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Q29491

- ALDH2_MACPR

UniProt

Q29491 - ALDH2_MACPR

Protein

Aldehyde dehydrogenase, cytosolic 2

Gene
N/A
Organism
Macroscelides proboscideus (Short-eared elephant shrew)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Elephant shrews, in contrast to other mammals, possess both a lens- and a non-lens specific class-1 aldehyde dehydrogenase. Can convert/oxidize retinaldehyde to retinoic acid.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81Sequence Analysis
    Active sitei42 – 421Sequence Analysis

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase, cytosolic 2 (EC:1.2.1.3)
    Alternative name(s):
    ALDH class 1
    ALDH1-NL
    Non-lens ALDH1
    OrganismiMacroscelides proboscideus (Short-eared elephant shrew)
    Taxonomic identifieri29082 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaMacroscelideaMacroscelididaeMacroscelides

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 240›240Aldehyde dehydrogenase, cytosolic 2PRO_0000056429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei106 – 1061N6-acetyllysineBy similarity
    Modified residuei149 – 1491N6-acetyllysineBy similarity
    Modified residuei151 – 1511N6-acetyllysineBy similarity
    Modified residuei174 – 1741N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ29491.

    Expressioni

    Tissue specificityi

    Non-lens specific, predominant form expressed in the liver.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ29491.
    SMRiQ29491. Positions 1-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    HOVERGENiHBG000097.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q29491-1 [UniParc]FASTAAdd to Basket

    « Hide

    NLKRVTLELG GKSPCIVFAD ADLDNAVEFA HRGLFFHQGQ CCVAASRLFV    50
    EESIYDEFVR RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKIIDLIESG 100
    KKEGAKLECG GGPWGNKGYF IQPTVFSNVT DEMRIAKEEI FGPVQQIMKF 150
    KSLDEVIKRA NNTFYGLAAG VFTKDLDKAV TVSAALQAGT VWVNCYMANS 200
    VQCPFGGFKM SGNGRELGEY GLHEYTEVKT VTMKISKKNS 240
    Length:240
    Mass (Da):26,515
    Last modified:November 1, 1996 - v1
    Checksum:i9E34DC9B4D5153A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40486 mRNA. Translation: AAC48589.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40486 mRNA. Translation: AAC48589.1 .

    3D structure databases

    ProteinModelPortali Q29491.
    SMRi Q29491. Positions 1-240.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q29491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000097.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A retinaldehyde dehydrogenase as a structural protein in a mammalian eye lens. Gene recruitment of eta-crystallin."
      Graham C., Hodin J., Wistow G.
      J. Biol. Chem. 271:15623-15628(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiALDH2_MACPR
    AccessioniPrimary (citable) accession number: Q29491
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3