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Protein

Cytochrome P450 2C30

Gene

CYP2C30

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi434 – 4341Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C30 (EC:1.14.14.1)
Alternative name(s):
CYPIIC30
Gene namesi
Name:CYP2C30
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Cytochrome P450 2C30PRO_0000051718Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016827.

Structurei

3D structure databases

ProteinModelPortaliQ29510.
SMRiQ29510. Positions 28-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ29510.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLFIVLVIC LSCLLLVSLL KQSYARRKLP PGPTAFPLVG NVLQLDRKNI
60 70 80 90 100
SKSISMLAKE YGPVFTVYFG TKPSVVLHGY EAVKEALVDH GEEFSGRVTV
110 120 130 140 150
PVFDRYAQGA GLFASQGELW KETRRFTLTV LRNMGMGKKT IEDRIQEEAS
160 170 180 190 200
CLVKALKETN ASPCDPSSLL FCVPCNVICS IIFQNRFEYN DQTFQTLVKH
210 220 230 240 250
FLDSIRLFNT PWMQLYNTFP ILHYLPGSHH ELFKVFNDQM KFFSEKIREH
260 270 280 290 300
QESLDHNNPR DFIDYLLIKM EKEKHNKQSQ FTMHHLLVTI WDVFDAGSQT
310 320 330 340 350
TSSTMQFGLL LLMKHPEIAA KVQEEIERVI GRDRSPCMQD RSCMPYTDAV
360 370 380 390 400
IHEIQRYIDM VPNNVPHAVT QDIQFRGYLI PKGTHILPSL TSVLYDEKEF
410 420 430 440 450
PNPEKFDPGH FLDASGNFKK SDYFLPFSIG KRACAGEGLA RMELFLVLTT
460 470 480
ILQHFTLKPL VDPKDIDPTP VDNGFLSVPP SYELCFVPV
Length:489
Mass (Da):55,915
Last modified:November 1, 1996 - v1
Checksum:iF2459438D858FB69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26153 mRNA. Translation: BAA05140.1.
RefSeqiNP_001164737.1. NM_001171266.1.
UniGeneiOcu.3054.

Genome annotation databases

GeneIDi100328935.
KEGGiocu:100328935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26153 mRNA. Translation: BAA05140.1.
RefSeqiNP_001164737.1. NM_001171266.1.
UniGeneiOcu.3054.

3D structure databases

ProteinModelPortaliQ29510.
SMRiQ29510. Positions 28-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328935.
KEGGiocu:100328935.

Organism-specific databases

CTDi100328935.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ29510.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A member of cytochrome P450 2C family."
    Noshiro M., Ishida H., Okuda K.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiCP2CU_RABIT
AccessioniPrimary (citable) accession number: Q29510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.