Q29476 (ST1A1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfotransferase 1A1
Short name=ST1A1
EC=2.8.2.1

Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name=P-PST

Gene names

Name:

SULT1A1

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Catalytic activity	3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Ubiquitously expressed in canine tissues with highest expression in male and female liver. Ref.2
Sequence similarities	Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
Biological process	Catecholamine metabolism Lipid metabolism Steroid metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	catecholamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW steroid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aryl sulfotransferase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Sulfotransferase 1A1		PRO_0000085126
Regions
	Nucleotide binding	48 – 53	6	PAPS By similarity
	Nucleotide binding	227 – 232	6	PAPS By similarity
	Nucleotide binding	255 – 259	5	PAPS By similarity
	Region	106 – 108	3	Substrate binding By similarity
Sites
	Active site	108	1	Proton acceptor By similarity
	Binding site	130	1	PAPS By similarity
	Binding site	138	1	PAPS By similarity
	Binding site	193	1	PAPS By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29476 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C297A9211A5609B6	FASTA	295	34,115
	10 20 30 40 50 60 MEDIPDTSRP PLKYVKGIPL IKYFAEALES LQDFQAQPDD LLISTYPKSG TTWVSEILDM 70 80 90 100 110 120 IYQDGDVEKC RRAPVFIRVP FLEFKAPGIP TGLEVLKDTP APRLIKTHLP LALLPQTLLD 130 140 150 160 170 180 QKVKVVYVAR NAKDVAVSYY HFYRMAKVHP DPDTWDSFLE KFMAGEVSYG SWYQHVQEWW 190 200 210 220 230 240 ELSHTHPVLY LFYEDMKENP KREIQKILKF VGRSLPEETV DLIVQHTSFK EMKNNSMANY 250 260 270 280 290 TTLSPDIMDH SISAFMRKGI SGDWKTTFTV AQNERFDADY AKKMEGCGLS FRTQL

References

[1]	"Molecular cloning and sequencing of a dog liver cDNA (dPST-1) encoding a phenol sulfotransferase." Satsukawa M., Ogura K., Nakamura T., Watabe T. Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Beagle. Tissue: Liver.
[2]	"Canine sulfotransferase SULT1A1: molecular cloning, expression, and characterization." Tsoi C., Morgenstern R., Swedmark S. Arch. Biochem. Biophys. 401:125-133(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D29807 mRNA. Translation: BAA06190.1. AY069922 mRNA. Translation: AAL57717.1.
RefSeq	NP_001003223.1. NM_001003223.1.
UniGene	Cfa.70.
3D structure databases
ProteinModelPortal	Q29476.
SMR	Q29476. Positions 7-295.
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000025221.
Proteomic databases
PaxDb	Q29476.
PRIDE	Q29476.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000027121; ENSCAFP00000025221; ENSCAFG00000017122. ENSCAFT00000046198; ENSCAFP00000036703; ENSCAFG00000017122.
GeneID	403892.
KEGG	cfa:403892.
Organism-specific databases
CTD	6817.
Phylogenomic databases
eggNOG	NOG260792.
GeneTree	ENSGT00560000076773.
HOGENOM	HOG000037209.
HOVERGEN	HBG001195.
InParanoid	Q29476.
KO	K01014.
OMA	WESFLEK.
OrthoDB	EOG4255T9.
Enzyme and pathway databases
BRENDA	2.8.2.1. 1154.
Family and domain databases
InterPro	IPR000863. Sulfotransferase_dom. [Graphical view]
Pfam	PF00685. Sulfotransfer_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20817384.

Entry information

Entry name

ST1A1_CANFA

Accession

Primary (citable) accession number: Q29476

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program