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Q29624

- CP191_PIG

UniProt

Q29624 - CP191_PIG

Protein

Aromatase 1

Gene

CYP19A1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase 1 (EC:1.14.14.14)
    Alternative name(s):
    CYPXIXA1
    Cytochrome P-450AROM
    Cytochrome P450 19 type I
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:CYP19
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Aromatase 1PRO_0000051958Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ29624.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.
    KOiK07434.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29624-1 [UniParc]FASTAAdd to Basket

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    MVLEMLNPMH YKVTSMVSEV VPFASIAVLL LTGFLLLVWN YKNTSSIPGP    50
    GYFLGIGPLI SYLRFLWMGI GSACNYYNKT YGEFIRVWIG GEETLIISKS 100
    SSVFHVMKHS HYTSRFGSKP GLQFIGMHEK GIIFNNNPVL WKAVRTYFMK 150
    ALSGPGLVRM VTVCADSITK HLDKLEEVRN DLGYVDVLTL MRRIMLDTSN 200
    NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PDIFFKIPWL YRKYEKSVKD 250
    LKEDMEILIE KKRRRIFTAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI 300
    LEMLIAAPDT MSVTVFFMLF LIAKHPQVEE ELMKEIQTVV GERDIRNDDM 350
    QKLEVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR 400
    MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVT 450
    LVILLRRFQV QTPQDRCVEK MQKKNDLSLH PDETSGLLEM IFIPRNSDKC 500
    FTK 503
    Length:503
    Mass (Da):58,227
    Last modified:November 1, 1997 - v1
    Checksum:i44644734885D35EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37311 mRNA. Translation: AAC48543.1.
    U37312 mRNA. Translation: AAC48544.1.
    U37309 mRNA. Translation: AAC48541.1.
    U37310 mRNA. Translation: AAC48542.1.
    L15471 Unassigned DNA. Translation: AAA19817.1.
    PIRiI46570.
    RefSeqiNP_999594.1. NM_214429.1.
    UniGeneiSsc.56422.
    Ssc.81397.
    Ssc.82401.

    Genome annotation databases

    GeneIDi403331.
    KEGGissc:403331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37311 mRNA. Translation: AAC48543.1 .
    U37312 mRNA. Translation: AAC48544.1 .
    U37309 mRNA. Translation: AAC48541.1 .
    U37310 mRNA. Translation: AAC48542.1 .
    L15471 Unassigned DNA. Translation: AAA19817.1 .
    PIRi I46570.
    RefSeqi NP_999594.1. NM_214429.1.
    UniGenei Ssc.56422.
    Ssc.81397.
    Ssc.82401.

    3D structure databases

    ProteinModelPortali Q29624.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403331.
    KEGGi ssc:403331.

    Organism-specific databases

    CTDi 1588.

    Phylogenomic databases

    HOVERGENi HBG050750.
    KOi K07434.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5'-untranslated exons expressed in embryos, endometrium, and placenta."
      Choi I., Simmen R.C.M., Simmen F.A.
      Endocrinology 137:1457-1467(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blastocyst.
    2. "Transient expression of the cytochrome P450 aromatase gene in elongating porcine blastocysts is correlated with uterine insulin-like growth factor levels during peri-implantation development."
      Ko Y., Choi I., Green M.L., Simmen F.A., Simmen R.C.
      Mol. Reprod. Dev. 37:1-11(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 342-421.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP191_PIG
    AccessioniPrimary (citable) accession number: Q29624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3