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Q298P4

- PDE6_DROPS

UniProt

Q298P4 - PDE6_DROPS

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Protein
cGMP-specific 3',5'-cyclic phosphodiesterase
Gene
Pde6, GA20950
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei707 – 7071Proton donor By similarity
Metal bindingi711 – 7111Divalent metal cation 1 By similarity
Metal bindingi747 – 7471Divalent metal cation 1 By similarity
Metal bindingi748 – 7481Divalent metal cation 1 By similarity
Metal bindingi748 – 7481Divalent metal cation 2 By similarity
Metal bindingi858 – 8581Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GA20950
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0080939. Dpse\GA20950.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11071107cGMP-specific 3',5'-cyclic phosphodiesterase
PRO_0000363694Add
BLAST
Propeptidei1108 – 11103Removed in mature form By similarity
PRO_0000363695

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1107 – 11071Cysteine methyl ester By similarity
Lipidationi1107 – 11071S-farnesyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Protein-protein interaction databases

STRINGi7237.FBpp0282030.

Structurei

3D structure databases

ProteinModelPortaliQ298P4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini233 – 385153GAF 1
Add
BLAST
Domaini417 – 601185GAF 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 6055Ala-rich
Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiQ298P4.
KOiK13763.
OrthoDBiEOG7RRF69.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q298P4-1 [UniParc]FASTAAdd to Basket

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MTDVSAAAGG ATAPAETAAT SSSASKPLTN GANKTSTAMA APTATPTTAA     50
TASGAAEAGA ITSVAGISNQ VKLEHHHHRQ SNNNRPVAPY PPVPAAKPKP 100
TPTPESKFKS TSREPGMSSS SSSAQQDVDE VARLFEEKPE AFEKWLTERA 150
PPEALSRLQE FIESRKPLKR PSVTSDLFQQ WMSASPTVQQ KSPRSLSNSS 200
ASSTLPECRR HLMDLDEGEL FMELIRDVAN ELDIDVLCHK ILVNVGLLTH 250
ADRGSLFLAK GTPHNKYLVA KLFDVTQKTA LKDAVTRASA EEIIIPFGIG 300
IAGMVAQTKQ MINIKEAYKD ARFNCEIDLK TGYKTNAILC MPICNYEGDI 350
IGVAQIINKT NGCMEFDEHD VEIFRRYLTF CGIGIQNAQL FEMSVQEYRR 400
NQILLNLARS IFEEQNNLEC LVTKIMTEAR ELLNCERCSV FLVDLDCCEA 450
SHLEKIIEKP NQPEQRPTRA IMPGDSFDEK KMRNRFTVLF ELGGEYQAAS 500
VSRPSKTELS TSTLAQIAQF VATTGQTVNI CDVHEWVRDH NQIRAESEID 550
STQAILCMPI VNAQKVVIGV AQLINKANGV PFTESDASIF EAFAIFCGLG 600
IHNTQMYENA CKLMAKQKVA LECLSYHATA SQDQTEKLTQ DAIAEAESYN 650
LYSFTFTDFE LVDDDTCRAV LRMFLQCNLV SQFQIPYDVL CRWVLSVRKN 700
YRPVKYHNWR HALNVAQTMF AMLKTGKMER FMTDLEILGL LVACLCHDLD 750
HRGTNNAFQT KTESPLAILY TTSTMEHHHF DQCVMILNSE GNNIFQALSP 800
EDYRSVMKTV ESAILSTDLA MYFKKRNAFL ELVENGEFDW QGEEKKDLLC 850
GMMMTACDVS AIAKPWEVQH KVAKLVADEF FDQGDLEKLQ LNTQPVAMMD 900
RERKDELPKM QVGFIDVICL PLYRVLCDTF PWITPLYEGT LENRRNWQDL 950
AEKVEMGLTW IDHDTIDKPV EEFAGCADEE IKDIEFTVTT LNCNQQAQHG 1000
AGAGGDDSHT PEHQRSGSRL SMKKTGALGK AVRSKLSKTL YNSMDGSKPK 1050
TSLKLLESHV SEDMDDKSPT SPSQPHAGGS VGRMSASSST SSAGTVVDKS 1100
KKRSKLCSLL 1110
Length:1,110
Mass (Da):123,338
Last modified:October 3, 2012 - v3
Checksum:i4FB8DECD51B085A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000070 Genomic DNA. Translation: EAL27911.3.
RefSeqiXP_001358768.3. XM_001358731.3.

Genome annotation databases

EnsemblMetazoaiFBtr0307989; FBpp0300350; FBgn0080939.
GeneIDi4801723.
KEGGidpo:Dpse_GA20950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000070 Genomic DNA. Translation: EAL27911.3 .
RefSeqi XP_001358768.3. XM_001358731.3.

3D structure databases

ProteinModelPortali Q298P4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0282030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0307989 ; FBpp0300350 ; FBgn0080939 .
GeneIDi 4801723.
KEGGi dpo:Dpse_GA20950.

Organism-specific databases

FlyBasei FBgn0080939. Dpse\GA20950.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi Q298P4.
KOi K13763.
OrthoDBi EOG7RRF69.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiPDE6_DROPS
AccessioniPrimary (citable) accession number: Q298P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 49 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi