Reviewed,
UniProtKB/Swiss-Prot Q29548 (HEXB_PIG)
Last modified
September 1, 2009.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Beta-hexosaminidase subunit beta EC=3.2.1.52 Alternative name(s): N-acetyl-beta-glucosaminidase subunit beta Beta-N-acetylhexosaminidase subunit beta Short name=Hexosaminidase subunit B 65 kDa epididymal boar protein | ||
| Gene names |
| ||
| Organism | Sus scrofa (Pig) | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 531 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues By similarity. |
| Catalytic activity | Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
| Subcellular location | |
| Sequence similarities | Belongs to the glycosyl hydrolase 20 family. |
| Sequence caution | The sequence CAA63123.1 differs from that shown. Reason: Frameshift at positions 3 and 16. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Domain | Signal |
| Molecular function | Glycosidase Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: EC cation bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||||
| Chain | 22 – 531 | 510 | Beta-hexosaminidase subunit beta | PRO_0000012007 | |||||||
Sites | |||||||||||
| Active site | 329 | 1 | Proton donor By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 120 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 164 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 301 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 67 ↔ 111 | By similarity | |||||||||
| Disulfide bond | 283 ↔ 334 | By similarity | |||||||||
| Disulfide bond | 508 ↔ 525 | By similarity | |||||||||
Sequences
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References
| [1] | "Purification, cloning and sequencing analysis of B-N-acetyl-hexosaminidase from epididymal boar." Syntin P., Okamura N., Guillou F., Dacheux F., Dacheux J.-L. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis. |
| [2] | "Characterization and identification of proteins secreted in the various regions of the adult boar epididymis." Syntin P., Dacheux F., Druart X., Gatti J.L., Okamura N., Dacheux J.-L. Biol. Reprod. 55:956-974(1996) [PubMed: 8902205] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Epididymis. |
Cross-references
Sequence databases | |
|---|---|
| X92379 mRNA. Translation: CAA63123.1. Frameshift. | |
| RefSeq | NP_999086.1. |
| UniGene | Ssc.3196 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NOW based on UniProtKB P07686. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GH20. Glycoside Hydrolase Family 20. |
Genome annotation databases | |
| GeneID | 396958. |
| KEGG | ssc:396958. |
Organism-specific databases | |
| CTD | 396958. |
Phylogenomic databases | |
| HOVERGEN | Q29548. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.52. 249. |
Family and domain databases | |
| InterPro | IPR001540. Glyco_hydro_20. IPR015883. Glyco_hydro_20_cat-core. IPR013781. Glyco_hydro_sg_catalytic. IPR015882. HexNAc-like_b. [Graphical view] |
| Gene3D | G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit. |
| PANTHER | PTHR22600. Glyco_hydro_20. 1 hit. |
| Pfam | PF00728. Glyco_hydro_20. 1 hit. PF02838. Glyco_hydro_20b. 1 hit. [Graphical view] |
| PRINTS | PR00738. GLHYDRLASE20. |
| ProtoNet | Search... |
Entry information
| Entry name | HEXB_PIG | ||||||||
| Accession | Primary (citable) accession number: Q29548 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


