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Q297V5

- SETD8_DROPS

UniProt

Q297V5 - SETD8_DROPS

Protein

Histone-lysine N-methyltransferase pr-set7

Gene

pr-set7

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei610 – 6101S-adenosyl-L-methioninePROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone methyltransferase activity (H4-K20 specific) Source: UniProtKB

    GO - Biological processi

    1. histone H4-K20 methylation Source: GOC
    2. histone methylation Source: UniProtKB
    3. mitotic nuclear division Source: UniProtKB-KW
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase pr-set7 (EC:2.1.1.43)
    Alternative name(s):
    PR/SET domain-containing protein 07
    Gene namesi
    Name:pr-set7
    ORF Names:GA17259
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0077272. Dpse\GA17259.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity
    Note: Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions By similarity.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. polytene chromosome Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691Histone-lysine N-methyltransferase pr-set7PRO_0000317003Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7237.FBpp0284106.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini555 – 676122SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni565 – 5673S-adenosyl-L-methionine bindingPROSITE-ProRule annotation
    Regioni637 – 6382S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    InParanoidiQ297V5.
    KOiK11428.
    OrthoDBiEOG70KGRN.

    Family and domain databases

    InterProiIPR016858. Hist_H4-K20_MeTrfase.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q297V5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMVRRRARP AKETGGGSAA AAVASDGALS MDTAAAVAVA GGNHLLDDQY    50
    FASPKRKDCR LMKASENLKI SSDVVALEEE ANNKGVKPTK ALTDRTIGVP 100
    LATRSQTRTI ENFFKADAAA KCGITLNTHH PEPIKEQKTI STTELPLSDE 150
    LGDEELERVV GDLLYDGHST ASSDSPSYQN ENEHEEVMQD TFALRETSPV 200
    PVLMADFQTH RSGLRDSHSS SHSSSSSGGA SATTDNIFLQ EPVLTLDIDR 250
    TPTKASSIKI NKSFELASAV FSSPPSVLNA CRFNQIVTLN GGGQCEPQPV 300
    VVAQPQPQPQ LQLPPHHNGF ELDQHDSSSC DSGVACNLTI SAESPAAGGG 350
    AGAAARRRKP ATPHRILCPS PIKTLPRGDG GGLIVPGARK TSGIMMKGDL 400
    LSPRKSPRKL PTTTAAVAAC KSRRRLNQPK PQAPYQPQQP QPPPGTQPTN 450
    EDVVAAEELE NLNKIPIANS NKSNNHVKAM LKPAPAKPRA ALTKGSKTKT 500
    GSKIQPGPLP LAATNGNREM TDFFPVRRSV RKTKTAVKEE WLRNLEQAVL 550
    EERSEGLQVR NFMGKGRGVV AVRHFKRNEF VVEYVGDLIS ISDATDRERR 600
    YALDENAGCY MYYFKHKNQQ YCIDATVDTG KLGRLINHSR AGNLMTKVVV 650
    IKQRPHLVLL AKDDIAPGEE LTYDYGDRSK ESLLHHPWLA F 691
    Length:691
    Mass (Da):74,929
    Last modified:January 20, 2009 - v2
    Checksum:i6F565E222ABE4444
    GO

    Sequence cautioni

    The sequence EAL28100.2 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000070 Genomic DNA. Translation: EAL28100.2. Sequence problems.
    RefSeqiXP_001358957.2. XM_001358920.2.

    Genome annotation databases

    GeneIDi4801942.
    KEGGidpo:Dpse_GA17259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000070 Genomic DNA. Translation: EAL28100.2 . Sequence problems.
    RefSeqi XP_001358957.2. XM_001358920.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0284106.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4801942.
    KEGGi dpo:Dpse_GA17259.

    Organism-specific databases

    FlyBasei FBgn0077272. Dpse\GA17259.

    Phylogenomic databases

    eggNOGi COG2940.
    InParanoidi Q297V5.
    KOi K11428.
    OrthoDBi EOG70KGRN.

    Family and domain databases

    InterProi IPR016858. Hist_H4-K20_MeTrfase.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51571. SAM_MT43_PR_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiSETD8_DROPS
    AccessioniPrimary (citable) accession number: Q297V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3