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Q29980

- MICB_HUMAN

UniProt

Q29980 - MICB_HUMAN

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Protein

MHC class I polypeptide-related sequence B

Gene

MICB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.3 Publications

GO - Molecular functioni

  1. natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. gamma-delta T cell activation Source: UniProtKB
  4. immune response Source: InterPro
  5. immune response-activating cell surface receptor signaling pathway Source: UniProtKB
  6. negative regulation of defense response to virus by host Source: UniProtKB
  7. regulation of immune response Source: Reactome
  8. response to heat Source: UniProtKB
  9. response to oxidative stress Source: UniProtKB
  10. response to retinoic acid Source: UniProtKB
  11. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Cytolysis, Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
MHC class I polypeptide-related sequence B
Short name:
MIC-B
Gene namesi
Name:MICBImported
Synonyms:PERB11.2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:7091. MICB.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.By similarity1 Publication

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.
Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.

Organism-specific databases

MIMi180300. phenotype.
PharmGKBiPA30812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 383361MHC class I polypeptide-related sequence BSequence AnalysisPRO_0000341418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi119 ↔ 1871 PublicationPROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi225 ↔ 2821 PublicationPROSITE-ProRule annotation
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Proteolytically cleaved and released from the cell surface of tumor cells.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ29980.
PaxDbiQ29980.
PRIDEiQ29980.

PTM databases

PhosphoSiteiQ29980.

Expressioni

Tissue specificityi

Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.3 Publications

Inductioni

By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells.6 Publications

Gene expression databases

BgeeiQ29980.
GenevestigatoriQ29980.

Interactioni

Subunit structurei

Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.By similarity4 Publications

Protein-protein interaction databases

BioGridi110424. 3 interactions.

Structurei

Secondary structure

1
383
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 3712
Beta strandi46 – 516
Beta strandi54 – 607
Turni61 – 644
Beta strandi65 – 684
Helixi71 – 755
Helixi80 – 10122
Beta strandi104 – 1063
Beta strandi109 – 12113
Beta strandi123 – 1253
Beta strandi127 – 1359
Beta strandi138 – 1447
Turni145 – 1473
Helixi156 – 17015
Helixi176 – 19722
Helixi201 – 2033
Beta strandi208 – 2147
Beta strandi218 – 23316
Beta strandi236 – 2416
Beta strandi250 – 2534
Beta strandi264 – 27310
Helixi277 – 2793
Beta strandi280 – 2867
Beta strandi289 – 2946

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JE6X-ray2.50A24-297[»]
2WY3X-ray1.80A/C24-341[»]
ProteinModelPortaliQ29980.
SMRiQ29980. Positions 24-297.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ29980.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 309287ExtracellularSequence AnalysisAdd
BLAST
Topological domaini331 – 38353CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 29892Ig-like C1-typeSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family. MIC subfamily.Sequence Analysis

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77773.
HOVERGENiHBG106364.
InParanoidiQ29980.
KOiK07985.
OMAiSTWRIDS.
PhylomeDBiQ29980.
TreeFamiTF342166.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q29980-1) [UniParc]FASTAAdd to Basket

Also known as: MICB11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDES VQSGFLAEGH
60 70 80 90 100
LDGQPFLRYD RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL
110 120 130 140 150
THIKDQKGGL HSLQEIRVCE IHEDSSTRGS RHFYYDGELF LSQNLETQES
160 170 180 190 200
TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY RAMQADCLQK LQRYLKSGVA
210 220 230 240 250
IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR QDGVSLSHNT
260 270 280 290 300
QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKV
310 320 330 340 350
LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD
360 370 380
QHPVGTGDHR DAAQLGFQPL MSATGSTGST EGA
Length:383
Mass (Da):42,646
Last modified:November 1, 1996 - v1
Checksum:i4291DAA55583F9DA
GO
Isoform 21 Publication (identifier: Q29980-2) [UniParc]FASTAAdd to Basket

Also known as: MICB21 Publication

, ex3-del

The sequence of this isoform differs from the canonical sequence as follows:
     109-151: Missing.

Show »
Length:340
Mass (Da):37,651
Checksum:i3910DFA1B654C555
GO
Isoform 31 Publication (identifier: Q29980-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-41: EPHSLRYNLMVLSQDESV → VEMGFHRVSQDGLDLLTS
     42-383: Missing.

Note: A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication

Show »
Length:41
Mass (Da):4,287
Checksum:iF092DA8237AFA871
GO

Polymorphismi

The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391E → G in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*018, allele MICB*019, allele MICB*020 and allele MICB*022. 2 Publications
Corresponds to variant rs45578846 [ dbSNP | Ensembl ].
VAR_044068
Natural varianti68 – 681P → H in allele MICB*011.
Corresponds to variant rs45583740 [ dbSNP | Ensembl ].
VAR_044069
Natural varianti75 – 751D → N in allele MICB*004 and allele MICB*020.
Corresponds to variant rs3131639 [ dbSNP | Ensembl ].
VAR_044070
Natural varianti80 – 801K → E in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*019 and allele MICB*022. 2 Publications
Corresponds to variant rs1065075 [ dbSNP | Ensembl ].
VAR_044071
Natural varianti88 – 881D → G in allele MICB*022.
Corresponds to variant rs45486091 [ dbSNP | Ensembl ].
VAR_044072
Natural varianti105 – 1051D → G in allele MICB*012.
Corresponds to variant rs45502297 [ dbSNP | Ensembl ].
VAR_044073
Natural varianti121 – 1211I → M in allele MICB*008.
Corresponds to variant rs3134900 [ dbSNP | Ensembl ].
VAR_044074
Natural varianti136 – 1361D → H.
Corresponds to variant rs1051788 [ dbSNP | Ensembl ].
VAR_059527
Natural varianti136 – 1361D → N in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*018, allele MICB*020 and allele MICB*022. 1 Publication
Corresponds to variant rs1051788 [ dbSNP | Ensembl ].
VAR_044075
Natural varianti212 – 2121T → I in allele MICB*003.
Corresponds to variant rs41293883 [ dbSNP | Ensembl ].
VAR_044076
Natural varianti215 – 2151E → K in allele MICB*006 and allele MICB*015.
Corresponds to variant rs45624537 [ dbSNP | Ensembl ].
VAR_044077
Natural varianti279 – 2791R → K in allele MICB*007.
Corresponds to variant rs45587032 [ dbSNP | Ensembl ].
VAR_044078
Natural varianti291 – 2911G → S in allele MICB*013, allele MICB*014, allele MICB*015 and allele MICB*016.
Corresponds to variant rs41273040 [ dbSNP | Ensembl ].
VAR_044079
Natural varianti300 – 3001V → A in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014 and allele MICB*015. 2 Publications
Corresponds to variant rs45470602 [ dbSNP | Ensembl ].
VAR_044080
Natural varianti383 – 3831A → T in allele MICB*003, allele MICB*004, allele MICB*010 and allele MICB*011.
Corresponds to variant rs1065076 [ dbSNP | Ensembl ].
VAR_044081

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei24 – 4118EPHSL…QDESV → VEMGFHRVSQDGLDLLTS in isoform 3. 1 PublicationVSP_052801Add
BLAST
Alternative sequencei42 – 383342Missing in isoform 3. 1 PublicationVSP_052802Add
BLAST
Alternative sequencei109 – 15143Missing in isoform 2. 1 PublicationVSP_055246Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91625 mRNA. Translation: CAA62823.1.
U65416 Genomic DNA. Translation: AAB42011.1.
AY885251 mRNA. No translation available.
EF051579 Genomic DNA. Translation: ABO16470.1.
EF051580 Genomic DNA. Translation: ABO16471.1.
AK314228 mRNA. Translation: BAG36899.1.
BA000025 Genomic DNA. Translation: BAB63307.1.
AL662866 Genomic DNA. Translation: CAI17555.1.
AL663061 Genomic DNA. Translation: CAI18082.1.
BX001040 Genomic DNA. Translation: CAI18629.1.
BX005439 Genomic DNA. Translation: CAI18747.1.
CR753820 Genomic DNA. Translation: CAQ07170.1.
CR753864 Genomic DNA. Translation: CAQ10628.1.
CR788288 Genomic DNA. Translation: CAQ09224.1.
BC044218 mRNA. Translation: AAH44218.1.
U69978 Genomic DNA. Translation: AAB51802.1.
U95729 mRNA. Translation: AAB71642.1.
U95730 mRNA. Translation: AAB71643.1.
U95731 mRNA. Translation: AAB71644.1.
U95732 mRNA. Translation: AAB71645.1.
U95733 mRNA. Translation: AAB71646.1.
U95734 mRNA. Translation: AAB71647.1.
AJ563706 Genomic DNA. Translation: CAD91554.1.
AF021221 mRNA. Translation: AAC39846.1.
AF021222 mRNA. Translation: AAC39847.1.
AF021223 mRNA. Translation: AAC39848.1.
AF021224 mRNA. Translation: AAC39849.1.
AF021225 mRNA. Translation: AAC39850.1.
AF021226 mRNA. Translation: AAC39851.1.
AB003609 Genomic DNA. Translation: BAA23476.1.
AB003610 Genomic DNA. Translation: BAA23477.1.
AB003611 Genomic DNA. Translation: BAA23478.1.
AB003612 Genomic DNA. Translation: BAA23479.1.
AB003613 Genomic DNA. Translation: BAA23480.1.
AB003614 Genomic DNA. Translation: BAA23481.1.
AB003615 Genomic DNA. Translation: BAA23482.1.
AB003616 Genomic DNA. Translation: BAA23483.1.
AB003617 Genomic DNA. Translation: BAA23484.1.
AJ251156, AJ251157 Genomic DNA. Translation: CAB72101.1.
AJ251158, AJ251159 Genomic DNA. Translation: CAB72097.1.
AJ251160, AJ251161 Genomic DNA. Translation: CAB72098.1.
AJ606906 Genomic DNA. Translation: CAE54932.1.
AJ606907 Genomic DNA. Translation: CAE54933.1.
AJ606908 Genomic DNA. Translation: CAE54934.1.
AJ606909 Genomic DNA. Translation: CAE54935.1.
AJ606910 Genomic DNA. Translation: CAE54936.1.
AJ606911 Genomic DNA. Translation: CAE54937.1.
AJ606912 Genomic DNA. Translation: CAE54938.1.
AJ606913 Genomic DNA. Translation: CAE54939.1.
AJ606914 Genomic DNA. Translation: CAE54940.1.
AJ606915 Genomic DNA. Translation: CAE54941.1.
AJ606916 Genomic DNA. Translation: CAE54942.1.
AJ606917 Genomic DNA. Translation: CAE54943.1.
AJ606918 Genomic DNA. Translation: CAE54944.1.
AJ606919 Genomic DNA. Translation: CAE54945.1.
AJ606920 Genomic DNA. Translation: CAE54946.1.
AJ606921 Genomic DNA. Translation: CAE54947.1.
AJ606922 Genomic DNA. Translation: CAE54948.1.
AJ606923 Genomic DNA. Translation: CAE54949.1.
AJ606929 Genomic DNA. Translation: CAE54955.1.
AJ606930 Genomic DNA. Translation: CAE54956.1.
AJ606931 Genomic DNA. Translation: CAE54957.1.
RefSeqiNP_001276089.1. NM_001289160.1.
NP_001276090.1. NM_001289161.1.
NP_005922.2. NM_005931.4.
UniGeneiHs.731446.

Genome annotation databases

EnsembliENST00000399150; ENSP00000382103; ENSG00000204516.
ENST00000427115; ENSP00000395391; ENSG00000204516.
ENST00000428416; ENSP00000398412; ENSG00000206449.
ENST00000436531; ENSP00000409414; ENSG00000238289.
ENST00000436655; ENSP00000402484; ENSG00000238289.
ENST00000438954; ENSP00000398212; ENSG00000234218.
ENST00000443156; ENSP00000393355; ENSG00000227772.
ENST00000546706; ENSP00000449672; ENSG00000231179.
ENST00000551608; ENSP00000447696; ENSG00000224378.
GeneIDi4277.
KEGGihsa:4277.

Polymorphism databases

DMDMi74706857.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91625 mRNA. Translation: CAA62823.1 .
U65416 Genomic DNA. Translation: AAB42011.1 .
AY885251 mRNA. No translation available.
EF051579 Genomic DNA. Translation: ABO16470.1 .
EF051580 Genomic DNA. Translation: ABO16471.1 .
AK314228 mRNA. Translation: BAG36899.1 .
BA000025 Genomic DNA. Translation: BAB63307.1 .
AL662866 Genomic DNA. Translation: CAI17555.1 .
AL663061 Genomic DNA. Translation: CAI18082.1 .
BX001040 Genomic DNA. Translation: CAI18629.1 .
BX005439 Genomic DNA. Translation: CAI18747.1 .
CR753820 Genomic DNA. Translation: CAQ07170.1 .
CR753864 Genomic DNA. Translation: CAQ10628.1 .
CR788288 Genomic DNA. Translation: CAQ09224.1 .
BC044218 mRNA. Translation: AAH44218.1 .
U69978 Genomic DNA. Translation: AAB51802.1 .
U95729 mRNA. Translation: AAB71642.1 .
U95730 mRNA. Translation: AAB71643.1 .
U95731 mRNA. Translation: AAB71644.1 .
U95732 mRNA. Translation: AAB71645.1 .
U95733 mRNA. Translation: AAB71646.1 .
U95734 mRNA. Translation: AAB71647.1 .
AJ563706 Genomic DNA. Translation: CAD91554.1 .
AF021221 mRNA. Translation: AAC39846.1 .
AF021222 mRNA. Translation: AAC39847.1 .
AF021223 mRNA. Translation: AAC39848.1 .
AF021224 mRNA. Translation: AAC39849.1 .
AF021225 mRNA. Translation: AAC39850.1 .
AF021226 mRNA. Translation: AAC39851.1 .
AB003609 Genomic DNA. Translation: BAA23476.1 .
AB003610 Genomic DNA. Translation: BAA23477.1 .
AB003611 Genomic DNA. Translation: BAA23478.1 .
AB003612 Genomic DNA. Translation: BAA23479.1 .
AB003613 Genomic DNA. Translation: BAA23480.1 .
AB003614 Genomic DNA. Translation: BAA23481.1 .
AB003615 Genomic DNA. Translation: BAA23482.1 .
AB003616 Genomic DNA. Translation: BAA23483.1 .
AB003617 Genomic DNA. Translation: BAA23484.1 .
AJ251156 , AJ251157 Genomic DNA. Translation: CAB72101.1 .
AJ251158 , AJ251159 Genomic DNA. Translation: CAB72097.1 .
AJ251160 , AJ251161 Genomic DNA. Translation: CAB72098.1 .
AJ606906 Genomic DNA. Translation: CAE54932.1 .
AJ606907 Genomic DNA. Translation: CAE54933.1 .
AJ606908 Genomic DNA. Translation: CAE54934.1 .
AJ606909 Genomic DNA. Translation: CAE54935.1 .
AJ606910 Genomic DNA. Translation: CAE54936.1 .
AJ606911 Genomic DNA. Translation: CAE54937.1 .
AJ606912 Genomic DNA. Translation: CAE54938.1 .
AJ606913 Genomic DNA. Translation: CAE54939.1 .
AJ606914 Genomic DNA. Translation: CAE54940.1 .
AJ606915 Genomic DNA. Translation: CAE54941.1 .
AJ606916 Genomic DNA. Translation: CAE54942.1 .
AJ606917 Genomic DNA. Translation: CAE54943.1 .
AJ606918 Genomic DNA. Translation: CAE54944.1 .
AJ606919 Genomic DNA. Translation: CAE54945.1 .
AJ606920 Genomic DNA. Translation: CAE54946.1 .
AJ606921 Genomic DNA. Translation: CAE54947.1 .
AJ606922 Genomic DNA. Translation: CAE54948.1 .
AJ606923 Genomic DNA. Translation: CAE54949.1 .
AJ606929 Genomic DNA. Translation: CAE54955.1 .
AJ606930 Genomic DNA. Translation: CAE54956.1 .
AJ606931 Genomic DNA. Translation: CAE54957.1 .
RefSeqi NP_001276089.1. NM_001289160.1.
NP_001276090.1. NM_001289161.1.
NP_005922.2. NM_005931.4.
UniGenei Hs.731446.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JE6 X-ray 2.50 A 24-297 [» ]
2WY3 X-ray 1.80 A/C 24-341 [» ]
ProteinModelPortali Q29980.
SMRi Q29980. Positions 24-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110424. 3 interactions.

PTM databases

PhosphoSitei Q29980.

Polymorphism databases

DMDMi 74706857.

Proteomic databases

MaxQBi Q29980.
PaxDbi Q29980.
PRIDEi Q29980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399150 ; ENSP00000382103 ; ENSG00000204516 .
ENST00000427115 ; ENSP00000395391 ; ENSG00000204516 .
ENST00000428416 ; ENSP00000398412 ; ENSG00000206449 .
ENST00000436531 ; ENSP00000409414 ; ENSG00000238289 .
ENST00000436655 ; ENSP00000402484 ; ENSG00000238289 .
ENST00000438954 ; ENSP00000398212 ; ENSG00000234218 .
ENST00000443156 ; ENSP00000393355 ; ENSG00000227772 .
ENST00000546706 ; ENSP00000449672 ; ENSG00000231179 .
ENST00000551608 ; ENSP00000447696 ; ENSG00000224378 .
GeneIDi 4277.
KEGGi hsa:4277.

Organism-specific databases

GeneCardsi GC06P031465.
GC06Pi31477.
GC06Pj31453.
GC06Pk31447.
GC06Pm31542.
GC06Pn31456.
GC06Po31455.
H-InvDB HIX0057971.
HGNCi HGNC:7091. MICB.
MIMi 180300. phenotype.
602436. gene.
neXtProti NX_Q29980.
PharmGKBi PA30812.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77773.
HOVERGENi HBG106364.
InParanoidi Q29980.
KOi K07985.
OMAi STWRIDS.
PhylomeDBi Q29980.
TreeFami TF342166.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSi MICB. human.
EvolutionaryTracei Q29980.
GenomeRNAii 4277.
NextBioi 16829.
PROi Q29980.
SOURCEi Search...

Gene expression databases

Bgeei Q29980.
Genevestigatori Q29980.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a human MHC class I MICB cDNA."
    Bahram S., Spies T.
    Immunogenetics 43:230-233(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICB*001; ISOFORM 1).
  2. "Genomic structure of the human MHC class I MICB gene."
    Bahram S., Shiina T., Oka A., Tamiya G., Inoko H.
    Immunogenetics 45:161-162(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*002; ISOFORM 1).
  3. "The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence."
    Martinez-Borra J., Rodrigo L., Rodriguez-Rodero S., Fernandez-Morera J.L., Diaz-Pena R., Pruneda L., Lopez-Vazquez A., Lopez-Larrea C.
    Hum. Immunol. 68:705-707(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*005; ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-39; GLU-80; ASN-136 AND ALA-300.
  5. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE MICB*002).
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*008).
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-39; GLU-80 AND ALA-300.
    Tissue: Pancreas.
  8. "Allelic and interlocus comparison of the PERB11 multigene family in the MHC."
    Gaudieri S., Leelayuwat C., Townend D.C., Mullberg J., Cosman D., Dawkins R.L.
    Immunogenetics 45:209-216(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-341 (ALLELE MICB*003; ISOFORM 1).
  9. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*006; ISOFORM 1).
  10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-341 (ALLELE MICB*015; ISOFORM 1).
    Tissue: BloodImported.
  11. "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles."
    Visser C.J., Tilanus M.G., Schaeffer V., Tatari Z., Tamouza R., Janin A., Charron D.
    Tissue Antigens 51:649-652(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-383 (ALLELES MICB*002; MICB*005; MICB*008; MICB*010; MICB*011 AND MICB*012; ISOFORM 1).
  12. "Allelic variants of the human MHC class I chain-related B gene (MICB)."
    Ando H., Mizuki N., Ota M., Yamazaki M., Ohno S., Goto K., Miyata Y., Wakisaka K., Bahram S., Inoko H.
    Immunogenetics 46:499-508(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005; MICB*007 AND MICB*008; ISOFORM 1).
  13. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*008; MICB*013 AND MICB*014; ISOFORM 1).
  14. "Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients."
    Schroeder M., Elsner H.-A., Kim T.D., Blasczyk R.
    Tissue Antigens 64:276-280(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICB*005; MICB*014; MICB*016; MICB*018; MICB*019; MICB*020 AND MICB*022; ISOFORM 1).
  15. "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells."
    Groh V., Steinle A., Bauer S., Spies T.
    Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  16. "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."
    Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  17. "Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)."
    Yamamoto K., Fujiyama Y., Andoh A., Bamba T., Okabe H.
    Biochim. Biophys. Acta 1526:10-12(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  18. "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor."
    Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J.
    Immunity 14:123-133(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16.
  19. "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."
    Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T.
    Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KLRK1.
  20. "Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells."
    Zou Y., Stastny P.
    Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  21. "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."
    Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D.
    J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A LIGAND FOR KLRK1.
  22. "Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid."
    Jinushi M., Takehara T., Tatsumi T., Kanto T., Groh V., Spies T., Kimura R., Miyagi T., Mochizuki K., Sasaki Y., Hayashi N.
    Int. J. Cancer 104:354-361(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  23. "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity."
    Dunn C., Chalupny N.J., Sutherland C.L., Dosch S., Sivakumar P.V., Johnson D.C., Cosman D.
    J. Exp. Med. 197:1427-1439(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16, SUBCELLULAR LOCATION.
  24. "Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection."
    Jinushi M., Takehara T., Kanto T., Tatsumi T., Groh V., Spies T., Miyagi T., Suzuki T., Sasaki Y., Hayashi N.
    J. Immunol. 170:1249-1256(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  25. "Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients."
    Salih H.R., Goehlsdorf D., Steinle A.
    Hum. Immunol. 67:188-195(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
  26. "Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function."
    Roda-Navarro P., Vales-Gomez M., Chisholm S.E., Reyburn H.T.
    Proc. Natl. Acad. Sci. U.S.A. 103:11258-11263(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KLRK1.
  27. "In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer."
    Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.
    PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  28. Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
  29. "Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk."
    Shirts B.H., Kim J.J., Reich S., Dickerson F.B., Yolken R.H., Devlin B., Nimgaonkar V.L.
    Schizophr. Res. 94:342-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SCHIZOPHRENIA.
  30. Cited for: INDUCTION.
  31. Cited for: INDUCTION.
  32. "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D."
    Holmes M.A., Li P., Petersdorf E.W., Strong R.K.
    J. Immunol. 169:1395-1400(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 24-297, DISULFIDE BONDS.

Entry informationi

Entry nameiMICB_HUMAN
AccessioniPrimary (citable) accession number: Q29980
Secondary accession number(s): A2AC57
, A6NP85, B0UZ10, B2RAK2, O14499, O14500, O19798, O19799, O19800, O19801, O19802, O19803, O78099, O78100, O78101, O78102, O78103, O78104, P79525, P79541, Q5GR31, Q5GR37, Q5GR41, Q5GR42, Q5GR43, Q5GR44, Q5GR46, Q5GR48, Q5RIY6, Q5SSK1, Q5ST25, Q7JK51, Q7YQ89, Q861E6, Q9MY18, Q9MY19, Q9MY20, Q9UBH4, Q9UBZ8, Q9UEJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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