Reviewed,
UniProtKB/Swiss-Prot Q29577 (KCRU_PIG)
Last modified
November 4, 2008.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Creatine kinase, ubiquitous mitochondrial EC=2.7.3.2 Alternative name(s): U-MtCK Acidic-type mitochondrial creatine kinase Short name=Mia-CK | ||
| Gene names |
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| Organism | Sus scrofa (Pig) | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 78 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa By similarity. |
| Catalytic activity | ATP + creatine = ADP + phosphocreatine. |
| Subunit structure | Exists as an octamer composed of four MTCK homodimers By similarity. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane sideBy similarity. |
| Miscellaneous | Mitochondrial creatine kinase binds cardiolipin By similarity. |
| Sequence similarities | Belongs to the ATP:guanido phosphotransferase family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane Mitochondrion Mitochondrion inner membrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
Gene Ontology (GO) | |
| Cellular component | mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | creatine kinase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed: 8672129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine. |
Cross-references
Sequence databases | |
|---|---|
| F14801 mRNA. Translation: CAA23265.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QK1 based on UniProtKB P12532. |
| SMR | Q29577. Positions 1-78. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | Q29577. |
Family and domain databases | |
| InterPro | IPR000749. ATP-gua_Ptrans. IPR014746. Gln_synth/guanido_kin_cat. [Graphical view] |
| Gene3D | G3DSA:3.30.590.10. ATP-gua_Ptrans. 1 hit. |
| PANTHER | PTHR11547. ATP-gua_Ptrans. 1 hit. |
| Pfam | PF00217. ATP-gua_Ptrans. 1 hit. [Graphical view] |
| PROSITE | PS00112. GUANIDO_KINASE. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KCRU_PIG | ||||||||
| Accession | Primary (citable) accession number: Q29577 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


