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Q29473

- CP2DF_CANFA

UniProt

Q29473 - CP2DF_CANFA

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Protein
Cytochrome P450 2D15
Gene
CYP2D15
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D15 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID15
    Cytochrome P450 DUT2
    Gene namesi
    Name:CYP2D15
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 2D15
    PRO_0000051739Add
    BLAST

    Expressioni

    Tissue specificityi

    Liver. Also detected in several other tissues.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29473.
    SMRiQ29473. Positions 37-500.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG015789.
    KOiK07414.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29473-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLTGDTLG PLAVAVAIFL LLVDLMHRRR RWATRYPPGP TPVPMVGNLL    50
    QMDFQEPICY FSQLQGRFGN VFSLELAWTP VVVLNGLEAV REALVHRSED 100
    TADRPPMPIY DHLGLGPESQ GLFLARYGRA WREQRRFSLS TLRNFGLGRK 150
    SLEQWVTEEA SCLCAAFAEQ AGRPFGPGAL LNKAVSNVIS SLTYGRRFEY 200
    DDPRLLQLLE LTQQALKQDS GFLREALNSI PVLLHIPGLA SKVFSAQKAI 250
    ITLTNEMIQE HRKTRDPTQP PRHLIDAFVD EIEKAKGNPK TSFNEENLCM 300
    VTSDLFIAGM VSTSITLTWA LLLMILHPDV QRRVQQEIDE VIGREQLPEM 350
    GDQTRMPFTV AVIHEVQRFG DIVPLGVPHM TSRDTEVQGF LIPKGTTLIT 400
    NLSSVLKDEK VWKKPFRFYP EHFLDAQGHF VKHEAFMPFS AGRRVCLGEP 450
    LARMELFLFF TCLLQRFSFS VPAGQPRPSD HGVFTFLKVP APFQLCVEPR 500
    Length:500
    Mass (Da):56,432
    Last modified:January 23, 2007 - v3
    Checksum:iE7E352A01FABAED5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17397 mRNA. Translation: BAA04220.1.
    AB004268 mRNA. Translation: BAA20357.1.
    PIRiJC4157.
    RefSeqiNP_001003333.1. NM_001003333.1.
    UniGeneiCfa.15290.

    Genome annotation databases

    GeneIDi415120.
    KEGGicfa:415120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17397 mRNA. Translation: BAA04220.1 .
    AB004268 mRNA. Translation: BAA20357.1 .
    PIRi JC4157.
    RefSeqi NP_001003333.1. NM_001003333.1.
    UniGenei Cfa.15290.

    3D structure databases

    ProteinModelPortali Q29473.
    SMRi Q29473. Positions 37-500.
    ModBasei Search...

    Chemistry

    ChEMBLi CHEMBL1795137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 415120.
    KEGGi cfa:415120.

    Organism-specific databases

    CTDi 415120.

    Phylogenomic databases

    HOVERGENi HBG015789.
    KOi K07414.

    Miscellaneous databases

    NextBioi 20818799.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization."
      Sakamoto K., Kirita S., Baba T., Nakamura Y., Yamazoe Y., Kato R., Takanaka A., Matsubara T.
      Arch. Biochem. Biophys. 319:372-382(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.
    2. "Expression and characterization of dog CYP2D15 using baculovirus expression system."
      Tasaki T., Nakamura A., Itoh S., Ohashi K., Yamamoto Y., Masuda M., Iwata H., Kazusaka A., Kamataki T., Fujita S.
      J. Biochem. 123:162-168(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
    3. Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiCP2DF_CANFA
    AccessioniPrimary (citable) accession number: Q29473
    Secondary accession number(s): O02859
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: July 9, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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