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Q29478

- CP2CV_CAPHE

UniProt

Q29478 - CP2CV_CAPHE

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Protein

Cytochrome P450 2C31

Gene

CYP2C31

Organism
Capra hircus aegagrus (Wild goat) (Capra aegagrus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi229 – 2291Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C31 (EC:1.14.14.1)
Alternative name(s):
CYPIIC31
Gene namesi
Name:CYP2C31
OrganismiCapra hircus aegagrus (Wild goat) (Capra aegagrus)
Taxonomic identifieri9923 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 284›284Cytochrome P450 2C31PRO_0000051719Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliQ29478.
SMRiQ29478. Positions 1-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q29478-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LVSTPWIELF NAFPSLLRHF PGSHNTIFKN MTEQRKFILE EIKKHQESLD
60 70 80 90 100
LNNPQDFIDY FLIKMEKEKH NKHSEFTMDN LITTVWDVFS AGTETTSLTL
110 120 130 140 150
RYGLLLLLKH PEVTAKVQEE IDRVVGRNRS PCMQDRSRMP YTDAVLHEIQ
160 170 180 190 200
RYIDLVPSNL PHVATQDVKF REYLIPKGTA ILTSLTSVLH DGKEFPNPGQ
210 220 230 240 250
FDPAHFLDES GNFKKTDHFM AFSAGKRVCV GEGLARMELF LLLVSILQHF
260 270 280
TLKPVVDPKH IDIAPSFKGM LSIPPFCEMC FIPV
Length:284
Mass (Da):32,627
Last modified:November 1, 1996 - v1
Checksum:iC0A69EEAEC29E185
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76502 mRNA. Translation: CAA54037.1.
UniGeneiChi.33977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76502 mRNA. Translation: CAA54037.1 .
UniGenei Chi.33977.

3D structure databases

ProteinModelPortali Q29478.
SMRi Q29478. Positions 1-284.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and deduced amino acid sequence of a dwarf goat liver cytochrome P450 fragment belonging to the CYP2C gene subfamily."
    Zeilmaker W.M., van 't Klooster G.A.E., Gremmels-Gehrmann J.F., van Miert A.S.J.P.A., Horbach G.J.M.J.
    Biochem. Biophys. Res. Commun. 200:120-125(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: West-African dwarf.
    Tissue: Liver.

Entry informationi

Entry nameiCP2CV_CAPHE
AccessioniPrimary (citable) accession number: Q29478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3