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Q29555

- GNMT_PIG

UniProt

Q29555 - GNMT_PIG

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Protein
Glycine N-methyltransferase
Gene
GNMT
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine By similarity.

Catalytic activityi

S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191S-adenosyl-L-methionine By similarity
Binding sitei28 – 281S-adenosyl-L-methionine By similarity
Binding sitei31 – 311Substrate By similarity
Binding sitei38 – 381S-adenosyl-L-methionine By similarity
Binding sitei62 – 621S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei83 – 831S-adenosyl-L-methionine By similarity
Binding sitei136 – 1361S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei138 – 1381Substrate By similarity
Binding sitei175 – 1751Substrate By similarity
Binding sitei220 – 2201Substrate By similarity

GO - Molecular functioni

  1. folic acid binding Source: UniProtKB-KW
  2. glycine N-methyltransferase activity Source: UniProtKB
  3. glycine binding Source: UniProtKB

GO - Biological processi

  1. S-adenosylmethionine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

Folate-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKQ29555.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-methyltransferase (EC:2.1.1.20)
Gene namesi
Name:GNMT
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 292›292Glycine N-methyltransferase
PRO_0000087526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine By similarity
Modified residuei43 – 431N6-succinyllysine By similarity
Modified residuei190 – 1901N6-succinyllysine By similarity
Modified residuei195 – 1951N6-succinyllysine By similarity
Modified residuei200 – 2001N6-succinyllysine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ29555.

Expressioni

Tissue specificityi

Abundant in liver.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliQ29555.
SMRiQ29555. Positions 3-291.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni114 – 1152S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG78825.
HOVERGENiHBG051748.
KOiK00552.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR014369. Gly/Sar_N_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR16458. PTHR16458. 1 hit.
PIRSFiPIRSF000385. Gly_N-mtase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51600. SAM_GNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q29555-1 [UniParc]FASTAAdd to Basket

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SVYRTRSLGV AAEGLPDQYA DGEAARVWQL YIGDTRSRTA EYKAWLLGLL    50
RQHGCQRVLD VACGTGVDSI MLVEEGFSVT SVDASDKMLK YALKERWNRR 100
HEPAFDKWVI EEANWMTLDK DVPKSPMGGF DAVICQGNSF AHLPDCRGDQ 150
SEHRLALKNI TSMVRSGGLL VIDHRNYDHI LSTGCAPPGK NIYYKSDLIK 200
DITTSVLTVN NKAHMVTLDY TVQVPGTGHR GSPGLSKFRL SYYPHCLASF 250
TELLQTAFGG NGQHSVLGDF KPYKPGQAYI PCYFIHVLRK TD 292
Length:292
Mass (Da):32,548
Last modified:November 1, 1996 - v1
Checksum:iAD460DE3910E0633
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13308 mRNA. Translation: BAA02568.1.
RefSeqiNP_001103889.2. NM_001110419.2.
UniGeneiSsc.16163.

Genome annotation databases

GeneIDi397444.
KEGGissc:397444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13308 mRNA. Translation: BAA02568.1 .
RefSeqi NP_001103889.2. NM_001110419.2.
UniGenei Ssc.16163.

3D structure databases

ProteinModelPortali Q29555.
SMRi Q29555. Positions 3-291.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q29555.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397444.
KEGGi ssc:397444.

Organism-specific databases

CTDi 27232.

Phylogenomic databases

eggNOGi NOG78825.
HOVERGENi HBG051748.
KOi K00552.

Enzyme and pathway databases

SABIO-RK Q29555.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR014369. Gly/Sar_N_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR16458. PTHR16458. 1 hit.
PIRSFi PIRSF000385. Gly_N-mtase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51600. SAM_GNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers."
    Ogawa H., Gomi T., Fujioka M.
    Comp. Biochem. Physiol. 106B:601-611(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiGNMT_PIG
AccessioniPrimary (citable) accession number: Q29555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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