Q295Y7 (GMPPB_DROPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase beta
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta

Gene names

ORF Names:

GA10892

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly)

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Mannose-1-phosphate guanyltransferase beta		PRO_0000307172

Sequences

	Sequence		Length	Mass (Da)
	Q295Y7 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: FFB52C75F3AC9616	FASTA	371	40,603
	10 20 30 40 50 60 MCGSPNTTVG NGTRALILVG GYGTRLRPLT LSTPKPLVEF ANKPILLHQL EALVDAGCRQ 70 80 90 100 110 120 VILAVSYRAE QMEKELKVEA DKLGVELIFS HETEPLGTAG PLALAKSILS ASPEPFFVLN 130 140 150 160 170 180 SDVICDFPFK QLVQFHRNHG KEGTIVVTKV EEPSKYGVVL YDEDGCIKNF IEKPQEFVSN 190 200 210 220 230 240 KINAGIYIFN PSVLERIEVK PTSIEKEVFP AMAEQQELYA MDLTGFWMDI GQPKDFLTGM 250 260 270 280 290 300 CLYLSSLRQK QSPKLYTGPG VVGNVLVDPT ATIGEGCRIG PNVTIGPDVI IEDGVCIKRA 310 320 330 340 350 360 TILKGAIVRS HSWLDSCIVG WRSTVGRWVR IEGITVLGED VIVKDELYVN GGQVLPHKSI 370 AASVPEPQII M

References

[1]

"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CM000070 Genomic DNA. Translation: EAL28571.1.
RefSeq	XP_001359425.1. XM_001359388.2.
3D structure databases
ProteinModelPortal	Q295Y7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4802517.
KEGG	dpo:Dpse_GA10892.
Organism-specific databases
FlyBase	FBgn0070948. Dpse\GA10892.
Phylogenomic databases
InParanoid	Q295Y7.
OMA	DGVCIKR.
OrthoDB	EOG4N2Z4B.
PhylomeDB	Q295Y7.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPB_DROPS

Accession

Primary (citable) accession number: Q295Y7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	April 4, 2006
Last modified:	November 16, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project