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Q29476 (ST1A1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfotransferase 1A1

Short name=ST1A1
EC=2.8.2.1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name=P-PST
Gene names
Name:SULT1A1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Catalytic activity

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Ubiquitously expressed in canine tissues with highest expression in male and female liver. Ref.2

Sequence similarities

Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
   Biological processCatecholamine metabolism
Lipid metabolism
Steroid metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcatecholamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

steroid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaryl sulfotransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

nucleotide binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Sulfotransferase 1A1
PRO_0000085126

Regions

Nucleotide binding48 – 536PAPS By similarity
Nucleotide binding227 – 2326PAPS By similarity
Nucleotide binding255 – 2595PAPS By similarity
Region106 – 1083Substrate binding By similarity

Sites

Active site1081Proton acceptor By similarity
Binding site1301PAPS By similarity
Binding site1381PAPS By similarity
Binding site1931PAPS By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29476 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C297A9211A5609B6

FASTA29534,115
        10         20         30         40         50         60 
MEDIPDTSRP PLKYVKGIPL IKYFAEALES LQDFQAQPDD LLISTYPKSG TTWVSEILDM 

        70         80         90        100        110        120 
IYQDGDVEKC RRAPVFIRVP FLEFKAPGIP TGLEVLKDTP APRLIKTHLP LALLPQTLLD 

       130        140        150        160        170        180 
QKVKVVYVAR NAKDVAVSYY HFYRMAKVHP DPDTWDSFLE KFMAGEVSYG SWYQHVQEWW 

       190        200        210        220        230        240 
ELSHTHPVLY LFYEDMKENP KREIQKILKF VGRSLPEETV DLIVQHTSFK EMKNNSMANY 

       250        260        270        280        290 
TTLSPDIMDH SISAFMRKGI SGDWKTTFTV AQNERFDADY AKKMEGCGLS FRTQL 

« Hide

References

[1]"Molecular cloning and sequencing of a dog liver cDNA (dPST-1) encoding a phenol sulfotransferase."
Satsukawa M., Ogura K., Nakamura T., Watabe T.
Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
Tissue: Liver.
[2]"Canine sulfotransferase SULT1A1: molecular cloning, expression, and characterization."
Tsoi C., Morgenstern R., Swedmark S.
Arch. Biochem. Biophys. 401:125-133(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D29807 mRNA. Translation: BAA06190.1.
AY069922 mRNA. Translation: AAL57717.1.
RefSeqNP_001003223.1. NM_001003223.1.
UniGeneCfa.70.

3D structure databases

ProteinModelPortalQ29476.
SMRQ29476. Positions 7-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000025221.

Proteomic databases

PaxDbQ29476.
PRIDEQ29476.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000027121; ENSCAFP00000025221; ENSCAFG00000017122.
ENSCAFT00000046198; ENSCAFP00000036703; ENSCAFG00000017122.
GeneID403892.
KEGGcfa:403892.

Organism-specific databases

CTD6817.

Phylogenomic databases

eggNOGNOG260792.
GeneTreeENSGT00740000115442.
HOGENOMHOG000037209.
HOVERGENHBG001195.
InParanoidQ29476.
KOK01014.
OMAIMDHAVS.
OrthoDBEOG7V49ZK.
TreeFamTF321745.

Enzyme and pathway databases

BRENDA2.8.2.1. 1154.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio20817384.

Entry information

Entry nameST1A1_CANFA
AccessionPrimary (citable) accession number: Q29476
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families