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Protein
Submitted name:

Cardiac ryanodine receptor

Gene

RyR-2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Cardiac ryanodine receptorImported
Gene namesi
Name:RyR-2Imported
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4280 – 429920HelicalSequence analysisAdd
BLAST
Transmembranei4500 – 452021HelicalSequence analysisAdd
BLAST
Transmembranei4575 – 459420HelicalSequence analysisAdd
BLAST
Transmembranei4711 – 473222HelicalSequence analysisAdd
BLAST
Transmembranei4769 – 479022HelicalSequence analysisAdd
BLAST
Transmembranei4845 – 486824HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016860.

Structurei

3D structure databases

ProteinModelPortaliQ29621.
SMRiQ29621. Positions 3581-3607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 16556MIRInterPro annotationAdd
BLAST
Domaini172 – 21746MIRInterPro annotationAdd
BLAST
Domaini225 – 28056MIRInterPro annotationAdd
BLAST
Domaini286 – 34560MIRInterPro annotationAdd
BLAST
Domaini351 – 40858MIRInterPro annotationAdd
BLAST
Domaini599 – 809211B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1025 – 1222198B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1357 – 1562206B30.2/SPRYInterPro annotationAdd
BLAST
Domaini4023 – 405836EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4412 – 444534Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
KOiK04962.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 5 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50222. EF_HAND_2. 1 hit.
PS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE
60 70 80 90 100
STSNSKNVPP DLSICTFVLE QSLSVRALQE MLANTVEKSE GQVDVEKWKF
110 120 130 140 150
MMKTAQGGGH RTLLYGHAIL LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ
160 170 180 190 200
EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNGS
210 220 230 240 250
LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG
260 270 280 290 300
EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV
310 320 330 340 350
TTGKYLSLME DKNLLLMDKE KADVKSTAFT FRSSKEKLDG GVRKEVDGMG
360 370 380 390 400
TSEIKYGDSI CYIQHVDTGL WLTYQSVDVK SVRMGSIQRK AIMHHEGHMD
410 420 430 440 450
DGLNLSRSQH EESRTARVIR STVFLFNRFI RGLDALSKKA KASSVDLPIE
460 470 480 490 500
SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ EEGMINLVLE
510 520 530 540 550
CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ
560 570 580 590 600
FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL
610 620 630 640 650
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN
660 670 680 690 700
HVSSMRPNIF LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST
710 720 730 740 750
EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL HLWSGCIART VSSPNQHLLR
760 770 780 790 800
TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP VVSFSAGIKV
810 820 830 840 850
RFLLGGRHGE FKFLPPPGYA PCYEAVLPKE KLKVEHSREY KQERTYTRDL
860 870 880 890 900
LGPTVSLTQA AFTPIPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL
910 920 930 940 950
GWQYGPVRDD NKRQHPCLVE FSKLPEQERN YNLQMSLETL KTLLALGCHV
960 970 980 990 1000
GISDEHAEEK VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA
1010 1020 1030 1040 1050
ENAHNVWARD RIRQGWTYGI QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL
1060 1070 1080 1090 1100
REAVRTLLGY GYNLEAPDQD HAARAEVCSG TGERFRIFRA EKTYAVKAGR
1110 1120 1130 1140 1150
WYFEFEAVTS GDMRVGWSRP GCQPDQELGS DERAFAFDGF KAQRWHQGNE
1160 1170 1180 1190 1200
HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG
1210 1220 1230 1240 1250
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW
1260 1270 1280 1290 1300
LSKRLPQFLQ VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNSNTDIM
1310 1320 1330 1340 1350
FYRLSMPIEC AEVFSKTVPG GLPGAGLFGP KNDLEDYDAD SDFEVLMKTA
1360 1370 1380 1390 1400
HGHLVPDRVD KDKETTKAEF NNHKDYAQEK PSRLKQRFLL RRTKPDYSTS
1410 1420 1430 1440 1450
HSARLTEDVL ADDRDDYDFL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF
1460 1470 1480 1490 1500
HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR
1510 1520 1530 1540 1550
NNNGLEIGCV VDAASGLLTF IANGKELSTY YQVEPSTKLF PAVFAQATSP
1560 1570 1580 1590 1600
NVFQFELGRI KNVMPLSAGL FKSEHKNPVP QCPPRLHVQF LSHVLWSRMP
1610 1620 1630 1640 1650
NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL HIPEENRSVD ILELTEQEEL
1660 1670 1680 1690 1700
LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE NKYMPGLLRT
1710 1720 1730 1740 1750
GYYDLLIDIH LSSYATARLM MNNEFIVPMT EETKSITLFP DENKKHGLPG
1760 1770 1780 1790 1800
IGLSTSLRPR MQFSSPSFVS INNECYQYSP EFPLDILKAK TIQMLTEAVK
1810 1820 1830 1840 1850
EGSLHARDPV GGTTEFLFVP LIKLFYTLLI MGIFHNEDLR HILQLIEPSV
1860 1870 1880 1890 1900
FKDAATPEEE GDTLEEEPSV EDTKLEGAGE EEAKMGKRPK EGLLQMKLPE
1910 1920 1930 1940 1950
PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA
1960 1970 1980 1990 2000
LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH
2010 2020 2030 2040 2050
EDLMTHCGIE LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQTEKPVES
2060 2070 2080 2090 2100
DSRKSSTLQQ LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR
2110 2120 2130 2140 2150
ALPKTYTING VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM
2160 2170 2180 2190 2200
NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL
2210 2220 2230 2240 2250
CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN
2260 2270 2280 2290 2300
NELALALREP DLEKVVRYLA GCGLQSCQML VSKGYPDIGW NPVEGERYLD
2310 2320 2330 2340 2350
FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA
2360 2370 2380 2390 2400
IKIAEDPSRD GPSPTSGSSK TLDTEEEEDD TIHMGNAIMT FYAALIDLLG
2410 2420 2430 2440 2450
RCAPEMHLIH AGKGEAIRIR SILRSLIPLG DLVGVISIAF QMPTIAKDGN
2460 2470 2480 2490 2500
VVEPDMSAGF CPDHKAAMVL FLDRVYGIEV QDFLLHLLEV GFLPDLRAAA
2510 2520 2530 2540 2550
SLDTAALSAT DMALALNRYL CTAVLPLLTR CAPLFAGTEH HASLIDSLLH
2560 2570 2580 2590 2600
TVYRLSKGCS LTKAQRDSIE VCLLSICGQL RPSMMQHLLR RLVFDVPLLN
2610 2620 2630 2640 2650
EHAKMPLKLL TNHYERCWKY YCLPGGWGNF GAASEEELHL SRKLFWGIFD
2660 2670 2680 2690 2700
ALSQKKYEQE LFKLALPCLS AVAGALPPDY MESNYVSMME KQSSMDSEGN
2710 2720 2730 2740 2750
FNPQPVDTSN IIIPEKLEYF INKYAEHSHD KWSMDKLANG WIYGEIYSDS
2760 2770 2780 2790 2800
SKIQPLMKPY KLLSEKEKEI YRWPIKESLK TMLAWGWRIE RTREGDSMAL
2810 2820 2830 2840 2850
YNRTRRISQT SQVSVDAAHG YSPRAIDMSN VTLSRDLHAM AEMMAENYHN
2860 2870 2880 2890 2900
IWAKKKKLEL ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ DILKFLQING
2910 2920 2930 2940 2950
YAVSRGFKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRSK
2960 2970 2980 2990 3000
GEHFPYEQEI KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CSGGHASNKE
3010 3020 3030 3040 3050
KEMVTSLFCK LGVLVRHRIS LFGNDATSIV NCLHILGQTL DARTVMKTGL
3060 3070 3080 3090 3100
ESVKSALRAF LDNAAEDLEK TMENLKQGQF THTRNQPRGV TQIINYTTVA
3110 3120 3130 3140 3150
LLPMLSSLFE HIGQHQFGED LILEDVQVSC YRILTSLYAL GTSKSIYVER
3160 3170 3180 3190 3200
QRSALGECLA AFAGAFPVAF LETHLNKHNI YSIYNTKSSR ERAALSLPAN
3210 3220 3230 3240 3250
VEDVCPNIPS LEKLMEEIVE LAESGIRYTQ MPHVMEVILP MLCSYMSRWW
3260 3270 3280 3290 3300
EHGPESNPGR AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA
3310 3320 3330 3340 3350
VFSQPIINKV KPQLLKTHFL PLMEKLKKKA AMVVSEEDHL KAEARGDMSE
3360 3370 3380 3390 3400
AELLILDEFT TLARDLYAFY PLLIRFVDYN RAKWLKEPTP EAEELFRMVA
3410 3420 3430 3440 3450
EVFIYWSKSH NFKREEQNFV VQNEINNMSF LITDTKSKMS KAAVSDQERK
3460 3470 3480 3490 3500
KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKNRFSLKD
3510 3520 3530 3540 3550
TEDEVRDIIR NNIHLQGKLE DPAIRWQMAL YKDLPNRTEE TSDPEKTVER
3560 3570 3580 3590 3600
VLDIANVLFH LEQKSKFIGR RYYNLVEHPQ RSKKAVWHKL LSKQRKRAVV
3610 3620 3630 3640 3650
ACFRMAPLYN LPRHRAVNLF LQGYEKSWIE TEEHYFEDKL IEDLAKPGAE
3660 3670 3680 3690 3700
PPEEDEVTKR VDPLHQLILL FSRTALTEKC KLEEDFLYMA YADIMAKSCH
3710 3720 3730 3740 3750
DEEDDDGEEE VKSFEEKEME KQKLLYQQAR LHDRGAAEMV LQTISASKGE
3760 3770 3780 3790 3800
TGPMVAATLK LGIAILNGGN STVQQKMLDY LKEKKDVGFF QSLAGLMQSC
3810 3820 3830 3840 3850
SVLDLNAFER QNKAEGLGMV TEEGSGEKVL QDDEFTCDLF RFLQLLCEGH
3860 3870 3880 3890 3900
NSDFQNYLRT QTGNNTTVNI IISTVDYLLR VQESISDFYW YYSGKDVIDE
3910 3920 3930 3940 3950
QGQRNFSKAI QVAKQVFNTL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV
3960 3970 3980 3990 4000
FAHMQMKLSQ DSSQIELLKE LMDLQKDMVV MLLSMLEGNV VNGTIGKQMV
4010 4020 4030 4040 4050
DMLVESSNNV EMILKFFDMF LKLKDLTSSD TFKEYDPDGK GIISKRDFHK
4060 4070 4080 4090 4100
AMESHKHYTQ SETEFLLSCA ETDENETLDY EEFVKRFHEP AKDIGFNVAV
4110 4120 4130 4140 4150
LLTNLSEHMP NETRLQTFLE LAESVLNYFQ PFLGRIEIMG SAKRIERVYF
4160 4170 4180 4190 4200
EISESSRTQW EKPQVKESKR QFIFDVVNEG GEKEKMELFV NFCEDTIFEM
4210 4220 4230 4240 4250
QLAAQISESD LNERSANKEE SEKERPEEQG PKMGFFSVLT VRSALFALRY
4260 4270 4280 4290 4300
NILTLMRMLS LKSLKKQMKK MKKMTVKDMV TAFFSSYWSI FMTLLHFVAS
4310 4320 4330 4340 4350
VFRGFFRIVC SLLLGGSLVE GAKKIKVAEL LANMPDPTQD EVRGDGEEGE
4360 4370 4380 4390 4400
RKPMETTLPS EDLTDLKELT EESDLLSDIF GLDLKREGGQ YKLIPHNPNA
4410 4420 4430 4440 4450
GLSDLMSNPV LIPEEQEKFQ EQKTKEEEKE EKEETKSEPE KAEGEDGEKE
4460 4470 4480 4490 4500
EKVKEDKGKQ KLRQLHTHRY GEPEVPESAF WKKIIAYQQK LLNYFARNFY
4510 4520 4530 4540 4550
NMRMLALFVA FAINFILLFY KVSTSSVVEG KELPSRSTSE NAKVTTSLDS
4560 4570 4580 4590 4600
SSHRIIAVHY VLEESSGYME PTLRILAILH TVISFFCIIG YYCLKVPLVI
4610 4620 4630 4640 4650
FKREKEVARK LEFDGLYITE QPSEDDIKGQ WDRLVINTQS FPNNYWDKFV
4660 4670 4680 4690 4700
KRKVMDKYGE FYGRDRISEL LGMDKAALDF SDAREKKKPK KDSSLSAVLN
4710 4720 4730 4740 4750
SIDVKYQMWK LGVVFTDNSF LYLAWYMTMS ILGHYNNFFF AAHLLDIAMG
4760 4770 4780 4790 4800
FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDG
4810 4820 4830 4840 4850
DTPDMKCDDM LTCYMFHMYV GVRAGGGIGD EIEDPAGDEY EIYRIIFDIT
4860 4870 4880 4890 4900
FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMETKCF ICGIGNDYFD
4910 4920 4930 4940 4950
TVPHGFETHT LQEHNLANYL FFLMYLINKD ETEHTGQESY VWKMYQERCW
4960
EFFPAGDCFR KQYEDQLN
Length:4,968
Mass (Da):565,086
Last modified:November 1, 1996 - v1
Checksum:i04B16A35D06B852D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50465 mRNA. Translation: AAA93465.1.
RefSeqiNP_001076226.1. NM_001082757.1.
UniGeneiOcu.1832.

Genome annotation databases

GeneIDi100009536.
KEGGiocu:100009536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50465 mRNA. Translation: AAA93465.1.
RefSeqiNP_001076226.1. NM_001082757.1.
UniGeneiOcu.1832.

3D structure databases

ProteinModelPortaliQ29621.
SMRiQ29621. Positions 3581-3607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009536.
KEGGiocu:100009536.

Organism-specific databases

CTDi6262.

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
KOiK04962.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 5 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50222. EF_HAND_2. 1 hit.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ29621_RABIT
AccessioniPrimary (citable) accession number: Q29621
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.