Q29718 (1B82_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, B-82 alpha chain

Alternative name(s):
MHC class I antigen B*82

Gene names

Name:	HLA-B
Synonyms:	HLAB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of B-82 are known: B*82:01 and B*82:02. The sequence shown is that of B*82:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome regulation of immune response Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW early endosome membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 362	338	HLA class I histocompatibility antigen, B-82 alpha chain		PRO_0000018867
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 362	30	Cytoplasmic Potential
	Domain	209 – 295	87	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	48	1	S → A. Corresponds to variant rs713031 [ dbSNP | Ensembl ].		VAR_061441
	Natural variant	48	1	S → P. Corresponds to variant rs713031 [ dbSNP | Ensembl ].		VAR_061442
	Natural variant	48	1	S → T. Corresponds to variant rs713031 [ dbSNP | Ensembl ].		VAR_061443
	Natural variant	65	1	A → T. Corresponds to variant rs1050529 [ dbSNP | Ensembl ].		VAR_056450
	Natural variant	87	1	N → D. Corresponds to variant rs1050570 [ dbSNP | Ensembl ].		VAR_056451
	Natural variant	87	1	N → K. Corresponds to variant rs1065386 [ dbSNP | Ensembl ].		VAR_059504
	Natural variant	97	1	T → A. Corresponds to variant rs1050393 [ dbSNP | Ensembl ].		VAR_056452
	Natural variant	98	1	D → Y. Corresponds to variant rs1131215 [ dbSNP | Ensembl ].		VAR_059505
	Natural variant	101	1	S → N. Corresponds to variant rs1050388 [ dbSNP | Ensembl ].		VAR_056453
	Natural variant	186	1	D → G in allele B*82:02.		VAR_016543

Sequences

	Sequence		Length	Mass (Da)
	Q29718 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 273D957D582B3673	FASTA	362	40,421
	10 20 30 40 50 60 MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFISVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 130 140 150 160 170 180 RMFGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQD 190 200 210 220 230 240 RAYLEDLCVE SLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA

References

[1]	"Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity of serologic identification of HLA types." Hurley C.K., Steiner N.K., Hoyer R.J., Menchaca E., Mitton W., Simonis T., Hartzman R.J., Johnson A.H., Ng J. Tissue Antigens 47:179-187(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE B*82:01).
[2]	Ellexson M.E., Hildebrand W.H. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*82:01).
[3]	"Exon 1 sequence of HLA-B*8201." Blasczyk R. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-24 (ALLELE B*82:01).
[4]	Chopek M., Nielsen J., Zhang H. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*82:01).
[5]	"HLA-B*8202 identified in a Caucasoid potential bone marrow donor." Cox S.T., Hossain E., McWhinnie A., Prokupek B.M., Madrigal J.A., Little A.-M. Tissue Antigens 56:188-191(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*82:02).
[6]	"Confirmation of HLA-B*8202." Diviney M., Hepner J., Cantwell L., Boyle A., Kanaan C., Holdsworth R., Tait B. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*82:02).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36492 mRNA. Translation: AAB18369.1. U29241 Genomic DNA. Translation: AAC50691.1. U38800 mRNA. Translation: AAC99997.1. AJ278748 Genomic DNA. Translation: CAC00634.1. U43337 mRNA. Translation: AAA87573.1. AJ251755 Genomic DNA. Translation: CAB75360.1. AH011750 Genomic DNA. Translation: AAM83101.1.
IPI	IPI00472210.
3D structure databases
ProteinModelPortal	Q29718.
ModBase	Search...
Polymorphism databases
DMDM	34222509.
Proteomic databases
PRIDE	Q29718.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359635; ENSP00000352656; ENSG00000206450.
Organism-specific databases
GeneCards	GC06M031321.
HGNC	HGNC:4932. HLA-B.
MIM	142830. gene.
neXtProt	NX_Q29718.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
InParanoid	Q29718.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q29718.
CleanEx	HS_HLA-B.
Genevestigator	Q29718.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-B. human.
NextBio	35538315.
SOURCE	Search...

Entry information

Entry name

1B82_HUMAN

Accession

Primary (citable) accession number: Q29718
Secondary accession number(s): Q29695 , Q29742, Q8MHN4, Q9MY61, Q9MYB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.