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Q29974

- 2B1G_HUMAN

UniProt

Q29974 - 2B1G_HUMAN

Protein

HLA class II histocompatibility antigen, DRB1-16 beta chain

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

    GO - Molecular functioni

    1. MHC class II receptor activity Source: UniProtKB
    2. peptide antigen binding Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. detection of bacterium Source: UniProtKB
    4. humoral immune response mediated by circulating immunoglobulin Source: UniProtKB
    5. immune response Source: UniProtKB
    6. immunoglobulin production involved in immunoglobulin mediated immune response Source: UniProtKB
    7. inflammatory response to antigenic stimulus Source: UniProtKB
    8. interferon-gamma-mediated signaling pathway Source: Reactome
    9. negative regulation of interferon-gamma production Source: UniProtKB
    10. negative regulation of T cell proliferation Source: UniProtKB
    11. positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
    12. protein tetramerization Source: UniProtKB
    13. regulation of interleukin-10 secretion Source: UniProtKB
    14. regulation of interleukin-4 production Source: UniProtKB
    15. T cell costimulation Source: Reactome
    16. T cell receptor signaling pathway Source: Reactome
    17. T-helper 1 type immune response Source: UniProtKB

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class II histocompatibility antigen, DRB1-16 beta chain
    Alternative name(s):
    MHC class II antigen DRB1*16
    Short name:
    DR-16
    Short name:
    DR16
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4948. HLA-DRB1.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Late endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

    GO - Cellular componenti

    1. clathrin-coated endocytic vesicle membrane Source: Reactome
    2. endocytic vesicle membrane Source: Reactome
    3. ER to Golgi transport vesicle membrane Source: Reactome
    4. external side of plasma membrane Source: UniProtKB
    5. Golgi membrane Source: Reactome
    6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    7. late endosome membrane Source: UniProtKB
    8. lysosomal membrane Source: UniProtKB
    9. membrane Source: UniProtKB
    10. MHC class II protein complex Source: UniProtKB-KW
    11. plasma membrane Source: Reactome
    12. trans-Golgi network membrane Source: Reactome
    13. transport vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 266237HLA class II histocompatibility antigen, DRB1-16 beta chainPRO_0000391833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi146 ↔ 202PROSITE-ProRule annotation
    Cross-linki254 – 254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Post-translational modificationi

    Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiQ29974.

    Expressioni

    Gene expression databases

    ArrayExpressiQ29974.
    BgeeiQ29974.

    Organism-specific databases

    HPAiCAB015400.
    CAB034021.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

    Protein-protein interaction databases

    BioGridi109368. 15 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29974.
    SMRiQ29974. Positions 32-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini126 – 21489Ig-like C1-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG012730.
    KOiK06752.
    TreeFamiTF336626.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q29974-1 [UniParc]FASTAAdd to Basket

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    MVCLKLPGGS CMTALTVTLM VLSSPLALAG DTRPRFLWQP KRECHFFNGT    50
    ERVRFLDRYF YNQEESVRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR 100
    RAAVDTYCRH NYGVGESFTV QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG 150
    FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG DWTFQTLVML ETVPRSGEVY 200
    TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 250
    RNQKGHSGLQ PTGFLS 266
    Length:266
    Mass (Da):30,030
    Last modified:November 1, 1996 - v1
    Checksum:i871CC341692ECA4D
    GO

    Polymorphismi

    The following alleles of DRB1-16 are known: DRB1*16:01; DRB1*16:02; DRB1*16:03; DRB1*16:04; DRB1*16:05; DRB1*16:07; DRB1*16:08; DRB1*16:09; DRB1*16:10; DRB1*16:11 and DRB1*16:12. The sequence shown is that of DRB1*16:02.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421R → K in allele DRB1*16:12.
    VAR_062840
    Natural varianti43 – 431E → K in allele DRB1*16:11.
    VAR_062841
    Natural varianti56 – 561L → P in allele DRB1*16:07.
    VAR_062842
    Natural varianti66 – 661S → N in allele DRB1*16:08.
    VAR_062843
    Natural varianti76 – 761Y → F in allele DRB1*16:09 and allele DRB1*16:10.
    VAR_062844
    Natural varianti96 – 961F → I in allele DRB1*16:05 and allele DRB1*16:07.
    VAR_062845
    Natural varianti96 – 961F → L in allele DRB1*16:02, allele DRB1*16:10, allele DRB1*16:11 and allele DRB1*16:12.
    VAR_062846
    Natural varianti101 – 1011R → A in allele DRB1*16:03; requires 2 nucleotide substitutions.
    VAR_062847
    Natural varianti103 – 1031A → L in allele DRB1*16:04; requires 2 nucleotide substitutions.
    VAR_062848
    Natural varianti262 – 2621T → R.
    Corresponds to variant rs9269744 [ dbSNP | Ensembl ].
    VAR_062849

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28583 mRNA. Translation: AAA59680.1.
    M20504 mRNA. Translation: AAA59827.1.
    L02545 mRNA. Translation: AAA59777.1.
    AK291987 mRNA. Translation: BAF84676.1.
    M16959 mRNA. Translation: AAA36281.1.
    AM110006 Genomic DNA. Translation: CAJ33613.1.
    Z72424 Genomic DNA. No translation available.
    AY912074 Genomic DNA. Translation: AAY17287.1.
    DQ837166 Genomic DNA. Translation: ABH05946.1.
    AY428805 Genomic DNA. Translation: AAR07616.1.
    DQ192647 Genomic DNA. Translation: ABA39176.1.
    EU029801 Genomic DNA. Translation: ABU86860.1.
    U59686 Genomic DNA. Translation: AAB52230.1.
    U26659 Genomic DNA. Translation: AAD09441.1.
    PIRiB27618.
    D25239.
    F27060.
    I54509.
    RefSeqiNP_002115.2. NM_002124.3.
    UniGeneiHs.485130.
    Hs.534322.
    Hs.696211.
    Hs.716081.
    Hs.723344.
    Hs.736560.

    Genome annotation databases

    EnsembliENST00000360004; ENSP00000353099; ENSG00000196126.
    GeneIDi3123.
    KEGGihsa:3123.

    Polymorphism databases

    DMDMi74762149.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28583 mRNA. Translation: AAA59680.1 .
    M20504 mRNA. Translation: AAA59827.1 .
    L02545 mRNA. Translation: AAA59777.1 .
    AK291987 mRNA. Translation: BAF84676.1 .
    M16959 mRNA. Translation: AAA36281.1 .
    AM110006 Genomic DNA. Translation: CAJ33613.1 .
    Z72424 Genomic DNA. No translation available.
    AY912074 Genomic DNA. Translation: AAY17287.1 .
    DQ837166 Genomic DNA. Translation: ABH05946.1 .
    AY428805 Genomic DNA. Translation: AAR07616.1 .
    DQ192647 Genomic DNA. Translation: ABA39176.1 .
    EU029801 Genomic DNA. Translation: ABU86860.1 .
    U59686 Genomic DNA. Translation: AAB52230.1 .
    U26659 Genomic DNA. Translation: AAD09441.1 .
    PIRi B27618.
    D25239.
    F27060.
    I54509.
    RefSeqi NP_002115.2. NM_002124.3.
    UniGenei Hs.485130.
    Hs.534322.
    Hs.696211.
    Hs.716081.
    Hs.723344.
    Hs.736560.

    3D structure databases

    ProteinModelPortali Q29974.
    SMRi Q29974. Positions 32-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109368. 15 interactions.

    Polymorphism databases

    DMDMi 74762149.

    Proteomic databases

    PRIDEi Q29974.

    Protocols and materials databases

    DNASUi 3123.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360004 ; ENSP00000353099 ; ENSG00000196126 .
    GeneIDi 3123.
    KEGGi hsa:3123.

    Organism-specific databases

    CTDi 3123.
    GeneCardsi GC06M032546.
    HGNCi HGNC:4948. HLA-DRB1.
    HPAi CAB015400.
    CAB034021.
    MIMi 142857. gene.
    neXtProti NX_Q29974.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG012730.
    KOi K06752.
    TreeFami TF336626.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    ChiTaRSi HLA-DRB1. human.
    GenomeRNAii 3123.
    NextBioi 12394.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q29974.
    Bgeei Q29974.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope."
      Wu S.K., Yabe T., Madden M., Saunders T.L., Bach F.H.
      J. Immunol. 138:2953-2959(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*16:01).
    2. "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes."
      Liu C.P., Bach F.H., Wu S.K.
      J. Immunol. 140:3631-3639(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*16:02).
    3. "A novel HLA-DRB1-DR2 allele associated with HLA mistyping."
      Rosenlicht J.W., Hartung K., Deicher H., Frey J.
      Immunogenetics 37:479-479(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*16:03).
      Tissue: Blood.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DRB1*16:01).
      Tissue: Small intestine.
    5. "HLA-DR2 subtypes form an additional supertypic family of DR beta alleles."
      Lee B.S.M., Rust N.A., McMichael A.J., McDevitt H.O.
      Proc. Natl. Acad. Sci. U.S.A. 84:4591-4595(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB1*16:01).
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-216 (ALLELE DRB1*16:04).
      Tissue: Peripheral blood.
    7. "HLA-DRB1*1608: a new HLA-DRB1*16 allele with a short DRB1*03 sequence."
      Reviron D., Dormoy A., Andre M., Froelich N., Roudier J., Tongio M.M., Mercier P.
      Immunogenetics 46:444-445(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*16:08).
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*16:09).
    9. "A novel HLA-DRB1 allele, DRB*1611, is identified in two Taiwanese individuals."
      Chu C.-C., Lee H.-L., Lin M.
      Tissue Antigens 74:175-176(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*16:11).
    10. "Novel HLA-DRB1 allele."
      Gedil M.A., Steiner N.K., Hurley C.K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*16:05).
    11. "Identification a novel HLA-DRB1*16 allele by sequence based typing in Chinese."
      Yan L., Zhu F., He J.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*16:10).
    12. "Novel HLA class II allele."
      Lazaro A.M., Xiao Y., Hurley C.K.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*16:12).
    13. "Two DR2-associated novel alleles arose from the silent mutation of codon 72: DRB1*16012, DRB5*01012."
      Lin Y.S., Tang T.F., Ng J., Hartzman R., Hurley C.K.
      Tissue Antigens 54:405-408(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DRB1*16:01).
      Tissue: Blood.
    14. Brautbar C., Israel S., Safirman C., Smith A.G.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-120 (ALLELE DRB1*16:07).
    15. "Invariant chain structure and MHC class II function."
      Cresswell P.
      Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    16. "Presentation of antigens by MHC class II molecules: getting the most out of them."
      Villadangos J.A.
      Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    17. "Autophagy in MHC class II presentation: sampling from within."
      Menendez-Benito V., Neefjes J.
      Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    18. "MHC class II molecules on the move for successful antigen presentation."
      Rocha N., Neefjes J.
      EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    19. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
      De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
      Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
    20. "MHC class II transport at a glance."
      Berger A.C., Roche P.A.
      J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    21. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
      Beswick E.J., Reyes V.E.
      World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry namei2B1G_HUMAN
    AccessioniPrimary (citable) accession number: Q29974
    Secondary accession number(s): A7X5J4
    , O98212, Q0PGR5, Q29792, Q30120, Q30159, Q30200, Q3HUP9, Q3KTM1, Q3LA84, Q6T865, Q95383
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3