Reviewed, UniProtKB/Swiss-Prot Q29605 (CP19A_RABIT)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthase
    Cytochrome P-450AROM

Gene names

Name:	CYP19A1
Synonyms:	CYP19

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 19A1		PRO_0000051961
Sites
	Metal binding	437	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29605-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: DE4AD796D635AF3D	FASTA	503	57,402
	10 20 30 40 50 60 MVLEMLNPMH FNITTMVPAA MPAATMPILL LTCLLLLIWN YEGTSSIPGP GYCMGIGPLI 70 80 90 100 110 120 SYARFLWMGI GSACNYYNKM YGEFIRVWIC GEETLIISKS SSMFHVMKHS HYVSRFGSKP 130 140 150 160 170 180 GLQCIGMHEN GIIFNNNPAL WKVVRPFFMK ALTGPGLVQM VAICVGSIGR HLDKLEEVTT 190 200 210 220 230 240 RSGCVDVLTL MRRIMLDTSN TLFLGIPMDE SAIVVKIQGY FDAWQALLLK PNIFFKISWL 250 260 270 280 290 300 YKKYEKSVKD LKDAIDILVE KKRRRISTAE KLEDHMDFAT NLIFAEKRGD LTRENVNQCV 310 320 330 340 350 360 LEMLIAAPDT MSVSVFFMLF LIAKHPSVEE AIMEEIQTVV GERDIRIDDI QKLKVVENFI 370 380 390 400 410 420 YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 430 440 450 460 470 480 NVPYRYFQPF GFGPRGCAGK YIAMVMMKVI LVTLLRRFQV KALQGRSVEN IQKKNDLSLH 490 500 PDETSDLLEM IFTPRNSDTC LGQ

References

[1]	"Rapid sequencing of rabbit aromatase cDNA using RACE PCR." Delarue B., Mittre H., Feral C., Benhaim A., Leymarie P. C. R. Acad. Sci. III, Sci. Vie 319:663-670(1996) [PubMed: 8949389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: HY. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z70301 mRNA. Translation: CAA94314.1. Z68271 mRNA. Translation: CAA92574.1.
3D structure databases
SMR	Q29605. Positions 48-496.
ModBase	Search...
Protein-protein interaction databases
STRING	Q29605.
Genome annotation databases
Ensembl	ENSOCUT00000012304; ENSOCUP00000010591; ENSOCUG00000012303; Oryctolagus cuniculus. [Genome view]
Phylogenomic databases
HOVERGEN	Q29605.
Enzyme and pathway databases
BRENDA	1.14.14.1. 255.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP19A_RABIT

Accession

Primary (citable) accession number: Q29605

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	February 9, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)