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Protein
Submitted name:

Phosphotyrosyl phosphatase

Gene

PTP-oc

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphotyrosyl phosphataseImported (EC:3.1.3.48Imported)
Gene namesi
Name:PTP-ocImported
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3322HelicalSequence analysisAdd
BLAST
Transmembranei69 – 9022HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000684.

Structurei

3D structure databases

ProteinModelPortaliQ29500.
SMRiQ29500. Positions 105-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 384258Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini301 – 37575TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115792.
HOVERGENiHBG053969.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEMNPNVV VISVLAILST LLIGLLLVTL IILRKKHLQM ARECGAGTFV
60 70 80 90 100
NFASLERDGK LPYNWRRSIF AFLTLLPSCL WTDYLLAFYI NPWSKNGLKK
110 120 130 140 150
RKLTNPVQLD DFDAYIKDMA KDSDYKFSLQ FEELKLIGLD IPHFAADLPL
160 170 180 190 200
NRCKNRYTNI LPYDFSRVRL LSMNEEEGAD YINANYIPGY NSPQEYIATQ
210 220 230 240 250
GPLPETRNDF WKMVLQQKSQ MIVMLTQCNE KRRVKCDHYW PFTEEPIAYG
260 270 280 290 300
DITVEMISEE EQDDWAHRHF RINYADEMQD VMHFNYTAWP DHGVPTANAA
310 320 330 340 350
ESILQFVHMV RQQATKSKGP MIIHCSAGVG RTGTFIALDR LLQHIRDHEF
360 370 380 390 400
VDILGLVSEM RSYRMSMVQT EEQYIFIHQC VQLMWMKKKQ QFCISDVIYE

NVSKS
Length:405
Mass (Da):47,230
Last modified:November 1, 1996 - v1
Checksum:iD47A1E2448D46704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32587 mRNA. Translation: AAB16824.1.
PIRiS68250.
RefSeqiNP_001164451.1. NM_001170980.1.
UniGeneiOcu.2018.

Genome annotation databases

GeneIDi100009529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32587 mRNA. Translation: AAB16824.1.
PIRiS68250.
RefSeqiNP_001164451.1. NM_001170980.1.
UniGeneiOcu.2018.

3D structure databases

ProteinModelPortaliQ29500.
SMRiQ29500. Positions 105-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009529.

Organism-specific databases

CTDi5800.

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115792.
HOVERGENiHBG053969.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ29500_RABIT
AccessioniPrimary (citable) accession number: Q29500
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.