Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q29492

- G6PD_MACRO

UniProt

Q29492 - G6PD_MACRO

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Macropus robustus (Wallaroo) (Euro)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721NADP 1By similarity
    Binding sitei147 – 1471NADP 1By similarity
    Binding sitei171 – 1711NADP 1; via carbonyl oxygenBy similarity
    Binding sitei171 – 1711SubstrateBy similarity
    Binding sitei239 – 2391SubstrateBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Active sitei263 – 2631Proton acceptorBy similarity
    Binding sitei357 – 3571NADP 2By similarity
    Binding sitei360 – 3601SubstrateBy similarity
    Binding sitei365 – 3651SubstrateBy similarity
    Binding sitei366 – 3661NADP 2By similarity
    Binding sitei370 – 3701NADP 2By similarity
    Binding sitei393 – 3931NADP 2By similarity
    Binding sitei395 – 3951SubstrateBy similarity
    Binding sitei487 – 4871NADP 2By similarity
    Binding sitei503 – 5031NADP 2By similarity
    Binding sitei509 – 5091NADP 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458NADP 1By similarity
    Nucleotide bindingi401 – 4033NADP 2By similarity
    Nucleotide bindingi421 – 4233NADP 2By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:G6PD
    OrganismiMacropus robustus (Wallaroo) (Euro)
    Taxonomic identifieri9319 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaMacropodidaeMacropus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 515514Glucose-6-phosphate 1-dehydrogenasePRO_0000068084Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei89 – 891N6-acetyllysineBy similarity
    Modified residuei171 – 1711N6-acetyllysineBy similarity
    Modified residuei403 – 4031N6-acetyllysineBy similarity
    Modified residuei432 – 4321N6-acetyllysineBy similarity
    Modified residuei497 – 4971N6-acetyllysineBy similarity

    Post-translational modificationi

    Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity By similarity.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ29492.

    Interactioni

    Subunit structurei

    Homotetramer; dimer of dimers. Interacts with SIRT2; the interaction is enhanced by H2O2 treatment By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ29492.
    SMRiQ29492. Positions 28-515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni201 – 2055Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG000856.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q29492-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEQVALSRT QVCGILREEL YQGDAFHQSD THIFIIMGAS GDLAKKKIYP    50
    TIWWLFRDGL LPEDTFIVGY ARSNLTVDDI RKQSEPYFKA TPEENLKLEE 100
    FFSRNSYVAG QYDEPASFQR LNAHMNSLHH GSQANRLFYL ALPPTVYEAV 150
    TKNIKETCMS QIGWNRVIVE KPFGKDLQSS DKLSNHISSL FHEDQIYRID 200
    HYLGKEMVQN LMVLRFGNRI FGPIWNRDNI ACVIFTFKEP FGTLGRGGYF 250
    DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK VLKCISEVRA 300
    TDVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV VLYVENERWD 350
    GVPFILRCGK ALNERKAEVR LQFRDVAGDI FQRQCKRNEL VIRVQPNEAV 400
    YTKMMTKKPG MFFNPEESEL DLTYGNRYKD VKLPDAYERL ILDVFCGSQM 450
    HFVRSDELRE AWRIFTPLLH HIEKEKTQPI AYVYGSRGPP EADELMKRVG 500
    FQYEGTYKWV NPHKL 515
    Length:515
    Mass (Da):59,315
    Last modified:January 23, 2007 - v3
    Checksum:iD49BA95185A78952
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13899 mRNA. Translation: AAA76599.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13899 mRNA. Translation: AAA76599.1 .

    3D structure databases

    ProteinModelPortali Q29492.
    SMRi Q29492. Positions 28-515.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q29492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000856.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full-length cDNA sequence of X-linked G6PD of an Australian marsupial, the wallaroo."
      Loebel D.A., Longhurst T.J., Johnston P.G.
      Mamm. Genome 6:198-201(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiG6PD_MACRO
    AccessioniPrimary (citable) accession number: Q29492
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3