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Protein

MHC class I polypeptide-related sequence A

Gene

MICA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.5 Publications

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation Source: GO_Central
  • cellular response to DNA damage stimulus Source: UniProtKB
  • cytolysis Source: UniProtKB-KW
  • defense response to bacterium Source: UniProtKB
  • defense response to virus Source: UniProtKB
  • gamma-delta T cell activation Source: UniProtKB
  • immune response to tumor cell Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • negative regulation of natural killer cell activation Source: CACAO
  • negative regulation of natural killer cell mediated cytotoxicity Source: CACAO
  • regulation of immune response Source: Reactome
  • response to heat Source: UniProtKB
  • T cell mediated cytotoxicity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Cytolysis, Host-virus interaction, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135596-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
MHC class I polypeptide-related sequence A
Short name:
MIC-A
Gene namesi
Name:MICAImported
Synonyms:PERB11.11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7090. MICA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 307ExtracellularSequence analysisAdd BLAST284
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 383CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • extracellular space Source: BHF-UCL
  • integral component of plasma membrane Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.

Psoriasis 1 (PSORS1)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
See also OMIM:177900
Psoriatic arthritis (PSORAS)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
See also OMIM:607507

Organism-specific databases

DisGeNETi100507436.
MIMi177900. phenotype.
607507. phenotype.
OpenTargetsiENSG00000183214.
PharmGKBiPA30811.

Polymorphism and mutation databases

DMDMi74740024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000033714624 – 383MHC class I polypeptide-related sequence ASequence analysisAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi59 ↔ 64PROSITE-ProRule annotation1 Publication
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi119 ↔ 187PROSITE-ProRule annotation1 Publication
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi225 ↔ 282PROSITE-ProRule annotation1 Publication
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.1 Publication
Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ29983.
MaxQBiQ29983.
PeptideAtlasiQ29983.
PRIDEiQ29983.

PTM databases

iPTMnetiQ29983.
PhosphoSitePlusiQ29983.
SwissPalmiQ29983.

Miscellaneous databases

PMAP-CutDBQ29983.

Expressioni

Tissue specificityi

Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.7 Publications

Inductioni

By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.8 Publications

Gene expression databases

BgeeiENSG00000183214.

Organism-specific databases

HPAiHPA064618.

Interactioni

Subunit structurei

Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRK1P267182EBI-1031130,EBI-458344
LGALS3P179312EBI-1031130,EBI-1170392

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi319735. 32 interactors.
DIPiDIP-29681N.
IntActiQ29983. 3 interactors.
MINTiMINT-8214461.

Structurei

Secondary structure

1383
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 37Combined sources12
Beta strandi40 – 51Combined sources12
Beta strandi54 – 59Combined sources6
Beta strandi64 – 66Combined sources3
Beta strandi71 – 75Combined sources5
Helixi79 – 81Combined sources3
Helixi82 – 101Combined sources20
Beta strandi109 – 121Combined sources13
Beta strandi127 – 135Combined sources9
Beta strandi138 – 144Combined sources7
Turni145 – 148Combined sources4
Beta strandi149 – 151Combined sources3
Helixi156 – 170Combined sources15
Helixi177 – 196Combined sources20
Beta strandi208 – 213Combined sources6
Beta strandi217 – 233Combined sources17
Beta strandi236 – 241Combined sources6
Turni248 – 250Combined sources3
Beta strandi251 – 253Combined sources3
Beta strandi260 – 262Combined sources3
Beta strandi264 – 273Combined sources10
Helixi277 – 279Combined sources3
Beta strandi280 – 286Combined sources7
Beta strandi289 – 294Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B3JX-ray3.00A24-297[»]
1HYRX-ray2.70C24-297[»]
DisProtiDP00670.
ProteinModelPortaliQ29983.
SMRiQ29983.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ29983.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 296Ig-like C1-typeSequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the MHC class I family. MIC subfamily.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106364.
InParanoidiQ29983.
KOiK07985.
OMAiWNITLSW.
OrthoDBiEOG091G0ANY.
PhylomeDBiQ29983.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q29983-1) [UniParc]FASTAAdd to basket
Also known as: MICA11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH
60 70 80 90 100
LDGQPFLRCD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL
110 120 130 140 150
AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETKEW
160 170 180 190 200
TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLKSGVV
210 220 230 240 250
LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR QDGVSLSHDT
260 270 280 290 300
QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV
310 320 330 340 350
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD
360 370 380
QHPVGTSDHR DATQLGFQPL MSDLGSTGST EGA
Length:383
Mass (Da):42,915
Last modified:November 1, 1996 - v1
Checksum:i1FE084813DDA13A8
GO
Isoform 21 Publication (identifier: Q29983-2) [UniParc]FASTAAdd to basket
Also known as: MICA21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     109-204: Missing.

Note: Found in about 10% of examined clones.
Show »
Length:287
Mass (Da):31,577
Checksum:i0D41D7919769F469
GO

Polymorphismi

The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04362529R → P in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding. 1 PublicationCorresponds to variant rs9380254dbSNPEnsembl.1
Natural variantiVAR_04362637W → G in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055. Corresponds to variant rs1063630dbSNPEnsembl.1
Natural variantiVAR_04362747T → A in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056. Corresponds to variant rs1051785dbSNPEnsembl.1
Natural variantiVAR_04362849V → G in allele MICA*041. Corresponds to variant rs17200158dbSNPEnsembl.1
Natural variantiVAR_04362959C → Y in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056. Corresponds to variant rs1051786dbSNPEnsembl.1
Natural variantiVAR_043630114Q → R in allele MICA*017. Corresponds to variant rs41558312dbSNPEnsembl.1
Natural variantiVAR_043631128R → K in allele MICA*036. Corresponds to variant rs41557113dbSNPEnsembl.1
Natural variantiVAR_043632137G → R in allele MICA*014 and allele MICA*015. Corresponds to variant rs41556715dbSNPEnsembl.1
Natural variantiVAR_043633145L → V in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*044 and allele MICA*049. Corresponds to variant rs1051790dbSNPEnsembl.1
Natural variantiVAR_043634147T → S in allele MICA*033. Corresponds to variant rs41539919dbSNPEnsembl.1
Natural variantiVAR_043635148K → E in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*012, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*018, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056. Corresponds to variant rs1051791dbSNPEnsembl.1
Natural variantiVAR_043636152M → V in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056; reduces binding affinity for KLRK1. Corresponds to variant rs1051792dbSNPEnsembl.1
Natural variantiVAR_043637165V → I in allele MICA*029. Corresponds to variant rs3819269dbSNPEnsembl.1
Natural variantiVAR_043638174M → V in allele MICA*011 and allele MICA*034. Corresponds to variant rs41560824dbSNPEnsembl.1
Natural variantiVAR_043639179H → L in allele MICA*012, allele MICA*032 and allele MICA*043. Corresponds to variant rs3819268dbSNPEnsembl.1
Natural variantiVAR_043640196K → E in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*013, allele MICA*014, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*028, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant rs1051794dbSNPEnsembl.1
Natural variantiVAR_043641198G → S in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*031, allele MICA*033, allele MICA*036, allele MICA*044, allele MICA*049, allele MICA*054 and allele MICA*056. Corresponds to variant rs1131896dbSNPEnsembl.1
Natural variantiVAR_043642199V → I in allele MICA*006. Corresponds to variant rs41549718dbSNPEnsembl.1
Natural variantiVAR_043643204T → R in allele MICA*004, allele MICA*014, allele MICA*032 and allele MICA*044. Corresponds to variant rs1131897dbSNPEnsembl.1
Natural variantiVAR_043644229G → S in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant rs1131898dbSNPEnsembl.1
Natural variantiVAR_043645231Y → C in allele MICA*046. Corresponds to variant rs41546915dbSNPEnsembl.1
Natural variantiVAR_043646233W → R in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant rs1051798dbSNPEnsembl.1
Natural variantiVAR_043647236T → I in allele MICA*008, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant rs1140700dbSNPEnsembl.1
Natural variantiVAR_043648238S → T in allele MICA*004, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*024, allele MICA*027, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant rs1051799dbSNPEnsembl.1
Natural variantiVAR_043649244V → L in allele MICA*016 and allele MICA*039. Corresponds to variant rs41540613dbSNPEnsembl.1
Natural variantiVAR_043869253W → S in allele MICA*056. Corresponds to variant rs72558175dbSNPEnsembl.1
Natural variantiVAR_043650274Q → R in allele MICA*005, allele MICA*008, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*045, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056. Corresponds to variant rs1063635dbSNPEnsembl.1
Natural variantiVAR_043651279R → S in allele MICA*043. Corresponds to variant rs41557614dbSNPEnsembl.1
Natural variantiVAR_043652291S → G in allele MICA*054. Corresponds to variant rs61759927dbSNPEnsembl.1
Natural variantiVAR_043653294P → A in allele MICA*011, allele MICA*030 and allele MICA*047. Corresponds to variant rs41553616dbSNPEnsembl.1
Natural variantiVAR_043654300 – 383VLVLQ…STEGA → CWCFRVIGRHSMFLLLLLLL LLLLLFLLLLFSTSVVVRRK HQLQRVQSS in allele MICA*015 and allele MICA*017. Add BLAST84
Natural variantiVAR_043655318 – 383AAIFV…STEGA → GCCYFCYYYFLCPLL in allele MICA*008, allele MICA*023, allele MICA*028 and allele MICA*053. Add BLAST66
Natural variantiVAR_043656319A → AA in allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*027, allele MICA*033, allele MICA*048, allele MICA*054 and allele MICA*056. 1
Natural variantiVAR_043657319A → AAA in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*011, allele MICA*026, allele MICA*047 and allele MICA*049. 1
Natural variantiVAR_043658319A → AAAA in allele MICA*050. 1
Natural variantiVAR_043659319A → AAAAA in allele MICA*055. 1
Natural variantiVAR_043660319A → AAAAAA in allele MICA*002, allele MICA*041, allele MICA*046 and allele MICA*052. 1
Natural variantiVAR_043661319A → AAAAAAA in allele MICA*020. 1
Natural variantiVAR_043662328V → I in allele MICA*052. Corresponds to variant rs72558178dbSNPEnsembl.1
Natural variantiVAR_043663329R → C in allele MICA*002, allele MICA*011, allele MICA*020, allele MICA*041, allele MICA*043, allele MICA*046, allele MICA*047, allele MICA*050 and allele MICA*052. Corresponds to variant rs41554412dbSNPEnsembl.1
Natural variantiVAR_043664356T → M in allele MICA*049. Corresponds to variant rs41546114dbSNPEnsembl.1
Natural variantiVAR_043665373D → A in allele MICA*004, allele MICA*006, allele MICA*010, allele MICA*011, allele MICA*016, allele MICA*019, allele MICA*048 and allele MICA*049. Corresponds to variant rs9266825dbSNPEnsembl.1
Natural variantiVAR_043666377T → A in allele MICA*011. Corresponds to variant rs41545814dbSNPEnsembl.1
Natural variantiVAR_043667383A → T in allele MICA*018. Corresponds to variant rs1882dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055366109 – 204Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14848 mRNA. Translation: AAA21718.1.
X92841 Genomic DNA. Translation: CAA63427.1.
AL845443 Genomic DNA. Translation: CAI41907.1.
CR847852 Genomic DNA. Translation: CAQ11015.1.
BC016929 mRNA. Translation: AAH16929.1.
BG114064 mRNA. No translation available.
L29406 Genomic DNA. No translation available.
L29408 Genomic DNA. No translation available.
L29409 Genomic DNA. No translation available.
L29411 Genomic DNA. No translation available.
U56940 Genomic DNA. Translation: AAB41060.1.
U56941 Genomic DNA. Translation: AAB41061.1.
U56942 Genomic DNA. Translation: AAB41062.1.
U56943 Genomic DNA. Translation: AAB41063.1.
U56944 Genomic DNA. Translation: AAB41064.1.
U56945 Genomic DNA. Translation: AAB41065.1.
U56946 Genomic DNA. Translation: AAB41066.1.
U56947 Genomic DNA. Translation: AAB41067.1.
U56948 Genomic DNA. Translation: AAB41068.1.
U56949 Genomic DNA. Translation: AAB41069.1.
U56950 Genomic DNA. Translation: AAB41070.1.
U56951 Genomic DNA. Translation: AAB41071.1.
U56952 Genomic DNA. Translation: AAB41072.1.
U56953 Genomic DNA. Translation: AAB41073.1.
U56954 Genomic DNA. Translation: AAB41074.1.
U56955 Genomic DNA. Translation: AAB41075.1.
Y16801 Genomic DNA. Translation: CAA76393.1.
Y16802 Genomic DNA. Translation: CAA76394.1.
Y16803 Genomic DNA. Translation: CAA76395.1.
Y16804 Genomic DNA. Translation: CAA76396.1.
Y16805 Genomic DNA. Translation: CAA76397.1.
Y16806 Genomic DNA. Translation: CAA76398.1.
Y16807 Genomic DNA. Translation: CAA76399.1.
Y16808 Genomic DNA. Translation: CAA76400.1.
Y16809 Genomic DNA. Translation: CAA76401.1.
Y16810 Genomic DNA. Translation: CAA76402.1.
Y16811 Genomic DNA. Translation: CAA76403.1.
Y18110 Genomic DNA. Translation: CAA77029.1.
Y18111 Genomic DNA. Translation: CAA77030.1.
Y18112 Genomic DNA. Translation: CAA77031.1.
AF097403 Genomic DNA. Translation: AAD27006.1.
AF097404 Genomic DNA. Translation: AAD27007.1.
AF097405 Genomic DNA. Translation: AAD27008.1.
AF097406 Genomic DNA. Translation: AAD27009.1.
AB015600 Genomic DNA. Translation: BAA29034.1.
AJ563426 Genomic DNA. Translation: CAD91415.1.
AH007168 Genomic DNA. Translation: AAD01474.1.
AH007170 Genomic DNA. Translation: AAD01476.1.
AH007171 Genomic DNA. Translation: AAD01477.1.
AH007173 Genomic DNA. Translation: AAD01479.1.
AH007174 Genomic DNA. Translation: AAD01480.1.
AH007186 Genomic DNA. Translation: AAD01492.1.
AH007175 Genomic DNA. Translation: AAD01481.1.
AH007176 Genomic DNA. Translation: AAD01482.1.
AH007177 Genomic DNA. Translation: AAD01483.1.
AH007178 Genomic DNA. Translation: AAD01484.1.
AH007179 Genomic DNA. Translation: AAD01485.1.
AH007180 Genomic DNA. Translation: AAD01486.1.
AH007182 Genomic DNA. Translation: AAD01488.1.
AH007183 Genomic DNA. Translation: AAD01489.1.
AH007184 Genomic DNA. Translation: AAD01490.1.
AH007185 Genomic DNA. Translation: AAD01491.1.
AH008136 Genomic DNA. Translation: AAD52060.1.
AH008137 Genomic DNA. Translation: AAD52061.1.
AH008138 Genomic DNA. Translation: AAD52062.1.
AH008139 Genomic DNA. Translation: AAD52063.1.
AH008140 Genomic DNA. Translation: AAD52064.1.
AH008141 Genomic DNA. Translation: AAD52065.1.
AH008142 Genomic DNA. Translation: AAD52066.1.
AH008143 Genomic DNA. Translation: AAD52067.1.
AH008144 Genomic DNA. Translation: AAD52068.1.
AH008145 Genomic DNA. Translation: AAD52069.1.
AH008146 Genomic DNA. Translation: AAD52070.1.
AH008147 Genomic DNA. Translation: AAD52071.1.
AH008148 Genomic DNA. Translation: AAD52072.1.
AH007169 Genomic DNA. Translation: AAD01475.1.
AH007172 Genomic DNA. Translation: AAD01478.1.
AH007167 Genomic DNA. Translation: AAD01473.1.
AH007181 Genomic DNA. Translation: AAD01487.1.
AH010819 Genomic DNA. Translation: AAK58536.1.
AH011143 Genomic DNA. Translation: AAL13171.1.
AH010820 Genomic DNA. Translation: AAK58537.1.
AH010821 Genomic DNA. Translation: AAK58538.1.
AH010545 Genomic DNA. Translation: AAK19622.1.
AH010526 Genomic DNA. Translation: AAK17997.1.
AH010568 Genomic DNA. Translation: AAK25770.1.
AH010569 Genomic DNA. Translation: AAK25771.1.
AH010532 Genomic DNA. Translation: AAK18281.1.
AH010546 Genomic DNA. Translation: AAK19623.1.
AH010560 Genomic DNA. Translation: AAK20897.1.
AH010561 Genomic DNA. Translation: AAK20898.1.
AH010587 Genomic DNA. Translation: AAK27364.1.
AH010562 Genomic DNA. Translation: AAK20899.1.
AH010571 Genomic DNA. Translation: AAK26323.1.
AH010572 Genomic DNA. Translation: AAK26324.1.
AH010740 Genomic DNA. Translation: AAK51140.1.
AJ250499 Genomic DNA. Translation: CAC14280.1.
AJ250500 Genomic DNA. Translation: CAC14281.1.
AJ250501 Genomic DNA. Translation: CAC14282.1.
AJ250502 Genomic DNA. Translation: CAC14283.1.
AJ250503 Genomic DNA. Translation: CAC14284.1.
AJ250504 Genomic DNA. Translation: CAC14285.1.
AJ250505 Genomic DNA. Translation: CAC14286.1.
AJ250506 Genomic DNA. Translation: CAC14287.1.
AJ250507 Genomic DNA. Translation: CAC14288.1.
AJ250802 Genomic DNA. Translation: CAC15380.1.
AJ250803 Genomic DNA. Translation: CAC15381.1.
AJ250804 Genomic DNA. Translation: CAC15382.1.
AJ250805 Genomic DNA. Translation: CAC15383.1.
AJ250990 Genomic DNA. Translation: CAC16142.1.
AJ250991 Genomic DNA. Translation: CAC16143.1.
AJ271789 Genomic DNA. Translation: CAC27561.1.
AY603357 Genomic DNA. Translation: AAV39504.1.
AJ249394 Genomic DNA. Translation: CAB71317.1.
AJ295250, AJ295251 Genomic DNA. Translation: CAC88121.1.
AJ580805 Genomic DNA. Translation: CAE45581.1.
AJ580806 Genomic DNA. Translation: CAE45582.2.
AH014149 Genomic DNA. Translation: AAU95382.1.
AM899996 Genomic DNA. Translation: CAP12057.1.
EU254723 Genomic DNA. Translation: ABX54884.1.
AM944063 Genomic DNA. Translation: CAQ16171.1.
AH006330 Genomic DNA. Translation: AAC28941.1.
AH006331 Genomic DNA. Translation: AAC28942.1.
AH006332 Genomic DNA. Translation: AAC28943.1.
AH006333 Genomic DNA. Translation: AAC28944.1.
AH006334 Genomic DNA. Translation: AAC28945.1.
AH007472 Genomic DNA. Translation: AAD19598.1.
AH007473 Genomic DNA. Translation: AAD19599.1.
AH007474 Genomic DNA. Translation: AAD19600.1.
AH007475 Genomic DNA. Translation: AAD19601.1.
AH007476 Genomic DNA. Translation: AAD19602.1.
AH007477 Genomic DNA. Translation: AAD19603.1.
AF106652, AF106650, AF106651 Genomic DNA. Translation: AAD19604.1.
AH007479 Genomic DNA. Translation: AAD19605.1.
EU267602 Genomic DNA. Translation: ABX60404.1.
AY095537 Genomic DNA. Translation: AAM34484.1.
PIRiA55739.
RefSeqiNP_000238.1. NM_000247.2. [Q29983-1]
UniGeneiHs.130838.

Genome annotation databases

EnsembliENST00000400325; ENSP00000383179; ENSG00000183214. [Q29983-1]
ENST00000418465; ENSP00000402134; ENSG00000235233.
ENST00000547609; ENSP00000446963; ENSG00000183214. [Q29983-1]
GeneIDi100507436.
KEGGihsa:100507436.
UCSCiuc011ind.3. human. [Q29983-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14848 mRNA. Translation: AAA21718.1.
X92841 Genomic DNA. Translation: CAA63427.1.
AL845443 Genomic DNA. Translation: CAI41907.1.
CR847852 Genomic DNA. Translation: CAQ11015.1.
BC016929 mRNA. Translation: AAH16929.1.
BG114064 mRNA. No translation available.
L29406 Genomic DNA. No translation available.
L29408 Genomic DNA. No translation available.
L29409 Genomic DNA. No translation available.
L29411 Genomic DNA. No translation available.
U56940 Genomic DNA. Translation: AAB41060.1.
U56941 Genomic DNA. Translation: AAB41061.1.
U56942 Genomic DNA. Translation: AAB41062.1.
U56943 Genomic DNA. Translation: AAB41063.1.
U56944 Genomic DNA. Translation: AAB41064.1.
U56945 Genomic DNA. Translation: AAB41065.1.
U56946 Genomic DNA. Translation: AAB41066.1.
U56947 Genomic DNA. Translation: AAB41067.1.
U56948 Genomic DNA. Translation: AAB41068.1.
U56949 Genomic DNA. Translation: AAB41069.1.
U56950 Genomic DNA. Translation: AAB41070.1.
U56951 Genomic DNA. Translation: AAB41071.1.
U56952 Genomic DNA. Translation: AAB41072.1.
U56953 Genomic DNA. Translation: AAB41073.1.
U56954 Genomic DNA. Translation: AAB41074.1.
U56955 Genomic DNA. Translation: AAB41075.1.
Y16801 Genomic DNA. Translation: CAA76393.1.
Y16802 Genomic DNA. Translation: CAA76394.1.
Y16803 Genomic DNA. Translation: CAA76395.1.
Y16804 Genomic DNA. Translation: CAA76396.1.
Y16805 Genomic DNA. Translation: CAA76397.1.
Y16806 Genomic DNA. Translation: CAA76398.1.
Y16807 Genomic DNA. Translation: CAA76399.1.
Y16808 Genomic DNA. Translation: CAA76400.1.
Y16809 Genomic DNA. Translation: CAA76401.1.
Y16810 Genomic DNA. Translation: CAA76402.1.
Y16811 Genomic DNA. Translation: CAA76403.1.
Y18110 Genomic DNA. Translation: CAA77029.1.
Y18111 Genomic DNA. Translation: CAA77030.1.
Y18112 Genomic DNA. Translation: CAA77031.1.
AF097403 Genomic DNA. Translation: AAD27006.1.
AF097404 Genomic DNA. Translation: AAD27007.1.
AF097405 Genomic DNA. Translation: AAD27008.1.
AF097406 Genomic DNA. Translation: AAD27009.1.
AB015600 Genomic DNA. Translation: BAA29034.1.
AJ563426 Genomic DNA. Translation: CAD91415.1.
AH007168 Genomic DNA. Translation: AAD01474.1.
AH007170 Genomic DNA. Translation: AAD01476.1.
AH007171 Genomic DNA. Translation: AAD01477.1.
AH007173 Genomic DNA. Translation: AAD01479.1.
AH007174 Genomic DNA. Translation: AAD01480.1.
AH007186 Genomic DNA. Translation: AAD01492.1.
AH007175 Genomic DNA. Translation: AAD01481.1.
AH007176 Genomic DNA. Translation: AAD01482.1.
AH007177 Genomic DNA. Translation: AAD01483.1.
AH007178 Genomic DNA. Translation: AAD01484.1.
AH007179 Genomic DNA. Translation: AAD01485.1.
AH007180 Genomic DNA. Translation: AAD01486.1.
AH007182 Genomic DNA. Translation: AAD01488.1.
AH007183 Genomic DNA. Translation: AAD01489.1.
AH007184 Genomic DNA. Translation: AAD01490.1.
AH007185 Genomic DNA. Translation: AAD01491.1.
AH008136 Genomic DNA. Translation: AAD52060.1.
AH008137 Genomic DNA. Translation: AAD52061.1.
AH008138 Genomic DNA. Translation: AAD52062.1.
AH008139 Genomic DNA. Translation: AAD52063.1.
AH008140 Genomic DNA. Translation: AAD52064.1.
AH008141 Genomic DNA. Translation: AAD52065.1.
AH008142 Genomic DNA. Translation: AAD52066.1.
AH008143 Genomic DNA. Translation: AAD52067.1.
AH008144 Genomic DNA. Translation: AAD52068.1.
AH008145 Genomic DNA. Translation: AAD52069.1.
AH008146 Genomic DNA. Translation: AAD52070.1.
AH008147 Genomic DNA. Translation: AAD52071.1.
AH008148 Genomic DNA. Translation: AAD52072.1.
AH007169 Genomic DNA. Translation: AAD01475.1.
AH007172 Genomic DNA. Translation: AAD01478.1.
AH007167 Genomic DNA. Translation: AAD01473.1.
AH007181 Genomic DNA. Translation: AAD01487.1.
AH010819 Genomic DNA. Translation: AAK58536.1.
AH011143 Genomic DNA. Translation: AAL13171.1.
AH010820 Genomic DNA. Translation: AAK58537.1.
AH010821 Genomic DNA. Translation: AAK58538.1.
AH010545 Genomic DNA. Translation: AAK19622.1.
AH010526 Genomic DNA. Translation: AAK17997.1.
AH010568 Genomic DNA. Translation: AAK25770.1.
AH010569 Genomic DNA. Translation: AAK25771.1.
AH010532 Genomic DNA. Translation: AAK18281.1.
AH010546 Genomic DNA. Translation: AAK19623.1.
AH010560 Genomic DNA. Translation: AAK20897.1.
AH010561 Genomic DNA. Translation: AAK20898.1.
AH010587 Genomic DNA. Translation: AAK27364.1.
AH010562 Genomic DNA. Translation: AAK20899.1.
AH010571 Genomic DNA. Translation: AAK26323.1.
AH010572 Genomic DNA. Translation: AAK26324.1.
AH010740 Genomic DNA. Translation: AAK51140.1.
AJ250499 Genomic DNA. Translation: CAC14280.1.
AJ250500 Genomic DNA. Translation: CAC14281.1.
AJ250501 Genomic DNA. Translation: CAC14282.1.
AJ250502 Genomic DNA. Translation: CAC14283.1.
AJ250503 Genomic DNA. Translation: CAC14284.1.
AJ250504 Genomic DNA. Translation: CAC14285.1.
AJ250505 Genomic DNA. Translation: CAC14286.1.
AJ250506 Genomic DNA. Translation: CAC14287.1.
AJ250507 Genomic DNA. Translation: CAC14288.1.
AJ250802 Genomic DNA. Translation: CAC15380.1.
AJ250803 Genomic DNA. Translation: CAC15381.1.
AJ250804 Genomic DNA. Translation: CAC15382.1.
AJ250805 Genomic DNA. Translation: CAC15383.1.
AJ250990 Genomic DNA. Translation: CAC16142.1.
AJ250991 Genomic DNA. Translation: CAC16143.1.
AJ271789 Genomic DNA. Translation: CAC27561.1.
AY603357 Genomic DNA. Translation: AAV39504.1.
AJ249394 Genomic DNA. Translation: CAB71317.1.
AJ295250, AJ295251 Genomic DNA. Translation: CAC88121.1.
AJ580805 Genomic DNA. Translation: CAE45581.1.
AJ580806 Genomic DNA. Translation: CAE45582.2.
AH014149 Genomic DNA. Translation: AAU95382.1.
AM899996 Genomic DNA. Translation: CAP12057.1.
EU254723 Genomic DNA. Translation: ABX54884.1.
AM944063 Genomic DNA. Translation: CAQ16171.1.
AH006330 Genomic DNA. Translation: AAC28941.1.
AH006331 Genomic DNA. Translation: AAC28942.1.
AH006332 Genomic DNA. Translation: AAC28943.1.
AH006333 Genomic DNA. Translation: AAC28944.1.
AH006334 Genomic DNA. Translation: AAC28945.1.
AH007472 Genomic DNA. Translation: AAD19598.1.
AH007473 Genomic DNA. Translation: AAD19599.1.
AH007474 Genomic DNA. Translation: AAD19600.1.
AH007475 Genomic DNA. Translation: AAD19601.1.
AH007476 Genomic DNA. Translation: AAD19602.1.
AH007477 Genomic DNA. Translation: AAD19603.1.
AF106652, AF106650, AF106651 Genomic DNA. Translation: AAD19604.1.
AH007479 Genomic DNA. Translation: AAD19605.1.
EU267602 Genomic DNA. Translation: ABX60404.1.
AY095537 Genomic DNA. Translation: AAM34484.1.
PIRiA55739.
RefSeqiNP_000238.1. NM_000247.2. [Q29983-1]
UniGeneiHs.130838.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B3JX-ray3.00A24-297[»]
1HYRX-ray2.70C24-297[»]
DisProtiDP00670.
ProteinModelPortaliQ29983.
SMRiQ29983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi319735. 32 interactors.
DIPiDIP-29681N.
IntActiQ29983. 3 interactors.
MINTiMINT-8214461.

PTM databases

iPTMnetiQ29983.
PhosphoSitePlusiQ29983.
SwissPalmiQ29983.

Polymorphism and mutation databases

DMDMi74740024.

Proteomic databases

EPDiQ29983.
MaxQBiQ29983.
PeptideAtlasiQ29983.
PRIDEiQ29983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400325; ENSP00000383179; ENSG00000183214. [Q29983-1]
ENST00000418465; ENSP00000402134; ENSG00000235233.
ENST00000547609; ENSP00000446963; ENSG00000183214. [Q29983-1]
GeneIDi100507436.
KEGGihsa:100507436.
UCSCiuc011ind.3. human. [Q29983-1]

Organism-specific databases

CTDi100507436.
DisGeNETi100507436.
GeneCardsiMICA.
HGNCiHGNC:7090. MICA.
HPAiHPA064618.
MIMi177900. phenotype.
600169. gene.
607507. phenotype.
neXtProtiNX_Q29983.
OpenTargetsiENSG00000183214.
PharmGKBiPA30811.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG106364.
InParanoidiQ29983.
KOiK07985.
OMAiWNITLSW.
OrthoDBiEOG091G0ANY.
PhylomeDBiQ29983.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135596-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiMICA. human.
EvolutionaryTraceiQ29983.
GeneWikiiMHC_class_I_polypeptide-related_sequence_A.
GenomeRNAii100507436.
PMAP-CutDBQ29983.
PROiQ29983.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183214.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMICA_HUMAN
AccessioniPrimary (citable) accession number: Q29983
Secondary accession number(s): A8KQR0
, A9LRW5, A9QVE0, B1VJF1, O60917, O60918, O60919, O60920, O60933, O77956, O78150, O78151, O78152, O78153, O97987, O97988, O97989, O97990, O97991, O97992, O97993, O97994, O97995, O98234, O98235, O98236, O98237, O98238, P79506, P79507, P79508, P79509, P79510, P79511, P79512, P79513, P79514, P79515, P79516, P79517, P79518, P79519, P79520, P79521, Q5C9P8, Q5XM81, Q70I48, Q70I49, Q7JFH9, Q7JFI0, Q7JFI1, Q7JFI2, Q7YQ98, Q861I1, Q95464, Q95HA2, Q95HD6, Q95HN4, Q95HN5, Q95HN6, Q95IB2, Q95IY7, Q99692, Q9BCR3, Q9BCR4, Q9BCR5, Q9BCR6, Q9BCR7, Q9BCR8, Q9BCR9, Q9BCS0, Q9BCS1, Q9BCS2, Q9BCS3, Q9BCS4, Q9BD20, Q9GIZ1, Q9GIZ2, Q9GIZ3, Q9GIZ4, Q9GIZ5, Q9GIZ6, Q9GJ01, Q9GJ02, Q9GJ03, Q9GJ04, Q9GJ05, Q9GJ06, Q9GJ07, Q9GJ08, Q9GJ09, Q9MY21, Q9TQ86, Q9TQ87, Q9TQ88, Q9TQ89, Q9TQ92, Q9TQ93, Q9TQ94, Q9TQ95, Q9TQ96, Q9TQ97, Q9TQ98, Q9TQ99, Q9TQA0, Q9TQA1, Q9TQA2, Q9TQA3, Q9TQA4, Q9TQI9, Q9TQJ0, Q9TQJ1, Q9TQJ9, Q9TQK0, Q9TQK1, Q9TQK2, Q9TQK8, Q9TQK9, Q9TQL0, Q9TQL1, Q9TQL2, Q9TQL3, Q9TQL4, Q9UE04, Q9UE05, Q9UE06, Q9UE11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.