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Q29488 (CP2DH_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D17

EC=1.14.14.1
Alternative name(s):
CYPIID17
Gene names
Name:CYP2D17
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Cytochrome P450 2D17
PRO_0000051741

Sites

Metal binding4431Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29488 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 3594AA88F04E58B1

FASTA49756,011
        10         20         30         40         50         60 
MELDALVPLA VTVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FKNTPYCFDQ 

        70         80         90        100        110        120 
LRRRFGNVFS LQLAWTPVVV LNGLAAVREA LVTCGEDTAD RPPVPINQVL GFGPRSQGVF 

       130        140        150        160        170        180 
LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFTDQAGR PFRPNSLLDK 

       190        200        210        220        230        240 
AVSNVIASLT YGRRFEYDDP RFLRLFDLTH EALKEESGFL REVLNAIPLL LRIPGLAGKV 

       250        260        270        280        290        300 
LRSQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NEENLRMVVA 

       310        320        330        340        350        360 
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ ARMPYTTAVI 

       370        380        390        400        410        420 
HEVQRFGDIV PLGVTHMTSR DIELQGFLIP KGTTLFTNLS SVLKDEAVWE KPFRFHPEHF 

       430        440        450        460        470        480 
LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTCL LQRFSFSVPA GQPRPSHHGV 

       490 
FAFLVTPSPY ELCAVPR 

« Hide

References

[1]Lawton M.P., Laddison K.J., Speirs A.A., Mankowski D.C., Tweedie D.J.
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38218 mRNA. Translation: AAA79722.1.
PIRG02938.
UniGeneMfa.5090.

3D structure databases

ProteinModelPortalQ29488.
SMRQ29488. Positions 34-497.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2DH_MACFA
AccessionPrimary (citable) accession number: Q29488
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families