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Q29980

- MICB_HUMAN

UniProt

Q29980 - MICB_HUMAN

Protein

MHC class I polypeptide-related sequence B

Gene

MICB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.3 Publications

    GO - Molecular functioni

    1. natural killer cell lectin-like receptor binding Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. gamma-delta T cell activation Source: UniProtKB
    4. immune response Source: InterPro
    5. immune response-activating cell surface receptor signaling pathway Source: UniProtKB
    6. negative regulation of defense response to virus by host Source: UniProtKB
    7. regulation of immune response Source: Reactome
    8. response to heat Source: UniProtKB
    9. response to oxidative stress Source: UniProtKB
    10. response to retinoic acid Source: UniProtKB
    11. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Adaptive immunity, Cytolysis, Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MHC class I polypeptide-related sequence B
    Short name:
    MIC-B
    Gene namesi
    Name:MICBImported
    Synonyms:PERB11.2Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:7091. MICB.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.By similarity1 Publication

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.
    Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.

    Organism-specific databases

    MIMi180300. phenotype.
    PharmGKBiPA30812.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 383361MHC class I polypeptide-related sequence BSequence AnalysisPRO_0000341418Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi119 ↔ 1871 PublicationPROSITE-ProRule annotation
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi225 ↔ 2821 PublicationPROSITE-ProRule annotation
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Proteolytically cleaved and released from the cell surface of tumor cells.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ29980.
    PaxDbiQ29980.
    PRIDEiQ29980.

    PTM databases

    PhosphoSiteiQ29980.

    Expressioni

    Tissue specificityi

    Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.3 Publications

    Inductioni

    By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells.6 Publications

    Gene expression databases

    ArrayExpressiQ29980.
    BgeeiQ29980.
    GenevestigatoriQ29980.

    Interactioni

    Subunit structurei

    Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi110424. 3 interactions.

    Structurei

    Secondary structure

    1
    383
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 3712
    Beta strandi46 – 516
    Beta strandi54 – 607
    Turni61 – 644
    Beta strandi65 – 684
    Helixi71 – 755
    Helixi80 – 10122
    Beta strandi104 – 1063
    Beta strandi109 – 12113
    Beta strandi123 – 1253
    Beta strandi127 – 1359
    Beta strandi138 – 1447
    Turni145 – 1473
    Helixi156 – 17015
    Helixi176 – 19722
    Helixi201 – 2033
    Beta strandi208 – 2147
    Beta strandi218 – 23316
    Beta strandi236 – 2416
    Beta strandi250 – 2534
    Beta strandi264 – 27310
    Helixi277 – 2793
    Beta strandi280 – 2867
    Beta strandi289 – 2946

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JE6X-ray2.50A24-297[»]
    2WY3X-ray1.80A/C24-341[»]
    ProteinModelPortaliQ29980.
    SMRiQ29980. Positions 24-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ29980.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 309287ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini331 – 38353CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini207 – 29892Ig-like C1-typeSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class I family. MIC subfamily.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77773.
    HOVERGENiHBG106364.
    InParanoidiQ29980.
    KOiK07985.
    OMAiSTWRIDS.
    PhylomeDBiQ29980.
    TreeFamiTF342166.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q29980-1) [UniParc]FASTAAdd to Basket

    Also known as: MICB11 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDES VQSGFLAEGH    50
    LDGQPFLRYD RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL 100
    THIKDQKGGL HSLQEIRVCE IHEDSSTRGS RHFYYDGELF LSQNLETQES 150
    TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY RAMQADCLQK LQRYLKSGVA 200
    IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR QDGVSLSHNT 250
    QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKV 300
    LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD 350
    QHPVGTGDHR DAAQLGFQPL MSATGSTGST EGA 383
    Length:383
    Mass (Da):42,646
    Last modified:November 1, 1996 - v1
    Checksum:i4291DAA55583F9DA
    GO
    Isoform 21 Publication (identifier: Q29980-2) [UniParc]FASTAAdd to Basket

    Also known as: MICB21 Publication

    , ex3-del

    The sequence of this isoform differs from the canonical sequence as follows:
         109-151: Missing.

    Show »
    Length:340
    Mass (Da):37,651
    Checksum:i3910DFA1B654C555
    GO
    Isoform 31 Publication (identifier: Q29980-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-41: EPHSLRYNLMVLSQDESV → VEMGFHRVSQDGLDLLTS
         42-383: Missing.

    Note: A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication

    Show »
    Length:41
    Mass (Da):4,287
    Checksum:iF092DA8237AFA871
    GO

    Polymorphismi

    The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391E → G in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*018, allele MICB*019, allele MICB*020 and allele MICB*022. 2 Publications
    Corresponds to variant rs45578846 [ dbSNP | Ensembl ].
    VAR_044068
    Natural varianti68 – 681P → H in allele MICB*011.
    Corresponds to variant rs45583740 [ dbSNP | Ensembl ].
    VAR_044069
    Natural varianti75 – 751D → N in allele MICB*004 and allele MICB*020.
    Corresponds to variant rs3131639 [ dbSNP | Ensembl ].
    VAR_044070
    Natural varianti80 – 801K → E in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*019 and allele MICB*022. 2 Publications
    Corresponds to variant rs1065075 [ dbSNP | Ensembl ].
    VAR_044071
    Natural varianti88 – 881D → G in allele MICB*022.
    Corresponds to variant rs45486091 [ dbSNP | Ensembl ].
    VAR_044072
    Natural varianti105 – 1051D → G in allele MICB*012.
    Corresponds to variant rs45502297 [ dbSNP | Ensembl ].
    VAR_044073
    Natural varianti121 – 1211I → M in allele MICB*008.
    Corresponds to variant rs3134900 [ dbSNP | Ensembl ].
    VAR_044074
    Natural varianti136 – 1361D → H.
    Corresponds to variant rs1051788 [ dbSNP | Ensembl ].
    VAR_059527
    Natural varianti136 – 1361D → N in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*018, allele MICB*020 and allele MICB*022. 1 Publication
    Corresponds to variant rs1051788 [ dbSNP | Ensembl ].
    VAR_044075
    Natural varianti212 – 2121T → I in allele MICB*003.
    Corresponds to variant rs41293883 [ dbSNP | Ensembl ].
    VAR_044076
    Natural varianti215 – 2151E → K in allele MICB*006 and allele MICB*015.
    Corresponds to variant rs45624537 [ dbSNP | Ensembl ].
    VAR_044077
    Natural varianti279 – 2791R → K in allele MICB*007.
    Corresponds to variant rs45587032 [ dbSNP | Ensembl ].
    VAR_044078
    Natural varianti291 – 2911G → S in allele MICB*013, allele MICB*014, allele MICB*015 and allele MICB*016.
    Corresponds to variant rs41273040 [ dbSNP | Ensembl ].
    VAR_044079
    Natural varianti300 – 3001V → A in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014 and allele MICB*015. 2 Publications
    Corresponds to variant rs45470602 [ dbSNP | Ensembl ].
    VAR_044080
    Natural varianti383 – 3831A → T in allele MICB*003, allele MICB*004, allele MICB*010 and allele MICB*011.
    Corresponds to variant rs1065076 [ dbSNP | Ensembl ].
    VAR_044081

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei24 – 4118EPHSL…QDESV → VEMGFHRVSQDGLDLLTS in isoform 3. 1 PublicationVSP_052801Add
    BLAST
    Alternative sequencei42 – 383342Missing in isoform 3. 1 PublicationVSP_052802Add
    BLAST
    Alternative sequencei109 – 15143Missing in isoform 2. 1 PublicationVSP_055246Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91625 mRNA. Translation: CAA62823.1.
    U65416 Genomic DNA. Translation: AAB42011.1.
    AY885251 mRNA. No translation available.
    EF051579 Genomic DNA. Translation: ABO16470.1.
    EF051580 Genomic DNA. Translation: ABO16471.1.
    AK314228 mRNA. Translation: BAG36899.1.
    BA000025 Genomic DNA. Translation: BAB63307.1.
    AL662866 Genomic DNA. Translation: CAI17555.1.
    AL663061 Genomic DNA. Translation: CAI18082.1.
    BX001040 Genomic DNA. Translation: CAI18629.1.
    BX005439 Genomic DNA. Translation: CAI18747.1.
    CR753820 Genomic DNA. Translation: CAQ07170.1.
    CR753864 Genomic DNA. Translation: CAQ10628.1.
    CR788288 Genomic DNA. Translation: CAQ09224.1.
    BC044218 mRNA. Translation: AAH44218.1.
    U69978 Genomic DNA. Translation: AAB51802.1.
    U95729 mRNA. Translation: AAB71642.1.
    U95730 mRNA. Translation: AAB71643.1.
    U95731 mRNA. Translation: AAB71644.1.
    U95732 mRNA. Translation: AAB71645.1.
    U95733 mRNA. Translation: AAB71646.1.
    U95734 mRNA. Translation: AAB71647.1.
    AJ563706 Genomic DNA. Translation: CAD91554.1.
    AF021221 mRNA. Translation: AAC39846.1.
    AF021222 mRNA. Translation: AAC39847.1.
    AF021223 mRNA. Translation: AAC39848.1.
    AF021224 mRNA. Translation: AAC39849.1.
    AF021225 mRNA. Translation: AAC39850.1.
    AF021226 mRNA. Translation: AAC39851.1.
    AB003609 Genomic DNA. Translation: BAA23476.1.
    AB003610 Genomic DNA. Translation: BAA23477.1.
    AB003611 Genomic DNA. Translation: BAA23478.1.
    AB003612 Genomic DNA. Translation: BAA23479.1.
    AB003613 Genomic DNA. Translation: BAA23480.1.
    AB003614 Genomic DNA. Translation: BAA23481.1.
    AB003615 Genomic DNA. Translation: BAA23482.1.
    AB003616 Genomic DNA. Translation: BAA23483.1.
    AB003617 Genomic DNA. Translation: BAA23484.1.
    AJ251156, AJ251157 Genomic DNA. Translation: CAB72101.1.
    AJ251158, AJ251159 Genomic DNA. Translation: CAB72097.1.
    AJ251160, AJ251161 Genomic DNA. Translation: CAB72098.1.
    AJ606906 Genomic DNA. Translation: CAE54932.1.
    AJ606907 Genomic DNA. Translation: CAE54933.1.
    AJ606908 Genomic DNA. Translation: CAE54934.1.
    AJ606909 Genomic DNA. Translation: CAE54935.1.
    AJ606910 Genomic DNA. Translation: CAE54936.1.
    AJ606911 Genomic DNA. Translation: CAE54937.1.
    AJ606912 Genomic DNA. Translation: CAE54938.1.
    AJ606913 Genomic DNA. Translation: CAE54939.1.
    AJ606914 Genomic DNA. Translation: CAE54940.1.
    AJ606915 Genomic DNA. Translation: CAE54941.1.
    AJ606916 Genomic DNA. Translation: CAE54942.1.
    AJ606917 Genomic DNA. Translation: CAE54943.1.
    AJ606918 Genomic DNA. Translation: CAE54944.1.
    AJ606919 Genomic DNA. Translation: CAE54945.1.
    AJ606920 Genomic DNA. Translation: CAE54946.1.
    AJ606921 Genomic DNA. Translation: CAE54947.1.
    AJ606922 Genomic DNA. Translation: CAE54948.1.
    AJ606923 Genomic DNA. Translation: CAE54949.1.
    AJ606929 Genomic DNA. Translation: CAE54955.1.
    AJ606930 Genomic DNA. Translation: CAE54956.1.
    AJ606931 Genomic DNA. Translation: CAE54957.1.
    RefSeqiNP_001276089.1. NM_001289160.1.
    NP_001276090.1. NM_001289161.1.
    NP_005922.2. NM_005931.4.
    UniGeneiHs.731446.

    Genome annotation databases

    EnsembliENST00000399150; ENSP00000382103; ENSG00000204516.
    ENST00000427115; ENSP00000395391; ENSG00000204516. [Q29980-3]
    ENST00000428416; ENSP00000398412; ENSG00000206449.
    ENST00000436531; ENSP00000409414; ENSG00000238289.
    ENST00000436655; ENSP00000402484; ENSG00000238289.
    ENST00000438954; ENSP00000398212; ENSG00000234218.
    ENST00000443156; ENSP00000393355; ENSG00000227772.
    ENST00000546706; ENSP00000449672; ENSG00000231179. [Q29980-3]
    ENST00000551608; ENSP00000447696; ENSG00000224378. [Q29980-3]
    GeneIDi4277.
    KEGGihsa:4277.

    Polymorphism databases

    DMDMi74706857.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91625 mRNA. Translation: CAA62823.1 .
    U65416 Genomic DNA. Translation: AAB42011.1 .
    AY885251 mRNA. No translation available.
    EF051579 Genomic DNA. Translation: ABO16470.1 .
    EF051580 Genomic DNA. Translation: ABO16471.1 .
    AK314228 mRNA. Translation: BAG36899.1 .
    BA000025 Genomic DNA. Translation: BAB63307.1 .
    AL662866 Genomic DNA. Translation: CAI17555.1 .
    AL663061 Genomic DNA. Translation: CAI18082.1 .
    BX001040 Genomic DNA. Translation: CAI18629.1 .
    BX005439 Genomic DNA. Translation: CAI18747.1 .
    CR753820 Genomic DNA. Translation: CAQ07170.1 .
    CR753864 Genomic DNA. Translation: CAQ10628.1 .
    CR788288 Genomic DNA. Translation: CAQ09224.1 .
    BC044218 mRNA. Translation: AAH44218.1 .
    U69978 Genomic DNA. Translation: AAB51802.1 .
    U95729 mRNA. Translation: AAB71642.1 .
    U95730 mRNA. Translation: AAB71643.1 .
    U95731 mRNA. Translation: AAB71644.1 .
    U95732 mRNA. Translation: AAB71645.1 .
    U95733 mRNA. Translation: AAB71646.1 .
    U95734 mRNA. Translation: AAB71647.1 .
    AJ563706 Genomic DNA. Translation: CAD91554.1 .
    AF021221 mRNA. Translation: AAC39846.1 .
    AF021222 mRNA. Translation: AAC39847.1 .
    AF021223 mRNA. Translation: AAC39848.1 .
    AF021224 mRNA. Translation: AAC39849.1 .
    AF021225 mRNA. Translation: AAC39850.1 .
    AF021226 mRNA. Translation: AAC39851.1 .
    AB003609 Genomic DNA. Translation: BAA23476.1 .
    AB003610 Genomic DNA. Translation: BAA23477.1 .
    AB003611 Genomic DNA. Translation: BAA23478.1 .
    AB003612 Genomic DNA. Translation: BAA23479.1 .
    AB003613 Genomic DNA. Translation: BAA23480.1 .
    AB003614 Genomic DNA. Translation: BAA23481.1 .
    AB003615 Genomic DNA. Translation: BAA23482.1 .
    AB003616 Genomic DNA. Translation: BAA23483.1 .
    AB003617 Genomic DNA. Translation: BAA23484.1 .
    AJ251156 , AJ251157 Genomic DNA. Translation: CAB72101.1 .
    AJ251158 , AJ251159 Genomic DNA. Translation: CAB72097.1 .
    AJ251160 , AJ251161 Genomic DNA. Translation: CAB72098.1 .
    AJ606906 Genomic DNA. Translation: CAE54932.1 .
    AJ606907 Genomic DNA. Translation: CAE54933.1 .
    AJ606908 Genomic DNA. Translation: CAE54934.1 .
    AJ606909 Genomic DNA. Translation: CAE54935.1 .
    AJ606910 Genomic DNA. Translation: CAE54936.1 .
    AJ606911 Genomic DNA. Translation: CAE54937.1 .
    AJ606912 Genomic DNA. Translation: CAE54938.1 .
    AJ606913 Genomic DNA. Translation: CAE54939.1 .
    AJ606914 Genomic DNA. Translation: CAE54940.1 .
    AJ606915 Genomic DNA. Translation: CAE54941.1 .
    AJ606916 Genomic DNA. Translation: CAE54942.1 .
    AJ606917 Genomic DNA. Translation: CAE54943.1 .
    AJ606918 Genomic DNA. Translation: CAE54944.1 .
    AJ606919 Genomic DNA. Translation: CAE54945.1 .
    AJ606920 Genomic DNA. Translation: CAE54946.1 .
    AJ606921 Genomic DNA. Translation: CAE54947.1 .
    AJ606922 Genomic DNA. Translation: CAE54948.1 .
    AJ606923 Genomic DNA. Translation: CAE54949.1 .
    AJ606929 Genomic DNA. Translation: CAE54955.1 .
    AJ606930 Genomic DNA. Translation: CAE54956.1 .
    AJ606931 Genomic DNA. Translation: CAE54957.1 .
    RefSeqi NP_001276089.1. NM_001289160.1.
    NP_001276090.1. NM_001289161.1.
    NP_005922.2. NM_005931.4.
    UniGenei Hs.731446.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JE6 X-ray 2.50 A 24-297 [» ]
    2WY3 X-ray 1.80 A/C 24-341 [» ]
    ProteinModelPortali Q29980.
    SMRi Q29980. Positions 24-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110424. 3 interactions.

    PTM databases

    PhosphoSitei Q29980.

    Polymorphism databases

    DMDMi 74706857.

    Proteomic databases

    MaxQBi Q29980.
    PaxDbi Q29980.
    PRIDEi Q29980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399150 ; ENSP00000382103 ; ENSG00000204516 .
    ENST00000427115 ; ENSP00000395391 ; ENSG00000204516 . [Q29980-3 ]
    ENST00000428416 ; ENSP00000398412 ; ENSG00000206449 .
    ENST00000436531 ; ENSP00000409414 ; ENSG00000238289 .
    ENST00000436655 ; ENSP00000402484 ; ENSG00000238289 .
    ENST00000438954 ; ENSP00000398212 ; ENSG00000234218 .
    ENST00000443156 ; ENSP00000393355 ; ENSG00000227772 .
    ENST00000546706 ; ENSP00000449672 ; ENSG00000231179 . [Q29980-3 ]
    ENST00000551608 ; ENSP00000447696 ; ENSG00000224378 . [Q29980-3 ]
    GeneIDi 4277.
    KEGGi hsa:4277.

    Organism-specific databases

    CTDi 4277.
    GeneCardsi GC06P031465.
    GC06Pi31477.
    GC06Pj31453.
    GC06Pk31447.
    GC06Pm31542.
    GC06Pn31456.
    GC06Po31455.
    H-InvDB HIX0057971.
    HGNCi HGNC:7091. MICB.
    MIMi 180300. phenotype.
    602436. gene.
    neXtProti NX_Q29980.
    PharmGKBi PA30812.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77773.
    HOVERGENi HBG106364.
    InParanoidi Q29980.
    KOi K07985.
    OMAi STWRIDS.
    PhylomeDBi Q29980.
    TreeFami TF342166.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    ChiTaRSi MICB. human.
    EvolutionaryTracei Q29980.
    GenomeRNAii 4277.
    NextBioi 16829.
    PROi Q29980.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q29980.
    Bgeei Q29980.
    Genevestigatori Q29980.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a human MHC class I MICB cDNA."
      Bahram S., Spies T.
      Immunogenetics 43:230-233(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICB*001; ISOFORM 1).
    2. "Genomic structure of the human MHC class I MICB gene."
      Bahram S., Shiina T., Oka A., Tamiya G., Inoko H.
      Immunogenetics 45:161-162(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*002; ISOFORM 1).
    3. "The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence."
      Martinez-Borra J., Rodrigo L., Rodriguez-Rodero S., Fernandez-Morera J.L., Diaz-Pena R., Pruneda L., Lopez-Vazquez A., Lopez-Larrea C.
      Hum. Immunol. 68:705-707(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*005; ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-39; GLU-80; ASN-136 AND ALA-300.
    5. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE MICB*002).
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*008).
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-39; GLU-80 AND ALA-300.
      Tissue: Pancreas.
    8. "Allelic and interlocus comparison of the PERB11 multigene family in the MHC."
      Gaudieri S., Leelayuwat C., Townend D.C., Mullberg J., Cosman D., Dawkins R.L.
      Immunogenetics 45:209-216(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-341 (ALLELE MICB*003; ISOFORM 1).
    9. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*006; ISOFORM 1).
    10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-341 (ALLELE MICB*015; ISOFORM 1).
      Tissue: BloodImported.
    11. "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles."
      Visser C.J., Tilanus M.G., Schaeffer V., Tatari Z., Tamouza R., Janin A., Charron D.
      Tissue Antigens 51:649-652(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-383 (ALLELES MICB*002; MICB*005; MICB*008; MICB*010; MICB*011 AND MICB*012; ISOFORM 1).
    12. "Allelic variants of the human MHC class I chain-related B gene (MICB)."
      Ando H., Mizuki N., Ota M., Yamazaki M., Ohno S., Goto K., Miyata Y., Wakisaka K., Bahram S., Inoko H.
      Immunogenetics 46:499-508(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005; MICB*007 AND MICB*008; ISOFORM 1).
    13. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*008; MICB*013 AND MICB*014; ISOFORM 1).
    14. "Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients."
      Schroeder M., Elsner H.-A., Kim T.D., Blasczyk R.
      Tissue Antigens 64:276-280(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICB*005; MICB*014; MICB*016; MICB*018; MICB*019; MICB*020 AND MICB*022; ISOFORM 1).
    15. "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells."
      Groh V., Steinle A., Bauer S., Spies T.
      Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    16. "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."
      Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.
      Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    17. "Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)."
      Yamamoto K., Fujiyama Y., Andoh A., Bamba T., Okabe H.
      Biochim. Biophys. Acta 1526:10-12(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    18. "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor."
      Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J.
      Immunity 14:123-133(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16.
    19. "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."
      Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T.
      Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH KLRK1.
    20. "Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells."
      Zou Y., Stastny P.
      Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    21. "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."
      Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D.
      J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A LIGAND FOR KLRK1.
    22. "Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid."
      Jinushi M., Takehara T., Tatsumi T., Kanto T., Groh V., Spies T., Kimura R., Miyagi T., Mochizuki K., Sasaki Y., Hayashi N.
      Int. J. Cancer 104:354-361(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    23. "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity."
      Dunn C., Chalupny N.J., Sutherland C.L., Dosch S., Sivakumar P.V., Johnson D.C., Cosman D.
      J. Exp. Med. 197:1427-1439(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16, SUBCELLULAR LOCATION.
    24. "Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection."
      Jinushi M., Takehara T., Kanto T., Tatsumi T., Groh V., Spies T., Miyagi T., Suzuki T., Sasaki Y., Hayashi N.
      J. Immunol. 170:1249-1256(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    25. "Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients."
      Salih H.R., Goehlsdorf D., Steinle A.
      Hum. Immunol. 67:188-195(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
    26. "Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function."
      Roda-Navarro P., Vales-Gomez M., Chisholm S.E., Reyburn H.T.
      Proc. Natl. Acad. Sci. U.S.A. 103:11258-11263(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KLRK1.
    27. "In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer."
      Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.
      PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    28. Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
    29. "Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk."
      Shirts B.H., Kim J.J., Reich S., Dickerson F.B., Yolken R.H., Devlin B., Nimgaonkar V.L.
      Schizophr. Res. 94:342-353(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SCHIZOPHRENIA.
    30. Cited for: INDUCTION.
    31. Cited for: INDUCTION.
    32. "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D."
      Holmes M.A., Li P., Petersdorf E.W., Strong R.K.
      J. Immunol. 169:1395-1400(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 24-297, DISULFIDE BONDS.

    Entry informationi

    Entry nameiMICB_HUMAN
    AccessioniPrimary (citable) accession number: Q29980
    Secondary accession number(s): A2AC57
    , A6NP85, B0UZ10, B2RAK2, O14499, O14500, O19798, O19799, O19800, O19801, O19802, O19803, O78099, O78100, O78101, O78102, O78103, O78104, P79525, P79541, Q5GR31, Q5GR37, Q5GR41, Q5GR42, Q5GR43, Q5GR44, Q5GR46, Q5GR48, Q5RIY6, Q5SSK1, Q5ST25, Q7JK51, Q7YQ89, Q861E6, Q9MY18, Q9MY19, Q9MY20, Q9UBH4, Q9UBZ8, Q9UEJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3