ID   ALDH2_MACPR             Reviewed;         240 AA.
AC   Q29491;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Aldehyde dehydrogenase, cytosolic 2;
DE            EC=1.2.1.3;
DE   AltName: Full=ALDH class 1;
DE   AltName: Full=Non-lens ALDH1;
DE   AltName: Full=ALDH1-NL;
DE   Flags: Fragment;
OS   Macroscelides proboscideus (Short-eared elephant shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Macroscelidea; Macroscelididae;
OC   Macroscelides.
OX   NCBI_TaxID=29082;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=96279083; PubMed=8663049; DOI=10.1074/jbc.271.26.15623;
RA   Graham C., Hodin J., Wistow G.;
RT   "A retinaldehyde dehydrogenase as a structural protein in a mammalian
RT   eye lens. Gene recruitment of eta-crystallin.";
RL   J. Biol. Chem. 271:15623-15628(1996).
CC   -!- FUNCTION: Elephant shrews, in contrast to other mammals, possess
CC       both a lens- and a non-lens specific class-1 aldehyde
CC       dehydrogenase. Can convert/oxidize retinaldehyde to retinoic acid.
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH.
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from
CC       ethanol: step 2/2.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Non-lens specific, predominant form expressed
CC       in the liver.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; U40486; AAC48589.1; -; mRNA.
DR   HSSP; P51977; 1BXS.
DR   SMR; Q29491; 1-240.
DR   HOVERGEN; Q29491; -.
DR   BRENDA; 1.2.1.3; 317919.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NAD; Oxidoreductase.
FT   CHAIN        <1    240       Aldehyde dehydrogenase, cytosolic 2.
FT                                /FTId=PRO_0000056429.
FT   ACT_SITE      8      8       Potential.
FT   ACT_SITE     42     42       Potential.
FT   NON_TER       1      1
SQ   SEQUENCE   240 AA;  26515 MW;  9E34DC9B4D5153A9 CRC64;
     NLKRVTLELG GKSPCIVFAD ADLDNAVEFA HRGLFFHQGQ CCVAASRLFV EESIYDEFVR
     RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKIIDLIESG KKEGAKLECG GGPWGNKGYF
     IQPTVFSNVT DEMRIAKEEI FGPVQQIMKF KSLDEVIKRA NNTFYGLAAG VFTKDLDKAV
     TVSAALQAGT VWVNCYMANS VQCPFGGFKM SGNGRELGEY GLHEYTEVKT VTMKISKKNS
//