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Protein

Cytochrome P450 2D15

Gene

CYP2D15

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D15 (EC:1.14.14.1)
Alternative name(s):
CYPIID15
Cytochrome P450 DUT2
Gene namesi
Name:CYP2D15
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795137.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517391 – 500Cytochrome P450 2D15Add BLAST500

Expressioni

Tissue specificityi

Liver. Also detected in several other tissues.

Structurei

3D structure databases

ProteinModelPortaliQ29473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiQ29473.
KOiK07414.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLTGDTLG PLAVAVAIFL LLVDLMHRRR RWATRYPPGP TPVPMVGNLL
60 70 80 90 100
QMDFQEPICY FSQLQGRFGN VFSLELAWTP VVVLNGLEAV REALVHRSED
110 120 130 140 150
TADRPPMPIY DHLGLGPESQ GLFLARYGRA WREQRRFSLS TLRNFGLGRK
160 170 180 190 200
SLEQWVTEEA SCLCAAFAEQ AGRPFGPGAL LNKAVSNVIS SLTYGRRFEY
210 220 230 240 250
DDPRLLQLLE LTQQALKQDS GFLREALNSI PVLLHIPGLA SKVFSAQKAI
260 270 280 290 300
ITLTNEMIQE HRKTRDPTQP PRHLIDAFVD EIEKAKGNPK TSFNEENLCM
310 320 330 340 350
VTSDLFIAGM VSTSITLTWA LLLMILHPDV QRRVQQEIDE VIGREQLPEM
360 370 380 390 400
GDQTRMPFTV AVIHEVQRFG DIVPLGVPHM TSRDTEVQGF LIPKGTTLIT
410 420 430 440 450
NLSSVLKDEK VWKKPFRFYP EHFLDAQGHF VKHEAFMPFS AGRRVCLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPAGQPRPSD HGVFTFLKVP APFQLCVEPR
Length:500
Mass (Da):56,432
Last modified:January 23, 2007 - v3
Checksum:iE7E352A01FABAED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17397 mRNA. Translation: BAA04220.1.
AB004268 mRNA. Translation: BAA20357.1.
PIRiJC4157.
RefSeqiNP_001003333.1. NM_001003333.1.
UniGeneiCfa.15290.

Genome annotation databases

GeneIDi415120.
KEGGicfa:415120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17397 mRNA. Translation: BAA04220.1.
AB004268 mRNA. Translation: BAA20357.1.
PIRiJC4157.
RefSeqiNP_001003333.1. NM_001003333.1.
UniGeneiCfa.15290.

3D structure databases

ProteinModelPortaliQ29473.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1795137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415120.
KEGGicfa:415120.

Organism-specific databases

CTDi415120.

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiQ29473.
KOiK07414.

Miscellaneous databases

PROiQ29473.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2DF_CANLF
AccessioniPrimary (citable) accession number: Q29473
Secondary accession number(s): O02859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.