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Protein

Histone-lysine N-methyltransferase PR-Set7

Gene

PR-Set7

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei610S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase PR-Set7By similarity (EC:2.1.1.43)
Alternative name(s):
PR/SET domain-containing protein 07
Gene namesi
Name:PR-Set7By similarity
ORF Names:GA17259Imported
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componentsi: Chromosome 2, Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0077272 Dpse\GA17259

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170031 – 691Histone-lysine N-methyltransferase PR-Set7Add BLAST691

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0284106

Structurei

3D structure databases

SMRiQ297V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini555 – 676SETPROSITE-ProRule annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni565 – 567S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni637 – 638S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ297V5
KOiK11428

Family and domain databases

InterProiView protein in InterPro
IPR016858 Hist_H4-K20_MeTrfase
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51571 SAM_MT43_PR_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q297V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMVRRRARP AKETGGGSAA AAVASDGALS MDTAAAVAVA GGNHLLDDQY
60 70 80 90 100
FASPKRKDCR LMKASENLKI SSDVVALEEE ANNKGVKPTK ALTDRTIGVP
110 120 130 140 150
LATRSQTRTI ENFFKADAAA KCGITLNTHH PEPIKEQKTI STTELPLSDE
160 170 180 190 200
LGDEELERVV GDLLYDGHST ASSDSPSYQN ENEHEEVMQD TFALRETSPV
210 220 230 240 250
PVLMADFQTH RSGLRDSHSS SHSSSSSGGA SATTDNIFLQ EPVLTLDIDR
260 270 280 290 300
TPTKASSIKI NKSFELASAV FSSPPSVLNA CRFNQIVTLN GGGQCEPQPV
310 320 330 340 350
VVAQPQPQPQ LQLPPHHNGF ELDQHDSSSC DSGVACNLTI SAESPAAGGG
360 370 380 390 400
AGAAARRRKP ATPHRILCPS PIKTLPRGDG GGLIVPGARK TSGIMMKGDL
410 420 430 440 450
LSPRKSPRKL PTTTAAVAAC KSRRRLNQPK PQAPYQPQQP QPPPGTQPTN
460 470 480 490 500
EDVVAAEELE NLNKIPIANS NKSNNHVKAM LKPAPAKPRA ALTKGSKTKT
510 520 530 540 550
GSKIQPGPLP LAATNGNREM TDFFPVRRSV RKTKTAVKEE WLRNLEQAVL
560 570 580 590 600
EERSEGLQVR NFMGKGRGVV AVRHFKRNEF VVEYVGDLIS ISDATDRERR
610 620 630 640 650
YALDENAGCY MYYFKHKNQQ YCIDATVDTG KLGRLINHSR AGNLMTKVVV
660 670 680 690
IKQRPHLVLL AKDDIAPGEE LTYDYGDRSK ESLLHHPWLA F
Length:691
Mass (Da):74,929
Last modified:January 20, 2009 - v2
Checksum:i6F565E222ABE4444
GO

Sequence cautioni

The sequence EAL28100 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000070 Genomic DNA Translation: EAL28100.2 Sequence problems.
RefSeqiXP_001358957.2, XM_001358920.3

Genome annotation databases

GeneIDi4801942
KEGGidpo:Dpse_GA17259

Similar proteinsi

Entry informationi

Entry nameiKMT5A_DROPS
AccessioniPrimary (citable) accession number: Q297V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 20, 2009
Last modified: March 28, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health