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Q29476

- ST1A1_CANFA

UniProt

Q29476 - ST1A1_CANFA

Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

    Catalytic activityi

    3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Proton acceptorBy similarity
    Binding sitei130 – 1301PAPSBy similarity
    Binding sitei138 – 1381PAPSBy similarity
    Binding sitei193 – 1931PAPSBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi48 – 536PAPSBy similarity
    Nucleotide bindingi227 – 2326PAPSBy similarity
    Nucleotide bindingi255 – 2595PAPSBy similarity

    GO - Molecular functioni

    1. aryl sulfotransferase activity Source: UniProtKB-EC
    2. nucleotide binding Source: Ensembl

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW
    2. steroid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Catecholamine metabolism, Lipid metabolism, Steroid metabolism

    Enzyme and pathway databases

    BRENDAi2.8.2.1. 1154.
    ReactomeiREACT_208906. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfotransferase 1A1 (EC:2.8.2.1)
    Short name:
    ST1A1
    Alternative name(s):
    Aryl sulfotransferase
    Phenol sulfotransferase
    Phenol-sulfating phenol sulfotransferase
    Short name:
    P-PST
    Gene namesi
    Name:SULT1A1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 6

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Sulfotransferase 1A1PRO_0000085126Add
    BLAST

    Proteomic databases

    PaxDbiQ29476.
    PRIDEiQ29476.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in canine tissues with highest expression in male and female liver.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000025221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29476.
    SMRiQ29476. Positions 7-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni106 – 1083Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the sulfotransferase 1 family.Curated

    Phylogenomic databases

    eggNOGiNOG260792.
    GeneTreeiENSGT00740000115442.
    HOGENOMiHOG000037209.
    HOVERGENiHBG001195.
    InParanoidiQ29476.
    KOiK01014.
    OMAiWESFLEK.
    OrthoDBiEOG7V49ZK.
    TreeFamiTF321745.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q29476-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDIPDTSRP PLKYVKGIPL IKYFAEALES LQDFQAQPDD LLISTYPKSG    50
    TTWVSEILDM IYQDGDVEKC RRAPVFIRVP FLEFKAPGIP TGLEVLKDTP 100
    APRLIKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYRMAKVHP 150
    DPDTWDSFLE KFMAGEVSYG SWYQHVQEWW ELSHTHPVLY LFYEDMKENP 200
    KREIQKILKF VGRSLPEETV DLIVQHTSFK EMKNNSMANY TTLSPDIMDH 250
    SISAFMRKGI SGDWKTTFTV AQNERFDADY AKKMEGCGLS FRTQL 295
    Length:295
    Mass (Da):34,115
    Last modified:November 1, 1996 - v1
    Checksum:iC297A9211A5609B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29807 mRNA. Translation: BAA06190.1.
    AY069922 mRNA. Translation: AAL57717.1.
    RefSeqiNP_001003223.1. NM_001003223.1.
    UniGeneiCfa.70.

    Genome annotation databases

    EnsembliENSCAFT00000027121; ENSCAFP00000025221; ENSCAFG00000017122.
    ENSCAFT00000046198; ENSCAFP00000036703; ENSCAFG00000017122.
    GeneIDi403892.
    KEGGicfa:403892.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29807 mRNA. Translation: BAA06190.1 .
    AY069922 mRNA. Translation: AAL57717.1 .
    RefSeqi NP_001003223.1. NM_001003223.1.
    UniGenei Cfa.70.

    3D structure databases

    ProteinModelPortali Q29476.
    SMRi Q29476. Positions 7-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000025221.

    Proteomic databases

    PaxDbi Q29476.
    PRIDEi Q29476.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000027121 ; ENSCAFP00000025221 ; ENSCAFG00000017122 .
    ENSCAFT00000046198 ; ENSCAFP00000036703 ; ENSCAFG00000017122 .
    GeneIDi 403892.
    KEGGi cfa:403892.

    Organism-specific databases

    CTDi 6817.

    Phylogenomic databases

    eggNOGi NOG260792.
    GeneTreei ENSGT00740000115442.
    HOGENOMi HOG000037209.
    HOVERGENi HBG001195.
    InParanoidi Q29476.
    KOi K01014.
    OMAi WESFLEK.
    OrthoDBi EOG7V49ZK.
    TreeFami TF321745.

    Enzyme and pathway databases

    BRENDAi 2.8.2.1. 1154.
    Reactomei REACT_208906. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 20817384.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of a dog liver cDNA (dPST-1) encoding a phenol sulfotransferase."
      Satsukawa M., Ogura K., Nakamura T., Watabe T.
      Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.
    2. "Canine sulfotransferase SULT1A1: molecular cloning, expression, and characterization."
      Tsoi C., Morgenstern R., Swedmark S.
      Arch. Biochem. Biophys. 401:125-133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
      Tissue: Liver.

    Entry informationi

    Entry nameiST1A1_CANFA
    AccessioniPrimary (citable) accession number: Q29476
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3