Q29980 (MICB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MHC class I polypeptide-related sequence B
Short name=MIC-B

Gene names

Name:	MICB
Synonyms:	PERB11.2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Ref.13 Ref.17
Subunit structure	Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity. Ref.16 Ref.17 Ref.20 Ref.23 UniProtKB Q29983
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. Ref.20 UniProtKB Q29983
Tissue specificity	Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. Ref.14 Ref.19 Ref.24
Induction	By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells. Ref.13 Ref.15 Ref.19 Ref.21 Ref.27 Ref.28
Post-translational modification	Proteolytically cleaved and released from the cell surface of tumor cells. Ref.22
Polymorphism	The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.
Involvement in disease	Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis. Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
Sequence similarities	Belongs to the MHC class I family. MIC subfamily. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Adaptive immunity Cytolysis Host-virus interaction Immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW gamma-delta T cell activation Inferred from direct assay Ref.13. Source: UniProtKB immune response Inferred from electronic annotation. Source: InterPro immune response-activating cell surface receptor signaling pathway Inferred from direct assay Ref.17. Source: UniProtKB negative regulation of defense response to virus by host Inferred from direct assay Ref.16Ref.20. Source: UniProtKB response to heat Inferred from direct assay Ref.13. Source: UniProtKB response to oxidative stress Inferred from direct assay Ref.15. Source: UniProtKB response to retinoic acid Inferred from direct assay Ref.19. Source: UniProtKB virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: InterPro cell surface Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	natural killer cell lectin-like receptor binding Inferred from direct assay Ref.17. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.18 (identifier: Q29980-1)

Also known as: MICB1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.18 (identifier: Q29980-2)

Also known as: MICB2;

The sequence of this isoform is not available.

Isoform 3 Ref.3 (identifier: Q29980-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-41: EPHSLRYNLMVLSQDESV → VEMGFHRVSQDGLDLLTS
     42-383: Missing.

Note: A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

22

Potential

Chain

23 – 383

361

MHC class I polypeptide-related sequence B

PRO_0000341418

Regions

Topological domain

23 – 309

287

Extracellular Potential

Transmembrane

310 – 330

21

Helical; Potential

Topological domain

331 – 383

53

Cytoplasmic Potential

Domain

207 – 298

92

Ig-like C1-type

Amino acid modifications

Glycosylation

164

1

N-linked (GlcNAc...) Potential

Glycosylation

210

1

N-linked (GlcNAc...) Potential

Glycosylation

220

1

N-linked (GlcNAc...) Potential

Glycosylation

261

1

N-linked (GlcNAc...) Potential

Disulfide bond

119 ↔ 187

Ref.29

Disulfide bond

225 ↔ 282

Ref.29

Natural variations

Alternative sequence

24 – 41

18

EPHSL…QDESV → VEMGFHRVSQDGLDLLTS in isoform 3. Ref.3

VSP_052801

Alternative sequence

42 – 383

342

Missing in isoform 3. Ref.3

VSP_052802

Natural variant

39

1

E → G in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*018, allele MICB*019, allele MICB*020 and allele MICB*022.
Corresponds to variant rs45578846 [ dbSNP | Ensembl ].

VAR_044068

Natural variant

68

1

P → H in allele MICB*011.
Corresponds to variant rs45583740 [ dbSNP | Ensembl ].

VAR_044069

Natural variant

75

1

D → N in allele MICB*004 and allele MICB*020.
Corresponds to variant rs3131639 [ dbSNP | Ensembl ].

VAR_044070

Natural variant

80

1

K → E in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*019 and allele MICB*022.
Corresponds to variant rs1065075 [ dbSNP | Ensembl ].

VAR_044071

Natural variant

88

1

D → G in allele MICB*022.
Corresponds to variant rs45486091 [ dbSNP | Ensembl ].

VAR_044072

Natural variant

105

1

D → G in allele MICB*012.
Corresponds to variant rs45502297 [ dbSNP | Ensembl ].

VAR_044073

Natural variant

121

1

I → M in allele MICB*008.
Corresponds to variant rs3134900 [ dbSNP | Ensembl ].

VAR_044074

Natural variant

136

1

D → H.
Corresponds to variant rs1051788 [ dbSNP | Ensembl ].

VAR_059527

Natural variant

136

1

D → N in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*018, allele MICB*020 and allele MICB*022.
Corresponds to variant rs1051788 [ dbSNP | Ensembl ].

VAR_044075

Natural variant

212

1

T → I in allele MICB*003.
Corresponds to variant rs41293883 [ dbSNP | Ensembl ].

VAR_044076

Natural variant

215

1

E → K in allele MICB*006 and allele MICB*015.
Corresponds to variant rs45624537 [ dbSNP | Ensembl ].

VAR_044077

Natural variant

279

1

R → K in allele MICB*007.
Corresponds to variant rs45587032 [ dbSNP | Ensembl ].

VAR_044078

Natural variant

291

1

G → S in allele MICB*013, allele MICB*014, allele MICB*015 and allele MICB*016.
Corresponds to variant rs41273040 [ dbSNP | Ensembl ].

VAR_044079

Natural variant

300

1

V → A in allele MICB*002, allele MICB*003, allele MICB*004, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014 and allele MICB*015.
Corresponds to variant rs45470602 [ dbSNP | Ensembl ].

VAR_044080

Natural variant

383

1

A → T in allele MICB*003, allele MICB*004, allele MICB*010 and allele MICB*011.
Corresponds to variant rs1065076 [ dbSNP | Ensembl ].

VAR_044081

Secondary structure

1

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383

Helix Strand Turn

Details...

Beta strand

26 – 37

12

Beta strand

46 – 51

6

Beta strand

54 – 60

7

Turn

61 – 64

4

Beta strand

65 – 68

4

Helix

71 – 75

5

Helix

80 – 101

22

Beta strand

104 – 106

3

Beta strand

109 – 121

13

Beta strand

123 – 125

3

Beta strand

127 – 135

9

Beta strand

138 – 144

7

Turn

145 – 147

3

Helix

156 – 170

15

Helix

176 – 197

22

Helix

201 – 203

3

Beta strand

208 – 214

7

Beta strand

218 – 233

16

Beta strand

236 – 241

6

Beta strand

250 – 253

4

Beta strand

264 – 273

10

Helix

277 – 279

3

Beta strand

280 – 286

7

Beta strand

289 – 294

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MICB1) [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4291DAA55583F9DA	FASTA	383	42,646
	10 20 30 40 50 60 MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDES VQSGFLAEGH LDGQPFLRYD 70 80 90 100 110 120 RQKRRAKPQG QWAEDVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE 130 140 150 160 170 180 IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY 190 200 210 220 230 240 RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR 250 260 270 280 290 300 QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKV 310 320 330 340 350 360 LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR 370 380 DAAQLGFQPL MSATGSTGST EGA
	Isoform 2 (MICB2) (Sequence not available).		–	–
	Isoform 3 [UniParc]. Checksum: F092DA8237AFA871	FASTA	41	4,287
	10 20 30 40 MGLGRVLLFL AVAFPFAPPA AAAVEMGFHR VSQDGLDLLT S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a human MHC class I MICB cDNA." Bahram S., Spies T. Immunogenetics 43:230-233(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICB*001; ISOFORM 1).
[2]	"Genomic structure of the human MHC class I MICB gene." Bahram S., Shiina T., Oka A., Tamiya G., Inoko H. Immunogenetics 45:161-162(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*002; ISOFORM 1).
[3]	"The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence." Martinez-Borra J., Rodrigo L., Rodriguez-Rodero S., Fernandez-Morera J.L., Diaz-Pena R., Pruneda L., Lopez-Vazquez A., Lopez-Larrea C. Hum. Immunol. 68:705-707(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICB*005; ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., Oka A., Inoko H. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE MICB*002).
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*008).
[6]	"Allelic and interlocus comparison of the PERB11 multigene family in the MHC." Gaudieri S., Leelayuwat C., Townend D.C., Mullberg J., Cosman D., Dawkins R.L. Immunogenetics 45:209-216(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-341 (ALLELE MICB*003; ISOFORM 1).
[7]	"Allelic repertoire of the human MICB gene." Pellet P., Renaud M., Fodil N., Laloux L., Inoko H., Hauptmann G., Debre P., Bahram S., Theodorou I. Immunogenetics 46:434-436(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005 AND MICB*006; ISOFORM 1).
[8]	"A novel major histocompatibility complex class I-related chain allele." Quiroga I., Sweeney D., Sutton P.M., Chapple S.D.J., Souto-Grando J.P., Barnardo M.C.N.M., Fuggle S.V. Tissue Antigens 64:74-77(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-341 (ALLELE MICB*015; ISOFORM 1). Tissue: Blood.
[9]	"Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles." Visser C.J., Tilanus M.G., Schaeffer V., Tatari Z., Tamouza R., Janin A., Charron D. Tissue Antigens 51:649-652(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-383 (ALLELES MICB*002; MICB*005; MICB*008; MICB*010; MICB*011 AND MICB*012; ISOFORM 1).
[10]	"Allelic variants of the human MHC class I chain-related B gene (MICB)." Ando H., Mizuki N., Ota M., Yamazaki M., Ohno S., Goto K., Miyata Y., Wakisaka K., Bahram S., Inoko H. Immunogenetics 46:499-508(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*002; MICB*003; MICB*004; MICB*005; MICB*007 AND MICB*008; ISOFORM 1).
[11]	"Three novel MICB alleles." Fischer G., Perez-Rodriguez M., Arguello J.R., Cox S.T., McWhinnie A., Travers P.J., Madrigal J.A. Tissue Antigens 55:166-170(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICB*008; MICB*013 AND MICB*014; ISOFORM 1).
[12]	"Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients." Schroeder M., Elsner H.-A., Kim T.D., Blasczyk R. Tissue Antigens 64:276-280(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICB*005; MICB*014; MICB*016; MICB*018; MICB*019; MICB*020 AND MICB*022; ISOFORM 1).
[13]	"Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells." Groh V., Steinle A., Bauer S., Spies T. Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[14]	"Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB." Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T. Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[15]	"Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)." Yamamoto K., Fujiyama Y., Andoh A., Bamba T., Okabe H. Biochim. Biophys. Acta 1526:10-12(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[16]	"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor." Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J. Immunity 14:123-133(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16.
[17]	"Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family." Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K., Spies T. Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH KLRK1.
[18]	"Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells." Zou Y., Stastny P. Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[19]	"Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid." Jinushi M., Takehara T., Tatsumi T., Kanto T., Groh V., Spies T., Kimura R., Miyagi T., Mochizuki K., Sasaki Y., Hayashi N. Int. J. Cancer 104:354-361(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[20]	"Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity." Dunn C., Chalupny N.J., Sutherland C.L., Dosch S., Sivakumar P.V., Johnson D.C., Cosman D. J. Exp. Med. 197:1427-1439(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN UL16, SUBCELLULAR LOCATION.
[21]	"Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection." Jinushi M., Takehara T., Kanto T., Tatsumi T., Groh V., Spies T., Miyagi T., Suzuki T., Sasaki Y., Hayashi N. J. Immunol. 170:1249-1256(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[22]	"Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients." Salih H.R., Goehlsdorf D., Steinle A. Hum. Immunol. 67:188-195(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
[23]	"Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function." Roda-Navarro P., Vales-Gomez M., Chisholm S.E., Reyburn H.T. Proc. Natl. Acad. Sci. U.S.A. 103:11258-11263(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KLRK1.
[24]	"In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer." Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S. PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[25]	"MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility." Lopez-Arbesu R., Ballina-Garcia F.J., Alperi-Lopez M., Lopez-Soto A., Rodriguez-Rodero S., Martinez-Borra J., Lopez-Vazquez A., Fernandez-Morera J.L., Riestra-Noriega J.L., Queiro-Silva R., Quinones-Lombrana A., Lopez-Larrea C., Gonzalez S. Rheumatology 46:426-430(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
[26]	"Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk." Shirts B.H., Kim J.J., Reich S., Dickerson F.B., Yolken R.H., Devlin B., Nimgaonkar V.L. Schizophr. Res. 94:342-353(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SCHIZOPHRENIA.
[27]	"Host immune system gene targeting by a viral miRNA." Stern-Ginossar N., Elefant N., Zimmermann A., Wolf D.G., Saleh N., Biton M., Horwitz E., Prokocimer Z., Prichard M., Hahn G., Goldman-Wohl D., Greenfield C., Yagel S., Hengel H., Altuvia Y., Margalit H., Mandelboim O. Science 317:376-381(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[28]	"Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine." Tang K.-F., He C.-X., Zeng G.-L., Wu J., Song G.-B., Shi Y.-S., Zhang W.-G., Huang A.-L., Steinle A., Ren H. Biochem. Biophys. Res. Commun. 370:578-583(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[29]	"Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D." Holmes M.A., Li P., Petersdorf E.W., Strong R.K. J. Immunol. 169:1395-1400(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 24-297, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X91625 mRNA. Translation: CAA62823.1.
U65416 Genomic DNA. Translation: AAB42011.1.
AY885251 mRNA. No translation available.
EF051579 Genomic DNA. Translation: ABO16470.1.
EF051580 Genomic DNA. Translation: ABO16471.1.
BA000025 Genomic DNA. Translation: BAB63307.1.
AL662866 Genomic DNA. Translation: CAI17555.1.
AL663061 Genomic DNA. Translation: CAI18082.1.
BX001040 Genomic DNA. Translation: CAI18629.1.
BX005439 Genomic DNA. Translation: CAI18747.1.
CR753820 Genomic DNA. Translation: CAQ07170.1.
CR753864 Genomic DNA. Translation: CAQ10628.1.
CR788288 Genomic DNA. Translation: CAQ09224.1.
U69978 Genomic DNA. Translation: AAB51802.1.
U95729 mRNA. Translation: AAB71642.1.
U95730 mRNA. Translation: AAB71643.1.
U95731 mRNA. Translation: AAB71644.1.
U95732 mRNA. Translation: AAB71645.1.
U95733 mRNA. Translation: AAB71646.1.
U95734 mRNA. Translation: AAB71647.1.
AJ563706 Genomic DNA. Translation: CAD91554.1.
AF021221 mRNA. Translation: AAC39846.1.
AF021222 mRNA. Translation: AAC39847.1.
AF021223 mRNA. Translation: AAC39848.1.
AF021224 mRNA. Translation: AAC39849.1.
AF021225 mRNA. Translation: AAC39850.1.
AF021226 mRNA. Translation: AAC39851.1.
AB003609 Genomic DNA. Translation: BAA23476.1.
AB003610 Genomic DNA. Translation: BAA23477.1.
AB003611 Genomic DNA. Translation: BAA23478.1.
AB003612 Genomic DNA. Translation: BAA23479.1.
AB003613 Genomic DNA. Translation: BAA23480.1.
AB003614 Genomic DNA. Translation: BAA23481.1.
AB003615 Genomic DNA. Translation: BAA23482.1.
AB003616 Genomic DNA. Translation: BAA23483.1.
AB003617 Genomic DNA. Translation: BAA23484.1.
AJ251156, AJ251157 Genomic DNA. Translation: CAB72101.1.
AJ251158, AJ251159 Genomic DNA. Translation: CAB72097.1.
AJ251160, AJ251161 Genomic DNA. Translation: CAB72098.1.
AJ606906 Genomic DNA. Translation: CAE54932.1.
AJ606907 Genomic DNA. Translation: CAE54933.1.
AJ606908 Genomic DNA. Translation: CAE54934.1.
AJ606909 Genomic DNA. Translation: CAE54935.1.
AJ606910 Genomic DNA. Translation: CAE54936.1.
AJ606911 Genomic DNA. Translation: CAE54937.1.
AJ606912 Genomic DNA. Translation: CAE54938.1.
AJ606913 Genomic DNA. Translation: CAE54939.1.
AJ606914 Genomic DNA. Translation: CAE54940.1.
AJ606915 Genomic DNA. Translation: CAE54941.1.
AJ606916 Genomic DNA. Translation: CAE54942.1.
AJ606917 Genomic DNA. Translation: CAE54943.1.
AJ606918 Genomic DNA. Translation: CAE54944.1.
AJ606919 Genomic DNA. Translation: CAE54945.1.
AJ606920 Genomic DNA. Translation: CAE54946.1.
AJ606921 Genomic DNA. Translation: CAE54947.1.
AJ606922 Genomic DNA. Translation: CAE54948.1.
AJ606923 Genomic DNA. Translation: CAE54949.1.
AJ606929 Genomic DNA. Translation: CAE54955.1.
AJ606930 Genomic DNA. Translation: CAE54956.1.
AJ606931 Genomic DNA. Translation: CAE54957.1.

IPI

IPI00646545.
IPI00895817.

RefSeq

NP_005922.2. NM_005931.3.

UniGene

Hs.731446.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JE6	X-ray	2.50	A	24-297	[»]
2WY3	X-ray	1.80	A/C	24-341	[»]

ProteinModelPortal

Q29980.

ModBase

Search...

PTM databases

PhosphoSite

Q29980.

Polymorphism databases

DMDM

74706857.

Proteomic databases

PaxDb

Q29980.

PRIDE

Q29980.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000252229; ENSP00000252229; ENSG00000204516.
ENST00000383514; ENSP00000373006; ENSG00000224378.
ENST00000427115; ENSP00000395391; ENSG00000204516.
ENST00000428416; ENSP00000398412; ENSG00000206449.
ENST00000443156; ENSP00000393355; ENSG00000227772.
ENST00000451603; ENSP00000407561; ENSG00000231179.
ENST00000546706; ENSP00000449672; ENSG00000231179.
ENST00000547574; ENSP00000446846; ENSG00000238289.
ENST00000549014; ENSP00000450241; ENSG00000206449.
ENST00000551608; ENSP00000447696; ENSG00000224378.
ENST00000551950; ENSP00000448900; ENSG00000234218.
ENST00000551960; ENSP00000449653; ENSG00000227772.

GeneID

4277.

KEGG

hsa:4277.

Organism-specific databases

CTD

4277.

GeneCards

GC06P031465.

H-InvDB

HIX0057971.

HGNC

HGNC:7091. MICB.

MIM

180300. phenotype.
602436. gene.

neXtProt

NX_Q29980.

PharmGKB

PA30812.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG77773.

HOVERGEN

HBG106364.

InParanoid

Q29980.

KO

K07985.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q29980.

Bgee

Q29980.

Genevestigator

Q29980.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

MICB. human.

EvolutionaryTrace

Q29980.

GenomeRNAi

4277.

NextBio

16829.

SOURCE

Search...

Entry information

Entry name

MICB_HUMAN

Accession

Primary (citable) accession number: Q29980
Secondary accession number(s): A6NP85 , B0UZ10, O14499, O14500, O19798, O19799, O19800, O19801, O19802, O19803, O78099, O78100, O78101, O78102, O78103, O78104, P79525, P79541, Q5GR31, Q5GR37, Q5GR41, Q5GR42, Q5GR43, Q5GR44, Q5GR46, Q5GR48, Q5RIY6, Q5SSK1, Q5ST25, Q7JK51, Q7YQ89, Q9MY18, Q9MY19, Q9MY20, Q9UBH4, Q9UBZ8, Q9UEJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.