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Q29473 (CP2DF_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D15

EC=1.14.14.1
Alternative name(s):
CYPIID15
Cytochrome P450 DUT2
Gene names
Name:CYP2D15
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver. Also detected in several other tissues.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Cytochrome P450 2D15
PRO_0000051739

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29473 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: E7E352A01FABAED5

FASTA50056,432
        10         20         30         40         50         60 
MGLLTGDTLG PLAVAVAIFL LLVDLMHRRR RWATRYPPGP TPVPMVGNLL QMDFQEPICY 

        70         80         90        100        110        120 
FSQLQGRFGN VFSLELAWTP VVVLNGLEAV REALVHRSED TADRPPMPIY DHLGLGPESQ 

       130        140        150        160        170        180 
GLFLARYGRA WREQRRFSLS TLRNFGLGRK SLEQWVTEEA SCLCAAFAEQ AGRPFGPGAL 

       190        200        210        220        230        240 
LNKAVSNVIS SLTYGRRFEY DDPRLLQLLE LTQQALKQDS GFLREALNSI PVLLHIPGLA 

       250        260        270        280        290        300 
SKVFSAQKAI ITLTNEMIQE HRKTRDPTQP PRHLIDAFVD EIEKAKGNPK TSFNEENLCM 

       310        320        330        340        350        360 
VTSDLFIAGM VSTSITLTWA LLLMILHPDV QRRVQQEIDE VIGREQLPEM GDQTRMPFTV 

       370        380        390        400        410        420 
AVIHEVQRFG DIVPLGVPHM TSRDTEVQGF LIPKGTTLIT NLSSVLKDEK VWKKPFRFYP 

       430        440        450        460        470        480 
EHFLDAQGHF VKHEAFMPFS AGRRVCLGEP LARMELFLFF TCLLQRFSFS VPAGQPRPSD 

       490        500 
HGVFTFLKVP APFQLCVEPR 

« Hide

References

[1]"A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization."
Sakamoto K., Kirita S., Baba T., Nakamura Y., Yamazoe Y., Kato R., Takanaka A., Matsubara T.
Arch. Biochem. Biophys. 319:372-382(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Liver.
[2]"Expression and characterization of dog CYP2D15 using baculovirus expression system."
Tasaki T., Nakamura A., Itoh S., Ohashi K., Yamamoto Y., Masuda M., Iwata H., Kazusaka A., Kamataki T., Fujita S.
J. Biochem. 123:162-168(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
[3]"Expression and characterization of canine cytochrome P450 2D15."
Roussel F., Duignan D.B., Lawton M.P., Obach R.S., Strick C.A., Tweedie D.J.
Arch. Biochem. Biophys. 357:27-36(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D17397 mRNA. Translation: BAA04220.1.
AB004268 mRNA. Translation: BAA20357.1.
PIRJC4157.
RefSeqNP_001003333.1. NM_001003333.1.
UniGeneCfa.15290.

3D structure databases

ProteinModelPortalQ29473.
SMRQ29473. Positions 37-500.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1795137.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID415120.
KEGGcfa:415120.

Organism-specific databases

CTD415120.

Phylogenomic databases

HOVERGENHBG015789.
KOK07414.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818799.

Entry information

Entry nameCP2DF_CANFA
AccessionPrimary (citable) accession number: Q29473
Secondary accession number(s): O02859
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: December 11, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families