Q29606 (RNAS1_ORYLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease pancreatic
EC=3.1.27.5

Alternative name(s):
RNase 1
RNase A

Gene names

Name:	rnase1
Synonyms:	rns1

Organism

Oryx leucoryx (Arabian oryx)

Taxonomic identifier

39411 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Hippotraginae › Oryx

Protein attributes

Sequence length	75 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA By similarity.
Catalytic activity	Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Subunit structure	Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein By similarity.
Subcellular location	Secreted.
Tissue specificity	Pancreas.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›75	›75	Ribonuclease pancreatic		PRO_0000057209
Regions
	Region	22 – 26	5	Substrate binding By similarity
Sites
	Binding site	47	1	Substrate By similarity
	Binding site	66	1	Substrate By similarity
Amino acid modifications
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Disulfide bond	7 ↔ 65		By similarity
	Disulfide bond	46 ↔ 53		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	75	1

Sequences

	Sequence		Length	Mass (Da)
	Q29606 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FA077E851819065B	FASTA	75	8,367
	10 20 30 40 50 60 ASTSNYCNQM MKSRNLTQNR CKPVNTFVHE SLADVQAVCS QKNVACKNGQ TNCYQSYSTM 70 SITDCRETGS SKYPN

References

[1]	"Pseudogenes in ribonuclease evolution: a source of new biomacromolecular function?" Trabesinger-Ruef N., Jermann T., Zankel T., Durrant B., Frank G., Benner S.A. FEBS Lett. 382:319-322(1996) [PubMed: 8605993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S81527 Genomic DNA. Translation: AAB39845.1.
3D structure databases
ProteinModelPortal	Q29606.
SMR	Q29606. Positions 1-75.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001427. RNaseA. IPR023411. RNaseA_AS. IPR023412. RNaseA_domain. [Graphical view]
Gene3D	G3DSA:3.10.130.10. RNaseA. 1 hit.
PANTHER	PTHR11437. RNaseA. 1 hit.
Pfam	PF00074. RnaseA. 1 hit. [Graphical view]
PRINTS	PR00794. RIBONUCLEASE.
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00092. RNAse_Pc. 1 hit. [Graphical view]
SUPFAM	SSF54076. RNaseA. 1 hit.
PROSITE	PS00127. RNASE_PANCREATIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNAS1_ORYLE

Accession

Primary (citable) accession number: Q29606

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 31, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program