amino acid substitution causes loss of expression of a MICA allele."
    Li Z., Groh V., Strong R.K., Spies T.
    Immunogenetics 51:246-248(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PRO-29.
  39. "MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function."
    Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., Bukowski J.F.
    Immunity 15:83-93(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  40. "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."
    Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T.
    Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KLRK1, EFFECT OF VARIANT VAL-152 ON BINDING TO KLRK1.
  41. "Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells."
    Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R., Spies T.
    Nat. Immunol. 2:255-260(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A LIGAND FOR KLRK1, INDUCTION.
  42. "Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells."
    Zou Y., Stastny P.
    Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  43. "Down-regulation of MICA on human tumors by proteolytic shedding."
    Salih H.R., Rammensee H.-G., Steinle A.
    J. Immunol. 169:4098-4102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
  44. "Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation."
    Groh V., Wu J., Yee C., Spies T.
    Nature 419:734-738(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
  45. "Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA."
    Tieng V., Le Bouguenec C., du Merle L., Bertheau P., Desreumaux P., Janin A., Charron D., Toubert A.
    Proc. Natl. Acad. Sci. U.S.A. 99:2977-2982(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  46. "Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells."
    Hue S., Monteiro R.C., Berrih-Aknin S., Caillat-Zucman S.
    J. Immunol. 171:1909-1917(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  47. "The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor."
    Gasser S., Orsulic S., Brown E.J., Raulet D.H.
    Nature 436:1186-1190(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  48. "Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142."
    Chalupny N.J., Rein-Weston A., Dosch S., Cosman D.
    Biochem. Biophys. Res. Commun. 346:175-181(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  49. "Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands."
    Kaiser B.K., Yim D., Chow I.-T., Gonzalez S., Dai Z., Mann H.H., Strong R.K., Groh V., Spies T.
    Nature 447:482-486(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDIA6.
  50. "In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer."
    Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.
    PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  51. "Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands MICA and MICB."
    McSharry B.P., Burgert H.-G., Owen D.P., Stanton R.J., Prod'homme V., Sester M., Koebernick K., Groh V., Spies T., Cox S.T., Little A.-M., Wang E.C.Y., Tomasec P., Wilkinson G.W.
    J. Virol. 82:4585-4594(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.
  52. "MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma."
    Jinushi M., Vanneman M., Munshi N.C., Tai Y.-T., Prabhala R.H., Ritz J., Neuberg D., Anderson K.C., Carrasco D.R., Dranoff G.
    Proc. Natl. Acad. Sci. U.S.A. 105:1285-1290(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MULTIPLE MYELOMA.
  53. "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand."
    Li P., Willie S.T., Bauer S., Morris D.L., Spies T., Strong R.K.
    Immunity 10:577-584(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 24-297, DISULFIDE BONDS.
  54. "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA."
    Li P., Morris D.L., Willcox B.E., Steinle A., Spies T., Strong R.K.
    Nat. Immunol. 2:443-451(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-297 IN COMPLEX WITH KLRK1.

Entry informationi

Entry nameiMICA_HUMAN
AccessioniPrimary (citable) accession number: Q29983
Secondary accession number(s): A8KQR0
, A9LRW5, A9QVE0, B1VJF1, O60917, O60918, O60919, O60920, O60933, O77956, O78150, O78151, O78152, O78153, O97987, O97988, O97989, O97990, O97991, O97992, O97993, O97994, O97995, O98234, O98235, O98236, O98237, O98238, P79506, P79507, P79508, P79509, P79510, P79511, P79512, P79513, P79514, P79515, P79516, P79517, P79518, P79519, P79520, P79521, Q5C9P8, Q5XM81, Q70I48, Q70I49, Q7JFH9, Q7JFI0, Q7JFI1, Q7JFI2, Q7YQ98, Q861I1, Q95464, Q95HA2, Q95HD6, Q95HN4, Q95HN5, Q95HN6, Q95IB2, Q95IY7, Q99692, Q9BCR3, Q9BCR4, Q9BCR5, Q9BCR6, Q9BCR7, Q9BCR8, Q9BCR9, Q9BCS0, Q9BCS1, Q9BCS2, Q9BCS3, Q9BCS4, Q9BD20, Q9GIZ1, Q9GIZ2, Q9GIZ3, Q9GIZ4, Q9GIZ5, Q9GIZ6, Q9GJ01, Q9GJ02, Q9GJ03, Q9GJ04, Q9GJ05, Q9GJ06, Q9GJ07, Q9GJ08, Q9GJ09, Q9MY21, Q9TQ86, Q9TQ87, Q9TQ88, Q9TQ89, Q9TQ92, Q9TQ93, Q9TQ94, Q9TQ95, Q9TQ96, Q9TQ97, Q9TQ98, Q9TQ99, Q9TQA0, Q9TQA1, Q9TQA2, Q9TQA3, Q9TQA4, Q9TQI9, Q9TQJ0, Q9TQJ1, Q9TQJ9, Q9TQK0, Q9TQK1, Q9TQK2, Q9TQK8, Q9TQK9, Q9TQL0, Q9TQL1, Q9TQL2, Q9TQL3, Q9TQL4, Q9UE04, Q9UE05, Q9UE06, Q9UE11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3