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Q29605

- CP19A_RABIT

UniProt

Q29605 - CP19A_RABIT

Protein

Aromatase

Gene

CYP19A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:CYP19
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503AromatasePRO_0000051961Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ29605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29605-1 [UniParc]FASTAAdd to Basket

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    MVLEMLNPMH FNITTMVPAA MPAATMPILL LTCLLLLIWN YEGTSSIPGP    50
    GYCMGIGPLI SYARFLWMGI GSACNYYNKM YGEFIRVWIC GEETLIISKS 100
    SSMFHVMKHS HYVSRFGSKP GLQCIGMHEN GIIFNNNPAL WKVVRPFFMK 150
    ALTGPGLVQM VAICVGSIGR HLDKLEEVTT RSGCVDVLTL MRRIMLDTSN 200
    TLFLGIPMDE SAIVVKIQGY FDAWQALLLK PNIFFKISWL YKKYEKSVKD 250
    LKDAIDILVE KKRRRISTAE KLEDHMDFAT NLIFAEKRGD LTRENVNQCV 300
    LEMLIAAPDT MSVSVFFMLF LIAKHPSVEE AIMEEIQTVV GERDIRIDDI 350
    QKLKVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR 400
    MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKVI 450
    LVTLLRRFQV KALQGRSVEN IQKKNDLSLH PDETSDLLEM IFTPRNSDTC 500
    LGQ 503
    Length:503
    Mass (Da):57,402
    Last modified:November 1, 1997 - v1
    Checksum:iDE4AD796D635AF3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70301 mRNA. Translation: CAA94314.1.
    Z68271 mRNA. Translation: CAA92574.1.
    RefSeqiNP_001164392.1. NM_001170921.2.
    UniGeneiOcu.2124.

    Genome annotation databases

    GeneIDi100328545.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70301 mRNA. Translation: CAA94314.1 .
    Z68271 mRNA. Translation: CAA92574.1 .
    RefSeqi NP_001164392.1. NM_001170921.2.
    UniGenei Ocu.2124.

    3D structure databases

    ProteinModelPortali Q29605.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328545.

    Organism-specific databases

    CTDi 1588.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rapid sequencing of rabbit aromatase cDNA using RACE PCR."
      Delarue B., Mittre H., Feral C., Benhaim A., Leymarie P.
      C. R. Acad. Sci. III, Sci. Vie 319:663-670(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: HY.
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP19A_RABIT
    AccessioniPrimary (citable) accession number: Q29605
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3