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Q29488

- CP2DH_MACFA

UniProt

Q29488 - CP2DH_MACFA

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Protein

Cytochrome P450 2D17

Gene
CYP2D17
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D17 (EC:1.14.14.1)
Alternative name(s):
CYPIID17
Gene namesi
Name:CYP2D17
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Cytochrome P450 2D17PRO_0000051741Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ29488.
SMRiQ29488. Positions 34-497.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29488-1 [UniParc]FASTAAdd to Basket

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MELDALVPLA VTVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD    50
FKNTPYCFDQ LRRRFGNVFS LQLAWTPVVV LNGLAAVREA LVTCGEDTAD 100
RPPVPINQVL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE 150
QWVTEEAACL CAAFTDQAGR PFRPNSLLDK AVSNVIASLT YGRRFEYDDP 200
RFLRLFDLTH EALKEESGFL REVLNAIPLL LRIPGLAGKV LRSQKAFLTQ 250
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NEENLRMVVA 300
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ 350
ARMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIELQGFLIP KGTTLFTNLS 400
SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR 450
MELFLFFTCL LQRFSFSVPA GQPRPSHHGV FAFLVTPSPY ELCAVPR 497
Length:497
Mass (Da):56,011
Last modified:November 1, 1997 - v1
Checksum:i3594AA88F04E58B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38218 mRNA. Translation: AAA79722.1.
PIRiG02938.
UniGeneiMfa.5090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38218 mRNA. Translation: AAA79722.1 .
PIRi G02938.
UniGenei Mfa.5090.

3D structure databases

ProteinModelPortali Q29488.
SMRi Q29488. Positions 34-497.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Lawton M.P., Laddison K.J., Speirs A.A., Mankowski D.C., Tweedie D.J.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2DH_MACFA
AccessioniPrimary (citable) accession number: Q29488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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