Reviewed, UniProtKB/Swiss-Prot Q29577 (KCRU_PIG)

Names and origin

Protein names

Recommended name:
    Creatine kinase, ubiquitous mitochondrial
    EC=2.7.3.2
Alternative name(s):
    U-MtCK
    Acidic-type mitochondrial creatine kinase
      Short name=Mia-CK

Gene names

Name:

CKMT1

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	78 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa By similarity.
Catalytic activity	ATP + creatine = ADP + phosphocreatine.
Subunit structure	Exists as an octamer composed of four MTCK homodimers By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane sideBy similarity.
Miscellaneous	Mitochondrial creatine kinase binds cardiolipin By similarity.
Sequence similarities	Belongs to the ATP:guanido phosphotransferase family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	creatine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›78	›78	Creatine kinase, ubiquitous mitochondrial		PRO_0000211983
Regions
	Nucleotide binding	21 – 26	6	ATP By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	78	1

Sequences

	Sequence		Length	Mass (Da)
	Q29577-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E86C5944D2BAC4B7	FASTA	78	8,606
	10 20 30 40 50 60 PLLSKDSRFP KILENLRLQK RGTGGVDTAA TGESFDISNL DRLGKSEVEL VQLVIDGVNY 70 LIDLANGRLE RGQDIRIP

References

[1]	"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed: 8672129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBLGenBankDDBJ	F14801 mRNA. Translation: CAA23265.1.
3D structure databases
HSSP	HSSP built from PDB template 1QK1 based on UniProtKB P12532.
SMR	Q29577. Positions 1-78.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q29577.
Family and domain databases
InterPro	IPR000749. ATP-gua_Ptrans. IPR014746. Gln_synth/guanido_kin_cat. [Graphical view]
Gene3D	G3DSA:3.30.590.10. ATP-gua_Ptrans. 1 hit.
PANTHER	PTHR11547. ATP-gua_Ptrans. 1 hit.
Pfam	PF00217. ATP-gua_Ptrans. 1 hit. [Graphical view]
PROSITE	PS00112. GUANIDO_KINASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KCRU_PIG

Accession

Primary (citable) accession number: Q29577

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 4, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)