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Q29627

- PACR_BOVIN

UniProt

Q29627 - PACR_BOVIN

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Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

ADCYAP1R1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity).By similarity

GO - Molecular functioni

  1. vasoactive intestinal polypeptide receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_206547. G alpha (s) signalling events.
REACT_220607. Glucagon-type ligand receptors.
REACT_224969. NGF-independant TRKA activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
Gene namesi
Name:ADCYAP1R1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 172135ExtracellularSequence AnalysisAdd
BLAST
Transmembranei173 – 19523Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini196 – 2038CytoplasmicSequence Analysis
Transmembranei204 – 22219Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini223 – 24422ExtracellularSequence AnalysisAdd
BLAST
Transmembranei245 – 27026Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini271 – 28515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30823Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini309 – 32618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei327 – 34923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini350 – 39546CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei396 – 41621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini417 – 43014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei431 – 45020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini451 – 51363CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 513476Pituitary adenylate cyclase-activating polypeptide type I receptorPRO_0000012840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 80By similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi71 ↔ 135By similarity
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 151By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ29627.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1.By similarity

Protein-protein interaction databases

MINTiMINT-1512351.

Structurei

3D structure databases

ProteinModelPortaliQ29627.
SMRiQ29627. Positions 34-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni142 – 15615Important for ligand binding and specificityBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330024.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ29627.
KOiK04587.
OMAiKWRSWKV.
OrthoDBiEOG7TF78W.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform Long (identifier: Q29627-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGGRHWPEP PCRLRSVMAS IAQVSLAALL LLPMATAMHS DCIFKKEQAM
60 70 80 90 100
CLEKIQRVND LMGLNDSSPG CPGMWDNITC WKPAHVGEMV LVSCPELFRI
110 120 130 140 150
FNPDQVWETE TIGEFGFADS KSLDLSDMRV VSRNCTEDGW SEPFPHYFDA
160 170 180 190 200
CGFEEYESET GDQDYYYLSV KALYTVGYST SLVTLTTAMV ILCRFRKLHC
210 220 230 240 250
TRNFIHMNLF VSFMLRAISV FIKDWILYAE QDSNHCFVST VECKAVMVFF
260 270 280 290 300
HYCVVSNYFW LFIEGLYLFT LLVETFFPER RYFYWYIIIG WGTPTVCVSV
310 320 330 340 350
WAMLRLYFDD TGCWDMNDNT ALWWVIKGPV VGSIMVNFVL FIGIIVILVQ
360 370 380 390 400
KLQSPDMGGN ESSIYFSCVQ KCYCKPQRAQ QHSCKMSELS TITLRLARST
410 420 430 440 450
LLLIPLFGIH YTVFAFSPEN VSKRERLVFE LGLGSFQGFV VAVLYCFLNG
460 470 480 490 500
EVQAEIKRKW RSWKVNRYFT MDFKHRHPSL ASSGVNGGTQ LSILSKSSSQ
510
IRMSGLPADN LAT
Length:513
Mass (Da):58,785
Last modified:November 1, 1997 - v1
Checksum:i9A45753210CE9817
GO
Isoform Short (identifier: Q29627-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-393: Missing.

Show »
Length:485
Mass (Da):55,568
Checksum:i63CB3DA0AE155ED6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei366 – 39328Missing in isoform Short. 1 PublicationVSP_002004Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17290 mRNA. Translation: BAA04122.1.
D17290 mRNA. Translation: BAA04123.1.
PIRiS47631.
RefSeqiNP_783646.1. NM_175715.2. [Q29627-1]
XP_005205543.1. XM_005205486.1. [Q29627-1]
XP_005205545.1. XM_005205488.1. [Q29627-2]
UniGeneiBt.486.

Genome annotation databases

EnsembliENSBTAT00000026333; ENSBTAP00000026333; ENSBTAG00000020247. [Q29627-1]
ENSBTAT00000063163; ENSBTAP00000055102; ENSBTAG00000020247. [Q29627-2]
GeneIDi319095.
KEGGibta:319095.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17290 mRNA. Translation: BAA04122.1 .
D17290 mRNA. Translation: BAA04123.1 .
PIRi S47631.
RefSeqi NP_783646.1. NM_175715.2. [Q29627-1 ]
XP_005205543.1. XM_005205486.1. [Q29627-1 ]
XP_005205545.1. XM_005205488.1. [Q29627-2 ]
UniGenei Bt.486.

3D structure databases

ProteinModelPortali Q29627.
SMRi Q29627. Positions 34-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1512351.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q29627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000026333 ; ENSBTAP00000026333 ; ENSBTAG00000020247 . [Q29627-1 ]
ENSBTAT00000063163 ; ENSBTAP00000055102 ; ENSBTAG00000020247 . [Q29627-2 ]
GeneIDi 319095.
KEGGi bta:319095.

Organism-specific databases

CTDi 117.

Phylogenomic databases

eggNOGi NOG330024.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008249.
HOVERGENi HBG008318.
InParanoidi Q29627.
KOi K04587.
OMAi KWRSWKV.
OrthoDBi EOG7TF78W.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_206547. G alpha (s) signalling events.
REACT_220607. Glucagon-type ligand receptors.
REACT_224969. NGF-independant TRKA activation.

Miscellaneous databases

NextBioi 20807192.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a complementary DNA encoding the bovine receptor for pituitary adenylate cyclase-activating polypeptide (PACAP)."
    Miyamoto Y., Habata Y., Ohtaki T., Masuda Y., Ogi K., Onda H., Fujino M.
    Biochim. Biophys. Acta 1218:297-307(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Brain.

Entry informationi

Entry nameiPACR_BOVIN
AccessioniPrimary (citable) accession number: Q29627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3