Reviewed, UniProtKB/Swiss-Prot Q29594 (KCRB_PIG)

Names and origin

Protein names

Recommended name:
    Creatine kinase B-type
    EC=2.7.3.2
Alternative name(s):
    Creatine kinase B chain
    B-CK

Gene names

Name:

CKB

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	102 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Catalytic activity	ATP + creatine = ADP + phosphocreatine.
Subunit structure	Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATP:guanido phosphotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW creatine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›102	›102	Creatine kinase B-type		PRO_0000211968
Sites
	Binding site	51	1	ATP By similarity
	Binding site	96	1	ATP By similarity
Amino acid modifications
	Modified residue	24	1	Phosphoserine By similarity
	Modified residue	59	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	102	1

Sequences

	Sequence		Length	Mass (Da)
	Q29594-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D133CA1D97C90BAC	FASTA	102	11,566
	10 20 30 40 50 60 CLPPHCSXGX RRAIEKLAVE ALSSLDGDLA GRYYALKXMT EAEQQQLIDD HFLFDKPVSP 70 80 90 100 XLLASGMXAD XXDARGIWHN DNKXFLVWIN EEDHLRVIXM QK

References

[1]	"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed: 8672129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBLGenBankDDBJ	F14775 mRNA. Translation: CAA23244.1.
3D structure databases
HSSP	HSSP built from PDB template 1QH4 based on UniProtKB P05122.
SMR	Q29594. Positions 1-98.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q29594.
Enzyme and pathway databases
BRENDA	2.7.3.2. 249.
Family and domain databases
InterPro	IPR000749. ATP-guanido_PTrfase. IPR014746. Gln_synth/guanido_kin_cat. [Graphical view]
Gene3D	G3DSA:3.30.590.10. ATP-gua_Ptrans. 1 hit.
PANTHER	PTHR11547. ATP-gua_Ptrans. 1 hit.
Pfam	PF00217. ATP-gua_Ptrans. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KCRB_PIG

Accession

Primary (citable) accession number: Q29594

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)