Q29491 (ALDH2_MACPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Aldehyde dehydrogenase, cytosolic 2 EC=1.2.1.3 Alternative name(s): ALDH class 1 ALDH1-NL Non-lens ALDH1
Organism	Macroscelides proboscideus (Short-eared elephant shrew)
Taxonomic identifier	29082 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Afrotheria › Macroscelidea › Macroscelididae › Macroscelides

Protein attributes

Sequence length	240 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Elephant shrews, in contrast to other mammals, possess both a lens- and a non-lens specific class-1 aldehyde dehydrogenase. Can convert/oxidize retinaldehyde to retinoic acid.
Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Non-lens specific, predominant form expressed in the liver.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	ethanol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 240	›240	Aldehyde dehydrogenase, cytosolic 2		PRO_0000056429
Sites
	Active site	8	1	Potential
	Active site	42	1	Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q29491 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9E34DC9B4D5153A9	FASTA	240	26,515
	10 20 30 40 50 60 NLKRVTLELG GKSPCIVFAD ADLDNAVEFA HRGLFFHQGQ CCVAASRLFV EESIYDEFVR 70 80 90 100 110 120 RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKIIDLIESG KKEGAKLECG GGPWGNKGYF 130 140 150 160 170 180 IQPTVFSNVT DEMRIAKEEI FGPVQQIMKF KSLDEVIKRA NNTFYGLAAG VFTKDLDKAV 190 200 210 220 230 240 TVSAALQAGT VWVNCYMANS VQCPFGGFKM SGNGRELGEY GLHEYTEVKT VTMKISKKNS

References

[1]	"A retinaldehyde dehydrogenase as a structural protein in a mammalian eye lens. Gene recruitment of eta-crystallin." Graham C., Hodin J., Wistow G. J. Biol. Chem. 271:15623-15628(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40486 mRNA. Translation: AAC48589.1.
3D structure databases
ProteinModelPortal	Q29491.
SMR	Q29491. Positions 1-240.
ModBase	Search...
Proteomic databases
PRIDE	Q29491.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000097.
Enzyme and pathway databases
UniPathway	UPA00780; UER00768.
Family and domain databases
Gene3D	3.40.309.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH2_MACPR

Accession

Primary (citable) accession number: Q29491

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program