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Q29486

- PPBT_FELCA

UniProt

Q29486 - PPBT_FELCA

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Protein
Alkaline phosphatase, tissue-nonspecific isozyme
Gene
ALPL
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 magnesium ion By similarity.
Binds 2 zinc ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Magnesium By similarity
Metal bindingi60 – 601Zinc 1 By similarity
Active sitei110 – 1101Phosphoserine intermediate By similarity
Metal bindingi110 – 1101Zinc 1 By similarity
Metal bindingi173 – 1731Magnesium By similarity
Metal bindingi332 – 3321Magnesium By similarity
Metal bindingi337 – 3371Zinc 2 By similarity
Metal bindingi341 – 3411Zinc 2; via tele nitrogen By similarity
Metal bindingi378 – 3781Zinc 1 By similarity
Metal bindingi379 – 3791Zinc 1; via tele nitrogen By similarity
Metal bindingi454 – 4541Zinc 2; via tele nitrogen By similarity

GO - Molecular functioni

  1. alkaline phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphatase, tissue-nonspecific isozyme (EC:3.1.3.1)
Short name:
AP-TNAP
Short name:
TNSALP
Alternative name(s):
Alkaline phosphatase liver/bone/kidney isozyme
Gene namesi
Name:ALPL
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717
Add
BLAST
Chaini18 – 502485Alkaline phosphatase, tissue-nonspecific isozyme
PRO_0000024021Add
BLAST
Propeptidei503 – 52422Removed in mature form Reviewed prediction
PRO_0000024022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi139 ↔ 201 By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi230 – 2301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi489 ↔ 497 By similarity
Lipidationi502 – 5021GPI-anchor amidated serine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000002729.

Structurei

3D structure databases

ProteinModelPortaliQ29486.
SMRiQ29486. Positions 18-498.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1785.
HOGENOMiHOG000099118.
HOVERGENiHBG007345.
KOiK01077.
OrthoDBiEOG7SN8CH.
TreeFamiTF323513.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29486-1 [UniParc]FASTAAdd to Basket

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MISPFLVLAI GTCLTNSLVP EKEKDPKYWR DQAQQTLKNA LRLQKLNTNV    50
VKNVIMFLGD GMGVSTVTAA RILKGQLHHN PGEETRLEMD KFPYVALSKT 100
YNTNAQVPDS AGTATAYLCG VKANEGTVGV SAATQRTQCN TTQGNEVTSI 150
LRWAKDSGKS VGIVTTTRVN HATPSAAYAH SADRDWYSDN EMPPEALSQG 200
CKDIAYQLMH NVRDIEVIMG GGRKYMFPKN RTDVEYEMDE KARGTRLDGL 250
NLVDIWKSFK PRHKHSHYVW NRTELLTLDP YGVDYLLGLF EPGDMQYELN 300
RNSTTDPSLS EMVEIAIKIL SKNPKGFFLL VEGGRIDHGH HEGKAKQALH 350
EAVEMDQAIG RAGAMTSVED TLTIVTADHS HVFTFGGYTP RGNSIFGLAP 400
MVSDTDKKPF TSILYGNGPG YKVVGGEREN VSMVDYAHNN YQAQSAVPLR 450
HETHGGEDVA VFAKGPMAHL LHGVHEQNYI PHVMAYAACI GANLDHCASA 500
SSAGGPSPGP LFLLLALPSL GILF 524
Length:524
Mass (Da):57,345
Last modified:November 1, 1997 - v1
Checksum:iF4863A03C7882A72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31569 mRNA. Translation: AAA82993.1.
PIRiS66467.
RefSeqiNP_001036028.1. NM_001042563.1.

Genome annotation databases

GeneIDi727689.
KEGGifca:727689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31569 mRNA. Translation: AAA82993.1 .
PIRi S66467.
RefSeqi NP_001036028.1. NM_001042563.1.

3D structure databases

ProteinModelPortali Q29486.
SMRi Q29486. Positions 18-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000002729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 727689.
KEGGi fca:727689.

Organism-specific databases

CTDi 249.

Phylogenomic databases

eggNOGi COG1785.
HOGENOMi HOG000099118.
HOVERGENi HBG007345.
KOi K01077.
OrthoDBi EOG7SN8CH.
TreeFami TF323513.

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view ]
Pfami PF00245. Alk_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00113. ALKPHPHTASE.
SMARTi SM00098. alkPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 1 hit.
PROSITEi PS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA encoding a functional feline liver/bone/kidney-type alkaline phosphatase."
    Ghosh A.K., Mullins J.I.
    Arch. Biochem. Biophys. 322:240-249(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiPPBT_FELCA
AccessioniPrimary (citable) accession number: Q29486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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