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Protein

Aromatase 1

Gene

CYP19A1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase 1 (EC:1.14.14.14)
Alternative name(s):
CYPXIXA1
Cytochrome P-450AROM
Cytochrome P450 19 type I
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Aromatase 1PRO_0000051958Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ29624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.
InParanoidiQ29624.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLEMLNPMH YKVTSMVSEV VPFASIAVLL LTGFLLLVWN YKNTSSIPGP
60 70 80 90 100
GYFLGIGPLI SYLRFLWMGI GSACNYYNKT YGEFIRVWIG GEETLIISKS
110 120 130 140 150
SSVFHVMKHS HYTSRFGSKP GLQFIGMHEK GIIFNNNPVL WKAVRTYFMK
160 170 180 190 200
ALSGPGLVRM VTVCADSITK HLDKLEEVRN DLGYVDVLTL MRRIMLDTSN
210 220 230 240 250
NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PDIFFKIPWL YRKYEKSVKD
260 270 280 290 300
LKEDMEILIE KKRRRIFTAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTVFFMLF LIAKHPQVEE ELMKEIQTVV GERDIRNDDM
360 370 380 390 400
QKLEVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVT
460 470 480 490 500
LVILLRRFQV QTPQDRCVEK MQKKNDLSLH PDETSGLLEM IFIPRNSDKC

FTK
Length:503
Mass (Da):58,227
Last modified:November 1, 1997 - v1
Checksum:i44644734885D35EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37311 mRNA. Translation: AAC48543.1.
U37312 mRNA. Translation: AAC48544.1.
U37309 mRNA. Translation: AAC48541.1.
U37310 mRNA. Translation: AAC48542.1.
L15471 Unassigned DNA. Translation: AAA19817.1.
PIRiI46570.
RefSeqiNP_999594.1. NM_214429.1.
UniGeneiSsc.56422.
Ssc.81397.
Ssc.82401.

Genome annotation databases

GeneIDi403331.
KEGGissc:403331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37311 mRNA. Translation: AAC48543.1.
U37312 mRNA. Translation: AAC48544.1.
U37309 mRNA. Translation: AAC48541.1.
U37310 mRNA. Translation: AAC48542.1.
L15471 Unassigned DNA. Translation: AAA19817.1.
PIRiI46570.
RefSeqiNP_999594.1. NM_214429.1.
UniGeneiSsc.56422.
Ssc.81397.
Ssc.82401.

3D structure databases

ProteinModelPortaliQ29624.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403331.
KEGGissc:403331.

Organism-specific databases

CTDi1588.

Phylogenomic databases

HOVERGENiHBG050750.
InParanoidiQ29624.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5'-untranslated exons expressed in embryos, endometrium, and placenta."
    Choi I., Simmen R.C.M., Simmen F.A.
    Endocrinology 137:1457-1467(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blastocyst.
  2. "Transient expression of the cytochrome P450 aromatase gene in elongating porcine blastocysts is correlated with uterine insulin-like growth factor levels during peri-implantation development."
    Ko Y., Choi I., Green M.L., Simmen F.A., Simmen R.C.
    Mol. Reprod. Dev. 37:1-11(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 342-421.
    Tissue: Liver.

Entry informationi

Entry nameiCP191_PIG
AccessioniPrimary (citable) accession number: Q29624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.