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Protein

Aromatase 1

Gene

CYP19A1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = 17-beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity
Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-193144 Estrogen biosynthesis
R-SSC-211976 Endogenous sterols

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase 1 (EC:1.14.14.14By similarity)
Alternative name(s):
CYPXIXA1
Cytochrome P-450AROM
Cytochrome P450 19 type I
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519581 – 503Aromatase 1Add BLAST503

Proteomic databases

PeptideAtlasiQ29624
PRIDEiQ29624

Structurei

3D structure databases

ProteinModelPortaliQ29624
SMRiQ29624
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000129915
HOVERGENiHBG050750
InParanoidiQ29624
KOiK07434

Family and domain databases

Gene3Di1.10.630.101 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q29624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLEMLNPMH YKVTSMVSEV VPFASIAVLL LTGFLLLVWN YKNTSSIPGP
60 70 80 90 100
GYFLGIGPLI SYLRFLWMGI GSACNYYNKT YGEFIRVWIG GEETLIISKS
110 120 130 140 150
SSVFHVMKHS HYTSRFGSKP GLQFIGMHEK GIIFNNNPVL WKAVRTYFMK
160 170 180 190 200
ALSGPGLVRM VTVCADSITK HLDKLEEVRN DLGYVDVLTL MRRIMLDTSN
210 220 230 240 250
NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PDIFFKIPWL YRKYEKSVKD
260 270 280 290 300
LKEDMEILIE KKRRRIFTAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTVFFMLF LIAKHPQVEE ELMKEIQTVV GERDIRNDDM
360 370 380 390 400
QKLEVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVT
460 470 480 490 500
LVILLRRFQV QTPQDRCVEK MQKKNDLSLH PDETSGLLEM IFIPRNSDKC

FTK
Length:503
Mass (Da):58,227
Last modified:November 1, 1997 - v1
Checksum:i44644734885D35EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37311 mRNA Translation: AAC48543.1
U37312 mRNA Translation: AAC48544.1
U37309 mRNA Translation: AAC48541.1
U37310 mRNA Translation: AAC48542.1
L15471 Unassigned DNA Translation: AAA19817.1
PIRiI46570
RefSeqiNP_999594.1, NM_214429.1
UniGeneiSsc.56422
Ssc.81397
Ssc.82401

Genome annotation databases

EnsembliENSSSCT00000051289; ENSSSCP00000037848; ENSSSCG00000030168
GeneIDi403331
KEGGissc:403331

Similar proteinsi

Entry informationi

Entry nameiCP191_PIG
AccessioniPrimary (citable) accession number: Q29624
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome