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Q29527

- C11B1_PAPHU

UniProt

Q29527 - C11B1_PAPHU

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Protein

Cytochrome P450 11B1, mitochondrial

Gene
CYP11B1
Organism
Papio hamadryas ursinus (Chacma baboon)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi450 – 4501Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:CYP11B1
OrganismiPapio hamadryas ursinus (Chacma baboon)
Taxonomic identifieri36229 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion By similarityAdd
BLAST
Chaini25 – 503479Cytochrome P450 11B1, mitochondrialPRO_0000003601Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ29527.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29527-1 [UniParc]FASTAAdd to Basket

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MALRAKAEVC MAAPWLSLQR ARALGTRATR VPRTVLPFEA MPRRPGNRWL    50
RLLQIWREQG YEHLHLEVHQ TFQELGPIFR YDLGGAGMVC VMLPEDVEKL 100
QQVDSLNPRR MSLEPWVAYR QHRGHKCGVF LLNGPEWRFN RLRLNPDVLS 150
PKAVQRFLPM VDAVARDFSQ ALRKKVVQNA RESVTLDIQP SIFHYTIEAS 200
NLALFGERLG LVGHSPSSAS LSFLHALEVM FKSTVQLMFM PRSLSRWTSP 250
KVWKEHFEAW DCIFQYGDNC IQKIYQELAL SRPQQYTSIV AELLLNAELS 300
PDAIKANSME LTAGSVDTTV FPLLMTLFEL ARNPNVQQAL RQESLAAAAS 350
ISEHPQKATT ELPLLRAALK ETLRLYPVGL FLERVVSSDL VLQNYHIPAG 400
TLVRVFLYSL GRNPALFPRP ERYNPQRWLD IRGSGRNFYH VPFGFGMRQC 450
LGRRLAEAEM LLLLHHVLKH LQVETLTQED IKMVYSFILR PSTFPLLTFR 500
AIN 503
Length:503
Mass (Da):57,644
Last modified:November 1, 1997 - v1
Checksum:i413E7EFC3A578B86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52085
, U52081, U52082, U52083, U52084 Genomic DNA. Translation: AAA96967.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52085
, U52081 , U52082 , U52083 , U52084 Genomic DNA. Translation: AAA96967.1 .

3D structure databases

ProteinModelPortali Q29527.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051098.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00408. MITP450.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of the 11 beta-hydroxylase gene from the Cape baboon (Papio ursinus)."
    Hampf M., Swart A.C., Swart P.
    Endocr. Res. 22:495-499(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.

Entry informationi

Entry nameiC11B1_PAPHU
AccessioniPrimary (citable) accession number: Q29527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 11, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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