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Q29496

- CP3AO_SHEEP

UniProt

Q29496 - CP3AO_SHEEP

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Protein
Cytochrome P450 3A24
Gene
CYP3A24
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A24 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA24
    Gene namesi
    Name:CYP3A24
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A24
    PRO_0000051804Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29496.
    SMRiQ29496. Positions 30-496.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG108567.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29496-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELIPSFSLE TWVLLAISLV LLYLYGTYSH GLFKKLGVSG PRPLPYFGNV    50
    LSYRKGVCEF DEECFKKYGK MWGVFEGKQP LLVITDPDVI KTVLVKECYS 100
    VFTNRRVFGP MGIMKNAVSV AEDEQWKRIR TLLSPTFTSG KLKDMFPIIG 150
    KYGDVLVRNL RKEAEKGKSV NMKDIFGAYS MDVITSTSFG VNIDSLGNPQ 200
    DPFVENAKKL LRFNILDPFL LSVVLFPFLV PIFEVLNITM FPKSAVDFLT 250
    KSVKRIKESR LKDNQKPRVD FLQLMINSQN SKETDNHKAL SDQELMAQSV 300
    IFIFAGYETT SNTLSFLLYI LATHPDVQQK LQEEIDATFP NKAPPTYDVL 350
    AQMEYLDMVV NETLRMFPIA VRLDRLCKKD VEIHGVSIPK GTAVTVPIFV 400
    LHRDPQLWPE PEEFRPERFS KKNKDSINPY VYLPFGTGPR NCIGMRFAIM 450
    NMKLAIVRVL QNFSFKPCKE TQIPLKINSQ GLIRPEKPIF LKVVLRDETI 500
    SGA 503
    Length:503
    Mass (Da):57,360
    Last modified:November 1, 1996 - v1
    Checksum:i804223EAD0304238
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59378 mRNA. Translation: AAB02657.1.
    RefSeqiNP_001123376.1. NM_001129904.1.
    UniGeneiOar.492.

    Genome annotation databases

    GeneIDi100170111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59378 mRNA. Translation: AAB02657.1 .
    RefSeqi NP_001123376.1. NM_001129904.1.
    UniGenei Oar.492.

    3D structure databases

    ProteinModelPortali Q29496.
    SMRi Q29496. Positions 30-496.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100170111.

    Organism-specific databases

    CTDi 517246.

    Phylogenomic databases

    HOVERGENi HBG108567.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ovine foetal liver CYP3A24."
      Ching M.S., Chun-Jing J., Ghabrial H., Wookey P.J., Smallwood R.A., Morgan D.J.
      Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AO_SHEEP
    AccessioniPrimary (citable) accession number: Q29496
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: July 9, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3
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