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Q29624

- CP191_PIG

UniProt

Q29624 - CP191_PIG

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Protein

Aromatase 1

Gene

CYP19A1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase 1 (EC:1.14.14.14)
Alternative name(s):
CYPXIXA1
Cytochrome P-450AROM
Cytochrome P450 19 type I
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Aromatase 1PRO_0000051958Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ29624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.
InParanoidiQ29624.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLEMLNPMH YKVTSMVSEV VPFASIAVLL LTGFLLLVWN YKNTSSIPGP
60 70 80 90 100
GYFLGIGPLI SYLRFLWMGI GSACNYYNKT YGEFIRVWIG GEETLIISKS
110 120 130 140 150
SSVFHVMKHS HYTSRFGSKP GLQFIGMHEK GIIFNNNPVL WKAVRTYFMK
160 170 180 190 200
ALSGPGLVRM VTVCADSITK HLDKLEEVRN DLGYVDVLTL MRRIMLDTSN
210 220 230 240 250
NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PDIFFKIPWL YRKYEKSVKD
260 270 280 290 300
LKEDMEILIE KKRRRIFTAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTVFFMLF LIAKHPQVEE ELMKEIQTVV GERDIRNDDM
360 370 380 390 400
QKLEVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVT
460 470 480 490 500
LVILLRRFQV QTPQDRCVEK MQKKNDLSLH PDETSGLLEM IFIPRNSDKC

FTK
Length:503
Mass (Da):58,227
Last modified:November 1, 1997 - v1
Checksum:i44644734885D35EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37311 mRNA. Translation: AAC48543.1.
U37312 mRNA. Translation: AAC48544.1.
U37309 mRNA. Translation: AAC48541.1.
U37310 mRNA. Translation: AAC48542.1.
L15471 Unassigned DNA. Translation: AAA19817.1.
PIRiI46570.
RefSeqiNP_999594.1. NM_214429.1.
UniGeneiSsc.56422.
Ssc.81397.
Ssc.82401.

Genome annotation databases

GeneIDi403331.
KEGGissc:403331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37311 mRNA. Translation: AAC48543.1 .
U37312 mRNA. Translation: AAC48544.1 .
U37309 mRNA. Translation: AAC48541.1 .
U37310 mRNA. Translation: AAC48542.1 .
L15471 Unassigned DNA. Translation: AAA19817.1 .
PIRi I46570.
RefSeqi NP_999594.1. NM_214429.1.
UniGenei Ssc.56422.
Ssc.81397.
Ssc.82401.

3D structure databases

ProteinModelPortali Q29624.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403331.
KEGGi ssc:403331.

Organism-specific databases

CTDi 1588.

Phylogenomic databases

HOVERGENi HBG050750.
InParanoidi Q29624.
KOi K07434.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5'-untranslated exons expressed in embryos, endometrium, and placenta."
    Choi I., Simmen R.C.M., Simmen F.A.
    Endocrinology 137:1457-1467(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blastocyst.
  2. "Transient expression of the cytochrome P450 aromatase gene in elongating porcine blastocysts is correlated with uterine insulin-like growth factor levels during peri-implantation development."
    Ko Y., Choi I., Green M.L., Simmen F.A., Simmen R.C.
    Mol. Reprod. Dev. 37:1-11(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 342-421.
    Tissue: Liver.

Entry informationi

Entry nameiCP191_PIG
AccessioniPrimary (citable) accession number: Q29624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3