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Q29513

- GNMT_RABIT

UniProt

Q29513 - GNMT_RABIT

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Protein
Glycine N-methyltransferase
Gene
GNMT
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.

Catalytic activityi

S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201S-adenosyl-L-methionine By similarity
Binding sitei29 – 291S-adenosyl-L-methionine By similarity
Binding sitei32 – 321Substrate By similarity
Binding sitei39 – 391S-adenosyl-L-methionine By similarity
Binding sitei63 – 631S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei84 – 841S-adenosyl-L-methionine By similarity
Binding sitei137 – 1371S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei139 – 1391Substrate By similarity
Binding sitei176 – 1761Substrate By similarity
Binding sitei220 – 2201Substrate By similarity

GO - Molecular functioni

  1. folic acid binding Source: UniProtKB-KW
  2. glycine N-methyltransferase activity Source: UniProtKB
  3. glycine binding Source: UniProtKB

GO - Biological processi

  1. S-adenosylmethionine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

Folate-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKQ29513.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-methyltransferase (EC:2.1.1.20)
Gene namesi
Name:GNMT
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 292›292Glycine N-methyltransferase
PRO_0000087527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine By similarity
Modified residuei44 – 441N6-succinyllysine By similarity
Modified residuei190 – 1901N6-succinyllysine By similarity
Modified residuei195 – 1951N6-succinyllysine By similarity
Modified residuei200 – 2001N6-succinyllysine By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Abundant in liver.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003341.

Structurei

3D structure databases

ProteinModelPortaliQ29513.
SMRiQ29513. Positions 1-292.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1162S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG78825.
HOGENOMiHOG000276537.
HOVERGENiHBG051748.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR014369. Gly/Sar_N_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR16458. PTHR16458. 1 hit.
PIRSFiPIRSF000385. Gly_N-mtase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51600. SAM_GNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q29513-1 [UniParc]FASTAAdd to Basket

« Hide

DSVYRTRSLG VAAEGLPDQY ADGEAARVWQ LYIGDTRSRT SEYKTWLLGL    50
LRQHGCRRVL DVACGTGVDS IMLVEEGFSV TSVDASDKML KYALKERWNR 100
RHEPAFDKWV IEEANWMTLD KDVPQPAGGG FDAVICLGNS FAHLPDCKGD 150
QSEHRQALKN IASMVRTGGL LVIDHRNYDH ILSTLCAPGK NIYYKSDLTK 200
DVTTSVLTVN NKAHMVTLDY TVQVPAAGQD GPPSLSKFRL SYYPHCLAPF 250
TEFLRAAFEG KCQHSVLGDF KPYQPGQAYV PCYFIHVLKR TA 292
Length:292
Mass (Da):32,626
Last modified:November 1, 1996 - v1
Checksum:iCF36EF0379313CDA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13307 mRNA. Translation: BAA02567.1.
UniGeneiOcu.2139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13307 mRNA. Translation: BAA02567.1 .
UniGenei Ocu.2139.

3D structure databases

ProteinModelPortali Q29513.
SMRi Q29513. Positions 1-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000003341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG78825.
HOGENOMi HOG000276537.
HOVERGENi HBG051748.

Enzyme and pathway databases

SABIO-RK Q29513.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR014369. Gly/Sar_N_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR16458. PTHR16458. 1 hit.
PIRSFi PIRSF000385. Gly_N-mtase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51600. SAM_GNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers."
    Ogawa H., Gomi T., Fujioka M.
    Comp. Biochem. Physiol. 106B:601-611(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiGNMT_RABIT
AccessioniPrimary (citable) accession number: Q29513
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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