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Q29605 (CP19A_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:CYP19
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Aromatase
PRO_0000051961

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29605 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: DE4AD796D635AF3D

FASTA50357,402
        10         20         30         40         50         60 
MVLEMLNPMH FNITTMVPAA MPAATMPILL LTCLLLLIWN YEGTSSIPGP GYCMGIGPLI 

        70         80         90        100        110        120 
SYARFLWMGI GSACNYYNKM YGEFIRVWIC GEETLIISKS SSMFHVMKHS HYVSRFGSKP 

       130        140        150        160        170        180 
GLQCIGMHEN GIIFNNNPAL WKVVRPFFMK ALTGPGLVQM VAICVGSIGR HLDKLEEVTT 

       190        200        210        220        230        240 
RSGCVDVLTL MRRIMLDTSN TLFLGIPMDE SAIVVKIQGY FDAWQALLLK PNIFFKISWL 

       250        260        270        280        290        300 
YKKYEKSVKD LKDAIDILVE KKRRRISTAE KLEDHMDFAT NLIFAEKRGD LTRENVNQCV 

       310        320        330        340        350        360 
LEMLIAAPDT MSVSVFFMLF LIAKHPSVEE AIMEEIQTVV GERDIRIDDI QKLKVVENFI 

       370        380        390        400        410        420 
YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRGCAGK YIAMVMMKVI LVTLLRRFQV KALQGRSVEN IQKKNDLSLH 

       490        500 
PDETSDLLEM IFTPRNSDTC LGQ 

« Hide

References

[1]"Rapid sequencing of rabbit aromatase cDNA using RACE PCR."
Delarue B., Mittre H., Feral C., Benhaim A., Leymarie P.
C. R. Acad. Sci. III, Sci. Vie 319:663-670(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: HY.
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z70301 mRNA. Translation: CAA94314.1.
Z68271 mRNA. Translation: CAA92574.1.
RefSeqNP_001164392.1. NM_001170921.2.
UniGeneOcu.2124.

3D structure databases

ProteinModelPortalQ29605.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328545.

Organism-specific databases

CTD1588.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000111912.
HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_RABIT
AccessionPrimary (citable) accession number: Q29605
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 22, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families