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Q29478 (CP2CV_CAPAE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C31

EC=1.14.14.1
Alternative name(s):
CYPIIC31
Gene names
Name:CYP2C31
OrganismCapra aegagrus (Wild goat)
Taxonomic identifier9923 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Protein attributes

Sequence length284 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 284›284Cytochrome P450 2C31
PRO_0000051719

Sites

Metal binding2291Iron (heme axial ligand) By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q29478 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C0A69EEAEC29E185

FASTA28432,627
        10         20         30         40         50         60 
LVSTPWIELF NAFPSLLRHF PGSHNTIFKN MTEQRKFILE EIKKHQESLD LNNPQDFIDY 

        70         80         90        100        110        120 
FLIKMEKEKH NKHSEFTMDN LITTVWDVFS AGTETTSLTL RYGLLLLLKH PEVTAKVQEE 

       130        140        150        160        170        180 
IDRVVGRNRS PCMQDRSRMP YTDAVLHEIQ RYIDLVPSNL PHVATQDVKF REYLIPKGTA 

       190        200        210        220        230        240 
ILTSLTSVLH DGKEFPNPGQ FDPAHFLDES GNFKKTDHFM AFSAGKRVCV GEGLARMELF 

       250        260        270        280 
LLLVSILQHF TLKPVVDPKH IDIAPSFKGM LSIPPFCEMC FIPV 

« Hide

References

[1]"cDNA and deduced amino acid sequence of a dwarf goat liver cytochrome P450 fragment belonging to the CYP2C gene subfamily."
Zeilmaker W.M., van 't Klooster G.A.E., Gremmels-Gehrmann J.F., van Miert A.S.J.P.A., Horbach G.J.M.J.
Biochem. Biophys. Res. Commun. 200:120-125(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: West-African dwarf.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76502 mRNA. Translation: CAA54037.1.
UniGeneChi.33977.

3D structure databases

ProteinModelPortalQ29478.
SMRQ29478. Positions 1-284.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CV_CAPAE
AccessionPrimary (citable) accession number: Q29478
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families