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Protein
Submitted name:

MHC class II DR-beta

Gene

HLA-DRB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II DR-betaImported
Gene namesi
Name:HLA-DRB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 221HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiQ29972.

Structurei

3D structure databases

ProteinModelPortaliQ29972.
SMRiQ29972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 185Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328. MHC_II_b_N. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q29972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GDTRPCFLQQ DKYECHFFNG TERVRFLHRG IYNQEENVRF DSDVGEYRAV
60 70 80 90 100
TELGRPDAEY WNSQKDILEQ ARAAVDTYCR HNYGAVESFT VQRRVEPKVT
110 120 130 140 150
VYPARTQTLQ HHNLLVCSVN GFYPGSIEVR WFRNGQEEKA GVVSTGLIQN
160 170 180 190 200
GDWTFQILVM LETVPRSGEV YTCQVEHPSV TSPLTVEWRA QSESAQSKML
210 220 230
SGIGGFVLGL LFLGAGLFIY FKNQKGHSGL HPTGLVS
Length:237
Mass (Da):26,843
Last modified:November 1, 1996 - v1
Checksum:iAA217E3E41F4D425
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15992 mRNA. Translation: AAA59678.1.
PIRiD32526.
PT0171.
UniGeneiHs.485130.
Hs.534322.
Hs.696211.
Hs.736560.

Similar proteinsi

Entry informationi

Entry nameiQ29972_HUMAN
AccessioniPrimary (citable) accession number: Q29972
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.