Reviewed, UniProtKB/Swiss-Prot Q29491 (ALDH2_MACPR)

Names and origin

Protein names	Recommended name:     Aldehyde dehydrogenase, cytosolic 2     EC=1.2.1.3 Alternative name(s):     ALDH class 1     Non-lens ALDH1     ALDH1-NL
Organism	Macroscelides proboscideus (Short-eared elephant shrew)
Taxonomic identifier	29082 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Afrotheria › Macroscelidea › Macroscelididae › Macroscelides

Protein attributes

Sequence length	240 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Elephant shrews, in contrast to other mammals, possess both a lens- and a non-lens specific class-1 aldehyde dehydrogenase. Can convert/oxidize retinaldehyde to retinoic acid.
Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmBy similarity.
Tissue specificity	Non-lens specific, predominant form expressed in the liver.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 240	›240	Aldehyde dehydrogenase, cytosolic 2		PRO_0000056429
Sites
	Active site	8	1	Potential
	Active site	42	1	Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q29491-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9E34DC9B4D5153A9	FASTA	240	26,515
	10 20 30 40 50 60 NLKRVTLELG GKSPCIVFAD ADLDNAVEFA HRGLFFHQGQ CCVAASRLFV EESIYDEFVR 70 80 90 100 110 120 RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKIIDLIESG KKEGAKLECG GGPWGNKGYF 130 140 150 160 170 180 IQPTVFSNVT DEMRIAKEEI FGPVQQIMKF KSLDEVIKRA NNTFYGLAAG VFTKDLDKAV 190 200 210 220 230 240 TVSAALQAGT VWVNCYMANS VQCPFGGFKM SGNGRELGEY GLHEYTEVKT VTMKISKKNS

References

[1]	"A retinaldehyde dehydrogenase as a structural protein in a mammalian eye lens. Gene recruitment of eta-crystallin." Graham C., Hodin J., Wistow G. J. Biol. Chem. 271:15623-15628(1996) [PubMed: 8663049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U40486 mRNA. Translation: AAC48589.1.
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
SMR	Q29491. Positions 1-240.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q29491.
Family and domain databases
InterPro	IPR016163. Ald_DHase_C. IPR016160. Ald_DHase_CS. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH2_MACPR

Accession

Primary (citable) accession number: Q29491

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 4, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)