ID   I5P1_CANFA              Reviewed;         412 AA.
AC   Q29467;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Type I inositol-1,4,5-trisphosphate 5-phosphatase;
DE            Short=5PTase;
DE            EC=3.1.3.56;
GN   Name=INPP5A;
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thyroid;
RX   MEDLINE=94256960; PubMed=8198557;
RA   Verjans B., de Smedt F., Lecocq R., Vanweyenberg V., Moreau C.,
RA   Erneux C.;
RT   "Cloning and expression in Escherichia coli of a dog thyroid cDNA
RT   encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase.";
RL   Biochem. J. 300:85-90(1994).
CC   -!- FUNCTION: Major isoenzyme hydrolyzing the calcium-mobilizing
CC       second messenger Ins(1,4,5)P3, this is a signal-terminating
CC       reaction.
CC   -!- CATALYTIC ACTIVITY: D-myo-inositol 1,4,5-trisphosphate + H(2)O =
CC       myo-inositol 1,4-bisphosphate + phosphate.
CC   -!- CATALYTIC ACTIVITY: 1D-myo-inositol 1,3,4,5-tetrakisphosphate +
CC       H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
CC   -!- SIMILARITY: Belongs to the inositol-1,4,5-trisphosphate 5-
CC       phosphatase type I family.
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DR   EMBL; X75094; CAA52985.1; -; mRNA.
DR   PIR; S44357; S44357.
DR   RefSeq; NP_001003257.1; -.
DR   UniGene; Cfa.3798; -.
DR   Ensembl; ENSCAFG00000011136; Canis familiaris.
DR   GeneID; 403937; -.
DR   KEGG; cfa:403937; -.
DR   HOVERGEN; Q29467; -.
DR   BRENDA; 3.1.3.56; 463.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000300; IPPc.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SMART; SM00128; IPPc; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Lipoprotein; Membrane; Prenylation.
FT   CHAIN         1    412       Type I inositol-1,4,5-trisphosphate 5-
FT                                phosphatase.
FT                                /FTId=PRO_0000209718.
FT   LIPID       409    409       S-farnesyl cysteine (Potential).
SQ   SEQUENCE   412 AA;  47683 MW;  5FC100C4E135D545 CRC64;
     MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN
     YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENFKSQEH FTALGSFYFL HESLKNIYQF
     DFKAKKYKKV TGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFVRTR WCVADCAFDL
     VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK
     SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFHYFN QEVFRDNNGT
     ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDSGQGRQYM NTRCPAWCDR VLMSPSAREL
     ILKSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIAPGAGK PHAHVHKCCV VQ
//