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Q29496 (CP3AO_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A24

EC=1.14.14.1
Alternative name(s):
CYPIIIA24
Gene names
Name:CYP3A24
OrganismOvis aries (Sheep) [Complete proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A24
PRO_0000051804

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29496 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 804223EAD0304238

FASTA50357,360
        10         20         30         40         50         60 
MELIPSFSLE TWVLLAISLV LLYLYGTYSH GLFKKLGVSG PRPLPYFGNV LSYRKGVCEF 

        70         80         90        100        110        120 
DEECFKKYGK MWGVFEGKQP LLVITDPDVI KTVLVKECYS VFTNRRVFGP MGIMKNAVSV 

       130        140        150        160        170        180 
AEDEQWKRIR TLLSPTFTSG KLKDMFPIIG KYGDVLVRNL RKEAEKGKSV NMKDIFGAYS 

       190        200        210        220        230        240 
MDVITSTSFG VNIDSLGNPQ DPFVENAKKL LRFNILDPFL LSVVLFPFLV PIFEVLNITM 

       250        260        270        280        290        300 
FPKSAVDFLT KSVKRIKESR LKDNQKPRVD FLQLMINSQN SKETDNHKAL SDQELMAQSV 

       310        320        330        340        350        360 
IFIFAGYETT SNTLSFLLYI LATHPDVQQK LQEEIDATFP NKAPPTYDVL AQMEYLDMVV 

       370        380        390        400        410        420 
NETLRMFPIA VRLDRLCKKD VEIHGVSIPK GTAVTVPIFV LHRDPQLWPE PEEFRPERFS 

       430        440        450        460        470        480 
KKNKDSINPY VYLPFGTGPR NCIGMRFAIM NMKLAIVRVL QNFSFKPCKE TQIPLKINSQ 

       490        500 
GLIRPEKPIF LKVVLRDETI SGA 

« Hide

References

[1]"Ovine foetal liver CYP3A24."
Ching M.S., Chun-Jing J., Ghabrial H., Wookey P.J., Smallwood R.A., Morgan D.J.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59378 mRNA. Translation: AAB02657.1.
RefSeqNP_001123376.1. NM_001129904.1.
UniGeneOar.492.

3D structure databases

ProteinModelPortalQ29496.
SMRQ29496. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100170111.

Organism-specific databases

CTD517246.

Phylogenomic databases

HOVERGENHBG108567.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AO_SHEEP
AccessionPrimary (citable) accession number: Q29496
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families