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Q29476

- ST1A1_CANFA

UniProt

Q29476 - ST1A1_CANFA

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Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Proton acceptorBy similarity
Binding sitei130 – 1301PAPSBy similarity
Binding sitei138 – 1381PAPSBy similarity
Binding sitei193 – 1931PAPSBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 536PAPSBy similarity
Nucleotide bindingi227 – 2326PAPSBy similarity
Nucleotide bindingi255 – 2595PAPSBy similarity

GO - Molecular functioni

  1. aryl sulfotransferase activity Source: UniProtKB-EC
  2. nucleotide binding Source: Ensembl

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Catecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1. 1154.
ReactomeiREACT_208906. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name:
P-PST
Gene namesi
Name:SULT1A1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 6

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Sulfotransferase 1A1PRO_0000085126Add
BLAST

Proteomic databases

PaxDbiQ29476.
PRIDEiQ29476.

Expressioni

Tissue specificityi

Ubiquitously expressed in canine tissues with highest expression in male and female liver.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000025221.

Structurei

3D structure databases

ProteinModelPortaliQ29476.
SMRiQ29476. Positions 7-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1083Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiNOG260792.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiQ29476.
KOiK01014.
OMAiWESFLEK.
OrthoDBiEOG7V49ZK.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29476-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDIPDTSRP PLKYVKGIPL IKYFAEALES LQDFQAQPDD LLISTYPKSG
60 70 80 90 100
TTWVSEILDM IYQDGDVEKC RRAPVFIRVP FLEFKAPGIP TGLEVLKDTP
110 120 130 140 150
APRLIKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYRMAKVHP
160 170 180 190 200
DPDTWDSFLE KFMAGEVSYG SWYQHVQEWW ELSHTHPVLY LFYEDMKENP
210 220 230 240 250
KREIQKILKF VGRSLPEETV DLIVQHTSFK EMKNNSMANY TTLSPDIMDH
260 270 280 290
SISAFMRKGI SGDWKTTFTV AQNERFDADY AKKMEGCGLS FRTQL
Length:295
Mass (Da):34,115
Last modified:November 1, 1996 - v1
Checksum:iC297A9211A5609B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29807 mRNA. Translation: BAA06190.1.
AY069922 mRNA. Translation: AAL57717.1.
RefSeqiNP_001003223.1. NM_001003223.1.
UniGeneiCfa.70.

Genome annotation databases

EnsembliENSCAFT00000027121; ENSCAFP00000025221; ENSCAFG00000017122.
ENSCAFT00000046198; ENSCAFP00000036703; ENSCAFG00000017122.
GeneIDi403892.
KEGGicfa:403892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29807 mRNA. Translation: BAA06190.1 .
AY069922 mRNA. Translation: AAL57717.1 .
RefSeqi NP_001003223.1. NM_001003223.1.
UniGenei Cfa.70.

3D structure databases

ProteinModelPortali Q29476.
SMRi Q29476. Positions 7-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000025221.

Proteomic databases

PaxDbi Q29476.
PRIDEi Q29476.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000027121 ; ENSCAFP00000025221 ; ENSCAFG00000017122 .
ENSCAFT00000046198 ; ENSCAFP00000036703 ; ENSCAFG00000017122 .
GeneIDi 403892.
KEGGi cfa:403892.

Organism-specific databases

CTDi 6817.

Phylogenomic databases

eggNOGi NOG260792.
GeneTreei ENSGT00760000118932.
HOGENOMi HOG000037209.
HOVERGENi HBG001195.
InParanoidi Q29476.
KOi K01014.
OMAi WESFLEK.
OrthoDBi EOG7V49ZK.
TreeFami TF321745.

Enzyme and pathway databases

BRENDAi 2.8.2.1. 1154.
Reactomei REACT_208906. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 20817384.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequencing of a dog liver cDNA (dPST-1) encoding a phenol sulfotransferase."
    Satsukawa M., Ogura K., Nakamura T., Watabe T.
    Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.
  2. "Canine sulfotransferase SULT1A1: molecular cloning, expression, and characterization."
    Tsoi C., Morgenstern R., Swedmark S.
    Arch. Biochem. Biophys. 401:125-133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Liver.

Entry informationi

Entry nameiST1A1_CANFA
AccessioniPrimary (citable) accession number: Q29476
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3