ID   GMPPB_DROPS             Reviewed;         371 AA.
AC   Q295Y7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase beta;
DE            EC=2.7.7.13;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta;
DE   AltName: Full=GDP-mannose pyrophosphorylase B;
GN   ORFNames=GA10892;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- CATALYTIC ACTIVITY: GTP + alpha-D-mannose 1-phosphate =
CC       diphosphate + GDP-mannose.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
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DR   EMBL; CM000070; EAL28571.1; -; Genomic_DNA.
DR   RefSeq; XP_001359425.1; -.
DR   GeneID; 4802517; -.
DR   KEGG; dpo:Dpse_GA10892; -.
DR   FlyBase; FBgn0070948; Dpse\GA10892.
DR   OMA; Q295Y7; RRIQLQP.
DR   BRENDA; 2.7.7.13; 190795.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase act...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001451; Hexapep_transf.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00132; Hexapep; 3.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2.
PE   3: Inferred from homology;
KW   Complete proteome; GTP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN         1    371       Mannose-1-phosphate guanyltransferase
FT                                beta.
FT                                /FTId=PRO_0000307172.
SQ   SEQUENCE   371 AA;  40603 MW;  FFB52C75F3AC9616 CRC64;
     MCGSPNTTVG NGTRALILVG GYGTRLRPLT LSTPKPLVEF ANKPILLHQL EALVDAGCRQ
     VILAVSYRAE QMEKELKVEA DKLGVELIFS HETEPLGTAG PLALAKSILS ASPEPFFVLN
     SDVICDFPFK QLVQFHRNHG KEGTIVVTKV EEPSKYGVVL YDEDGCIKNF IEKPQEFVSN
     KINAGIYIFN PSVLERIEVK PTSIEKEVFP AMAEQQELYA MDLTGFWMDI GQPKDFLTGM
     CLYLSSLRQK QSPKLYTGPG VVGNVLVDPT ATIGEGCRIG PNVTIGPDVI IEDGVCIKRA
     TILKGAIVRS HSWLDSCIVG WRSTVGRWVR IEGITVLGED VIVKDELYVN GGQVLPHKSI
     AASVPEPQII M
//