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Q29624 (CP191_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase 1

EC=1.14.14.14
Alternative name(s):
CYPXIXA1
Cytochrome P-450AROM
Cytochrome P450 19 type I
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:CYP19
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Aromatase 1
PRO_0000051958

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29624 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 44644734885D35EC

FASTA50358,227
        10         20         30         40         50         60 
MVLEMLNPMH YKVTSMVSEV VPFASIAVLL LTGFLLLVWN YKNTSSIPGP GYFLGIGPLI 

        70         80         90        100        110        120 
SYLRFLWMGI GSACNYYNKT YGEFIRVWIG GEETLIISKS SSVFHVMKHS HYTSRFGSKP 

       130        140        150        160        170        180 
GLQFIGMHEK GIIFNNNPVL WKAVRTYFMK ALSGPGLVRM VTVCADSITK HLDKLEEVRN 

       190        200        210        220        230        240 
DLGYVDVLTL MRRIMLDTSN NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PDIFFKIPWL 

       250        260        270        280        290        300 
YRKYEKSVKD LKEDMEILIE KKRRRIFTAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVTVFFMLF LIAKHPQVEE ELMKEIQTVV GERDIRNDDM QKLEVVENFI 

       370        380        390        400        410        420 
YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRACAGK YIAMVMMKVT LVILLRRFQV QTPQDRCVEK MQKKNDLSLH 

       490        500 
PDETSGLLEM IFIPRNSDKC FTK 

« Hide

References

[1]"Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5'-untranslated exons expressed in embryos, endometrium, and placenta."
Choi I., Simmen R.C.M., Simmen F.A.
Endocrinology 137:1457-1467(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blastocyst.
[2]"Transient expression of the cytochrome P450 aromatase gene in elongating porcine blastocysts is correlated with uterine insulin-like growth factor levels during peri-implantation development."
Ko Y., Choi I., Green M.L., Simmen F.A., Simmen R.C.
Mol. Reprod. Dev. 37:1-11(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 342-421.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37311 mRNA. Translation: AAC48543.1.
U37312 mRNA. Translation: AAC48544.1.
U37309 mRNA. Translation: AAC48541.1.
U37310 mRNA. Translation: AAC48542.1.
L15471 Unassigned DNA. Translation: AAA19817.1.
PIRI46570.
RefSeqNP_999594.1. NM_214429.1.
UniGeneSsc.56422.
Ssc.81397.
Ssc.82401.

3D structure databases

ProteinModelPortalQ29624.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403331.
KEGGssc:403331.

Organism-specific databases

CTD1588.

Phylogenomic databases

HOVERGENHBG050750.
KOK07434.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP191_PIG
AccessionPrimary (citable) accession number: Q29624
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 22, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families