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Q29627

- PACR_BOVIN

UniProt

Q29627 - PACR_BOVIN

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Protein
Pituitary adenylate cyclase-activating polypeptide type I receptor
Gene
ADCYAP1R1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract By similarity.

GO - Molecular functioni

  1. vasoactive intestinal polypeptide receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_206547. G alpha (s) signalling events.
REACT_220607. Glucagon-type ligand receptors.
REACT_224969. NGF-independant TRKA activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
Gene namesi
Name:ADCYAP1R1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 172135Extracellular Reviewed prediction
Add
BLAST
Transmembranei173 – 19523Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini196 – 2038Cytoplasmic Reviewed prediction
Transmembranei204 – 22219Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini223 – 24422Extracellular Reviewed prediction
Add
BLAST
Transmembranei245 – 27026Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini271 – 28515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei286 – 30823Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini309 – 32618Extracellular Reviewed prediction
Add
BLAST
Transmembranei327 – 34923Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini350 – 39546Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei396 – 41621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini417 – 43014Extracellular Reviewed prediction
Add
BLAST
Transmembranei431 – 45020Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini451 – 51363Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 Reviewed prediction
Add
BLAST
Chaini38 – 513476Pituitary adenylate cyclase-activating polypeptide type I receptor
PRO_0000012840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 80 By similarity
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi71 ↔ 135 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi94 ↔ 151 By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ29627.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1 By similarity.

Protein-protein interaction databases

MINTiMINT-1512351.

Structurei

3D structure databases

ProteinModelPortaliQ29627.
SMRiQ29627. Positions 34-160.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni142 – 15615Important for ligand binding and specificity By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330024.
GeneTreeiENSGT00620000087538.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ29627.
KOiK04587.
OMAiKWRSWKV.
OrthoDBiEOG7TF78W.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform Long (identifier: Q29627-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRGGRHWPEP PCRLRSVMAS IAQVSLAALL LLPMATAMHS DCIFKKEQAM    50
CLEKIQRVND LMGLNDSSPG CPGMWDNITC WKPAHVGEMV LVSCPELFRI 100
FNPDQVWETE TIGEFGFADS KSLDLSDMRV VSRNCTEDGW SEPFPHYFDA 150
CGFEEYESET GDQDYYYLSV KALYTVGYST SLVTLTTAMV ILCRFRKLHC 200
TRNFIHMNLF VSFMLRAISV FIKDWILYAE QDSNHCFVST VECKAVMVFF 250
HYCVVSNYFW LFIEGLYLFT LLVETFFPER RYFYWYIIIG WGTPTVCVSV 300
WAMLRLYFDD TGCWDMNDNT ALWWVIKGPV VGSIMVNFVL FIGIIVILVQ 350
KLQSPDMGGN ESSIYFSCVQ KCYCKPQRAQ QHSCKMSELS TITLRLARST 400
LLLIPLFGIH YTVFAFSPEN VSKRERLVFE LGLGSFQGFV VAVLYCFLNG 450
EVQAEIKRKW RSWKVNRYFT MDFKHRHPSL ASSGVNGGTQ LSILSKSSSQ 500
IRMSGLPADN LAT 513
Length:513
Mass (Da):58,785
Last modified:November 1, 1997 - v1
Checksum:i9A45753210CE9817
GO
Isoform Short (identifier: Q29627-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-393: Missing.

Show »
Length:485
Mass (Da):55,568
Checksum:i63CB3DA0AE155ED6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei366 – 39328Missing in isoform Short.
VSP_002004Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17290 mRNA. Translation: BAA04122.1.
D17290 mRNA. Translation: BAA04123.1.
PIRiS47631.
RefSeqiNP_783646.1. NM_175715.2. [Q29627-1]
XP_005205543.1. XM_005205486.1. [Q29627-1]
XP_005205545.1. XM_005205488.1. [Q29627-2]
UniGeneiBt.486.

Genome annotation databases

EnsembliENSBTAT00000026333; ENSBTAP00000026333; ENSBTAG00000020247. [Q29627-1]
ENSBTAT00000063163; ENSBTAP00000055102; ENSBTAG00000020247. [Q29627-2]
GeneIDi319095.
KEGGibta:319095.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17290 mRNA. Translation: BAA04122.1 .
D17290 mRNA. Translation: BAA04123.1 .
PIRi S47631.
RefSeqi NP_783646.1. NM_175715.2. [Q29627-1 ]
XP_005205543.1. XM_005205486.1. [Q29627-1 ]
XP_005205545.1. XM_005205488.1. [Q29627-2 ]
UniGenei Bt.486.

3D structure databases

ProteinModelPortali Q29627.
SMRi Q29627. Positions 34-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1512351.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q29627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000026333 ; ENSBTAP00000026333 ; ENSBTAG00000020247 . [Q29627-1 ]
ENSBTAT00000063163 ; ENSBTAP00000055102 ; ENSBTAG00000020247 . [Q29627-2 ]
GeneIDi 319095.
KEGGi bta:319095.

Organism-specific databases

CTDi 117.

Phylogenomic databases

eggNOGi NOG330024.
GeneTreei ENSGT00620000087538.
HOGENOMi HOG000008249.
HOVERGENi HBG008318.
InParanoidi Q29627.
KOi K04587.
OMAi KWRSWKV.
OrthoDBi EOG7TF78W.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_206547. G alpha (s) signalling events.
REACT_220607. Glucagon-type ligand receptors.
REACT_224969. NGF-independant TRKA activation.

Miscellaneous databases

NextBioi 20807192.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a complementary DNA encoding the bovine receptor for pituitary adenylate cyclase-activating polypeptide (PACAP)."
    Miyamoto Y., Habata Y., Ohtaki T., Masuda Y., Ogi K., Onda H., Fujino M.
    Biochim. Biophys. Acta 1218:297-307(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Brain.

Entry informationi

Entry nameiPACR_BOVIN
AccessioniPrimary (citable) accession number: Q29627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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