Q29496 (CP3AO_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 3A24
EC=1.14.14.1

Alternative name(s):
CYPIIIA24

Gene names

Name:

CYP3A24

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 3A24		PRO_0000051804
Sites
	Metal binding	442	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29496 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 804223EAD0304238	FASTA	503	57,360
	10 20 30 40 50 60 MELIPSFSLE TWVLLAISLV LLYLYGTYSH GLFKKLGVSG PRPLPYFGNV LSYRKGVCEF 70 80 90 100 110 120 DEECFKKYGK MWGVFEGKQP LLVITDPDVI KTVLVKECYS VFTNRRVFGP MGIMKNAVSV 130 140 150 160 170 180 AEDEQWKRIR TLLSPTFTSG KLKDMFPIIG KYGDVLVRNL RKEAEKGKSV NMKDIFGAYS 190 200 210 220 230 240 MDVITSTSFG VNIDSLGNPQ DPFVENAKKL LRFNILDPFL LSVVLFPFLV PIFEVLNITM 250 260 270 280 290 300 FPKSAVDFLT KSVKRIKESR LKDNQKPRVD FLQLMINSQN SKETDNHKAL SDQELMAQSV 310 320 330 340 350 360 IFIFAGYETT SNTLSFLLYI LATHPDVQQK LQEEIDATFP NKAPPTYDVL AQMEYLDMVV 370 380 390 400 410 420 NETLRMFPIA VRLDRLCKKD VEIHGVSIPK GTAVTVPIFV LHRDPQLWPE PEEFRPERFS 430 440 450 460 470 480 KKNKDSINPY VYLPFGTGPR NCIGMRFAIM NMKLAIVRVL QNFSFKPCKE TQIPLKINSQ 490 500 GLIRPEKPIF LKVVLRDETI SGA

References

[1]	"Ovine foetal liver CYP3A24." Ching M.S., Chun-Jing J., Ghabrial H., Wookey P.J., Smallwood R.A., Morgan D.J. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59378 mRNA. Translation: AAB02657.1.
RefSeq	NP_001123376.1. NM_001129904.1.
UniGene	Oar.492.
3D structure databases
ProteinModelPortal	Q29496.
SMR	Q29496. Positions 30-496.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100170111.
Organism-specific databases
CTD	517246.
Phylogenomic databases
HOVERGEN	HBG108567.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR008072. Cyt_P450_E_CYP3A. IPR002402. Cyt_P450_E_grp-II. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00464. EP450II. PR01689. EP450IICYP3A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP3AO_SHEEP

Accession

Primary (citable) accession number: Q29496

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	March 6, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program