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Q29478

- CP2CV_CAPHE

UniProt

Q29478 - CP2CV_CAPHE

Protein

Cytochrome P450 2C31

Gene

CYP2C31

Organism
Capra hircus aegagrus (Wild goat) (Capra aegagrus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi229 – 2291Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C31 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC31
    Gene namesi
    Name:CYP2C31
    OrganismiCapra hircus aegagrus (Wild goat) (Capra aegagrus)
    Taxonomic identifieri9923 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 284›284Cytochrome P450 2C31PRO_0000051719Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29478.
    SMRiQ29478. Positions 1-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q29478-1 [UniParc]FASTAAdd to Basket

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    LVSTPWIELF NAFPSLLRHF PGSHNTIFKN MTEQRKFILE EIKKHQESLD    50
    LNNPQDFIDY FLIKMEKEKH NKHSEFTMDN LITTVWDVFS AGTETTSLTL 100
    RYGLLLLLKH PEVTAKVQEE IDRVVGRNRS PCMQDRSRMP YTDAVLHEIQ 150
    RYIDLVPSNL PHVATQDVKF REYLIPKGTA ILTSLTSVLH DGKEFPNPGQ 200
    FDPAHFLDES GNFKKTDHFM AFSAGKRVCV GEGLARMELF LLLVSILQHF 250
    TLKPVVDPKH IDIAPSFKGM LSIPPFCEMC FIPV 284
    Length:284
    Mass (Da):32,627
    Last modified:November 1, 1996 - v1
    Checksum:iC0A69EEAEC29E185
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76502 mRNA. Translation: CAA54037.1.
    UniGeneiChi.33977.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76502 mRNA. Translation: CAA54037.1 .
    UniGenei Chi.33977.

    3D structure databases

    ProteinModelPortali Q29478.
    SMRi Q29478. Positions 1-284.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequence of a dwarf goat liver cytochrome P450 fragment belonging to the CYP2C gene subfamily."
      Zeilmaker W.M., van 't Klooster G.A.E., Gremmels-Gehrmann J.F., van Miert A.S.J.P.A., Horbach G.J.M.J.
      Biochem. Biophys. Res. Commun. 200:120-125(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: West-African dwarf.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2CV_CAPHE
    AccessioniPrimary (citable) accession number: Q29478
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3