HLA class I histocompatibility antigen, B-82 alpha chain precursor

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Q29718 (1B82_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, B-82 alpha chain

Alternative name(s):
MHC class I antigen B*82

Gene names

Name:	HLA-B
Synonyms:	HLAB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of B-82 are known: B82:01 and B82:02. The sequence shown is that of B*82:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW regulation of immune response Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Chain

25 – 362

338

HLA class I histocompatibility antigen, B-82 alpha chain

PRO_0000018867

Regions

Topological domain

25 – 308

284

Extracellular Potential

Transmembrane

309 – 332

Helical; Potential

Topological domain

333 – 362

Cytoplasmic Potential

Domain

209 – 295

Ig-like C1-type

Region

25 – 114

Alpha-1

Region

115 – 206

Alpha-2

Region

207 – 298

Alpha-3

Region

299 – 308

Connecting peptide

Amino acid modifications

Glycosylation

110

N-linked (GlcNAc...) By similarity

Disulfide bond

125 ↔ 188

By similarity

Disulfide bond

227 ↔ 283

By similarity

Natural variations

Natural variant

S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061441

Natural variant

S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061442

Natural variant

S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061443

Natural variant

A → T.
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].

VAR_056450

Natural variant

N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].

VAR_056451

Natural variant

N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].

VAR_059504

Natural variant

T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].

VAR_056452

Natural variant

D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].

VAR_059505

Natural variant

101

S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].

VAR_056453

Natural variant

186

D → G in allele B*82:02.

VAR_016543

Sequences

Sequence

Length

Mass (Da)

Tools

Q29718 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 273D957D582B3673
Show »

FASTA

362

40,421

        10         20         30         40         50         60 
MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
RMFGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD 

       190        200        210        220        230        240 
RAYLEDLCVE SLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL 


TA

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References

[1]	*"Novel HLA-B alleles, B8201, B3515 and B5106, add to the complexity of serologic identification of HLA types."** Hurley C.K., Steiner N.K., Hoyer R.J., Menchaca E., Mitton W., Simonis T., Hartzman R.J., Johnson A.H., Ng J. Tissue Antigens 47:179-187(1996) [PubMed: 8740766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE B*82:01).
[2]	Ellexson M.E., Hildebrand W.H. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*82:01).
[3]	*"Exon 1 sequence of HLA-B8201."** Blasczyk R. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-24 (ALLELE B*82:01).
[4]	Chopek M., Nielsen J., Zhang H. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*82:01).
[5]	*"HLA-B8202 identified in a Caucasoid potential bone marrow donor."** Cox S.T., Hossain E., McWhinnie A., Prokupek B.M., Madrigal J.A., Little A.-M. Tissue Antigens 56:188-191(2000) [PubMed: 11019925] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*82:02).
[6]	*"Confirmation of HLA-B8202."** Diviney M., Hepner J., Cantwell L., Boyle A., Kanaan C., Holdsworth R., Tait B. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*82:02).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36492 mRNA. Translation: AAB18369.1. U29241 Genomic DNA. Translation: AAC50691.1. U38800 mRNA. Translation: AAC99997.1. AJ278748 Genomic DNA. Translation: CAC00634.1. U43337 mRNA. Translation: AAA87573.1. AJ251755 Genomic DNA. Translation: CAB75360.1. AF525410, AF525409 Genomic DNA. Translation: AAM83101.1.
IPI	IPI00472210.
3D structure databases
ProteinModelPortal	Q29718.
SMR	Q29718. Positions 25-300.
ModBase	Search...
Protein-protein interaction databases
STRING	Q29718.
Polymorphism databases
DMDM	34222509.
Proteomic databases
PRIDE	Q29718.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359635; ENSP00000352656; ENSG00000206450.
Organism-specific databases
GeneCards	GC06M031321.
HGNC	HGNC:4932. HLA-B.
MIM	142830. gene.
neXtProt	NX_Q29718.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
InParanoid	Q29718.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
CleanEx	HS_HLA-B.
Genevestigator	Q29718.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

1B82_HUMAN

Accession

Primary (citable) accession number: Q29718
Secondary accession number(s): Q29695

Q9MYB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents