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Q297V5

- SETD8_DROPS

UniProt

Q297V5 - SETD8_DROPS

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Protein

Histone-lysine N-methyltransferase pr-set7

Gene
pr-set7, GA17259
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei610 – 6101S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. histone methyltransferase activity (H4-K20 specific) Source: UniProtKB

GO - Biological processi

  1. histone H4-K20 methylation Source: GOC
  2. histone methylation Source: UniProtKB
  3. mitotic nuclear division Source: UniProtKB-KW
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase pr-set7 (EC:2.1.1.43)
Alternative name(s):
PR/SET domain-containing protein 07
Gene namesi
Name:pr-set7
ORF Names:GA17259
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0077272. Dpse\GA17259.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity
Note: Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions By similarity.

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. polytene chromosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Histone-lysine N-methyltransferase pr-set7PRO_0000317003Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0284106.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 676122SETAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni565 – 5673S-adenosyl-L-methionine binding By similarity
Regioni637 – 6382S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ297V5.
KOiK11428.
OrthoDBiEOG70KGRN.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q297V5-1 [UniParc]FASTAAdd to Basket

« Hide

MIMVRRRARP AKETGGGSAA AAVASDGALS MDTAAAVAVA GGNHLLDDQY    50
FASPKRKDCR LMKASENLKI SSDVVALEEE ANNKGVKPTK ALTDRTIGVP 100
LATRSQTRTI ENFFKADAAA KCGITLNTHH PEPIKEQKTI STTELPLSDE 150
LGDEELERVV GDLLYDGHST ASSDSPSYQN ENEHEEVMQD TFALRETSPV 200
PVLMADFQTH RSGLRDSHSS SHSSSSSGGA SATTDNIFLQ EPVLTLDIDR 250
TPTKASSIKI NKSFELASAV FSSPPSVLNA CRFNQIVTLN GGGQCEPQPV 300
VVAQPQPQPQ LQLPPHHNGF ELDQHDSSSC DSGVACNLTI SAESPAAGGG 350
AGAAARRRKP ATPHRILCPS PIKTLPRGDG GGLIVPGARK TSGIMMKGDL 400
LSPRKSPRKL PTTTAAVAAC KSRRRLNQPK PQAPYQPQQP QPPPGTQPTN 450
EDVVAAEELE NLNKIPIANS NKSNNHVKAM LKPAPAKPRA ALTKGSKTKT 500
GSKIQPGPLP LAATNGNREM TDFFPVRRSV RKTKTAVKEE WLRNLEQAVL 550
EERSEGLQVR NFMGKGRGVV AVRHFKRNEF VVEYVGDLIS ISDATDRERR 600
YALDENAGCY MYYFKHKNQQ YCIDATVDTG KLGRLINHSR AGNLMTKVVV 650
IKQRPHLVLL AKDDIAPGEE LTYDYGDRSK ESLLHHPWLA F 691
Length:691
Mass (Da):74,929
Last modified:January 20, 2009 - v2
Checksum:i6F565E222ABE4444
GO

Sequence cautioni

The sequence EAL28100.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000070 Genomic DNA. Translation: EAL28100.2. Sequence problems.
RefSeqiXP_001358957.2. XM_001358920.2.

Genome annotation databases

GeneIDi4801942.
KEGGidpo:Dpse_GA17259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000070 Genomic DNA. Translation: EAL28100.2 . Sequence problems.
RefSeqi XP_001358957.2. XM_001358920.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0284106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4801942.
KEGGi dpo:Dpse_GA17259.

Organism-specific databases

FlyBasei FBgn0077272. Dpse\GA17259.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi Q297V5.
KOi K11428.
OrthoDBi EOG70KGRN.

Family and domain databases

InterProi IPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiSETD8_DROPS
AccessioniPrimary (citable) accession number: Q297V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 20, 2009
Last modified: September 3, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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