Q29576 (PSB8_PIG) Reviewed, UniProtKB/Swiss-Prot
Last modified June 11, 2014. Version 83. History...
Names and origin
|Protein names||Recommended name:|
Proteasome subunit beta type-8
Macropain subunit C13
Multicatalytic endopeptidase complex subunit C13
Proteasome component C13
Proteasome subunit beta-5i
|Organism||Sus scrofa (Pig) [Reference proteome]|
|Taxonomic identifier||9823 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus|
|Sequence length||104 AA.|
|Protein existence||Evidence at protein level|
General annotation (Comments)
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Required for adipocyte differentiation By similarity.
Cleavage of peptide bonds with very broad specificity.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP By similarity.
Up-regulated by interferon gamma (at protein level).
Belongs to the peptidase T1B family.
Sequence annotation (Features)
|F14798 mRNA. Translation: CAA23263.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|Gene3D||188.8.131.52. 1 hit. |
|InterPro||IPR029055. Ntn_hydrolases_N. |
|Pfam||PF00227. Proteasome. 1 hit. |
|PRINTS||PR00141. PROTEASOME. |
|SUPFAM||SSF56235. SSF56235. 1 hit. |
|PROSITE||PS51476. PROTEASOME_BETA_2. 1 hit. |
|Accession||Primary (citable) accession number: Q29576|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|