ID CP19A_PIG Reviewed; 503 AA. AC Q29624; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 24-JAN-2024, entry version 122. DE RecName: Full=Aromatase 1; DE EC=1.14.14.14 {ECO:0000250|UniProtKB:P11511}; DE AltName: Full=CYPXIXA1; DE AltName: Full=Cytochrome P-450AROM; DE AltName: Full=Cytochrome P450 19 type I; DE AltName: Full=Estrogen synthase; GN Name=CYP19A1; Synonyms=CYP19; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Blastocyst; RX PubMed=8625924; DOI=10.1210/endo.137.4.8625924; RA Choi I., Simmen R.C.M., Simmen F.A.; RT "Molecular cloning of cytochrome P450 aromatase complementary RT deoxyribonucleic acid from periimplantation porcine and equine blastocysts RT identifies multiple novel 5'-untranslated exons expressed in embryos, RT endometrium, and placenta."; RL Endocrinology 137:1457-1467(1996). RN [2] RP NUCLEOTIDE SEQUENCE OF 342-421. RC TISSUE=Liver; RX PubMed=8129925; DOI=10.1002/mrd.1080370102; RA Ko Y., Choi I., Green M.L., Simmen F.A., Simmen R.C.; RT "Transient expression of the cytochrome P450 aromatase gene in elongating RT porcine blastocysts is correlated with uterine insulin-like growth factor RT levels during peri-implantation development."; RL Mol. Reprod. Dev. 37:1-11(1994). CC -!- FUNCTION: Catalyzes the formation of aromatic C18 estrogens from C19 CC androgens. CC -!- CATALYTIC ACTIVITY: CC Reaction=3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone CC = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized CC [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38191, Rhea:RHEA- CC COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, CC ChEBI:CHEBI:16469, ChEBI:CHEBI:17347, ChEBI:CHEBI:57618, CC ChEBI:CHEBI:58210; EC=1.14.14.14; CC Evidence={ECO:0000250|UniProtKB:P11511}; CC -!- CATALYTIC ACTIVITY: CC Reaction=androst-4-ene-3,17-dione + 3 O2 + 3 reduced CC [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + CC 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38195, CC Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, CC ChEBI:CHEBI:16422, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, CC ChEBI:CHEBI:58210; EC=1.14.14.14; CC Evidence={ECO:0000250|UniProtKB:P11511}; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250}; CC -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U37311; AAC48543.1; -; mRNA. DR EMBL; U37312; AAC48544.1; -; mRNA. DR EMBL; U37309; AAC48541.1; -; mRNA. DR EMBL; U37310; AAC48542.1; -; mRNA. DR EMBL; L15471; AAA19817.1; -; Unassigned_DNA. DR PIR; I46570; I46570. DR RefSeq; NP_999594.1; NM_214429.1. DR AlphaFoldDB; Q29624; -. DR SMR; Q29624; -. DR PeptideAtlas; Q29624; -. DR Ensembl; ENSSSCT00070009182.1; ENSSSCP00070007532.1; ENSSSCG00070004855.1. DR GeneID; 403331; -. DR KEGG; ssc:403331; -. DR CTD; 1588; -. DR InParanoid; Q29624; -. DR OrthoDB; 5385594at2759; -. DR Reactome; R-SSC-193144; Estrogen biosynthesis. DR Reactome; R-SSC-211976; Endogenous sterols. DR Proteomes; UP000008227; Unplaced. DR Proteomes; UP000314985; Chromosome 1. DR Proteomes; UP000694570; Unplaced. DR Proteomes; UP000694571; Unplaced. DR Proteomes; UP000694720; Unplaced. DR Proteomes; UP000694722; Unplaced. DR Proteomes; UP000694723; Unplaced. DR Proteomes; UP000694724; Unplaced. DR Proteomes; UP000694725; Unplaced. DR Proteomes; UP000694726; Unplaced. DR Proteomes; UP000694727; Unplaced. DR Proteomes; UP000694728; Unplaced. DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070330; F:aromatase activity; IBA:GO_Central. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0008585; P:female gonad development; IBA:GO_Central. DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW. DR GO; GO:0032355; P:response to estradiol; IBA:GO_Central. DR CDD; cd20616; CYP19A1; 1. DR Gene3D; 1.10.630.10; Cytochrome P450; 1. DR InterPro; IPR001128; Cyt_P450. DR InterPro; IPR017972; Cyt_P450_CS. DR InterPro; IPR002401; Cyt_P450_E_grp-I. DR InterPro; IPR036396; Cyt_P450_sf. DR PANTHER; PTHR24291:SF43; AROMATASE; 1. DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1. DR Pfam; PF00067; p450; 1. DR PRINTS; PR00463; EP450I. DR PRINTS; PR00385; P450. DR SUPFAM; SSF48264; Cytochrome P450; 1. DR PROSITE; PS00086; CYTOCHROME_P450; 1. PE 2: Evidence at transcript level; KW Heme; Iron; Lipid metabolism; Membrane; Metal-binding; Monooxygenase; KW Oxidoreductase; Reference proteome. FT CHAIN 1..503 FT /note="Aromatase 1" FT /id="PRO_0000051958" FT BINDING 437 FT /ligand="heme" FT /ligand_id="ChEBI:CHEBI:30413" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000250" SQ SEQUENCE 503 AA; 58227 MW; 44644734885D35EC CRC64; MVLEMLNPMH YKVTSMVSEV VPFASIAVLL LTGFLLLVWN YKNTSSIPGP GYFLGIGPLI SYLRFLWMGI GSACNYYNKT YGEFIRVWIG GEETLIISKS SSVFHVMKHS HYTSRFGSKP GLQFIGMHEK GIIFNNNPVL WKAVRTYFMK ALSGPGLVRM VTVCADSITK HLDKLEEVRN DLGYVDVLTL MRRIMLDTSN NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PDIFFKIPWL YRKYEKSVKD LKEDMEILIE KKRRRIFTAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI LEMLIAAPDT MSVTVFFMLF LIAKHPQVEE ELMKEIQTVV GERDIRNDDM QKLEVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVT LVILLRRFQV QTPQDRCVEK MQKKNDLSLH PDETSGLLEM IFIPRNSDKC FTK //