Q29594 (KCRB_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Creatine kinase B-type
EC=2.7.3.2

Alternative name(s):
B-CK
Creatine kinase B chain

Gene names

Name:

CKB

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	102 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Catalytic activity	ATP + creatine = ADP + phosphocreatine.
Subunit structure	Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATP:guanido phosphotransferase family. Contains 1 phosphagen kinase C-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW creatine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›102	›102	Creatine kinase B-type		PRO_0000211968
Regions
	Domain	‹1 – ›102	›102	Phosphagen kinase C-terminal
Sites
	Binding site	51	1	ATP By similarity
	Binding site	92	1	Substrate By similarity
	Binding site	96	1	ATP By similarity
Amino acid modifications
	Modified residue	24	1	Phosphoserine By similarity
	Modified residue	59	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	102	1

Sequences

	Sequence		Length	Mass (Da)
	Q29594 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D133CA1D97C90BAC	FASTA	102	11,566
	10 20 30 40 50 60 CLPPHCSXGX RRAIEKLAVE ALSSLDGDLA GRYYALKXMT EAEQQQLIDD HFLFDKPVSP 70 80 90 100 XLLASGMXAD XXDARGIWHN DNKXFLVWIN EEDHLRVIXM QK

References

[1]	"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBL GenBank DDBJ	F14775 mRNA. Translation: CAA23244.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG001339.
Family and domain databases
Gene3D	3.30.590.10. 1 hit.
InterPro	IPR000749. ATP-guanido_PTrfase. IPR022414. ATP-guanido_PTrfase_cat. IPR014746. Gln_synth/guanido_kin_cat_dom. [Graphical view]
PANTHER	PTHR11547. PTHR11547. 1 hit.
Pfam	PF00217. ATP-gua_Ptrans. 1 hit. [Graphical view]
PROSITE	PS51510. PHOSPHAGEN_KINASE_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KCRB_PIG

Accession

Primary (citable) accession number: Q29594

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program