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Protein

Aldehyde dehydrogenase, cytosolic 2

Gene
N/A
Organism
Macroscelides proboscideus (Short-eared elephant shrew)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Elephant shrews, in contrast to other mammals, possess both a lens- and a non-lens specific class-1 aldehyde dehydrogenase. Can convert/oxidize retinaldehyde to retinoic acid.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, cytosolic 1 (ALDH1), Aldehyde dehydrogenase, cytosolic 2
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Sequence Analysis
Active sitei42 – 421Sequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, cytosolic 2 (EC:1.2.1.3)
Alternative name(s):
ALDH class 1
ALDH1-NL
Non-lens ALDH1
OrganismiMacroscelides proboscideus (Short-eared elephant shrew)
Taxonomic identifieri29082 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaMacroscelideaMacroscelididaeMacroscelides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 240›240Aldehyde dehydrogenase, cytosolic 2PRO_0000056429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei106 – 1061N6-acetyllysine; alternateBy similarity
Modified residuei106 – 1061N6-succinyllysine; alternateBy similarity
Modified residuei137 – 1371N6-acetyllysine; alternateBy similarity
Modified residuei137 – 1371N6-succinyllysine; alternateBy similarity
Modified residuei149 – 1491N6-acetyllysine; alternateBy similarity
Modified residuei149 – 1491N6-succinyllysine; alternateBy similarity
Modified residuei151 – 1511N6-acetyllysineBy similarity
Modified residuei174 – 1741N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ29491.

Expressioni

Tissue specificityi

Non-lens specific, predominant form expressed in the liver.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ29491.
SMRiQ29491. Positions 1-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOVERGENiHBG000097.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q29491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NLKRVTLELG GKSPCIVFAD ADLDNAVEFA HRGLFFHQGQ CCVAASRLFV
60 70 80 90 100
EESIYDEFVR RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKIIDLIESG
110 120 130 140 150
KKEGAKLECG GGPWGNKGYF IQPTVFSNVT DEMRIAKEEI FGPVQQIMKF
160 170 180 190 200
KSLDEVIKRA NNTFYGLAAG VFTKDLDKAV TVSAALQAGT VWVNCYMANS
210 220 230 240
VQCPFGGFKM SGNGRELGEY GLHEYTEVKT VTMKISKKNS
Length:240
Mass (Da):26,515
Last modified:November 1, 1996 - v1
Checksum:i9E34DC9B4D5153A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40486 mRNA. Translation: AAC48589.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40486 mRNA. Translation: AAC48589.1.

3D structure databases

ProteinModelPortaliQ29491.
SMRiQ29491. Positions 1-240.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ29491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000097.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A retinaldehyde dehydrogenase as a structural protein in a mammalian eye lens. Gene recruitment of eta-crystallin."
    Graham C., Hodin J., Wistow G.
    J. Biol. Chem. 271:15623-15628(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiALDH2_MACPR
AccessioniPrimary (citable) accession number: Q29491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.