Q29972 (Q29972_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MHC class II DR-beta EMBL AAA59678.1

Gene names

Name:

HLA-DRB2 EMBL AAA59678.1

Organism

Homo sapiens (Human) EMBL AAA59678.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	237 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS003597

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC II RuleBase RU000321 SAAS SAAS003597 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS014745
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAA59678.1

Sequences

	Sequence		Length	Mass (Da)
	Q29972 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: AA217E3E41F4D425	FASTA	237	26,843
	10 20 30 40 50 60 GDTRPCFLQQ DKYECHFFNG TERVRFLHRG IYNQEENVRF DSDVGEYRAV TELGRPDAEY 70 80 90 100 110 120 WNSQKDILEQ ARAAVDTYCR HNYGAVESFT VQRRVEPKVT VYPARTQTLQ HHNLLVCSVN 130 140 150 160 170 180 GFYPGSIEVR WFRNGQEEKA GVVSTGLIQN GDWTFQILVM LETVPRSGEV YTCQVEHPSV 190 200 210 220 230 TSPLTVEWRA QSESAQSKML SGIGGFVLGL LFLGAGLFIY FKNQKGHSGL HPTGLVS

References

[1]

"cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope." Wu S.K., Yabe T., Madden M., Saunders T.L., Bach F.H. J. Immunol. 138:2953-2959(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15992 mRNA. Translation: AAA59678.1.
IPI	IPI00107714.
PIR	D32526. PT0171.
UniGene	Hs.485130. Hs.534322. Hs.696211. Hs.736560.
3D structure databases
HSSP	HSSP built from PDB template 1JWU based on UniProtKB P01903.
ProteinModelPortal	Q29972.
ModBase	Search...
Protein-protein interaction databases
STRING	Q29972.
Proteomic databases
PRIDE	Q29972.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG012730.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit. [Graphical view]
ProDom	PD000328. MHC_II_b_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q29972_HUMAN

Accession

Primary (citable) accession number: Q29972

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.