Q29512 (HMDH_RABIT) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 82.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase Short name=HMG-CoA reductase EC=1.1.1.34 | ||
| Gene names |
| ||
| Organism | Oryctolagus cuniculus (Rabbit) [Complete proteome] | ||
| Taxonomic identifier | 9986 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Protein attributes
| Sequence length | 888 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis. |
| Catalytic activity | (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. |
| Sequence similarities | Belongs to the HMG-CoA reductase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 888 | 888 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | PRO_0000114423 | |||||
Regions | |||||||||
| Transmembrane | 10 – 39 | 30 | Helical; Potential | ||||||
| Transmembrane | 57 – 78 | 22 | Helical; Potential | ||||||
| Transmembrane | 90 – 114 | 25 | Helical; Potential | ||||||
| Transmembrane | 124 – 149 | 26 | Helical; Potential | ||||||
| Transmembrane | 160 – 187 | 28 | Helical; Potential | ||||||
| Transmembrane | 192 – 220 | 29 | Helical; Potential | ||||||
| Transmembrane | 315 – 339 | 25 | Helical; Potential | ||||||
| Region | 340 – 449 | 110 | Linker | ||||||
| Region | 450 – 888 | 439 | Catalytic | ||||||
Sites | |||||||||
| Active site | 559 | 1 | Charge relay system By similarity | ||||||
| Active site | 691 | 1 | Charge relay system By similarity | ||||||
| Active site | 767 | 1 | Charge relay system By similarity | ||||||
| Active site | 866 | 1 | Proton donor By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 872 | 1 | Phosphoserine; by AMPK By similarity | ||||||
| Glycosylation | 281 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 296 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 518 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 870 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | Yamada M., Yoshimatsu M., Kinowaki M., Kai M., Kondo K., Setoguchi T. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: New Zealand white. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
3D structure databases | |
|---|---|
| ProteinModelPortal | Q29512. |
| SMR | Q29512. Positions 441-865. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q29512. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| eggNOG | maNOG11482. |
| HOVERGEN | HBG000453. |
Family and domain databases | |
| InterPro | IPR002202. HMG_CoA_Rdtase. IPR023074. HMG_CoA_Rdtase_cat. IPR023076. HMG_CoA_Rdtase_CS. IPR004554. HMG_CoA_Rdtase_eu_arc. IPR004816. HMG_CoA_Rdtase_metazoan. IPR023282. HMG_CoA_Rdtase_N. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. IPR000731. SSD. [Graphical view] |
| Gene3D | G3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit. G3DSA:3.90.770.10. HMG-CoA_red. 2 hits. G3DSA:1.10.3270.10. HMG_CoA_Rdtase_N. 1 hit. |
| PANTHER | PTHR10572. HMG-CoA_red. 1 hit. |
| Pfam | PF00368. HMG-CoA_red. 1 hit. [Graphical view] |
| PRINTS | PR00071. HMGCOARDTASE. |
| SUPFAM | SSF55035. HMG_CoA_NAD_bind. 1 hit. SSF56542. HMG_CoA_sub_bind. 1 hit. |
| TIGRFAMs | TIGR00920. 2A060605. 1 hit. TIGR00533. HMG_CoA_R_NADP. 1 hit. |
| PROSITE | PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS00318. HMG_COA_REDUCTASE_2. 1 hit. PS01192. HMG_COA_REDUCTASE_3. 1 hit. PS50065. HMG_COA_REDUCTASE_4. 1 hit. PS50156. SSD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HMDH_RABIT | ||||||||
| Accession | Primary (citable) accession number: Q29512 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with