Reviewed, UniProtKB/Swiss-Prot Q29624 (CP191_PIG)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 19 type I
    EC=1.14.14.1
Alternative name(s):
    CYPXIXA1
    Aromatase
    Estrogen synthetase
    P-450AROM

Gene names

Name:	CYP19A1
Synonyms:	CYP19

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 19 type I		PRO_0000051958
Sites
	Metal binding	437	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29624-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 44644734885D35EC	FASTA	503	58,227
	10 20 30 40 50 60 MVLEMLNPMH YKVTSMVSEV VPFASIAVLL LTGFLLLVWN YKNTSSIPGP GYFLGIGPLI 70 80 90 100 110 120 SYLRFLWMGI GSACNYYNKT YGEFIRVWIG GEETLIISKS SSVFHVMKHS HYTSRFGSKP 130 140 150 160 170 180 GLQFIGMHEK GIIFNNNPVL WKAVRTYFMK ALSGPGLVRM VTVCADSITK HLDKLEEVRN 190 200 210 220 230 240 DLGYVDVLTL MRRIMLDTSN NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PDIFFKIPWL 250 260 270 280 290 300 YRKYEKSVKD LKEDMEILIE KKRRRIFTAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI 310 320 330 340 350 360 LEMLIAAPDT MSVTVFFMLF LIAKHPQVEE ELMKEIQTVV GERDIRNDDM QKLEVVENFI 370 380 390 400 410 420 YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 430 440 450 460 470 480 NVPYRYFQPF GFGPRACAGK YIAMVMMKVT LVILLRRFQV QTPQDRCVEK MQKKNDLSLH 490 500 PDETSGLLEM IFIPRNSDKC FTK

References

[1]	"Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5'-untranslated exons expressed in embryos, endometrium, and placenta." Choi I., Simmen R.C.M., Simmen F.A. Endocrinology 137:1457-1467(1996) [PubMed: 8625924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blastocyst.
[2]	"Transient expression of the cytochrome P450 aromatase gene in elongating porcine blastocysts is correlated with uterine insulin-like growth factor levels during peri-implantation development." Ko Y., Choi I., Green M.L., Simmen F.A., Simmen R.C. Mol. Reprod. Dev. 37:1-11(1994) [PubMed: 8129925] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 342-421. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U37311 mRNA. Translation: AAC48543.1. U37312 mRNA. Translation: AAC48544.1. U37309 mRNA. Translation: AAC48541.1. U37310 mRNA. Translation: AAC48542.1. L15471 Unassigned DNA. Translation: AAA19817.1.
PIR	I46570.
RefSeq	NP_999594.1.
UniGene	Ssc.56422
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	403331.
KEGG	ssc:403331.
Organism-specific databases
CTD	403331.
Phylogenomic databases
HOVERGEN	Q29624.
Enzyme and pathway databases
BRENDA	1.14.14.1. 249.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP191_PIG

Accession

Primary (citable) accession number: Q29624

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	October 13, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)