Reviewed, UniProtKB/Swiss-Prot Q29527 (C11B1_PAPHU)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 11B1, mitochondrial
    EC=1.14.15.4
Alternative name(s):
    CYPXIB1
    P450C11
    Steroid 11-beta-hydroxylase

Gene names

Name:

CYP11B1

Organism

Papio hamadryas ursinus (Chacma baboon)

Taxonomic identifier

36229 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Papio

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	A steroid + reduced adrenal ferredoxin + O(2) = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H(2)O.
Cofactor	Heme group By similarity.
Subcellular location	Mitochondrion membrane.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Biological process	Steroidogenesis
Cellular component	Membrane Mitochondrion
Domain	Transit peptide
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	C21-steroid hormone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro steroid 11-beta-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 24	24	Mitochondrion By similarity
	Chain	25 – 503	479	Cytochrome P450 11B1, mitochondrial		PRO_0000003601
Sites
	Metal binding	450	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29527-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 413E7EFC3A578B86	FASTA	503	57,644
	10 20 30 40 50 60 MALRAKAEVC MAAPWLSLQR ARALGTRATR VPRTVLPFEA MPRRPGNRWL RLLQIWREQG 70 80 90 100 110 120 YEHLHLEVHQ TFQELGPIFR YDLGGAGMVC VMLPEDVEKL QQVDSLNPRR MSLEPWVAYR 130 140 150 160 170 180 QHRGHKCGVF LLNGPEWRFN RLRLNPDVLS PKAVQRFLPM VDAVARDFSQ ALRKKVVQNA 190 200 210 220 230 240 RESVTLDIQP SIFHYTIEAS NLALFGERLG LVGHSPSSAS LSFLHALEVM FKSTVQLMFM 250 260 270 280 290 300 PRSLSRWTSP KVWKEHFEAW DCIFQYGDNC IQKIYQELAL SRPQQYTSIV AELLLNAELS 310 320 330 340 350 360 PDAIKANSME LTAGSVDTTV FPLLMTLFEL ARNPNVQQAL RQESLAAAAS ISEHPQKATT 370 380 390 400 410 420 ELPLLRAALK ETLRLYPVGL FLERVVSSDL VLQNYHIPAG TLVRVFLYSL GRNPALFPRP 430 440 450 460 470 480 ERYNPQRWLD IRGSGRNFYH VPFGFGMRQC LGRRLAEAEM LLLLHHVLKH LQVETLTQED 490 500 IKMVYSFILR PSTFPLLTFR AIN

References

[1]	"Sequence of the 11 beta-hydroxylase gene from the Cape baboon (Papio ursinus)." Hampf M., Swart A.C., Swart P. Endocr. Res. 22:495-499(1996) [PubMed: 8969902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U52085 , U52081, U52082, U52083, U52084 Genomic DNA. Translation: AAA96967.1.
3D structure databases
HSSP	HSSP built from PDB template 1SCC based on UniProtKB P00189.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q29527.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR002399. Cyt_P450_mit. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00408. MITP450. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C11B1_PAPHU

Accession

Primary (citable) accession number: Q29527

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)