ID   UB2R2_RABIT             Reviewed;         238 AA.
AC   Q29503;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Ubiquitin-conjugating enzyme E2 R2;
DE            EC=6.3.2.19;
DE   AltName: Full=Ubiquitin-protein ligase R2;
DE   AltName: Full=Ubiquitin carrier protein R2;
DE   AltName: Full=E2-CDC34B;
GN   Name=UBE2R2; Synonyms=CDC34B;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   MEDLINE=97236448; PubMed=9116038; DOI=10.1016/S0167-4781(96)00209-6;
RA   Sun B.G., Jeyaseelan K., Chung M.C.M., Tan T.-W., Chock P.B.,
RA   Teo T.-S.;
RT   "Cloning, characterization and expression of a cDNA clone encoding
RT   rabbit ubiquitin-conjugating enzyme, E2(32k).";
RL   Biochim. Biophys. Acta 1351:231-238(1997).
CC   -!- FUNCTION: Catalyzes the covalent attachment of ubiquitin to other
CC       proteins. May be involved in degradation of katenin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP +
CC       diphosphate + protein N-ubiquityllysine.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: When phosphorylated, interacts with beta-TrCP (BTRC) (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC   -!- CAUTION: Was originally (PubMed:9116038) thought to be
CC       UBE2R1/CDC34.
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DR   EMBL; U58652; AAB02656.1; ALT_INIT; mRNA.
DR   UniGene; Ocu.2110; -.
DR   HSSP; P34477; 1PZV.
DR   SMR; Q29503; 9-181.
DR   HOVERGEN; Q29503; -.
DR   BRENDA; 6.3.2.19; 255.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   GO; GO:0043687; P:post-translational protein modification; IEA:InterPro.
DR   GO; GO:0051246; P:regulation of protein metabolic process; IEA:InterPro.
DR   InterPro; IPR016135; UBQ-conjugat/RWD-like.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   Gene3D; G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
DR   Pfam; PF00179; UQ_con; 1.
DR   ProDom; PD000461; UBQ_conjugat; 1.
DR   SMART; SM00212; UBCc; 1.
DR   PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1.
DR   PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Ligase; Nucleotide-binding; Phosphoprotein;
KW   Ubl conjugation pathway.
FT   CHAIN         1    238       Ubiquitin-conjugating enzyme E2 R2.
FT                                /FTId=PRO_0000082453.
FT   COMPBIAS    200    238       Asp/Glu-rich (acidic).
FT   ACT_SITE     93     93       Glycyl thioester intermediate (By
FT                                similarity).
FT   MOD_RES     233    233       Phosphoserine; by CK2 (By similarity).
SQ   SEQUENCE   238 AA;  27166 MW;  E896CF0116A56308 CRC64;
     MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN TLYEGGYFKA
     HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP VDDPQSGELP SERWNPTQNV
     RTILLSVISL LNEPNTFSPA NVDASVMFRK WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG
     VKVPTTLAEY CIKTKVPSND NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES
//