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Q29496

- CP3AO_SHEEP

UniProt

Q29496 - CP3AO_SHEEP

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Protein

Cytochrome P450 3A24

Gene

CYP3A24

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A24 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA24
Gene namesi
Name:CYP3A24
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A24PRO_0000051804Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliQ29496.
SMRiQ29496. Positions 30-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG108567.
KOiK07424.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29496-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIPSFSLE TWVLLAISLV LLYLYGTYSH GLFKKLGVSG PRPLPYFGNV
60 70 80 90 100
LSYRKGVCEF DEECFKKYGK MWGVFEGKQP LLVITDPDVI KTVLVKECYS
110 120 130 140 150
VFTNRRVFGP MGIMKNAVSV AEDEQWKRIR TLLSPTFTSG KLKDMFPIIG
160 170 180 190 200
KYGDVLVRNL RKEAEKGKSV NMKDIFGAYS MDVITSTSFG VNIDSLGNPQ
210 220 230 240 250
DPFVENAKKL LRFNILDPFL LSVVLFPFLV PIFEVLNITM FPKSAVDFLT
260 270 280 290 300
KSVKRIKESR LKDNQKPRVD FLQLMINSQN SKETDNHKAL SDQELMAQSV
310 320 330 340 350
IFIFAGYETT SNTLSFLLYI LATHPDVQQK LQEEIDATFP NKAPPTYDVL
360 370 380 390 400
AQMEYLDMVV NETLRMFPIA VRLDRLCKKD VEIHGVSIPK GTAVTVPIFV
410 420 430 440 450
LHRDPQLWPE PEEFRPERFS KKNKDSINPY VYLPFGTGPR NCIGMRFAIM
460 470 480 490 500
NMKLAIVRVL QNFSFKPCKE TQIPLKINSQ GLIRPEKPIF LKVVLRDETI

SGA
Length:503
Mass (Da):57,360
Last modified:November 1, 1996 - v1
Checksum:i804223EAD0304238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59378 mRNA. Translation: AAB02657.1.
RefSeqiNP_001123376.1. NM_001129904.1.
UniGeneiOar.492.

Genome annotation databases

GeneIDi100170111.
KEGGioas:100170111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59378 mRNA. Translation: AAB02657.1 .
RefSeqi NP_001123376.1. NM_001129904.1.
UniGenei Oar.492.

3D structure databases

ProteinModelPortali Q29496.
SMRi Q29496. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100170111.
KEGGi oas:100170111.

Organism-specific databases

CTDi 517246.

Phylogenomic databases

HOVERGENi HBG108567.
KOi K07424.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ovine foetal liver CYP3A24."
    Ching M.S., Chun-Jing J., Ghabrial H., Wookey P.J., Smallwood R.A., Morgan D.J.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP3AO_SHEEP
AccessioniPrimary (citable) accession number: Q29496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3