Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q29980 (MICB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MHC class I polypeptide-related sequence B

Short name=MIC-B
Gene names
Name:MICB
Synonyms:PERB11.2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Ref.15 Ref.19 Ref.21

Subunit structure

Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity. Ref.18 Ref.19 Ref.23 Ref.26 UniProtKB Q29983

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. Ref.23 UniProtKB Q29983

Tissue specificity

Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. Ref.16 Ref.22 Ref.27

Induction

By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells. Ref.15 Ref.17 Ref.22 Ref.24 Ref.30 Ref.31

Post-translational modification

Proteolytically cleaved and released from the cell surface of tumor cells. Ref.25

Polymorphism

The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.

Involvement in disease

Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.

Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.

Sequence similarities

Belongs to the MHC class I family. MIC subfamily.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processAdaptive immunity
Cytolysis
Host-virus interaction
Immunity
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell mediated cytotoxicity

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytolysis

Inferred from electronic annotation. Source: UniProtKB-KW

gamma-delta T cell activation

Inferred from direct assay Ref.15. Source: UniProtKB

immune response-activating cell surface receptor signaling pathway

Inferred from direct assay Ref.19. Source: UniProtKB

natural killer cell mediated cytotoxicity

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of defense response to virus by host

Inferred from direct assay Ref.18Ref.23. Source: UniProtKB

regulation of immune response

Traceable author statement. Source: Reactome

response to heat

Inferred from direct assay Ref.15. Source: UniProtKB

response to oxidative stress

Inferred from direct assay Ref.17. Source: UniProtKB

response to retinoic acid

Inferred from direct assay Ref.22. Source: UniProtKB

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell surface

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionantigen binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell lectin-like receptor binding

Inferred from direct assay Ref.19. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.20 (identifier: Q29980-1)

Also known as: MICB1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q29980-2)

Also known as: MICB2; ex3-del;

The sequence of this isoform differs from the canonical sequence as follows:
     109-151: Missing.
Isoform 3 Ref.3 (identifier: Q29980-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-41: EPHSLRYNLMVLSQDESV → VEMGFHRVSQDGLDLLTS
     42-383: Missing.
Note: A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 383361MHC class I polypeptide-related sequence B
PRO_0000341418

Regions

Topological domain23 – 309287Extracellular Potential
Transmembrane310 – 33021Helical; Potential
Topological domain331 – 38353Cytoplasmic Potential
Domain207 – 29892Ig-like C1-type

Amino acid modifications

Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Disulfide bond119 ↔ 187 Ref.32
Disulfide bond225 ↔ 282 Ref.32

Natural variations

Alternative sequence24 – 4118EPHSL…QDESV → VEMGFHRVSQDGLDLLTS in isoform 3. Ref.3
VSP_052801
Alternative sequence42 – 383342Missing in isoform 3. Ref.3
VSP_052802
Alternative sequence109 – 15143Missing in isoform 2.
VSP_055246
Natural variant391E → G in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*018, allele MICB*019, allele MICB*020 and allele MICB*022. Ref.4 Ref.7
Corresponds to variant rs45578846 [ dbSNP | Ensembl ].
VAR_044068
Natural variant681P → H in allele MICB*011.
Corresponds to variant rs45583740 [ dbSNP | Ensembl ].
VAR_044069
Natural variant751D → N in allele MICB*004 and allele MICB*020.
Corresponds to variant rs3131639 [ dbSNP | Ensembl ].
VAR_044070
Natural variant801K → E in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*019 and allele MICB*022. Ref.4 Ref.7
Corresponds to variant rs1065075 [ dbSNP | Ensembl ].
VAR_044071
Natural variant881D → G in allele MICB*022.
Corresponds to variant rs45486091 [ dbSNP | Ensembl ].
VAR_044072
Natural variant1051D → G in allele MICB*012.
Corresponds to variant rs45502297 [ dbSNP | Ensembl ].
VAR_044073
Natural variant1211I → M in allele MICB*008.
Corresponds to variant rs3134900 [ dbSNP | Ensembl ].
VAR_044074
Natural variant1361D → H.
Corresponds to variant rs1051788 [ dbSNP | Ensembl ].
VAR_059527
Natural variant1361D → N in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*018, allele MICB*020 and allele MICB*022. Ref.4
Corresponds to variant rs1051788 [ dbSNP | Ensembl ].
VAR_044075
Natural variant2121T → I in allele MICB*003.
Corresponds to variant rs41293883 [ dbSNP | Ensembl ].
VAR_044076
Natural variant2151E → K in allele MICB*006 and allele MICB*015.
Corresponds to variant rs45624537 [ dbSNP | Ensembl ].
VAR_044077
Natural variant2791R → K in allele MICB*007.
Corresponds to variant rs45587032 [ dbSNP | Ensembl ].
VAR_044078
Natural variant2911G → S in allele MICB*013, allele MICB*014, allele MICB*015 and allele MICB*016.
Corresponds to variant rs41273040 [ dbSNP | Ensembl ].
VAR_044079
Natural variant3001V → A in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014 and allele MICB*015. Ref.4 Ref.7
Corresponds to variant rs45470602 [ dbSNP | Ensembl ].
VAR_044080
Natural variant3831A → T in allele MICB*003, allele MICB*004, allele MICB*010 and allele MICB*011.
Corresponds to variant rs1065076 [ dbSNP | Ensembl ].
VAR_044081

Secondary structure

............................................. 383
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (MICB1) [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4291DAA55583F9DA

FASTA38342,646
        10         20         30         40         50         60 
MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDES VQSGFLAEGH LDGQPFLRYD 

        70         80         90        100        110        120 
RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE 

       130        140        150        160        170        180 
IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY 

       190        200        210        220        230        240 
RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR 

       250        260        270        280        290        300 
QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKV 

       310        320        330        340        350        360 
LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR 

       370        380 
DAAQLGFQPL MSATGSTGST EGA 

« Hide

Isoform 2 (MICB2) (ex3-del) [UniParc].

Checksum: 3910DFA1B654C555
Show »

FASTA34037,651
Isoform 3 [UniParc].

Checksum: F092DA8237AFA871
Show »

FASTA414,287

References

« Hide 'large scale' references
[1]"Nucleotide sequence of a human MHC class I MICB cDNA."
Bahram S., Spies T.
Immunogenetics 43:230-233(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICB*001; ISOFORM 1).
[2]"Genomic structure of the human MHC class I MICB gene."
Bahram S., Shiina T., Oka A., Tamiya G., Inoko H.
Immunogenetics 45:161-162(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*002; ISOFORM 1).
[3]"The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence."
Martinez-Borra J., Rodrigo L., Rodriguez-Rodero S., Fernandez-Morera J.L., Diaz-Pena R., Pruneda L., Lopez-Vazquez A., Lopez-Larrea C.
Hum. Immunol. 68:705-707(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*005; ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-39; GLU-80; ASN-136 AND ALA-300.
[5]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE MICB*002).
[6]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*008).
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-39; GLU-80 AND ALA-300.
Tissue: Pancreas.
[8]"Allelic and interlocus comparison of the PERB11 multigene family in the MHC."
Gaudieri S., Leelayuwat C., Townend D.C., Mullberg J., Cosman D., Dawkins R.L.
Immunogenetics 45:209-216(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-341 (ALLELE MICB*003; ISOFORM 1).
[9]"Allelic repertoire of the human MICB gene."
Pellet P., Renaud M., Fodil N., Laloux L., Inoko H., Hauptmann G., Debre P., Bahram S., Theodorou I.
Immunogenetics 46:434-436(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*006; ISOFORM 1).
[10]"A novel major histocompatibility complex class I-related chain allele."
Quiroga I., Sweeney D., Sutton P.M., Chapple S.D.J., Souto-Grando J.P., Barnardo M.C.N.M., Fuggle S.V.
Tissue Antigens 64:74-77(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-341 (ALLELE MICB*015; ISOFORM 1).
Tissue: Blood.
[11]"Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles."
Visser C.J., Tilanus M.G., Schaeffer V., Tatari Z., Tamouza R., Janin A., Charron D.
Tissue Antigens 51:649-652(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-383 (ALLELES MICB*002; MICB*005; MICB*008; MICB*010; MICB*011 AND MICB*012; ISOFORM 1).
[12]"Allelic variants of the human MHC class I chain-related B gene (MICB)."
Ando H., Mizuki N., Ota M., Yamazaki M., Ohno S., Goto K., Miyata Y., Wakisaka K., Bahram S., Inoko H.
Immunogenetics 46:499-508(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005; MICB*007 AND MICB*008; ISOFORM 1).
[13]"Three novel MICB alleles."
Fischer G., Perez-Rodriguez M., Arguello J.R., Cox S.T., McWhinnie A., Travers P.J., Madrigal J.A.
Tissue Antigens 55:166-170(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*008; MICB*013 AND MICB*014; ISOFORM 1).
[14]"Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients."
Schroeder M., Elsner H.-A., Kim T.D., Blasczyk R.
Tissue Antigens 64:276-280(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICB*005; MICB*014; MICB*016; MICB*018; MICB*019; MICB*020 AND MICB*022; ISOFORM 1).
[15]"Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells."
Groh V., Steinle A., Bauer S., Spies T.
Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[16]"Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."
Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[17]"Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)."
Yamamoto K., Fujiyama Y., Andoh A., Bamba T., Okabe H.
Biochim. Biophys. Acta 1526:10-12(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[18]"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor."
Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J.
Immunity 14:123-133(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16.
[19]"Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."
Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T.
Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH KLRK1.
[20]"Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells."
Zou Y., Stastny P.
Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
[21]"UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."
Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D.
J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A LIGAND FOR KLRK1.
[22]"Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid."
Jinushi M., Takehara T., Tatsumi T., Kanto T., Groh V., Spies T., Kimura R., Miyagi T., Mochizuki K., Sasaki Y., Hayashi N.
Int. J. Cancer 104:354-361(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.
[23]"Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity."
Dunn C., Chalupny N.J., Sutherland C.L., Dosch S., Sivakumar P.V., Johnson D.C., Cosman D.
J. Exp. Med. 197:1427-1439(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16, SUBCELLULAR LOCATION.
[24]"Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection."
Jinushi M., Takehara T., Kanto T., Tatsumi T., Groh V., Spies T., Miyagi T., Suzuki T., Sasaki Y., Hayashi N.
J. Immunol. 170:1249-1256(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[25]"Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients."
Salih H.R., Goehlsdorf D., Steinle A.
Hum. Immunol. 67:188-195(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
[26]"Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function."
Roda-Navarro P., Vales-Gomez M., Chisholm S.E., Reyburn H.T.
Proc. Natl. Acad. Sci. U.S.A. 103:11258-11263(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KLRK1.
[27]"In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer."
Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.
PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[28]"MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility."
Lopez-Arbesu R., Ballina-Garcia F.J., Alperi-Lopez M., Lopez-Soto A., Rodriguez-Rodero S., Martinez-Borra J., Lopez-Vazquez A., Fernandez-Morera J.L., Riestra-Noriega J.L., Queiro-Silva R., Quinones-Lombrana A., Lopez-Larrea C., Gonzalez S.
Rheumatology 46:426-430(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
[29]"Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk."
Shirts B.H., Kim J.J., Reich S., Dickerson F.B., Yolken R.H., Devlin B., Nimgaonkar V.L.
Schizophr. Res. 94:342-353(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SCHIZOPHRENIA.
[30]"Host immune system gene targeting by a viral miRNA."
Stern-Ginossar N., Elefant N., Zimmermann A., Wolf D.G., Saleh N., Biton M., Horwitz E., Prokocimer Z., Prichard M., Hahn G., Goldman-Wohl D., Greenfield C., Yagel S., Hengel H., Altuvia Y., Margalit H., Mandelboim O.
Science 317:376-381(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[31]"Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine."
Tang K.-F., He C.-X., Zeng G.-L., Wu J., Song G.-B., Shi Y.-S., Zhang W.-G., Huang A.-L., Steinle A., Ren H.
Biochem. Biophys. Res. Commun. 370:578-583(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[32]"Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D."
Holmes M.A., Li P., Petersdorf E.W., Strong R.K.
J. Immunol. 169:1395-1400(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 24-297, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91625 mRNA. Translation: CAA62823.1.
U65416 Genomic DNA. Translation: AAB42011.1.
AY885251 mRNA. No translation available.
EF051579 Genomic DNA. Translation: ABO16470.1.
EF051580 Genomic DNA. Translation: ABO16471.1.
AK314228 mRNA. Translation: BAG36899.1.
BA000025 Genomic DNA. Translation: BAB63307.1.
AL662866 Genomic DNA. Translation: CAI17555.1.
AL663061 Genomic DNA. Translation: CAI18082.1.
BX001040 Genomic DNA. Translation: CAI18629.1.
BX005439 Genomic DNA. Translation: CAI18747.1.
CR753820 Genomic DNA. Translation: CAQ07170.1.
CR753864 Genomic DNA. Translation: CAQ10628.1.
CR788288 Genomic DNA. Translation: CAQ09224.1.
BC044218 mRNA. Translation: AAH44218.1.
U69978 Genomic DNA. Translation: AAB51802.1.
U95729 mRNA. Translation: AAB71642.1.
U95730 mRNA. Translation: AAB71643.1.
U95731 mRNA. Translation: AAB71644.1.
U95732 mRNA. Translation: AAB71645.1.
U95733 mRNA. Translation: AAB71646.1.
U95734 mRNA. Translation: AAB71647.1.
AJ563706 Genomic DNA. Translation: CAD91554.1.
AF021221 mRNA. Translation: AAC39846.1.
AF021222 mRNA. Translation: AAC39847.1.
AF021223 mRNA. Translation: AAC39848.1.
AF021224 mRNA. Translation: AAC39849.1.
AF021225 mRNA. Translation: AAC39850.1.
AF021226 mRNA. Translation: AAC39851.1.
AB003609 Genomic DNA. Translation: BAA23476.1.
AB003610 Genomic DNA. Translation: BAA23477.1.
AB003611 Genomic DNA. Translation: BAA23478.1.
AB003612 Genomic DNA. Translation: BAA23479.1.
AB003613 Genomic DNA. Translation: BAA23480.1.
AB003614 Genomic DNA. Translation: BAA23481.1.
AB003615 Genomic DNA. Translation: BAA23482.1.
AB003616 Genomic DNA. Translation: BAA23483.1.
AB003617 Genomic DNA. Translation: BAA23484.1.
AJ251156, AJ251157 Genomic DNA. Translation: CAB72101.1.
AJ251158, AJ251159 Genomic DNA. Translation: CAB72097.1.
AJ251160, AJ251161 Genomic DNA. Translation: CAB72098.1.
AJ606906 Genomic DNA. Translation: CAE54932.1.
AJ606907 Genomic DNA. Translation: CAE54933.1.
AJ606908 Genomic DNA. Translation: CAE54934.1.
AJ606909 Genomic DNA. Translation: CAE54935.1.
AJ606910 Genomic DNA. Translation: CAE54936.1.
AJ606911 Genomic DNA. Translation: CAE54937.1.
AJ606912 Genomic DNA. Translation: CAE54938.1.
AJ606913 Genomic DNA. Translation: CAE54939.1.
AJ606914 Genomic DNA. Translation: CAE54940.1.
AJ606915 Genomic DNA. Translation: CAE54941.1.
AJ606916 Genomic DNA. Translation: CAE54942.1.
AJ606917 Genomic DNA. Translation: CAE54943.1.
AJ606918 Genomic DNA. Translation: CAE54944.1.
AJ606919 Genomic DNA. Translation: CAE54945.1.
AJ606920 Genomic DNA. Translation: CAE54946.1.
AJ606921 Genomic DNA. Translation: CAE54947.1.
AJ606922 Genomic DNA. Translation: CAE54948.1.
AJ606923 Genomic DNA. Translation: CAE54949.1.
AJ606929 Genomic DNA. Translation: CAE54955.1.
AJ606930 Genomic DNA. Translation: CAE54956.1.
AJ606931 Genomic DNA. Translation: CAE54957.1.
UniGeneHs.731446.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JE6X-ray2.50A24-297[»]
2WY3X-ray1.80A/C24-341[»]
ProteinModelPortalQ29980.
SMRQ29980. Positions 24-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110424. 3 interactions.

PTM databases

PhosphoSiteQ29980.

Polymorphism databases

DMDM74706857.

Proteomic databases

MaxQBQ29980.
PaxDbQ29980.
PRIDEQ29980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399150; ENSP00000382103; ENSG00000204516.
ENST00000427115; ENSP00000395391; ENSG00000204516. [Q29980-3]
ENST00000428416; ENSP00000398412; ENSG00000206449.
ENST00000443156; ENSP00000393355; ENSG00000227772.
ENST00000546706; ENSP00000449672; ENSG00000231179. [Q29980-3]
ENST00000547574; ENSP00000446846; ENSG00000238289. [Q29980-3]
ENST00000549014; ENSP00000450241; ENSG00000206449. [Q29980-3]
ENST00000551608; ENSP00000447696; ENSG00000224378. [Q29980-3]
ENST00000551950; ENSP00000448900; ENSG00000234218. [Q29980-3]
ENST00000551960; ENSP00000449653; ENSG00000227772. [Q29980-3]

Organism-specific databases

GeneCardsGC06P031465.
GC06Pi31477.
GC06Pj31453.
GC06Pk31447.
GC06Pm31542.
GC06Pn31456.
GC06Po31455.
H-InvDBHIX0057971.
HGNCHGNC:7091. MICB.
MIM180300. phenotype.
602436. gene.
neXtProtNX_Q29980.
PharmGKBPA30812.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG77773.
HOVERGENHBG106364.
InParanoidQ29980.
OMASTWRIDS.
PhylomeDBQ29980.
TreeFamTF342166.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ29980.
BgeeQ29980.
GenevestigatorQ29980.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMICB. human.
EvolutionaryTraceQ29980.
GenomeRNAi4277.
NextBio16829.
PROQ29980.
SOURCESearch...

Entry information

Entry nameMICB_HUMAN
AccessionPrimary (citable) accession number: Q29980
Secondary accession number(s): A2AC57 expand/collapse secondary AC list , A6NP85, B0UZ10, B2RAK2, O14499, O14500, O19798, O19799, O19800, O19801, O19802, O19803, O78099, O78100, O78101, O78102, O78103, O78104, P79525, P79541, Q5GR31, Q5GR37, Q5GR41, Q5GR42, Q5GR43, Q5GR44, Q5GR46, Q5GR48, Q5RIY6, Q5SSK1, Q5ST25, Q7JK51, Q7YQ89, Q861E6, Q9MY18, Q9MY19, Q9MY20, Q9UBH4, Q9UBZ8, Q9UEJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM