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Q29510 (CP2CU_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C30

EC=1.14.14.1
Alternative name(s):
CYPIIC30
Gene names
Name:CYP2C30
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Cytochrome P450 2C30
PRO_0000051718

Sites

Metal binding4341Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29510 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F2459438D858FB69

FASTA48955,915
        10         20         30         40         50         60 
MDLFIVLVIC LSCLLLVSLL KQSYARRKLP PGPTAFPLVG NVLQLDRKNI SKSISMLAKE 

        70         80         90        100        110        120 
YGPVFTVYFG TKPSVVLHGY EAVKEALVDH GEEFSGRVTV PVFDRYAQGA GLFASQGELW 

       130        140        150        160        170        180 
KETRRFTLTV LRNMGMGKKT IEDRIQEEAS CLVKALKETN ASPCDPSSLL FCVPCNVICS 

       190        200        210        220        230        240 
IIFQNRFEYN DQTFQTLVKH FLDSIRLFNT PWMQLYNTFP ILHYLPGSHH ELFKVFNDQM 

       250        260        270        280        290        300 
KFFSEKIREH QESLDHNNPR DFIDYLLIKM EKEKHNKQSQ FTMHHLLVTI WDVFDAGSQT 

       310        320        330        340        350        360 
TSSTMQFGLL LLMKHPEIAA KVQEEIERVI GRDRSPCMQD RSCMPYTDAV IHEIQRYIDM 

       370        380        390        400        410        420 
VPNNVPHAVT QDIQFRGYLI PKGTHILPSL TSVLYDEKEF PNPEKFDPGH FLDASGNFKK 

       430        440        450        460        470        480 
SDYFLPFSIG KRACAGEGLA RMELFLVLTT ILQHFTLKPL VDPKDIDPTP VDNGFLSVPP 


SYELCFVPV 

« Hide

References

[1]"A member of cytochrome P450 2C family."
Noshiro M., Ishida H., Okuda K.
Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26153 mRNA. Translation: BAA05140.1.
RefSeqNP_001164737.1. NM_001171266.1.
UniGeneOcu.3054.

3D structure databases

ProteinModelPortalQ29510.
SMRQ29510. Positions 28-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000016827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328935.

Organism-specific databases

CTD100328935.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CU_RABIT
AccessionPrimary (citable) accession number: Q29510
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families