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Protein

Inhibitor of carbonic anhydrase

Gene

ICA

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions.

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiS60.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of carbonic anhydrase
Gene namesi
Name:ICA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 704685Inhibitor of carbonic anhydrasePRO_0000035745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 67PROSITE-ProRule annotation
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation
Modified residuei42 – 421Dimethylated arginineBy similarity
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation
Disulfide bondi172 ↔ 188PROSITE-ProRule annotation
Disulfide bondi175 ↔ 196PROSITE-ProRule annotation
Disulfide bondi185 ↔ 198PROSITE-ProRule annotation
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation
Disulfide bondi360 ↔ 392PROSITE-ProRule annotation
Disulfide bondi370 ↔ 383PROSITE-ProRule annotation
Disulfide bondi417 ↔ 699PROSITE-ProRule annotation
Disulfide bondi440 ↔ 662PROSITE-ProRule annotation
Disulfide bondi472 ↔ 549PROSITE-ProRule annotation
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi496 ↔ 690PROSITE-ProRule annotation
Disulfide bondi506 ↔ 520PROSITE-ProRule annotation
Disulfide bondi517 ↔ 532PROSITE-ProRule annotation
Disulfide bondi589 ↔ 603PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDbiQ29545.
PeptideAtlasiQ29545.
PRIDEiQ29545.

Expressioni

Tissue specificityi

Blood plasma.

Interactioni

Subunit structurei

Monomer. Interacts (via transferrin-like domain 2) with CA2. Has nanomolar affinity for CA2.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021371.

Structurei

3D structure databases

ProteinModelPortaliQ29545.
SMRiQ29545. Positions 22-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 347323Transferrin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini357 – 689333Transferrin-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
HOVERGENiHBG000055.
InParanoidiQ29545.
KOiK14736.

Family and domain databases

InterProiIPR029785. ICA.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PANTHERiPTHR11485:SF20. PTHR11485:SF20. 1 hit.
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 1 hit.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAFCVLLC AGSLGLCLAF PKETVRWCTV SSQEASKCSS FRHNMKKILP
60 70 80 90 100
VEGPHVSCVK RTSYLECIRA ILANEADAVT IDGGLVFEAG LAPYNLKPVV
110 120 130 140 150
AEFYGSKDDP QTHYYAVAVV KKGSDFQLSQ LRGKKSCHTG LGWSAGWNIP
160 170 180 190 200
MGILLPPDSG EEAAAKFFSS SCVPCADRMA FPKMCQLCAG KGVEKCACSN
210 220 230 240 250
HERYFGYSGA FKCLQEDVGD VAFVRHVTVF ENLPDKADRD QYELLCKDNT
260 270 280 290 300
RRPVDDYENC YLAQVPSHAV VARSVDGKED LIWELLNQAQ ENFGKDKSAE
310 320 330 340 350
FQLFSSSHGK DLLFTDACLG FLRVPPKMDA KLYLGYEYFA AIQHLRRVQG
360 370 380 390 400
TEEPQRVMWC AVGQHERTKC DSWSVLSGGI LNCNSEDTME DCIAAIAKGE
410 420 430 440 450
ADAMSLDGGF LYTAGKCGLV PVLAENYLSQ DGKERFGSKC VNTPVEGYYV
460 470 480 490 500
VAVVKKSDAD LTWNSLRGKK SCHIAVGTSA GWIIPMGFIY NQTGSCKLDE
510 520 530 540 550
FFSQSCAPGS DPESRLCALC SGSISGQPAH TCAPNSHEGY HGFSGALRCL
560 570 580 590 600
VEKGDVAFVK HPTVLQNTDG RNPEAWAKDL KQEDFQLLCP DGTRKPVTEA
610 620 630 640 650
QSCHLAAVPS HAVVSRKDKA DFVRRMLFNQ QELFGRNGFE YMMFQLFKSS
660 670 680 690 700
TEDLLFSDDT ECLANLQDKI TYQKYLGPEY LQAIANVRQC FPSELLDACT

FHGN
Length:704
Mass (Da):77,634
Last modified:November 1, 1996 - v1
Checksum:i16BB0E651931E336
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36916 mRNA. Translation: AAB58956.1.
PIRiI47228.
RefSeqiNP_999012.1. NM_213847.1.
UniGeneiSsc.100428.
Ssc.1137.

Genome annotation databases

GeneIDi396845.
KEGGissc:396845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36916 mRNA. Translation: AAB58956.1.
PIRiI47228.
RefSeqiNP_999012.1. NM_213847.1.
UniGeneiSsc.100428.
Ssc.1137.

3D structure databases

ProteinModelPortaliQ29545.
SMRiQ29545. Positions 22-702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021371.

Protein family/group databases

MEROPSiS60.979.

Proteomic databases

PaxDbiQ29545.
PeptideAtlasiQ29545.
PRIDEiQ29545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396845.
KEGGissc:396845.

Organism-specific databases

CTDi396845.

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
HOVERGENiHBG000055.
InParanoidiQ29545.
KOiK14736.

Family and domain databases

InterProiIPR029785. ICA.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PANTHERiPTHR11485:SF20. PTHR11485:SF20. 1 hit.
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 1 hit.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICA_PIG
AccessioniPrimary (citable) accession number: Q29545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.