Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

ADCYAP1R1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
Gene namesi
Name:ADCYAP1R1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini38 – 172ExtracellularSequence analysisAdd BLAST135
Transmembranei173 – 195Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini196 – 203CytoplasmicSequence analysis8
Transmembranei204 – 222Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini223 – 244ExtracellularSequence analysisAdd BLAST22
Transmembranei245 – 270Helical; Name=3Sequence analysisAdd BLAST26
Topological domaini271 – 285CytoplasmicSequence analysisAdd BLAST15
Transmembranei286 – 308Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini309 – 326ExtracellularSequence analysisAdd BLAST18
Transmembranei327 – 349Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini350 – 395CytoplasmicSequence analysisAdd BLAST46
Transmembranei396 – 416Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini417 – 430ExtracellularSequence analysisAdd BLAST14
Transmembranei431 – 450Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini451 – 513CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000001284038 – 513Pituitary adenylate cyclase-activating polypeptide type I receptorAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 80By similarity
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi71 ↔ 135By similarity
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 151By similarity
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Modified residuei479PhosphoserineBy similarity1
Modified residuei492PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ29627.
PRIDEiQ29627.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020247.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1.By similarity

Protein-protein interaction databases

MINTiMINT-1512351.
STRINGi9913.ENSBTAP00000026333.

Structurei

3D structure databases

ProteinModelPortaliQ29627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni142 – 156Important for ligand binding and specificityBy similarityAdd BLAST15

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ29627.
KOiK04587.
OMAiCKAIMVF.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: Q29627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGGRHWPEP PCRLRSVMAS IAQVSLAALL LLPMATAMHS DCIFKKEQAM
60 70 80 90 100
CLEKIQRVND LMGLNDSSPG CPGMWDNITC WKPAHVGEMV LVSCPELFRI
110 120 130 140 150
FNPDQVWETE TIGEFGFADS KSLDLSDMRV VSRNCTEDGW SEPFPHYFDA
160 170 180 190 200
CGFEEYESET GDQDYYYLSV KALYTVGYST SLVTLTTAMV ILCRFRKLHC
210 220 230 240 250
TRNFIHMNLF VSFMLRAISV FIKDWILYAE QDSNHCFVST VECKAVMVFF
260 270 280 290 300
HYCVVSNYFW LFIEGLYLFT LLVETFFPER RYFYWYIIIG WGTPTVCVSV
310 320 330 340 350
WAMLRLYFDD TGCWDMNDNT ALWWVIKGPV VGSIMVNFVL FIGIIVILVQ
360 370 380 390 400
KLQSPDMGGN ESSIYFSCVQ KCYCKPQRAQ QHSCKMSELS TITLRLARST
410 420 430 440 450
LLLIPLFGIH YTVFAFSPEN VSKRERLVFE LGLGSFQGFV VAVLYCFLNG
460 470 480 490 500
EVQAEIKRKW RSWKVNRYFT MDFKHRHPSL ASSGVNGGTQ LSILSKSSSQ
510
IRMSGLPADN LAT
Length:513
Mass (Da):58,785
Last modified:November 1, 1997 - v1
Checksum:i9A45753210CE9817
GO
Isoform Short (identifier: Q29627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-393: Missing.

Show »
Length:485
Mass (Da):55,568
Checksum:i63CB3DA0AE155ED6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002004366 – 393Missing in isoform Short. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17290 mRNA. Translation: BAA04122.1.
D17290 mRNA. Translation: BAA04123.1.
PIRiS47631.
RefSeqiNP_783646.1. NM_175715.2. [Q29627-1]
XP_010802598.1. XM_010804296.1. [Q29627-1]
XP_010802600.1. XM_010804298.1. [Q29627-2]
UniGeneiBt.486.

Genome annotation databases

EnsembliENSBTAT00000026333; ENSBTAP00000026333; ENSBTAG00000020247. [Q29627-1]
ENSBTAT00000063163; ENSBTAP00000055102; ENSBTAG00000020247. [Q29627-2]
GeneIDi319095.
KEGGibta:319095.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17290 mRNA. Translation: BAA04122.1.
D17290 mRNA. Translation: BAA04123.1.
PIRiS47631.
RefSeqiNP_783646.1. NM_175715.2. [Q29627-1]
XP_010802598.1. XM_010804296.1. [Q29627-1]
XP_010802600.1. XM_010804298.1. [Q29627-2]
UniGeneiBt.486.

3D structure databases

ProteinModelPortaliQ29627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1512351.
STRINGi9913.ENSBTAP00000026333.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ29627.
PRIDEiQ29627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026333; ENSBTAP00000026333; ENSBTAG00000020247. [Q29627-1]
ENSBTAT00000063163; ENSBTAP00000055102; ENSBTAG00000020247. [Q29627-2]
GeneIDi319095.
KEGGibta:319095.

Organism-specific databases

CTDi117.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ29627.
KOiK04587.
OMAiCKAIMVF.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-420092. Glucagon-type ligand receptors.

Gene expression databases

BgeeiENSBTAG00000020247.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPACR_BOVIN
AccessioniPrimary (citable) accession number: Q29627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.