Reviewed, UniProtKB/Swiss-Prot Q29492 (G6PD_MACRO)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:

G6PD

Organism

Macropus robustus (Wallaroo) (Euro)

Taxonomic identifier

9319 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Metatheria › Diprotodontia › Macropodidae › Macropus

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 515	514	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068084
Sites
	Active site	263	1	Proton acceptor By similarity
	Binding site	40	1	NADP By similarity
	Binding site	72	1	NADP By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	401	1	Phosphotyrosine By similarity
	Modified residue	503	1	Phosphotyrosine By similarity
	Modified residue	507	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29492-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: D49BA95185A78952	FASTA	515	59,315
	10 20 30 40 50 60 MAEQVALSRT QVCGILREEL YQGDAFHQSD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL 70 80 90 100 110 120 LPEDTFIVGY ARSNLTVDDI RKQSEPYFKA TPEENLKLEE FFSRNSYVAG QYDEPASFQR 130 140 150 160 170 180 LNAHMNSLHH GSQANRLFYL ALPPTVYEAV TKNIKETCMS QIGWNRVIVE KPFGKDLQSS 190 200 210 220 230 240 DKLSNHISSL FHEDQIYRID HYLGKEMVQN LMVLRFGNRI FGPIWNRDNI ACVIFTFKEP 250 260 270 280 290 300 FGTLGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK VLKCISEVRA 310 320 330 340 350 360 TDVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV VLYVENERWD GVPFILRCGK 370 380 390 400 410 420 ALNERKAEVR LQFRDVAGDI FQRQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL 430 440 450 460 470 480 DLTYGNRYKD VKLPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH HIEKEKTQPI 490 500 510 AYVYGSRGPP EADELMKRVG FQYEGTYKWV NPHKL

References

[1]	"Full-length cDNA sequence of X-linked G6PD of an Australian marsupial, the wallaroo." Loebel D.A., Longhurst T.J., Johnston P.G. Mamm. Genome 6:198-201(1995) [PubMed: 7749228] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U13899 mRNA. Translation: AAA76599.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
SMR	Q29492. Positions 28-515.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q29492.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_MACRO

Accession

Primary (citable) accession number: Q29492

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)