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Q297V5 (SETD8_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase pr-set7

EC=2.1.1.43
Alternative name(s):
PR/SET domain-containing protein 07
Gene names
Name:pr-set7
ORF Names:GA17259
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length691 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity. Note: Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.

Contains 1 SET domain.

Sequence caution

The sequence EAL28100.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 691691Histone-lysine N-methyltransferase pr-set7
PRO_0000317003

Regions

Domain555 – 676122SET
Region565 – 5673S-adenosyl-L-methionine binding By similarity
Region637 – 6382S-adenosyl-L-methionine binding By similarity

Sites

Binding site6101S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q297V5 [UniParc].

Last modified January 20, 2009. Version 2.
Checksum: 6F565E222ABE4444

FASTA69174,929
        10         20         30         40         50         60 
MIMVRRRARP AKETGGGSAA AAVASDGALS MDTAAAVAVA GGNHLLDDQY FASPKRKDCR 

        70         80         90        100        110        120 
LMKASENLKI SSDVVALEEE ANNKGVKPTK ALTDRTIGVP LATRSQTRTI ENFFKADAAA 

       130        140        150        160        170        180 
KCGITLNTHH PEPIKEQKTI STTELPLSDE LGDEELERVV GDLLYDGHST ASSDSPSYQN 

       190        200        210        220        230        240 
ENEHEEVMQD TFALRETSPV PVLMADFQTH RSGLRDSHSS SHSSSSSGGA SATTDNIFLQ 

       250        260        270        280        290        300 
EPVLTLDIDR TPTKASSIKI NKSFELASAV FSSPPSVLNA CRFNQIVTLN GGGQCEPQPV 

       310        320        330        340        350        360 
VVAQPQPQPQ LQLPPHHNGF ELDQHDSSSC DSGVACNLTI SAESPAAGGG AGAAARRRKP 

       370        380        390        400        410        420 
ATPHRILCPS PIKTLPRGDG GGLIVPGARK TSGIMMKGDL LSPRKSPRKL PTTTAAVAAC 

       430        440        450        460        470        480 
KSRRRLNQPK PQAPYQPQQP QPPPGTQPTN EDVVAAEELE NLNKIPIANS NKSNNHVKAM 

       490        500        510        520        530        540 
LKPAPAKPRA ALTKGSKTKT GSKIQPGPLP LAATNGNREM TDFFPVRRSV RKTKTAVKEE 

       550        560        570        580        590        600 
WLRNLEQAVL EERSEGLQVR NFMGKGRGVV AVRHFKRNEF VVEYVGDLIS ISDATDRERR 

       610        620        630        640        650        660 
YALDENAGCY MYYFKHKNQQ YCIDATVDTG KLGRLINHSR AGNLMTKVVV IKQRPHLVLL 

       670        680        690 
AKDDIAPGEE LTYDYGDRSK ESLLHHPWLA F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000070 Genomic DNA. Translation: EAL28100.2. Sequence problems.
RefSeqXP_001358957.2. XM_001358920.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0284106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4801942.
KEGGdpo:Dpse_GA17259.

Organism-specific databases

FlyBaseFBgn0077272. Dpse\GA17259.

Phylogenomic databases

eggNOGCOG2940.
InParanoidQ297V5.
KOK11428.
OrthoDBEOG70KGRN.

Family and domain databases

InterProIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
[Graphical view]
SMARTSM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSETD8_DROPS
AccessionPrimary (citable) accession number: Q297V5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 20, 2009
Last modified: March 19, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase