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Q29552

- C11B1_PIG

UniProt

Q29552 - C11B1_PIG

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Protein
Cytochrome P450 11B1, mitochondrial
Gene
CYP11B1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts 11-deoxycorticosterone to corticosterone and 18-hydroxycorticosterone, and also produces aldosterone. May play a role in the biosynthesis of glucocorticoids as well as mineralocorticoids. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Catalytic activityi

A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi450 – 4501Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:CYP11B1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion By similarity
Add
BLAST
Chaini25 – 503479Cytochrome P450 11B1, mitochondrial
PRO_0000003602Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ29552.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29552-1 [UniParc]FASTAAdd to Basket

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MAIWAKAEAW LAGPWLALNR ARTLGTRAVL APKGVLPFEA IPQFPGKKWM    50
RVLQLWREQG FENNHLEMHQ TFQELGPIFR FDVGGRNMVL VMLPEDVERC 100
QKVEGLHPQR DVPGPWLAYR HLRGHKCGVF LLNGPTWRLD RLQLNPGVLS 150
LQAMQKFTPL VDGVARDFSQ ALRARVMQNA RGSLTLDIKP SIFRYTIEAS 200
NLVLFGERLG LLAHQPNPES LDFIHALEVM FKSTVQLMFM PRSLSRWTST 250
GTWKEHFEAW DCIFQYANKA IQRLYQELTL GHPWHYSGVV AELLTHANMT 300
VDAIKANSID LTAGSVDTTA YPLLMTLFEL ARNPEVQQAL RQESLAAAAR 350
ISENPQKAIT ELPLLRAALK ETLRLYPVGI FLDRCVTSDL VLQNYHIPAG 400
TLVKVLLYSL GRNPAVFARP ERYHPQRWLD NQGSGTRFPH LAFGFGMRQC 450
LGRRLAQVEM LLLLHHVLKN FLVETLVQED IKMIYRFIMT PSTLPLLTFR 500
AIS 503
Length:503
Mass (Da):57,340
Last modified:November 1, 1997 - v1
Checksum:i4C40B1EEAAC49B05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38590 mRNA. Translation: BAA07600.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38590 mRNA. Translation: BAA07600.1 .

3D structure databases

ProteinModelPortali Q29552.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051098.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of cytochrome P450(11 beta) of porcine adrenal cortex."
    Sun T., Zhao Y., Nonaka Y., Okamoto M.
    J. Steroid Biochem. Mol. Biol. 52:227-232(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland.

Entry informationi

Entry nameiC11B1_PIG
AccessioniPrimary (citable) accession number: Q29552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 11, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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