ID   GNMT_RABIT              Reviewed;         292 AA.
AC   Q29513;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Glycine N-methyltransferase;
DE            EC=2.1.1.20;
DE   Flags: Fragment;
GN   Name=GNMT;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=8281755;
RA   Ogawa H., Gomi T., Fujioka M.;
RT   "Mammalian glycine N-methyltransferases. Comparative kinetic and
RT   structural properties of the enzymes from human, rat, rabbit and pig
RT   livers.";
RL   Comp. Biochem. Physiol. 106B:601-611(1993).
CC   -!- FUNCTION: Catalyzes the methylation of glycine by using S-
CC       adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine)
CC       with the concomitant production of S-adenosylhomocysteine
CC       (AdoHcy). Possible crucial role in the regulation of tissue
CC       concentration of AdoMet and of metabolism of methionine.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + glycine = S-
CC       adenosyl-L-homocysteine + sarcosine.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Abundant in liver.
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DR   EMBL; D13307; BAA02567.1; -; mRNA.
DR   UniGene; Ocu.2139; -.
DR   HSSP; P13255; 1XVA.
DR   SMR; Q29513; 1-292.
DR   Ensembl; ENSOCUG00000003858; Oryctolagus cuniculus.
DR   HOVERGEN; Q29513; -.
DR   BRENDA; 2.1.1.20; 255.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005542; F:folic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:0017174; F:glycine N-methyltransferase activity; IEA:EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   InterPro; IPR014369; Gly_N_MeTrfase.
DR   InterPro; IPR013217; Methyltransf_12.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   PIRSF; PIRSF000385; Gly_N-mtase; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Folate-binding; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN        <1    292       Glycine N-methyltransferase.
FT                                /FTId=PRO_0000087527.
FT   NON_TER       1      1
SQ   SEQUENCE   292 AA;  32626 MW;  CF36EF0379313CDA CRC64;
     DSVYRTRSLG VAAEGLPDQY ADGEAARVWQ LYIGDTRSRT SEYKTWLLGL LRQHGCRRVL
     DVACGTGVDS IMLVEEGFSV TSVDASDKML KYALKERWNR RHEPAFDKWV IEEANWMTLD
     KDVPQPAGGG FDAVICLGNS FAHLPDCKGD QSEHRQALKN IASMVRTGGL LVIDHRNYDH
     ILSTLCAPGK NIYYKSDLTK DVTTSVLTVN NKAHMVTLDY TVQVPAAGQD GPPSLSKFRL
     SYYPHCLAPF TEFLRAAFEG KCQHSVLGDF KPYQPGQAYV PCYFIHVLKR TA
//