Reviewed, UniProtKB/Swiss-Prot Q29503 (UB2R2_RABIT)

Names and origin

Protein names

Recommended name:
    Ubiquitin-conjugating enzyme E2 R2
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase R2
    Ubiquitin carrier protein R2
    E2-CDC34B

Gene names

Name:	UBE2R2
Synonyms:	CDC34B

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	When phosphorylated, interacts with beta-TrCP (BTRC) By similarity.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.
Caution	Was originally (Ref.1) thought to be UBE2R1/CDC34.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW post-translational protein modification Inferred from electronic annotation. Source: InterPro regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Ubiquitin-conjugating enzyme E2 R2		PRO_0000082453
Regions
	Compositional bias	200 – 238	39	Asp/Glu-rich (acidic)
Sites
	Active site	93	1	Glycyl thioester intermediate By similarity
Amino acid modifications
	Modified residue	233	1	Phosphoserine; by CK2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29503-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: E896CF0116A56308	FASTA	238	27,166
	10 20 30 40 50 60 MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN TLYEGGYFKA 70 80 90 100 110 120 HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP VDDPQSGELP SERWNPTQNV 130 140 150 160 170 180 RTILLSVISL LNEPNTFSPA NVDASVMFRK WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG 190 200 210 220 230 VKVPTTLAEY CIKTKVPSND NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES

References

[1]

"Cloning, characterization and expression of a cDNA clone encoding rabbit ubiquitin-conjugating enzyme, E2(32k)." Sun B.G., Jeyaseelan K., Chung M.C.M., Tan T.-W., Chock P.B., Teo T.-S. Biochim. Biophys. Acta 1351:231-238(1997) [PubMed: 9116038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U58652 mRNA. Translation: AAB02656.1. Different initiation.
UniGene	Ocu.2110
3D structure databases
HSSP	HSSP built from PDB template 1PZV based on UniProtKB P34477.
SMR	Q29503. Positions 9-181.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q29503.
Enzyme and pathway databases
BRENDA	6.3.2.19. 255.
Family and domain databases
InterPro	IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
ProDom	PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UB2R2_RABIT

Accession

Primary (citable) accession number: Q29503

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)