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Q29510

- CP2CU_RABIT

UniProt

Q29510 - CP2CU_RABIT

Protein

Cytochrome P450 2C30

Gene

CYP2C30

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi434 – 4341Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C30 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC30
    Gene namesi
    Name:CYP2C30
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Cytochrome P450 2C30PRO_0000051718Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000016827.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29510.
    SMRiQ29510. Positions 28-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29510-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLFIVLVIC LSCLLLVSLL KQSYARRKLP PGPTAFPLVG NVLQLDRKNI    50
    SKSISMLAKE YGPVFTVYFG TKPSVVLHGY EAVKEALVDH GEEFSGRVTV 100
    PVFDRYAQGA GLFASQGELW KETRRFTLTV LRNMGMGKKT IEDRIQEEAS 150
    CLVKALKETN ASPCDPSSLL FCVPCNVICS IIFQNRFEYN DQTFQTLVKH 200
    FLDSIRLFNT PWMQLYNTFP ILHYLPGSHH ELFKVFNDQM KFFSEKIREH 250
    QESLDHNNPR DFIDYLLIKM EKEKHNKQSQ FTMHHLLVTI WDVFDAGSQT 300
    TSSTMQFGLL LLMKHPEIAA KVQEEIERVI GRDRSPCMQD RSCMPYTDAV 350
    IHEIQRYIDM VPNNVPHAVT QDIQFRGYLI PKGTHILPSL TSVLYDEKEF 400
    PNPEKFDPGH FLDASGNFKK SDYFLPFSIG KRACAGEGLA RMELFLVLTT 450
    ILQHFTLKPL VDPKDIDPTP VDNGFLSVPP SYELCFVPV 489
    Length:489
    Mass (Da):55,915
    Last modified:November 1, 1996 - v1
    Checksum:iF2459438D858FB69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26153 mRNA. Translation: BAA05140.1.
    RefSeqiNP_001164737.1. NM_001171266.1.
    UniGeneiOcu.3054.

    Genome annotation databases

    GeneIDi100328935.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26153 mRNA. Translation: BAA05140.1 .
    RefSeqi NP_001164737.1. NM_001171266.1.
    UniGenei Ocu.3054.

    3D structure databases

    ProteinModelPortali Q29510.
    SMRi Q29510. Positions 28-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000016827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328935.

    Organism-specific databases

    CTDi 100328935.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A member of cytochrome P450 2C family."
      Noshiro M., Ishida H., Okuda K.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2CU_RABIT
    AccessioniPrimary (citable) accession number: Q29510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3