ID   C11B1_PAPHU             Reviewed;         503 AA.
AC   Q29527;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   26-MAY-2009, entry version 52.
DE   RecName: Full=Cytochrome P450 11B1, mitochondrial;
DE   AltName: Full=CYPXIB1;
DE   AltName: Full=P450C11;
DE   AltName: Full=Steroid 11-beta-hydroxylase;
DE            EC=1.14.15.4;
DE   Flags: Precursor;
GN   Name=CYP11B1;
OS   Papio hamadryas ursinus (Chacma baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=36229;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   MEDLINE=97124766; PubMed=8969902;
RA   Hampf M., Swart A.C., Swart P.;
RT   "Sequence of the 11 beta-hydroxylase gene from the Cape baboon (Papio
RT   ursinus).";
RL   Endocr. Res. 22:495-499(1996).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate
CC       monooxygenases. They oxidize a variety of structurally unrelated
CC       compounds, including steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY: A steroid + reduced adrenal ferredoxin + O(2)
CC       = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
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DR   EMBL; U52085; AAA96967.1; -; Genomic_DNA.
DR   EMBL; U52081; AAA96967.1; JOINED; Genomic_DNA.
DR   EMBL; U52082; AAA96967.1; JOINED; Genomic_DNA.
DR   EMBL; U52083; AAA96967.1; JOINED; Genomic_DNA.
DR   EMBL; U52084; AAA96967.1; JOINED; Genomic_DNA.
DR   HSSP; P00189; 1SCC.
DR   HOVERGEN; Q29527; -.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0004507; F:steroid 11-beta-monooxygenase activity; IEA:EC.
DR   GO; GO:0006700; P:C21-steroid hormone biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017973; Cyt_P450_C.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002399; Cyt_P450_mit_N.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00408; MITP450.
DR   PRINTS; PR00385; P450.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Mitochondrion; Monooxygenase;
KW   Oxidoreductase; Steroidogenesis; Transit peptide.
FT   TRANSIT       1     24       Mitochondrion (By similarity).
FT   CHAIN        25    503       Cytochrome P450 11B1, mitochondrial.
FT                                /FTId=PRO_0000003601.
FT   METAL       450    450       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   503 AA;  57644 MW;  413E7EFC3A578B86 CRC64;
     MALRAKAEVC MAAPWLSLQR ARALGTRATR VPRTVLPFEA MPRRPGNRWL RLLQIWREQG
     YEHLHLEVHQ TFQELGPIFR YDLGGAGMVC VMLPEDVEKL QQVDSLNPRR MSLEPWVAYR
     QHRGHKCGVF LLNGPEWRFN RLRLNPDVLS PKAVQRFLPM VDAVARDFSQ ALRKKVVQNA
     RESVTLDIQP SIFHYTIEAS NLALFGERLG LVGHSPSSAS LSFLHALEVM FKSTVQLMFM
     PRSLSRWTSP KVWKEHFEAW DCIFQYGDNC IQKIYQELAL SRPQQYTSIV AELLLNAELS
     PDAIKANSME LTAGSVDTTV FPLLMTLFEL ARNPNVQQAL RQESLAAAAS ISEHPQKATT
     ELPLLRAALK ETLRLYPVGL FLERVVSSDL VLQNYHIPAG TLVRVFLYSL GRNPALFPRP
     ERYNPQRWLD IRGSGRNFYH VPFGFGMRQC LGRRLAEAEM LLLLHHVLKH LQVETLTQED
     IKMVYSFILR PSTFPLLTFR AIN
//