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Q29491 (ALDH2_MACPR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase, cytosolic 2

EC=1.2.1.3
Alternative name(s):
ALDH class 1
ALDH1-NL
Non-lens ALDH1
OrganismMacroscelides proboscideus (Short-eared elephant shrew)
Taxonomic identifier29082 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaMacroscelideaMacroscelididaeMacroscelides

Protein attributes

Sequence length240 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Elephant shrews, in contrast to other mammals, possess both a lens- and a non-lens specific class-1 aldehyde dehydrogenase. Can convert/oxidize retinaldehyde to retinoic acid.

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Non-lens specific, predominant form expressed in the liver.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   PTMAcetylation
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 240›240Aldehyde dehydrogenase, cytosolic 2
PRO_0000056429

Sites

Active site81 Potential
Active site421 Potential

Amino acid modifications

Modified residue1061N6-acetyllysine By similarity
Modified residue1491N6-acetyllysine By similarity
Modified residue1511N6-acetyllysine By similarity
Modified residue1741N6-acetyllysine By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q29491 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9E34DC9B4D5153A9

FASTA24026,515
        10         20         30         40         50         60 
NLKRVTLELG GKSPCIVFAD ADLDNAVEFA HRGLFFHQGQ CCVAASRLFV EESIYDEFVR 

        70         80         90        100        110        120 
RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKIIDLIESG KKEGAKLECG GGPWGNKGYF 

       130        140        150        160        170        180 
IQPTVFSNVT DEMRIAKEEI FGPVQQIMKF KSLDEVIKRA NNTFYGLAAG VFTKDLDKAV 

       190        200        210        220        230        240 
TVSAALQAGT VWVNCYMANS VQCPFGGFKM SGNGRELGEY GLHEYTEVKT VTMKISKKNS 

« Hide

References

[1]"A retinaldehyde dehydrogenase as a structural protein in a mammalian eye lens. Gene recruitment of eta-crystallin."
Graham C., Hodin J., Wistow G.
J. Biol. Chem. 271:15623-15628(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40486 mRNA. Translation: AAC48589.1.

3D structure databases

ProteinModelPortalQ29491.
SMRQ29491. Positions 1-240.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ29491.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000097.

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH2_MACPR
AccessionPrimary (citable) accession number: Q29491
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways