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Q29605

- CP19A_RABIT

UniProt

Q29605 - CP19A_RABIT

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Protein

Aromatase

Gene

CYP19A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051961Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ29605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ29605.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29605-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLEMLNPMH FNITTMVPAA MPAATMPILL LTCLLLLIWN YEGTSSIPGP
60 70 80 90 100
GYCMGIGPLI SYARFLWMGI GSACNYYNKM YGEFIRVWIC GEETLIISKS
110 120 130 140 150
SSMFHVMKHS HYVSRFGSKP GLQCIGMHEN GIIFNNNPAL WKVVRPFFMK
160 170 180 190 200
ALTGPGLVQM VAICVGSIGR HLDKLEEVTT RSGCVDVLTL MRRIMLDTSN
210 220 230 240 250
TLFLGIPMDE SAIVVKIQGY FDAWQALLLK PNIFFKISWL YKKYEKSVKD
260 270 280 290 300
LKDAIDILVE KKRRRISTAE KLEDHMDFAT NLIFAEKRGD LTRENVNQCV
310 320 330 340 350
LEMLIAAPDT MSVSVFFMLF LIAKHPSVEE AIMEEIQTVV GERDIRIDDI
360 370 380 390 400
QKLKVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKVI
460 470 480 490 500
LVTLLRRFQV KALQGRSVEN IQKKNDLSLH PDETSDLLEM IFTPRNSDTC

LGQ
Length:503
Mass (Da):57,402
Last modified:November 1, 1997 - v1
Checksum:iDE4AD796D635AF3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70301 mRNA. Translation: CAA94314.1.
Z68271 mRNA. Translation: CAA92574.1.
RefSeqiNP_001164392.1. NM_001170921.2.
UniGeneiOcu.2124.

Genome annotation databases

GeneIDi100328545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70301 mRNA. Translation: CAA94314.1 .
Z68271 mRNA. Translation: CAA92574.1 .
RefSeqi NP_001164392.1. NM_001170921.2.
UniGenei Ocu.2124.

3D structure databases

ProteinModelPortali Q29605.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328545.

Organism-specific databases

CTDi 1588.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi Q29605.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rapid sequencing of rabbit aromatase cDNA using RACE PCR."
    Delarue B., Mittre H., Feral C., Benhaim A., Leymarie P.
    C. R. Acad. Sci. III, Sci. Vie 319:663-670(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: HY.
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_RABIT
AccessioniPrimary (citable) accession number: Q29605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3