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Q29627 (PACR_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name=PACAP type I receptor
Short name=PACAP-R-1
Short name=PACAP-R1
Gene names
Name:ADCYAP1R1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract By similarity.

Subunit structure

Interacts (via N-terminal extracellular domain) with ADCYAP1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionvasoactive intestinal polypeptide receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform Long (identifier: Q29627-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q29627-2)

The sequence of this isoform differs from the canonical sequence as follows:
     366-393: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 513476Pituitary adenylate cyclase-activating polypeptide type I receptor
PRO_0000012840

Regions

Topological domain38 – 172135Extracellular Potential
Transmembrane173 – 19523Helical; Name=1; Potential
Topological domain196 – 2038Cytoplasmic Potential
Transmembrane204 – 22219Helical; Name=2; Potential
Topological domain223 – 24422Extracellular Potential
Transmembrane245 – 27026Helical; Name=3; Potential
Topological domain271 – 28515Cytoplasmic Potential
Transmembrane286 – 30823Helical; Name=4; Potential
Topological domain309 – 32618Extracellular Potential
Transmembrane327 – 34923Helical; Name=5; Potential
Topological domain350 – 39546Cytoplasmic Potential
Transmembrane396 – 41621Helical; Name=6; Potential
Topological domain417 – 43014Extracellular Potential
Transmembrane431 – 45020Helical; Name=7; Potential
Topological domain451 – 51363Cytoplasmic Potential
Region142 – 15615Important for ligand binding and specificity By similarity

Amino acid modifications

Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 80 By similarity
Disulfide bond71 ↔ 135 By similarity
Disulfide bond94 ↔ 151 By similarity

Natural variations

Alternative sequence366 – 39328Missing in isoform Short.
VSP_002004

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 9A45753210CE9817

FASTA51358,785
        10         20         30         40         50         60 
MRGGRHWPEP PCRLRSVMAS IAQVSLAALL LLPMATAMHS DCIFKKEQAM CLEKIQRVND 

        70         80         90        100        110        120 
LMGLNDSSPG CPGMWDNITC WKPAHVGEMV LVSCPELFRI FNPDQVWETE TIGEFGFADS 

       130        140        150        160        170        180 
KSLDLSDMRV VSRNCTEDGW SEPFPHYFDA CGFEEYESET GDQDYYYLSV KALYTVGYST 

       190        200        210        220        230        240 
SLVTLTTAMV ILCRFRKLHC TRNFIHMNLF VSFMLRAISV FIKDWILYAE QDSNHCFVST 

       250        260        270        280        290        300 
VECKAVMVFF HYCVVSNYFW LFIEGLYLFT LLVETFFPER RYFYWYIIIG WGTPTVCVSV 

       310        320        330        340        350        360 
WAMLRLYFDD TGCWDMNDNT ALWWVIKGPV VGSIMVNFVL FIGIIVILVQ KLQSPDMGGN 

       370        380        390        400        410        420 
ESSIYFSCVQ KCYCKPQRAQ QHSCKMSELS TITLRLARST LLLIPLFGIH YTVFAFSPEN 

       430        440        450        460        470        480 
VSKRERLVFE LGLGSFQGFV VAVLYCFLNG EVQAEIKRKW RSWKVNRYFT MDFKHRHPSL 

       490        500        510 
ASSGVNGGTQ LSILSKSSSQ IRMSGLPADN LAT

« Hide

Isoform Short [UniParc].

Checksum: 63CB3DA0AE155ED6
Show »

FASTA48555,568

References

[1]"Cloning and expression of a complementary DNA encoding the bovine receptor for pituitary adenylate cyclase-activating polypeptide (PACAP)."
Miyamoto Y., Habata Y., Ohtaki T., Masuda Y., Ogi K., Onda H., Fujino M.
Biochim. Biophys. Acta 1218:297-307(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D17290 mRNA. Translation: BAA04122.1.
D17290 mRNA. Translation: BAA04123.1.
IPIIPI00712019.
IPI00713134.
PIRS47631.
RefSeqNP_783646.1. NM_175715.2.
UniGeneBt.486.

3D structure databases

ProteinModelPortalQ29627.
SMRQ29627. Positions 34-160.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1512351.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ29627.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000026333; ENSBTAP00000026333; ENSBTAG00000020247.
ENSBTAT00000063163; ENSBTAP00000055102; ENSBTAG00000020247.
GeneID319095.
KEGGbta:319095.

Organism-specific databases

CTD117.

Phylogenomic databases

eggNOGNOG330024.
GeneTreeENSGT00620000087538.
HOGENOMHOG000008249.
HOVERGENHBG008318.
InParanoidQ29627.
KOK04587.
OMAKWRSWKV.
OrthoDBEOG4B5P5B.

Enzyme and pathway databases

BioCycCATTLE:319095-MONOMER.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERPTHR12011:SF30. PTHR12011:SF30. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20807192.

Entry information

Entry namePACR_BOVIN
AccessionPrimary (citable) accession number: Q29627
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents