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Q29627

- PACR_BOVIN

UniProt

Q29627 - PACR_BOVIN

Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

ADCYAP1R1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract By similarity.By similarity

    GO - Molecular functioni

    1. vasoactive intestinal polypeptide receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_206547. G alpha (s) signalling events.
    REACT_220607. Glucagon-type ligand receptors.
    REACT_224969. NGF-independant TRKA activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide type I receptor
    Short name:
    PACAP type I receptor
    Short name:
    PACAP-R-1
    Short name:
    PACAP-R1
    Gene namesi
    Name:ADCYAP1R1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 513476Pituitary adenylate cyclase-activating polypeptide type I receptorPRO_0000012840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 80By similarity
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi71 ↔ 135By similarity
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 151By similarity
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ29627.

    Interactioni

    Subunit structurei

    Interacts (via N-terminal extracellular domain) with ADCYAP1.By similarity

    Protein-protein interaction databases

    MINTiMINT-1512351.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29627.
    SMRiQ29627. Positions 34-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini38 – 172135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini196 – 2038CytoplasmicSequence Analysis
    Topological domaini223 – 24422ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini271 – 28515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini350 – 39546CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini417 – 43014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini451 – 51363CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei173 – 19523Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22219Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 27026Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30823Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei327 – 34923Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei431 – 45020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni142 – 15615Important for ligand binding and specificityBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330024.
    GeneTreeiENSGT00620000087538.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    InParanoidiQ29627.
    KOiK04587.
    OMAiKWRSWKV.
    OrthoDBiEOG7TF78W.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002285. GPCR_2_PACAP_1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01156. PACAPRECEPTR.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform Long (identifier: Q29627-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGGRHWPEP PCRLRSVMAS IAQVSLAALL LLPMATAMHS DCIFKKEQAM    50
    CLEKIQRVND LMGLNDSSPG CPGMWDNITC WKPAHVGEMV LVSCPELFRI 100
    FNPDQVWETE TIGEFGFADS KSLDLSDMRV VSRNCTEDGW SEPFPHYFDA 150
    CGFEEYESET GDQDYYYLSV KALYTVGYST SLVTLTTAMV ILCRFRKLHC 200
    TRNFIHMNLF VSFMLRAISV FIKDWILYAE QDSNHCFVST VECKAVMVFF 250
    HYCVVSNYFW LFIEGLYLFT LLVETFFPER RYFYWYIIIG WGTPTVCVSV 300
    WAMLRLYFDD TGCWDMNDNT ALWWVIKGPV VGSIMVNFVL FIGIIVILVQ 350
    KLQSPDMGGN ESSIYFSCVQ KCYCKPQRAQ QHSCKMSELS TITLRLARST 400
    LLLIPLFGIH YTVFAFSPEN VSKRERLVFE LGLGSFQGFV VAVLYCFLNG 450
    EVQAEIKRKW RSWKVNRYFT MDFKHRHPSL ASSGVNGGTQ LSILSKSSSQ 500
    IRMSGLPADN LAT 513
    Length:513
    Mass (Da):58,785
    Last modified:November 1, 1997 - v1
    Checksum:i9A45753210CE9817
    GO
    Isoform Short (identifier: Q29627-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         366-393: Missing.

    Show »
    Length:485
    Mass (Da):55,568
    Checksum:i63CB3DA0AE155ED6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei366 – 39328Missing in isoform Short. 1 PublicationVSP_002004Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17290 mRNA. Translation: BAA04122.1.
    D17290 mRNA. Translation: BAA04123.1.
    PIRiS47631.
    RefSeqiNP_783646.1. NM_175715.2. [Q29627-1]
    XP_005205543.1. XM_005205486.1. [Q29627-1]
    XP_005205545.1. XM_005205488.1. [Q29627-2]
    UniGeneiBt.486.

    Genome annotation databases

    EnsembliENSBTAT00000026333; ENSBTAP00000026333; ENSBTAG00000020247. [Q29627-1]
    ENSBTAT00000063163; ENSBTAP00000055102; ENSBTAG00000020247. [Q29627-2]
    GeneIDi319095.
    KEGGibta:319095.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17290 mRNA. Translation: BAA04122.1 .
    D17290 mRNA. Translation: BAA04123.1 .
    PIRi S47631.
    RefSeqi NP_783646.1. NM_175715.2. [Q29627-1 ]
    XP_005205543.1. XM_005205486.1. [Q29627-1 ]
    XP_005205545.1. XM_005205488.1. [Q29627-2 ]
    UniGenei Bt.486.

    3D structure databases

    ProteinModelPortali Q29627.
    SMRi Q29627. Positions 34-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1512351.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q29627.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000026333 ; ENSBTAP00000026333 ; ENSBTAG00000020247 . [Q29627-1 ]
    ENSBTAT00000063163 ; ENSBTAP00000055102 ; ENSBTAG00000020247 . [Q29627-2 ]
    GeneIDi 319095.
    KEGGi bta:319095.

    Organism-specific databases

    CTDi 117.

    Phylogenomic databases

    eggNOGi NOG330024.
    GeneTreei ENSGT00620000087538.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    InParanoidi Q29627.
    KOi K04587.
    OMAi KWRSWKV.
    OrthoDBi EOG7TF78W.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_206547. G alpha (s) signalling events.
    REACT_220607. Glucagon-type ligand receptors.
    REACT_224969. NGF-independant TRKA activation.

    Miscellaneous databases

    NextBioi 20807192.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002285. GPCR_2_PACAP_1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01156. PACAPRECEPTR.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a complementary DNA encoding the bovine receptor for pituitary adenylate cyclase-activating polypeptide (PACAP)."
      Miyamoto Y., Habata Y., Ohtaki T., Masuda Y., Ogi K., Onda H., Fujino M.
      Biochim. Biophys. Acta 1218:297-307(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Tissue: Brain.

    Entry informationi

    Entry nameiPACR_BOVIN
    AccessioniPrimary (citable) accession number: Q29627
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3